{"id":"https://openalex.org/W635403289","doi":"https://doi.org/10.1007/8904_2015_453","title":"The Pigment in Alkaptonuria Relationship to Melanin and Other Coloured Substances: A Review of Metabolism, Composition and Chemical Analysis","display_name":"The Pigment in Alkaptonuria Relationship to Melanin and Other Coloured Substances: A Review of Metabolism, Composition and Chemical Analysis","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W635403289","doi":"https://doi.org/10.1007/8904_2015_453","mag":"635403289","pmid":"https://pubmed.ncbi.nlm.nih.gov/26093627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4582024"},"language":"en","primary_location":{"id":"doi:10.1007/8904_2015_453","doi":"https://doi.org/10.1007/8904_2015_453","is_oa":true,"landing_page_url":"https://doi.org/10.1007/8904_2015_453","pdf_url":"https://link.springer.com/content/pdf/10.1007/8904_2015_453.pdf","source":{"id":"https://openalex.org/S4210211695","display_name":"JIMD Reports","issn_l":"2192-8304","issn":["2192-8304","2192-8312"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JIMD Reports","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2475437079","display_name":"JIMD Reports, Volume 24"},"type":"book-chapter","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/8904_2015_453.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111804174","display_name":"N B Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802729160","display_name":"Royal Liverpool and Broadgreen University Hospital NHS Trust","ror":"https://ror.org/009sa0g06","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"N. B. Roberts","raw_affiliation_strings":["Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK. n.b.roberts@liverpool.ac.uk","Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK. n.b.roberts@liverpool.ac.uk","institution_ids":["https://openalex.org/I2802729160"]},{"raw_affiliation_string":"Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK","institution_ids":["https://openalex.org/I2802729160"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. A. Curtis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802729160","display_name":"Royal Liverpool and Broadgreen University Hospital NHS Trust","ror":"https://ror.org/009sa0g06","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. A. Curtis","raw_affiliation_strings":["Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK","institution_ids":["https://openalex.org/I2802729160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059359403","display_name":"Anna M. Milan","orcid":"https://orcid.org/0000-0002-0452-2338","observed_orcids":["https://orcid.org/0000-0002-0452-2338"]},"institutions":[{"id":"https://openalex.org/I2802729160","display_name":"Royal Liverpool and Broadgreen University Hospital NHS Trust","ror":"https://ror.org/009sa0g06","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. M. Milan","raw_affiliation_strings":["Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK","institution_ids":["https://openalex.org/I2802729160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038647485","display_name":"Lakshminarayan R Ranganath","orcid":"https://orcid.org/0000-0002-4205-2269","observed_orcids":["https://orcid.org/0000-0002-4205-2269"]},"institutions":[{"id":"https://openalex.org/I2802729160","display_name":"Royal Liverpool and Broadgreen University Hospital NHS Trust","ror":"https://ror.org/009sa0g06","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802729160"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. R. Ranganath","raw_affiliation_strings":["Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry and Metabolic Medicine, The Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, L7 8XP, UK","institution_ids":["https://openalex.org/I2802729160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111804174"],"corresponding_institution_ids":["https://openalex.org/I2802729160"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":null,"fwci":5.5489,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.96537678,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":null,"first_page":"51","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkaptonuria","display_name":"alkaptonuria","score":0.9950000047683716},{"id":"https://openalex.org/keywords/homogentisic-acid","display_name":"homogentisic acid","score":0.824999988079071},{"id":"https://openalex.org/keywords/pyomelanin","display_name":"pyomelanin","score":0.921999990940094},{"id":"https://openalex.org/keywords/melanin","display_name":"melanin","score":0.8539999723434448},{"id":"https://openalex.org/keywords/melanin-like-pigment","display_name":"melanin-like pigment","score":0.6439999938011169},{"id":"https://openalex.org/keywords/pigment-composition","display_name":"pigment composition","score":0.3449999988079071},{"id":"https://openalex.org/keywords/collagen-damage","display_name":"collagen damage","score":0.6290000081062317},{"id":"https://openalex.org/keywords/connective-tissue-damage","display_name":"connective tissue damage","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C2776743390","wikidata":"https://www.wikidata.org/wiki/Q651680","display_name":"Alkaptonuria","level":2,"score":0.9237043857574463},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.747764527797699},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.7007404565811157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5412248373031616},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4942183792591095},{"id":"https://openalex.org/C2776255415","wikidata":"https://www.wikidata.org/wiki/Q416054","display_name":"Homogentisic acid","level":2,"score":0.4590929448604584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34901535511016846},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21789252758026123}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/8904_2015_453","doi":"https://doi.org/10.1007/8904_2015_453","is_oa":true,"landing_page_url":"https://doi.org/10.1007/8904_2015_453","pdf_url":"https://link.springer.com/content/pdf/10.1007/8904_2015_453.pdf","source":{"id":"https://openalex.org/S4210211695","display_name":"JIMD Reports","issn_l":"2192-8304","issn":["2192-8304","2192-8312"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JIMD Reports","raw_type":"book-chapter"},{"id":"pmh:oai:pubmedcentral.nih.gov:4582024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4582024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JIMD Rep","raw_type":"Text"},{"id":"pmid:26093627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26093627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JIMD reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/8904_2015_453","doi":"https://doi.org/10.1007/8904_2015_453","is_oa":true,"landing_page_url":"https://doi.org/10.1007/8904_2015_453","pdf_url":"https://link.springer.com/content/pdf/10.1007/8904_2015_453.pdf","source":{"id":"https://openalex.org/S4210211695","display_name":"JIMD Reports","issn_l":"2192-8304","issn":["2192-8304","2192-8312"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JIMD Reports","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W635403289.pdf","grobid_xml":"https://content.openalex.org/works/W635403289.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W97319181","https://openalex.org/W1503393361","https://openalex.org/W1503853200","https://openalex.org/W1514187524","https://openalex.org/W1518409257","https://openalex.org/W1521630811","https://openalex.org/W1543483476","https://openalex.org/W1574706468","https://openalex.org/W1586033428","https://openalex.org/W1775587524","https://openalex.org/W1780994009","https://openalex.org/W1839582337","https://openalex.org/W1965777211","https://openalex.org/W1966748491","https://openalex.org/W1967915575","https://openalex.org/W1973223169","https://openalex.org/W1974941490","https://openalex.org/W1977044733","https://openalex.org/W1977056090","https://openalex.org/W1977209543","https://openalex.org/W1977599289","https://openalex.org/W1979423615","https://openalex.org/W1981505282","https://openalex.org/W1981605211","https://openalex.org/W1982635732","https://openalex.org/W1985782120","https://openalex.org/W1986351290","https://openalex.org/W1987699755","https://openalex.org/W1988874671","https://openalex.org/W1989387667","https://openalex.org/W1990940043","https://openalex.org/W1995063207","https://openalex.org/W1996146467","https://openalex.org/W1999608519","https://openalex.org/W2004578554","https://openalex.org/W2005258249","https://openalex.org/W2006117571","https://openalex.org/W2006597186","https://openalex.org/W2011055829","https://openalex.org/W2012184523","https://openalex.org/W2018670030","https://openalex.org/W2019869152","https://openalex.org/W2026685126","https://openalex.org/W2027827700","https://openalex.org/W2028077829","https://openalex.org/W2029143230","https://openalex.org/W2029377520","https://openalex.org/W2032674187","https://openalex.org/W2033739436","https://openalex.org/W2035762801","https://openalex.org/W2037275975","https://openalex.org/W2038289966","https://openalex.org/W2039183762","https://openalex.org/W2042056482","https://openalex.org/W2042747499","https://openalex.org/W2057155063","https://openalex.org/W2057683367","https://openalex.org/W2057719322","https://openalex.org/W2058468405","https://openalex.org/W2066237038","https://openalex.org/W2097237123","https://openalex.org/W2102246325","https://openalex.org/W2105202236","https://openalex.org/W2111025546","https://openalex.org/W2114385757","https://openalex.org/W2125960725","https://openalex.org/W2127501217","https://openalex.org/W2130995172","https://openalex.org/W2133768386","https://openalex.org/W2137072501","https://openalex.org/W2137504359","https://openalex.org/W2139222158","https://openalex.org/W2143606342","https://openalex.org/W2147796818","https://openalex.org/W2154418484","https://openalex.org/W2155955293","https://openalex.org/W2164168718","https://openalex.org/W2170235747","https://openalex.org/W2170792683","https://openalex.org/W2323236978","https://openalex.org/W2325212304","https://openalex.org/W2586876181","https://openalex.org/W2724780140","https://openalex.org/W2925964618","https://openalex.org/W4245449132"],"related_works":["https://openalex.org/W3182002139","https://openalex.org/W2559996669","https://openalex.org/W3025278748","https://openalex.org/W1971371692","https://openalex.org/W3214027370","https://openalex.org/W2109945528","https://openalex.org/W4414792970","https://openalex.org/W6989387092","https://openalex.org/W2999118195","https://openalex.org/W3027538137"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}