{"id":"https://openalex.org/W633198751","doi":"https://doi.org/10.1002/9783527630110","title":"The Chemical Biology of DNA Damage","display_name":"The Chemical Biology of DNA Damage","publication_year":2010,"publication_date":"2010-06-23","ids":{"openalex":"https://openalex.org/W633198751","doi":"https://doi.org/10.1002/9783527630110","mag":"633198751"},"language":"en","primary_location":{"id":"doi:10.1002/9783527630110","doi":"https://doi.org/10.1002/9783527630110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527630110","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"edited-book"},"volume":null,"type":"book","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018460703","display_name":"Nicholas E. Geacintov","orcid":"https://orcid.org/0000-0002-7961-2231","observed_orcids":["https://orcid.org/0000-0002-7961-2231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geacintov, Nicholas E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045073997","display_name":"Suse B. Broyde","orcid":"https://orcid.org/0000-0002-3802-7511","observed_orcids":["https://orcid.org/0000-0002-3802-7511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Broyde, Suse","raw_affiliation_strings":["Biology and Genomics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology and Genomics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.3589,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.95629139,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dna-lesions","display_name":"DNA lesions","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6520000100135803},{"id":"https://openalex.org/keywords/dna-repair-mechanisms","display_name":"DNA repair mechanisms","score":0.7950000166893005},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dna-oxidation","display_name":"DNA oxidation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-deamination","display_name":"DNA deamination","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8799999952316284},{"id":"https://openalex.org/keywords/radical-reactions","display_name":"radical reactions","score":0.6880000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.6470000147819519},{"id":"https://openalex.org/keywords/acrolein","display_name":"acrolein","score":0.6710000038146973},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.49000000953674316},{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.5199999809265137},{"id":"https://openalex.org/keywords/dna-glycosylase-activity","display_name":"DNA glycosylase activity","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.4701675772666931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45528870820999146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4440295696258545},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4408329129219055},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4133094847202301},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.394543319940567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28513631224632263}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/9783527630110","doi":"https://doi.org/10.1002/9783527630110","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527630110","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"edited-book"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-020159984","doi":null,"is_oa":false,"landing_page_url":"http://deposit.dnb.de/cgi-bin/dokserv?id=3294465&prov=M&dok_var=1&dok_ext=htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-028811013","doi":null,"is_oa":false,"landing_page_url":"https://onlinelibrary.wiley.com/doi/book/10.1002/9783527630110","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7051569090","https://openalex.org/W2386020541","https://openalex.org/W2048043985","https://openalex.org/W4387696304","https://openalex.org/W1793176136","https://openalex.org/W594401720","https://openalex.org/W2055055073","https://openalex.org/W307904722","https://openalex.org/W2429877822","https://openalex.org/W2135736919"],"abstract_inverted_index":{"Preface.":[0],"List":[2],"of":[3,11,24,36,85,91,98,179,189,196,211,220,236,257,268,287,293,299,370,379,388,397,438,475,481,564,596,602,618,639,650,669,690,722,732,743,750,761,774,787,794,808,810,825,856,886,951,955,974,1015,1034,1056,1062,1075,1079,1089,1111,1162,1170,1184,1206],"Contributors.":[4],"PART":[6,502],"ONE":[7],"Chemistry":[8,21,90,563],"and":[9,17,22,30,50,56,82,93,105,116,144,151,184,201,242,259,272,313,345,364,373,381,390,399,422,429,436,443,468,498,506,511,552,654,661,672,688,712,746,798,803,833,846,883,897,903,931,982,989,998,1046,1060,1140,1216,1220,1248],"Biology":[10,23],"DNA":[12,25,41,48,54,63,73,86,94,114,120,146,197,229,263,294,300,315,517,597,640,692,755,766,795,835,871,905,917,941,957,963,1029,1068,1091,1101,1147,1163,1214,1242,1249,1264],"Lesions.":[13,74,87,166,970,1164],"1":[15],"Introduction":[16],"Perspectives":[18],"on":[19,800,815,828],"the":[20,37,79,194,314,565,574,695,747,759,772,785,811,884,952,975,1035,1086,1168,1182,1187,1204,1207],"Damage":[26,42,49,55,64,130,141,198,230,865,1215],"(Nicolas":[27],"E.":[28,203,714,933,1009,1023,1063,1080],"Geacintov":[29],"Susan":[31],"Broyde).":[32],"1.1":[34],"Overview":[35,721,1033,1110],"Field.":[38],"1.2":[40],"A":[43,1255],"Constant":[44],"Threat.":[45],"1.3":[47],"Disease.":[51],"1.4":[53],"Chemotherapeutic":[57],"Applications.":[58],"1.5":[60],"The":[61],"Cellular":[62,145],"Response":[65],"(DDR).":[66],"1.6":[68],"Repair":[69,292,653,657],"Mechanisms":[70,219,480,649,773],"that":[71,1194,1202],"Remove":[72],"1.7":[76],"Relationships":[77,510,527,783,914,966],"between":[78],"Chemical,":[80],"Structural,":[81],"Biological":[83,96,225,395,512,609],"Features":[84,668],"2":[89],"Inflammation":[92],"Damage:":[95],"Impact":[97,824],"Reactive":[99],"Nitrogen":[100],"Species":[101],"(Michael":[102,528],"S.":[103],"DeMott":[104],"Peter":[106,848],"C.":[107],"Dedon).":[108],"2.1":[110],"Introduction.":[111,156,207,323,360,558,626,718,852,937,1004,1107,1239],"2.2":[113],"Oxidation":[115,172,177],"Nitration.":[117],"2.3":[119],"Deamination.":[121],"2.4":[123],"2'-Deoxyribose":[124,252],"Oxidation.":[125],"2.5":[127],"Indirect":[128],"Base":[129,160,165,651,670,816],"Caused":[131,231],"by":[132,232,573,584,694,735,863,1143,1197],"RNS.":[133],"2.6":[135],"Conclusions.":[136,304,613,646,684,821,909,1211,1268],"3":[138],"Oxidatively":[139],"Generated":[140,234,862],"to":[142,352,839,866,922,1038],"Isolated":[143],"(Jean":[147],"Cadet,":[148],"Thierry":[149],"Douki":[150],"Jean-Luc":[152],"Ravanat).":[153],"3.1":[155],"3.2":[158],"Single":[159],"Damage.":[161,295,301,1250,1265],"3.3":[163],"Tandem":[164],"3.4":[168],"Hydroxyl":[169],"Radical-Mediated":[170],"2-Deoxyribose":[171],"Reactions.":[173],"3.5":[175],"Secondary":[176],"Reactions":[178,192,214,256,760],"Bases.":[180,264],"3.6":[182],"Conslusions":[183],"Perspectives.":[185,984],"4":[187],"Role":[188,595,601,1152],"Free":[190,212],"Radical":[191,213,326],"in":[193,413,420,433,447,604,784,831,915,959,992,1008,1017,1093,1156,1200],"Formation":[195,432,446],"(Vladimir":[199],"Shafirovich":[200],"Nicholas":[202,713,932],"Geacintov).":[204,715,934],"4.1":[206],"4.2":[209],"Importance":[210],"with":[215,262,274,383,765,968,1098,1118],"DNA.":[216,384,867,877],"4.3":[218],"Product":[221],"Formation.":[222],"4.4":[224],"Implications.":[226],"5":[228],"Endogenously":[233],"Products":[235],"Oxidative":[237,864],"Stress":[238],"(Charles":[239],"G.":[240],"Knutson":[241],"Lawrence":[243],"J.":[244,356,554,663,710,929],"Marnett).":[245],"5.1":[247],"Lipid":[248],"Peroxidation.":[249,253],"5.2":[251],"5.3":[255],"MDA":[258],"ss-Substituted":[260],"Acroleins":[261],"5.4":[266],"Stability":[267],"M1dG:":[269],"Hydrolytic":[270],"Ring-Opening":[271],"Reaction":[273],"Nucleophiles.":[275],"5.5":[277],"Propano":[278],"Adducts.":[279,283,289,392,401,790],"5.6":[281],"Etheno":[282],"5.7":[285],"Mutagenicity":[286],"Peroxidation-Derived":[288],"5.8":[291],"5.9":[297],"Assessment":[298],"5.10":[303],"6":[306],"Polycyclic":[307,880],"Aromatic":[308,343,347,619,881],"Hydrocarbons:":[309],"Multiple":[310],"Metabolic":[311,371],"Pathways":[312,991],"Lesions":[316,693,734,756,861,942,958,1102,1120,1135],"Formed":[317],"(Trevor":[318],"M.":[319,550],"Penning).":[320],"6.1":[322],"6.2":[325],"Cation":[327],"Pathway.":[328],"6.3":[330],"Diol":[331,763],"Epoxides.":[332],"6.4":[334],"PAH":[335,762,801],"o-Quinones.":[336],"6.5":[338],"Future":[339,451,499,983],"Directions.":[340,452,500],"7":[342],"Amines":[344],"Heterocyclic":[346],"Amines:":[348],"From":[349,522,837,919],"Tobacco":[350],"Smoke":[351],"Food":[353],"Mutagens.":[354],"(Robert":[355,841],"Turesky)":[357],"7.1":[359],"7.2":[362],"Exposure":[363],"Cancer":[365],"Epidemiology.":[366],"7.3":[368],"Enzymes":[369],"Activation":[372],"Genetic":[374,418],"Polymorphisms.":[375],"7.4":[377],"Reactivity":[378],"N-Hydroxy-AAs":[380],"N-Hydroxy-HAAs":[382],"7.5":[386],"Synthesis":[387,830,988,1028,1092],"AA-DNA":[389,398,428,442],"HAA-DNA":[391,400,430,444],"7.6":[394],"Effects":[396],"7.7":[403],"Bacterial":[404],"Mutagenesis.":[405,409],"7.8":[407],"Mammalian":[408,723,736,744,1130],"7.9":[411],"Mutagenesis":[412,1007,1016],"Transgenic":[414],"Rodents.":[415],"7.10":[417],"Alterations":[419],"Oncogenes":[421],"Tumor":[423],"Suppressor":[424],"Genes.":[425],"7.11":[427],"Adduct":[431,445,567,796,814,872,887],"Experimental":[434],"Animals":[435],"Methods":[437],"Detection.":[439],"7.12":[441],"Humans.":[448],"7.13":[450],"8":[454],"Genotoxic":[455],"Estrogen":[456,461,476,482,486],"Pathway:":[457],"Endogenous":[458],"And":[459],"Equine":[460],"Hormone":[462],"Replacement":[463],"Theory":[464],"(Judy":[465],"L.":[466,842,1000],"Bolton":[467],"Gregory":[469],"R.J.":[470],"Thatcher).":[471],"8.1":[473],"Risks":[474],"Exposure.":[477],"8.2":[479],"Carcinogenesis.":[483],"8.3":[485],"Receptor":[487],"as":[488,943,1050],"a":[489,944,1159,1178],"Trojan":[490],"Horse":[491],"(Combined":[492],"Hormonal/Chemical":[493],"Mechanism).":[494],"8.4":[496],"Conclusions":[497,981],"TWO":[503],"New":[504],"Frontiers":[505],"Challenges:":[507],"Understanding":[508,1014],"Structure-Function":[509,526,616,782,913,965,1054],"Activity.":[513],"9":[515],"Interstrand":[516,561,571,582],"Cross-Linking":[518,562,572,583],"1,N2-Deoxyguanosine":[519],"Adducts":[520,576,621,827],"Derived":[521,577,757],"a,":[523],"ss-Unsatruated":[524],"Aldehydes:":[525],"P.":[529],"Stone,":[530],"hai":[531],"Huang,":[532],"Young-Jin":[533],"Cho,":[534],"Hye-Young":[535],"Kim,":[536],"Ivan":[537],"D.":[538,659],"Kozekov,":[539],"Albena":[540],"Kozekova,":[541],"Hao":[542],"Wang,":[543,927],"Irina":[544],"G.Minko,":[545],"R.":[546],"Stephen":[547],"Lloyd,":[548],"Thomas":[549],"Harris":[551],"Carmelo":[553],"Rizzo).":[555],"9.1":[557],"9.2":[560],"?-OH-PdG":[566],"(9).":[568],"9.3":[570],"a-CH3-?-OH-PG":[575],"from":[578,758],"Crotonaldehyde.":[579],"9.4":[581],"4-HNE.":[585],"9.5":[587],"Carbinolamine":[588],"Cross-Links":[589],"Maintain":[590],"Watson-Crick":[591],"Base-Pairing.":[592],"9.6":[594],"Sequence.":[598],"9.7":[600],"Stereochemistry":[603],"Modulating":[605],"Cross-Linking.":[606],"9.8":[608],"Significance.":[610],"9.9":[612],"10":[615],"Characteristics":[617],"Amine-DNA":[620],"(Bongsup":[622],"Cho).":[623],"10.1":[625],"10.2":[628],"Major":[629],"Conformational":[630,634],"Motifs.":[631],"10.3":[633],"Heterogeneity.":[635],"10.4":[637],"Structures":[638,921],"Lesion-DNA":[641],"Polymerase":[642,890,964,1069,1261],"Complexes.":[643],"10.5":[645],"11":[648],"Excision":[652,656,671,674,697],"Nucleotide":[655,673,696],"(Orlando":[658],"Scharer":[660],"Arthur":[662],"Campbell).":[664],"11.1":[666],"General":[667],"Repair.":[675,1243],"11.2":[677],"BER.":[678],"11.3":[680],"NER.":[681,724,728,775],"11.4":[683],"12":[686],"Recognition":[687,731],"Removal":[689],"Bulky":[691,733,788,916],"Repait":[698],"System":[699],"(Yuqin":[700],"Cai,Konstantin":[701],"Kropachev,":[702],"Marina":[703],"Kolbanovskiy,":[704],"Alwxander":[705],"Kobanovskiy,":[706],"Suse":[707],"Broyde,":[708,925],"Dinshaw":[709,928],"Patel":[711,930],"12.1":[717],"12.2":[720],"12.3":[726],"Prokaryotic":[727],"12.4":[730],"NER":[737,745,786,799,809],"Factors.":[738],"12.5":[740],"Bipartite":[741],"Model":[742,749,1116],"Multipartite":[748],"Lesion":[751],"Recognition.":[752],"12.6":[754],"Epoxides":[764],"are":[767,1136],"Excellent":[768],"Substrates":[769],"for":[770,1121,1129,1153,1181],"Probing":[771],"12.7":[777],"Multidisciplinary":[778],"Approach":[779],"Towards":[780],"Investigating":[781],"PAH-DNA":[789],"12.8":[792],"Dependence":[793,807],"Conformations":[797],"Topology":[802],"Stereochemistry.":[804],"12.9":[806],"10S":[812],"(+)-trans-anti-B[a]P-N2-dG":[813],"Sequence":[817],"Contexts.":[818],"12.10":[820],"13":[823],"Chemical":[826],"Translesion":[829,987,1027,1039,1090],"Replicative":[832],"Bypass":[834,855],"Polymerases:":[836,1254],"Structure":[838,1074],"Function":[840],"Eoff,":[843],"Martin":[844],"Egli":[845],"F.":[847],"Guengerich).":[849],"13.1":[851],"13.2":[854],"Abasic":[857],"Sites.":[858],"13.3":[860],"13.4":[869],"Exocyclic":[870],"Bypass.":[873],"13.5":[875],"Alkylated":[876],"13.6":[879],"Hydrocarbons":[882],"Effect":[885],"Size":[888],"upon":[889],"Catalysis.":[891],"13.7":[893],"Cyclobutane":[894],"Pyrimidine":[895],"Dimers":[896],"UV":[898],"Photoproducts.":[899],"13.8":[901],"Inter-":[902],"Intrastrand":[904],"Cross-Links.":[906],"13.9":[908],"14":[911],"Elucidating":[912],"Lesions:":[918],"Solution":[920],"Polymerases":[923,1172],"(Suse":[924],"Lihua":[926],"14.1":[936],"14.2":[939],"Benzo[a]pyrene-Derived":[940],"Useful":[945],"Model.":[946],"14.3":[948],"Computational":[949],"Elucidation":[950],"Structural":[953],"Properties":[954],"B[a]P-Derived":[956,969],"Solution.":[960],"14.4":[962],"Elucidated":[967],"14.5":[972],"Mechanism":[973,1088],"Nucleotidyl":[976],"Transfer":[977],"Reaction.":[978],"14.6":[980],"15":[986],"Mutagenic":[990],"Escherichia":[993],"Coli":[994],"Cells":[995,1095],"(Sushil":[996],"Chandani":[997],"Edward":[999],"Loechler).":[1001],"15.1":[1003],"15.2":[1006],"coli":[1010,1024],"has":[1011],"Illuminated":[1012],"Our":[1013],"General.":[1018],"15.3":[1020],"Why":[1021],"Does":[1022],"have":[1025],"Three":[1026],"Polymerases?":[1030],"15.4":[1032],"Steps":[1036],"Leading":[1037],"Synthesis.":[1040],"15.5":[1042],"Case":[1043],"Studies:":[1044],"AAF-C8-dG":[1045],"N2-dG":[1047],"Adducts,":[1048],"Such":[1049],"+BP.":[1051],"15.6":[1053],"Analysis":[1055,1183],"Y-Family":[1057,1067],"Pols":[1058],"IV":[1059],"V":[1061],"coli.":[1064,1081],"15.7":[1066],"Mechanistic":[1070],"Steps.":[1071],"15.8":[1073],"B-Family":[1076],"Pol":[1077,1154],"II":[1078],"16":[1083],"Insight":[1084],"into":[1085],"Molecular":[1087],"Human":[1094],"Using":[1096],"Probes":[1097],"Chemically":[1099],"Defined":[1100,1119],"(Zvi":[1103],"Livneh).":[1104],"16.1":[1106],"16.2":[1109],"TLS.":[1112,1123,1131],"16.3":[1114],"Plasmid":[1115,1127,1189],"Systems":[1117],"Studying":[1122],"16.4":[1125],"Gap-Lesion":[1126],"Assay":[1128],"16.5":[1133],"Some":[1134],"Bypassed":[1137],"Most":[1138,1141],"Effectively":[1139],"Accurately":[1142],"Specific":[1144],"Cognate":[1145],"TLS":[1146,1157,1171,1185,1195],"Polymerases.":[1148],"16.6":[1150],"Pivotal":[1151],"?":[1155],"Across":[1158],"Wide":[1160],"Variety":[1161],"16.7":[1166],"Knocking-Down":[1167],"Expression":[1169],"using":[1173,1186],"Small":[1174],"Interfering":[1175],"RNA":[1176,1221,1253,1260],"Provides":[1177],"useful":[1179],"Tool":[1180],"Gapped":[1188],"Assay.":[1190],"16.8":[1192],"Evidence":[1193],"Occurs":[1196],"Two-Polymerase":[1198],"Mechanisms,":[1199],"Combinations":[1201],"Determine":[1203],"Accuracy":[1205],"Process.":[1208],"16.9":[1210],"17":[1213],"Transciption":[1217],"Elongation:":[1218],"Consequences":[1219],"Integrity":[1222],"(Kristian":[1223],"Dreij,":[1224],"John":[1225],"A.":[1226,1235],"burns,":[1227],"Alexandra":[1228],"Dimitri,":[1229],"Lana":[1230],"Nirenstein,":[1231],"Taissia":[1232],"Noujnykh,":[1233],"David":[1234],"Scicchitano).":[1236],"17.1":[1238],"17.2":[1241],"17.3":[1245],"Transcription":[1246],"Elongation":[1247,1262],"17.4":[1252],"Brief":[1256],"Overview.":[1257],"17.5":[1259],"Past":[1263],"17.6":[1267],"Index.":[1270]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}