{"id":"https://openalex.org/W633430213","doi":"https://doi.org/10.1161/str.44.suppl_1.a91","title":"Abstract 91: Remodeling After Stroke: The Recovering Brain Is Vulnerable To Lipoxygenase-dependent Semaphorin Signaling","display_name":"Abstract 91: Remodeling After Stroke: The Recovering Brain Is Vulnerable To Lipoxygenase-dependent Semaphorin Signaling","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W633430213","doi":"https://doi.org/10.1161/str.44.suppl_1.a91","mag":"633430213"},"language":"en","primary_location":{"id":"doi:10.1161/str.44.suppl_1.a91","doi":"https://doi.org/10.1161/str.44.suppl_1.a91","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.44.suppl_1.a91","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047056425","display_name":"Anton Pekcec","orcid":"https://orcid.org/0000-0001-9045-4740","observed_orcids":["https://orcid.org/0000-0001-9045-4740"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anton Pekcec","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Anton Pekcec"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Anton Pekcec","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053396624","display_name":"Kaz\u0131m Yi\u011fitkanl\u0131","orcid":"https://orcid.org/0000-0003-0628-0173","observed_orcids":["https://orcid.org/0000-0003-0628-0173"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazim Yigitkanli","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Kazim Yigitkanli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Kazim Yigitkanli","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110250217","display_name":"Joo Eun Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joo Eun Jung","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Joo Eun Jung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Joo Eun Jung","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064189943","display_name":"H\u00fclya Karata\u015f","orcid":"https://orcid.org/0000-0001-6312-5028","observed_orcids":["https://orcid.org/0000-0001-6312-5028","https://orcid.org/0000-0003-4838-6320"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hulya Karatas","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Hulya Karatas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Hulya Karatas","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091447153","display_name":"Eng H. Lo","orcid":"https://orcid.org/0000-0002-9327-2915","observed_orcids":["https://orcid.org/0000-0002-9327-2915"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng H Lo","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Eng H Lo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Eng H Lo","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067880502","display_name":"Klaus van Leyen","orcid":"https://orcid.org/0000-0003-1032-3754","observed_orcids":["https://orcid.org/0000-0003-1032-3754"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klaus Van Leyen","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSP, Charlestown, MA","Klaus Van Leyen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSP, Charlestown, MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Klaus Van Leyen","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.24169999361038208,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.24169999361038208,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.19020000100135803,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semaphorin-3a","display_name":"semaphorin 3A","score":0.906000018119812},{"id":"https://openalex.org/keywords/12-15-lipoxygenase","display_name":"12/15-lipoxygenase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.8109999895095825},{"id":"https://openalex.org/keywords/12-hydroxyeicosatetraenoic-acid","display_name":"12-hydroxyeicosatetraenoic acid","score":0.9800000190734863},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.578000009059906},{"id":"https://openalex.org/keywords/stroke-recovery","display_name":"stroke recovery","score":0.492000013589859},{"id":"https://openalex.org/keywords/ischemic-brain-injury","display_name":"ischemic brain injury","score":0.597000002861023},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8939999938011169},{"id":"https://openalex.org/keywords/axon-growth","display_name":"axon growth","score":0.5559999942779541},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.8420951962471008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6667956113815308},{"id":"https://openalex.org/C2776805952","wikidata":"https://www.wikidata.org/wiki/Q18035334","display_name":"SEMA3A","level":4,"score":0.6640983819961548},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48352980613708496},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.4774359166622162},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.44132545590400696},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.43659693002700806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43192344903945923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32973140478134155},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29527777433395386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.201531320810318},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15960904955863953},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.44.suppl_1.a91","doi":"https://doi.org/10.1161/str.44.suppl_1.a91","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.44.suppl_1.a91","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978916450","https://openalex.org/W2890425979","https://openalex.org/W1995994458","https://openalex.org/W2807924145","https://openalex.org/W2120209337","https://openalex.org/W3163526729","https://openalex.org/W2015846798","https://openalex.org/W2034737379","https://openalex.org/W2015631464","https://openalex.org/W2910892871"],"abstract_inverted_index":{"Background":[0],"and":[1,51,80,87,160,173,188,213,263,288],"Purpose\u2014":[2],"Recovery":[3],"from":[4,33,68,83,191],"stroke":[5,107,206,311],"is":[6,231],"limited":[7],"in":[8,14,108,110,167,177,207,217,248,285],"part":[9],"by":[10,185,261,269],"an":[11],"inhibitory":[12,49],"environment":[13],"the":[15,34,54,77,119,155,218,240,274,286,300],"post-ischemic":[16,255],"brain,":[17],"but":[18],"factors":[19],"preventing":[20],"successful":[21],"remodeling":[22],"are":[23,215],"not":[24,245],"well":[25],"known.":[26],"We":[27],"sought":[28],"to":[29,47,104,148,170,197,204,221,309],"investigate":[30],"if":[31,52,226],"signaling":[32],"axon":[35,165],"guidance":[36],"molecule":[37],"semaphorin":[38,301],"3A":[39],"(Sema3A)":[40],"via":[41],"eicosanoid":[42],"second":[43],"messengers":[44],"can":[45,57],"contribute":[46],"this":[48,265],"environment,":[50],"blocking":[53,299],"Sema3A":[55,114,181,212,238,242,257],"pathway":[56,230,302],"provide":[58,304],"a":[59,88,227,305],"benefit":[60],"following":[61,233],"experimental":[62,106],"stroke.":[63],"Methods\u2014":[64],"Cultured":[65],"cortical":[66,259],"neurons":[67,147,168,189],"mice":[69,194],"were":[70,94,138,195],"treated":[71,95],"with":[72,76],"recombinant":[73,150,237],"Sema3A,":[74,153],"or":[75,154],"eicosanoids":[78],"12-HETE":[79,159],"12-HPETE.":[81],"Neurons":[82],"ALOX15":[84],"knockout":[85,193],"mice,":[86,109,208],"human":[89],"brain":[90],"endothelial":[91,178],"cell":[92],"line,":[93],"similarly.":[96],"The":[97,121,180],"filament":[98],"model":[99],"of":[100,112,135,145,273],"MCAO":[101,282],"was":[102,115,125,183,267],"used":[103],"induce":[105,205],"some":[111],"which":[113],"injected":[116,126,236,253],"stereotactically":[117],"into":[118,239,254],"striatum.":[120,241],"12/15-LOX":[122,192,214,270,275],"inhibitor":[123,276],"LOXBlock-1":[124,277],"intraperitoneally":[127],"one":[128,291],"week":[129,292],"after":[130,143,280],"MCAO.":[131],"Results\u2014":[132],"Expression":[133],"levels":[134],"12/15-lipoxygenase":[136,156],"(12/15-LOX)":[137,157],"increased":[139,216,258,283],"within":[140],"two":[141,222],"hours":[142],"exposure":[144],"primary":[146],"90nM":[149],"Sema3A.":[151,198],"Either":[152],"metabolites":[158],"12-HPETE":[161],"at":[162],"300nM,":[163],"blocked":[164],"extension":[166],"compared":[169],"solvent":[171],"controls,":[172],"decreased":[174],"tube":[175],"formation":[176],"cells.":[179],"effect":[182,266],"reversed":[184,268],"inhibiting":[186],"12/15-LOX,":[187],"derived":[190],"insensitive":[196],"Following":[199],"middle":[200],"cerebral":[201],"artery":[202],"occlusion":[203],"immunohistochemistry":[209],"showed":[210],"both":[211],"cortex":[219],"up":[220],"weeks.":[223],"To":[224],"determine":[225],"Sema3A-dependent":[228],"damage":[229,260],"activated":[232],"ischemia,":[234],"we":[235],"alone":[243],"did":[244],"cause":[246],"injury":[247],"normal":[249],"brains.":[250],"But":[251],"when":[252],"brains,":[256],"79%,":[262],"again":[264],"inhibition.":[271],"Administration":[272],"7":[278],"days":[279],"transient":[281],"vascularization":[284],"infarcted":[287],"peri-infarct":[289],"area":[290],"later.":[293],"Conclusions\u2014":[294],"Our":[295],"findings":[296],"suggest":[297],"that":[298],"may":[303],"novel":[306],"therapeutic":[307],"strategy":[308],"improve":[310],"recovery.":[312]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
