{"id":"https://openalex.org/W635798655","doi":null,"title":"Control of epileptic seizures by the basal ganglia: clinical and experimental approaches","display_name":"Control of epileptic seizures by the basal ganglia: clinical and experimental approaches","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W635798655","mag":"635798655"},"language":"en","primary_location":{"id":"mag:2234941506","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00413972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00413972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110088513","display_name":"Berend Feddersen","orcid":"https://orcid.org/0000-0002-4172-2232","observed_orcids":["https://orcid.org/0000-0002-4172-2232"]},"institutions":[{"id":"https://openalex.org/I4210151160","display_name":"Grenoble Institute of Neurosciences","ror":"https://ror.org/04as3rk94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I4210151160","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B Feddersen","raw_affiliation_strings":["Grenoble Institut des Neurosciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grenoble Institut des Neurosciences","institution_ids":["https://openalex.org/I4210151160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110088513"],"corresponding_institution_ids":["https://openalex.org/I4210151160"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.11699999868869781,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.996999979019165},{"id":"https://openalex.org/keywords/substantia-nigra-pars-reticulata","display_name":"substantia nigra pars reticulata","score":0.9399999976158142},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/absence-epilepsy","display_name":"absence epilepsy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/seizure-propagation","display_name":"seizure propagation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/secondary-generalization","display_name":"secondary generalization","score":0.765999972820282},{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/seizure-onset-detection","display_name":"seizure onset detection","score":0.5149999856948853},{"id":"https://openalex.org/keywords/eeg-coherence","display_name":"EEG coherence","score":0.9509999752044678},{"id":"https://openalex.org/keywords/closed-loop-stimulation","display_name":"closed-loop stimulation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antiepileptic-drug-resistance","display_name":"antiepileptic drug resistance","score":0.7419999837875366},{"id":"https://openalex.org/keywords/seizure-suppression","display_name":"seizure suppression","score":0.41100001335144043},{"id":"https://openalex.org/keywords/stimulation-parameters","display_name":"stimulation parameters","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bipolar-stimulation","display_name":"bipolar stimulation","score":0.4090000092983246},{"id":"https://openalex.org/keywords/high-frequency-stimulation","display_name":"high-frequency stimulation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6846631765365601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6114256978034973}],"mesh":[],"locations_count":3,"locations":[{"id":"mag:2234941506","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00413972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:HAL:tel-00413972v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00413972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurons and Cognition [q-bio.NC]. Universit\u00e9 Joseph-Fourier - Grenoble I, 2009. English. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:635798655","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2009GRE10111","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"mag:2234941506","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00413972","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":449,"referenced_works":["https://openalex.org/W13425038","https://openalex.org/W73737722","https://openalex.org/W79076903","https://openalex.org/W87052936","https://openalex.org/W94104510","https://openalex.org/W97163389","https://openalex.org/W110438660","https://openalex.org/W110975777","https://openalex.org/W158081179","https://openalex.org/W189844531","https://openalex.org/W196026329","https://openalex.org/W587635596","https://openalex.org/W605830443","https://openalex.org/W634350609","https://openalex.org/W971185581","https://openalex.org/W1479790262","https://openalex.org/W1487443352","https://openalex.org/W1496224101","https://openalex.org/W1502549816","https://openalex.org/W1505171539","https://openalex.org/W1509015817","https://openalex.org/W1510581503","https://openalex.org/W1523290851","https://openalex.org/W1524241920","https://openalex.org/W1545396860","https://openalex.org/W1553486550","https://openalex.org/W1558419262","https://openalex.org/W1562087774","https://openalex.org/W1571175443","https://openalex.org/W1585240869","https://openalex.org/W1587094587","https://openalex.org/W1588053646","https://openalex.org/W1601087798","https://openalex.org/W1607171655","https://openalex.org/W1626618769","https://openalex.org/W1735118772","https://openalex.org/W1769572743","https://openalex.org/W1809188141","https://openalex.org/W1822120225","https://openalex.org/W1851361558","https://openalex.org/W1860410442","https://openalex.org/W1886118302","https://openalex.org/W1893200196","https://openalex.org/W1921718891","https://openalex.org/W1932392058","https://openalex.org/W1938089779","https://openalex.org/W1944949697","https://openalex.org/W1964349101","https://openalex.org/W1964509600","https://openalex.org/W1965270310","https://openalex.org/W1965584252","https://openalex.org/W1965726662","https://openalex.org/W1965965316","https://openalex.org/W1966617461","https://openalex.org/W1966907340","https://openalex.org/W1967152978","https://openalex.org/W1967344009","https://openalex.org/W1971250530","https://openalex.org/W1971266900","https://openalex.org/W1971369569","https://openalex.org/W1971471010","https://openalex.org/W1971683300","https://openalex.org/W1972435223","https://openalex.org/W1972474164","https://openalex.org/W1973028756","https://openalex.org/W1974228896","https://openalex.org/W1974809694","https://openalex.org/W1974813897","https://openalex.org/W1975011346","https://openalex.org/W1975914042","https://openalex.org/W1976075516","https://openalex.org/W1976117761","https://openalex.org/W1976446154","https://openalex.org/W1977172001","https://openalex.org/W1977221546","https://openalex.org/W1977261687","https://openalex.org/W1977696445","https://openalex.org/W1977737539","https://openalex.org/W1977885381","https://openalex.org/W1979047980","https://openalex.org/W1979219463","https://openalex.org/W1979670846","https://openalex.org/W1979819271","https://openalex.org/W1979892327","https://openalex.org/W1979971214","https://openalex.org/W1980734822","https://openalex.org/W1980896402","https://openalex.org/W1982223745","https://openalex.org/W1983062533","https://openalex.org/W1984322553","https://openalex.org/W1984324505","https://openalex.org/W1984446252","https://openalex.org/W1984471283","https://openalex.org/W1984694895","https://openalex.org/W1985094165","https://openalex.org/W1985097491","https://openalex.org/W1985146875","https://openalex.org/W1985460051","https://openalex.org/W1986188909","https://openalex.org/W1986518373","https://openalex.org/W1987024745","https://openalex.org/W1987911844","https://openalex.org/W1988202396","https://openalex.org/W1988402979","https://openalex.org/W1988485414","https://openalex.org/W1989017031","https://openalex.org/W1989189053","https://openalex.org/W1989613108","https://openalex.org/W1990370606","https://openalex.org/W1990470247","https://openalex.org/W1990488728","https://openalex.org/W1991336180","https://openalex.org/W1992328374","https://openalex.org/W1992425391","https://openalex.org/W1992767102","https://openalex.org/W1992997151","https://openalex.org/W1993113754","https://openalex.org/W1993407150","https://openalex.org/W1993580946","https://openalex.org/W1993682442","https://openalex.org/W1994067708","https://openalex.org/W1994568892","https://openalex.org/W1994951309","https://openalex.org/W1995232709","https://openalex.org/W1995492219","https://openalex.org/W1995908151","https://openalex.org/W1997078684","https://openalex.org/W1997635536","https://openalex.org/W1997919216","https://openalex.org/W1998353450","https://openalex.org/W1999545273","https://openalex.org/W2001115339","https://openalex.org/W2002467817","https://openalex.org/W2002471302","https://openalex.org/W2002859264","https://openalex.org/W2003411364","https://openalex.org/W2003710403","https://openalex.org/W2004538941","https://openalex.org/W2005112198","https://openalex.org/W2005269174","https://openalex.org/W2005366709","https://openalex.org/W2005695716","https://openalex.org/W2005762229","https://openalex.org/W2006120343","https://openalex.org/W2006484399","https://openalex.org/W2007332549","https://openalex.org/W2007598165","https://openalex.org/W2007781589","https://openalex.org/W2007965380","https://openalex.org/W2008474726","https://openalex.org/W2009918786","https://openalex.org/W2010462985","https://openalex.org/W2011289638","https://openalex.org/W2011527367","https://openalex.org/W2012126908","https://openalex.org/W2012386455","https://openalex.org/W2012499677","https://openalex.org/W2013468174","https://openalex.org/W2013511059","https://openalex.org/W2013695267","https://openalex.org/W2013995983","https://openalex.org/W2014117691","https://openalex.org/W2014367829","https://openalex.org/W2016037805","https://openalex.org/W2016463930","https://openalex.org/W2017288974","https://openalex.org/W2017403397","https://openalex.org/W2017549188","https://openalex.org/W2018928715","https://openalex.org/W2019418767","https://openalex.org/W2019749368","https://openalex.org/W2020994423","https://openalex.org/W2021243100","https://openalex.org/W2021273944","https://openalex.org/W2021356296","https://openalex.org/W2022888014","https://openalex.org/W2022907828","https://openalex.org/W2023642970","https://openalex.org/W2024124362","https://openalex.org/W2024963127","https://openalex.org/W2024985045","https://openalex.org/W2025629036","https://openalex.org/W2025890033","https://openalex.org/W2026054275","https://openalex.org/W2027129354","https://openalex.org/W2027598649","https://openalex.org/W2027740558","https://openalex.org/W2027970152","https://openalex.org/W2028068151","https://openalex.org/W2028466298","https://openalex.org/W2028681020","https://openalex.org/W2029046897","https://openalex.org/W2029092021","https://openalex.org/W2029445248","https://openalex.org/W2029625022","https://openalex.org/W2030183678","https://openalex.org/W2031170958","https://openalex.org/W2032576068","https://openalex.org/W2032763785","https://openalex.org/W2032974045","https://openalex.org/W2033884252","https://openalex.org/W2033910757","https://openalex.org/W2034052169","https://openalex.org/W2034471764","https://openalex.org/W2034753893","https://openalex.org/W2034952028","https://openalex.org/W2035401777","https://openalex.org/W2035541773","https://openalex.org/W2035779117","https://openalex.org/W2035998176","https://openalex.org/W2036189539","https://openalex.org/W2036905446","https://openalex.org/W2037210235","https://openalex.org/W2037388851","https://openalex.org/W2037608973","https://openalex.org/W2037746973","https://openalex.org/W2037872004","https://openalex.org/W2037997999","https://openalex.org/W2038484009","https://openalex.org/W2039098979","https://openalex.org/W2039673011","https://openalex.org/W2040076525","https://openalex.org/W2040208805","https://openalex.org/W2040213858","https://openalex.org/W2040801939","https://openalex.org/W2042577734","https://openalex.org/W2042610891","https://openalex.org/W2042983737","https://openalex.org/W2043479178","https://openalex.org/W2044143697","https://openalex.org/W2044192677","https://openalex.org/W2046687782","https://openalex.org/W2048424859","https://openalex.org/W2048440475","https://openalex.org/W2049758098","https://openalex.org/W2049800034","https://openalex.org/W2050409620","https://openalex.org/W2050580600","https://openalex.org/W2050866724","https://openalex.org/W2051703153","https://openalex.org/W2052247517","https://openalex.org/W2052329772","https://openalex.org/W2052849256","https://openalex.org/W2052942819","https://openalex.org/W2052990681","https://openalex.org/W2053258270","https://openalex.org/W2053432769","https://openalex.org/W2053779019","https://openalex.org/W2054806127","https://openalex.org/W2055404631","https://openalex.org/W2055951674","https://openalex.org/W2056344069","https://openalex.org/W2056501144","https://openalex.org/W2056710691","https://openalex.org/W2057217520","https://openalex.org/W2059003107","https://openalex.org/W2059281868","https://openalex.org/W2059540959","https://openalex.org/W2060146172","https://openalex.org/W2060314229","https://openalex.org/W2060441889","https://openalex.org/W2060588252","https://openalex.org/W2060649966","https://openalex.org/W2061257628","https://openalex.org/W2061522482","https://openalex.org/W2062112379","https://openalex.org/W2063464796","https://openalex.org/W2064180388","https://openalex.org/W2064424149","https://openalex.org/W2064990442","https://openalex.org/W2065260015","https://openalex.org/W2065263269","https://openalex.org/W2065653411","https://openalex.org/W2065723600","https://openalex.org/W2066161608","https://openalex.org/W2066211612","https://openalex.org/W2066575542","https://openalex.org/W2067219685","https://openalex.org/W2067970991","https://openalex.org/W2068047137","https://openalex.org/W2069543630","https://openalex.org/W2070034033","https://openalex.org/W2070962050","https://openalex.org/W2071280486","https://openalex.org/W2071403564","https://openalex.org/W2071627776","https://openalex.org/W2071926957","https://openalex.org/W2072210345","https://openalex.org/W2072517098","https://openalex.org/W2072779402","https://openalex.org/W2073434986","https://openalex.org/W2073838518","https://openalex.org/W2074901227","https://openalex.org/W2075526633","https://openalex.org/W2075913367","https://openalex.org/W2077198764","https://openalex.org/W2077658432","https://openalex.org/W2078014777","https://openalex.org/W2078222721","https://openalex.org/W2078759460","https://openalex.org/W2078872477","https://openalex.org/W2079514156","https://openalex.org/W2079581471","https://openalex.org/W2081507220","https://openalex.org/W2082281443","https://openalex.org/W2082404901","https://openalex.org/W2083244753","https://openalex.org/W2083479233","https://openalex.org/W2083932518","https://openalex.org/W2084139065","https://openalex.org/W2084462975","https://openalex.org/W2084676793","https://openalex.org/W2084824093","https://openalex.org/W2084922577","https://openalex.org/W2086573043","https://openalex.org/W2086712277","https://openalex.org/W2086752457","https://openalex.org/W2087096064","https://openalex.org/W2087217890","https://openalex.org/W2087901757","https://openalex.org/W2088139873","https://openalex.org/W2088222765","https://openalex.org/W2088743657","https://openalex.org/W2089513832","https://openalex.org/W2091474479","https://openalex.org/W2091552689","https://openalex.org/W2093599464","https://openalex.org/W2094500750","https://openalex.org/W2094586045","https://openalex.org/W2095143979","https://openalex.org/W2096401332","https://openalex.org/W2097549023","https://openalex.org/W2098571961","https://openalex.org/W2099166619","https://openalex.org/W2099652807","https://openalex.org/W2100942964","https://openalex.org/W2102430048","https://openalex.org/W2103178226","https://openalex.org/W2103596611","https://openalex.org/W2104863543","https://openalex.org/W2105885719","https://openalex.org/W2106532696","https://openalex.org/W2106728217","https://openalex.org/W2107165214","https://openalex.org/W2107184087","https://openalex.org/W2107647020","https://openalex.org/W2107974789","https://openalex.org/W2108442080","https://openalex.org/W2110170311","https://openalex.org/W2110306569","https://openalex.org/W2110661716","https://openalex.org/W2111003378","https://openalex.org/W2112682198","https://openalex.org/W2113078968","https://openalex.org/W2113092926","https://openalex.org/W2113407406","https://openalex.org/W2114311601","https://openalex.org/W2114622428","https://openalex.org/W2115414869","https://openalex.org/W2116575348","https://openalex.org/W2116686895","https://openalex.org/W2119148931","https://openalex.org/W2120357670","https://openalex.org/W2121480308","https://openalex.org/W2122239141","https://openalex.org/W2123040621","https://openalex.org/W2123843070","https://openalex.org/W2124690680","https://openalex.org/W2126488639","https://openalex.org/W2126937607","https://openalex.org/W2127729116","https://openalex.org/W2129393918","https://openalex.org/W2129442763","https://openalex.org/W2129750349","https://openalex.org/W2130227826","https://openalex.org/W2130890266","https://openalex.org/W2132239918","https://openalex.org/W2133396463","https://openalex.org/W2134193208","https://openalex.org/W2134686712","https://openalex.org/W2140651812","https://openalex.org/W2140684369","https://openalex.org/W2141269860","https://openalex.org/W2141469601","https://openalex.org/W2142268315","https://openalex.org/W2143817103","https://openalex.org/W2144096853","https://openalex.org/W2148683493","https://openalex.org/W2149223331","https://openalex.org/W2152449109","https://openalex.org/W2153253611","https://openalex.org/W2153552370","https://openalex.org/W2153787766","https://openalex.org/W2153979783","https://openalex.org/W2155503913","https://openalex.org/W2156503695","https://openalex.org/W2156969532","https://openalex.org/W2160587950","https://openalex.org/W2161214826","https://openalex.org/W2161353647","https://openalex.org/W2163815564","https://openalex.org/W2164172082","https://openalex.org/W2167758534","https://openalex.org/W2167835965","https://openalex.org/W2169207893","https://openalex.org/W2169815799","https://openalex.org/W2170461188","https://openalex.org/W2170552040","https://openalex.org/W2185218987","https://openalex.org/W2200353029","https://openalex.org/W2237028671","https://openalex.org/W2246319695","https://openalex.org/W2265943157","https://openalex.org/W2275823602","https://openalex.org/W2302617493","https://openalex.org/W2317495993","https://openalex.org/W2320849562","https://openalex.org/W2327016378","https://openalex.org/W2328435466","https://openalex.org/W2331306807","https://openalex.org/W2335974296","https://openalex.org/W2394981991","https://openalex.org/W2403115942","https://openalex.org/W2404726145","https://openalex.org/W2406951786","https://openalex.org/W2408889052","https://openalex.org/W2410227703","https://openalex.org/W2412793778","https://openalex.org/W2413874424","https://openalex.org/W2418192796","https://openalex.org/W2427757993","https://openalex.org/W2435974579","https://openalex.org/W2461887561","https://openalex.org/W2468920169","https://openalex.org/W2470355469","https://openalex.org/W2500140139","https://openalex.org/W2531896427","https://openalex.org/W2625768766","https://openalex.org/W2744453576","https://openalex.org/W2748435152","https://openalex.org/W2899211783","https://openalex.org/W2911423155","https://openalex.org/W2916046214","https://openalex.org/W2922111843","https://openalex.org/W3024123175","https://openalex.org/W3027356717","https://openalex.org/W3133772728","https://openalex.org/W3197596407","https://openalex.org/W4393219467"],"related_works":["https://openalex.org/W79124547","https://openalex.org/W1895101658","https://openalex.org/W7100636187","https://openalex.org/W6979729038","https://openalex.org/W2234941506","https://openalex.org/W434660377","https://openalex.org/W2110306569","https://openalex.org/W4223912054","https://openalex.org/W769899237","https://openalex.org/W597308321"],"abstract_inverted_index":{"As":[0],"about":[1],"one":[2],"third":[3],"of":[4,15,30,56,70,80,97,104,126,153,181,200,212,248,251,257,274,297,327,363,387],"epileptic":[5,76,159,403],"patients":[6,88,436],"are":[7,17,51,171,286,382,426,438],"resistant":[8],"to":[9,157,173,186,192,266,280,301,359,384,415],"antiepileptic":[10],"drugs,":[11],"and":[12,45,229,245,288,338,379,389,440],"only":[13,315],"30%":[14],"them":[16],"candidates":[18,442],"for":[19,27,136,239,352,435,443],"resective":[20,445],"surgery,":[21],"it":[22,369],"exists":[23],"a":[24,133,197,324,412,419,444],"great":[25],"demand":[26],"the":[28,42,47,54,68,71,84,95,105,121,154,175,188,204,209,249,275,295,320,333,336,361,364,385,416],"development":[29],"alternative":[31],"surgical":[32,446],"therapies.":[33],"It":[34],"has":[35],"been":[36],"shown":[37],"in":[38,53,74,87,129,164,196,203,305,332,375,395],"animal":[39,397],"studies,":[40],"that":[41,102,408,423],"basal":[43,72,85,106,155],"ganglia":[44,73,86,107,156],"especially":[46],"substantia":[48,214],"nigra":[49,215],"(SN)":[50],"involved":[52],"control":[55,193],"epilepsy.":[57],"Clinical":[58],"evidence,":[59],"using":[60],"either":[61],"electrophysiological":[62],"or":[63,399],"imaging":[64],"approaches,":[65],"also":[66,394,427],"supports":[67],"involvement":[69],"some":[75,165],"syndromes.":[77,404],"The":[78,124,179],"influence":[79],"seizure":[81,115,321,420],"spread":[82,119],"into":[83,120],"with":[89,110,401],"focal":[90],"epilepsies":[91],"was":[92,108,185,253,262],"investigated":[93],"on":[94,114],"rate":[96],"secondary":[98],"generalization.":[99],"We":[100],"showed":[101,161],"activation":[103],"associated":[109],"an":[111,309,350],"inhibitory":[112,127],"effect":[113],"propagation,":[116],"when":[117,316],"seizures":[118,195,252,304],"frontal":[122],"lobe.":[123],"elucidation":[125],"mechanisms":[128],"epilepsy":[130,202,329,409],"may":[131],"open":[132,146,431],"new":[134,432],"approach":[135,184],"therapeutic":[137,433],"strategies":[138],"such":[139,330,373,391],"as":[140,222,349,418],"electrical":[141],"deep":[142,150],"brain":[143,151],"stimulation.":[144],"First":[145],"case":[147],"series,":[148],"investigating":[149],"stimulation":[152,177,190,219,273,285,299,358],"suppress":[158,281,303],"seizures,":[160,283,292],"encouraging":[162],"results":[163],"patients.":[166],"However,":[167],"more":[168],"preclinical":[169],"studies":[170],"mandatory":[172],"investigate":[174],"optimal":[176,189,210],"parameters.":[178],"aim":[180],"our":[182],"experimental":[183],"determine":[187],"parameters":[191,211,236],"spontaneous":[194],"genetic":[198,325],"model":[199,326,386],"absence":[201,328],"rat.":[205],"In":[206,323],"this":[207],"model,":[208],"single":[213,271,357],"pars":[216],"reticulata":[217],"(SNr)":[218],"were":[220,237],"determined":[221],"bilateral,":[223],"bipolar,":[224],"monophasic,":[225],"60":[226,230,260],"Hz":[227],"frequency":[228],"\u00b5s":[231],"pulse":[232],"width.":[233],"When":[234],"these":[235],"used":[238,279,348],"repeated":[240,284],"stimulations,":[241],"no":[242,441],"long-term":[243],"suppression":[244],"even":[246,290],"increase":[247],"number":[250],"observed.":[254],"A":[255],"delay":[256],"at":[258],"least":[259],"sec":[261],"necessary":[263],"between":[264,335,377],"stimulations":[265],"be":[267,278,313,342,347],"fully":[268],"effective.":[269],"Although":[270],"high-frequency":[272],"SNr":[276,340],"can":[277],"ongoing":[282],"ineffective":[287],"could":[289,341],"aggravate":[291],"thus":[293],"supporting":[294],"need":[296],"closed-loop":[298],"procedures":[300,354],"chronically":[302],"therapeutical":[306],"applications.":[307],"Such":[308,344],"adaptative":[310,353],"device":[311],"would":[312],"effective":[314],"detectable":[317],"changes":[318,331,345,374,392],"heralds":[319],"onset.":[322],"EEG-coherence":[334],"left":[337,378],"right":[339,380],"identified.":[343],"might":[346,430],"hallmark":[351],"like":[355],"triggered":[356],"avoid":[360],"occurrence":[362],"presumed":[365],"seizures.":[366],"To":[367],"date":[368],"remains":[370],"unknown,":[371],"if":[372,390],"coherence":[376],"SNr,":[381],"specific":[383],"GAERS":[388],"occur":[393],"other":[396],"models":[398],"humans":[400],"different":[402],"Accumulating":[405],"evidences":[406],"support":[407],"is":[410],"not":[411],"pathology":[413],"restricted":[414],"cortex":[417],"generator,":[421],"but":[422],"subcortical":[424],"structures":[425],"involved,":[428],"which":[429],"options":[434],"who":[437],"pharmacoresistant":[439],"treatment.":[447]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}