{"id":"https://openalex.org/W636071358","doi":null,"title":"BIOCHEMICAL INVESTIGATION INTO INITIATION OF FATTY ACID SYNTHESIS IN THE AFRICAN TRYPANOSOMES","display_name":"BIOCHEMICAL INVESTIGATION INTO INITIATION OF FATTY ACID SYNTHESIS IN THE AFRICAN TRYPANOSOMES","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W636071358","mag":"636071358"},"language":"en","primary_location":{"id":"pmh:oai:open.clemson.edu:all_dissertations-2193","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/1193","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086047246","display_name":"Sunayan S. Ray","orcid":"https://orcid.org/0000-0003-4260-8092","observed_orcids":["https://orcid.org/0000-0003-4260-8092"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sunayan S. Ray","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4260-8092","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086047246"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.20399999618530273,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9570000171661377},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9509999752044678},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.8709999918937683},{"id":"https://openalex.org/keywords/trypanosomiasis","display_name":"trypanosomiasis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/african-trypanosomes","display_name":"African trypanosomes","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.7601004838943481},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6526268124580383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5645695328712463},{"id":"https://openalex.org/C2776941171","wikidata":"https://www.wikidata.org/wiki/Q900209","display_name":"Fatty acid synthesis","level":3,"score":0.4367789924144745},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.42496517300605774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4223371148109436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3502891957759857},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.345512330532074},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2695557475090027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13200852274894714}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:open.clemson.edu:all_dissertations-2193","doi":null,"is_oa":false,"landing_page_url":"https://open.clemson.edu/all_dissertations/1193","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"pmh:oai:tigerprints.clemson.edu:all_dissertations-2193","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/cgi/viewcontent.cgi?article=2193&context=all_dissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196397","display_name":"TigerPrints (Clemson University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I8078737","host_organization_name":"Clemson University","host_organization_lineage":["https://openalex.org/I8078737"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"All Dissertations","raw_type":"text"},{"id":"mag:636071358","doi":null,"is_oa":false,"landing_page_url":"https://tigerprints.clemson.edu/all_dissertations/1193/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W13450615","https://openalex.org/W70595557","https://openalex.org/W125599112","https://openalex.org/W145861983","https://openalex.org/W993608645","https://openalex.org/W1493962880","https://openalex.org/W1495185153","https://openalex.org/W1857221469","https://openalex.org/W1889619561","https://openalex.org/W1939117002","https://openalex.org/W1966517854","https://openalex.org/W1968069269","https://openalex.org/W1969826464","https://openalex.org/W1971416505","https://openalex.org/W1975755717","https://openalex.org/W1975955075","https://openalex.org/W1977827476","https://openalex.org/W1977967386","https://openalex.org/W1978423834","https://openalex.org/W1979824753","https://openalex.org/W1989964995","https://openalex.org/W1990876232","https://openalex.org/W1992371135","https://openalex.org/W1995867836","https://openalex.org/W1996810555","https://openalex.org/W1997470658","https://openalex.org/W1999034430","https://openalex.org/W2000949759","https://openalex.org/W2002086112","https://openalex.org/W2002744790","https://openalex.org/W2003153226","https://openalex.org/W2003805328","https://openalex.org/W2009983406","https://openalex.org/W2011183594","https://openalex.org/W2011624740","https://openalex.org/W2020016897","https://openalex.org/W2023893231","https://openalex.org/W2024864454","https://openalex.org/W2025277548","https://openalex.org/W2028356785","https://openalex.org/W2029360079","https://openalex.org/W2029875505","https://openalex.org/W2034413541","https://openalex.org/W2036975087","https://openalex.org/W2043940430","https://openalex.org/W2049454720","https://openalex.org/W2052347239","https://openalex.org/W2053868390","https://openalex.org/W2056122422","https://openalex.org/W2061725130","https://openalex.org/W2061980259","https://openalex.org/W2064921878","https://openalex.org/W2064982906","https://openalex.org/W2065092551","https://openalex.org/W2065099482","https://openalex.org/W2071561398","https://openalex.org/W2074050302","https://openalex.org/W2078314383","https://openalex.org/W2085823346","https://openalex.org/W2086546138","https://openalex.org/W2087452610","https://openalex.org/W2087714970","https://openalex.org/W2087877223","https://openalex.org/W2091131014","https://openalex.org/W2094976414","https://openalex.org/W2100310514","https://openalex.org/W2100526533","https://openalex.org/W2106986625","https://openalex.org/W2107673483","https://openalex.org/W2111565312","https://openalex.org/W2111851472","https://openalex.org/W2120499084","https://openalex.org/W2123139638","https://openalex.org/W2123954892","https://openalex.org/W2124056180","https://openalex.org/W2124425948","https://openalex.org/W2127101467","https://openalex.org/W2130071037","https://openalex.org/W2135785702","https://openalex.org/W2144495216","https://openalex.org/W2146723716","https://openalex.org/W2148042269","https://openalex.org/W2150046668","https://openalex.org/W2151877638","https://openalex.org/W2152835156","https://openalex.org/W2155322793","https://openalex.org/W2155771090","https://openalex.org/W2156747505","https://openalex.org/W2157193327","https://openalex.org/W2157236463","https://openalex.org/W2157974457","https://openalex.org/W2160134374","https://openalex.org/W2169952400","https://openalex.org/W2222407951","https://openalex.org/W2394556440"],"related_works":["https://openalex.org/W4225426141","https://openalex.org/W3167706073","https://openalex.org/W1992371135","https://openalex.org/W796143015","https://openalex.org/W6981791453","https://openalex.org/W2873437360","https://openalex.org/W1523163054","https://openalex.org/W105412879","https://openalex.org/W3175003782","https://openalex.org/W1495185153"],"abstract_inverted_index":{"My":[0],"doctoral":[1],"studies":[2,182],"focused":[3],"on":[4,138,150,187],"studying":[5],"FA":[6,36,196],"metabolism":[7],"in":[8,35,48,56,62,70,91,112,129,163,205,212,220],"the":[9,25,31,39,79,98,107,134,146,156,188,199,206,221],"deadly":[10,210],"protozoan":[11],"parasite":[12,211],"T.":[13,191],"brucei.":[14],"In":[15,38,97,155],"my":[16],"dissertation,":[17],"I":[18,42,53,76,159,172],"will":[19],"be":[20,218],"addressing":[21],"various":[22,169],"aspects":[23],"of":[24,27,67,109,124,136,148,190,208],"regulation":[26],"TbACC,":[28],"which":[29,82,101,126],"catalyzes":[30],"first":[32],"committed":[33],"step":[34],"synthesis.":[37],"second":[40],"chapter,":[41,100,158],"hypothesized":[43],"that":[44,161,175],"TbACC":[45,57,83,151,162,176],"is":[46,87,165],"regulated":[47,88,167],"response":[49,63,92],"to":[50,64,93,193,223],"environmental":[51,68],"lipids.":[52],"examined":[54,145],"changes":[55],"RNA,":[58],"protein,":[59],"and":[60,73,85,140,153,198],"activity":[61,86,152],"different":[65],"levels":[66],"lipids":[69],"both":[71],"BF":[72,139],"PF":[74,141,164],"cells.":[75],"also":[77,144,166,173],"delineated":[78],"mechanisms":[80],"by":[81,89,168],"expression":[84],"phosphorylation":[90],"altered":[94],"lipid":[95],"environments.":[96],"third":[99],"has":[102],"been":[103],"published,":[104],"we":[105],"tested":[106,133],"effects":[108],"a":[110,121,225],"compound":[111],"green":[113],"tea":[114],"extract":[115],"known":[116,122],"as":[117],"epigallocatechin":[118],"gallate":[119],"(EGCG),":[120],"inducer":[123],"AMPK,":[125],"phosphorylates":[127],"ACC":[128],"other":[130],"organisms.":[131],"We":[132,143],"effect":[135,147],"EGCG":[137,149],"growth.":[142],"phosphorylation.":[154],"fourth":[157],"demonstrated":[160],"allosteric":[170],"regulators.":[171],"showed":[174],"might":[177],"form":[178],"oligomers.":[179],"Together":[180],"these":[181],"have":[183],"given":[184],"an":[185],"insight":[186],"ability":[189],"brucei":[192],"regulate":[194],"its":[195,213],"synthesis":[197],"role":[200],"this":[201,209],"pathway":[202],"may":[203,217],"play":[204],"survival":[207],"hosts.":[214],"This":[215],"knowledge":[216],"exploited":[219],"future":[222],"find":[224],"better":[226],"cure":[227],"for":[228],"Trypanosomiasis.":[229]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
