{"id":"https://openalex.org/W63297889","doi":null,"title":"Acid stress response of a mycobacterial proteome: insight from a gene ontology analysis.","display_name":"Acid stress response of a mycobacterial proteome: insight from a gene ontology analysis.","publication_year":2009,"publication_date":"2009-11-10","ids":{"openalex":"https://openalex.org/W63297889","mag":"63297889","pmid":"https://pubmed.ncbi.nlm.nih.gov/20057975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2802051"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2802051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2802051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2802051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069774623","display_name":"Bryan AP Roxas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan Ap Roxas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101722792","display_name":"Qingbo Li","orcid":"https://orcid.org/0000-0002-5397-8251","observed_orcids":["https://orcid.org/0000-0002-5397-8251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingbo Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6104,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81582492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"4","first_page":"309","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-stress","display_name":"acid stress","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mycobacterium-smegmatis","display_name":"Mycobacterium smegmatis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/acid-tolerance","display_name":"acid resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mycobacteria","display_name":"mycobacteria","score":0.6819999814033508},{"id":"https://openalex.org/keywords/proteome","display_name":"proteome","score":0.7089999914169312},{"id":"https://openalex.org/keywords/transmembrane-transporters","display_name":"transmembrane transporters","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene Ontology","score":0.527999997138977},{"id":"https://openalex.org/keywords/label-free-proteomics","display_name":"label-free quantitative proteomics","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.897079348564148},{"id":"https://openalex.org/C2777204207","wikidata":"https://www.wikidata.org/wiki/Q606230","display_name":"Mycobacterium smegmatis","level":4,"score":0.7158528566360474},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6183965802192688},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5734411478042603},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5673859119415283},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.5490848422050476},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.5061168074607849},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5043200254440308},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.49321621656417847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4707116484642029},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.45500844717025757},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.43767303228378296},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4307533800601959},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42456763982772827},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.41614842414855957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.395605206489563},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36796802282333374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.365729421377182},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2543778121471405},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.2278304100036621},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11807030439376831},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2802051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2802051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"pmid:20057975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20057975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"mag:63297889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20057975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2802051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2802051","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1550648844","https://openalex.org/W1578079615","https://openalex.org/W1592027665","https://openalex.org/W1966448483","https://openalex.org/W1974234256","https://openalex.org/W1976768342","https://openalex.org/W1981057775","https://openalex.org/W1983429163","https://openalex.org/W1989669752","https://openalex.org/W1994057917","https://openalex.org/W1996638297","https://openalex.org/W1997604729","https://openalex.org/W2000110235","https://openalex.org/W2006421614","https://openalex.org/W2007097682","https://openalex.org/W2017495709","https://openalex.org/W2021396047","https://openalex.org/W2024119959","https://openalex.org/W2025187029","https://openalex.org/W2027852704","https://openalex.org/W2033536968","https://openalex.org/W2034454594","https://openalex.org/W2034515571","https://openalex.org/W2036420717","https://openalex.org/W2046954682","https://openalex.org/W2055848875","https://openalex.org/W2078299535","https://openalex.org/W2078663039","https://openalex.org/W2079678142","https://openalex.org/W2081298443","https://openalex.org/W2081613861","https://openalex.org/W2086241510","https://openalex.org/W2091400130","https://openalex.org/W2095781267","https://openalex.org/W2096742175","https://openalex.org/W2103017472","https://openalex.org/W2108260926","https://openalex.org/W2114088731","https://openalex.org/W2117144170","https://openalex.org/W2119028507","https://openalex.org/W2123036801","https://openalex.org/W2124597233","https://openalex.org/W2125112523","https://openalex.org/W2129957930","https://openalex.org/W2130394726","https://openalex.org/W2130727456","https://openalex.org/W2139492141","https://openalex.org/W2140629544","https://openalex.org/W2147251439","https://openalex.org/W2151612737","https://openalex.org/W2155448089","https://openalex.org/W2155515147","https://openalex.org/W2170620850","https://openalex.org/W2171030481","https://openalex.org/W2171646475"],"related_works":["https://openalex.org/W2156129359","https://openalex.org/W4285802851","https://openalex.org/W7128773314","https://openalex.org/W2136801390","https://openalex.org/W2585516904","https://openalex.org/W4407836631","https://openalex.org/W2029012358","https://openalex.org/W2898298513","https://openalex.org/W2032983500","https://openalex.org/W2958023764"],"abstract_inverted_index":{"Acidity":[0],"in":[1,23,56,123,147],"vesicles":[2],"of":[3,19,78,113,120],"macrophages":[4,24],"is":[5],"a":[6,63,85,111],"general":[7],"signal":[8],"that":[9,25,100,130],"bacteria":[10],"respond":[11],"to":[12,37,48,141],"during":[13],"infection.":[14],"Mycobacteria":[15],"are":[16],"particularly":[17],"capable":[18],"resisting":[20],"the":[21,27,39,53,93,101,107],"acidification":[22],"engulf":[26],"bacteria.":[28],"In":[29],"this":[30],"work,":[31],"we":[32],"used":[33],"label-free":[34],"quantitative":[35],"proteomics":[36],"study":[38],"Mycobacterium":[40],"smegmatis":[41],"proteome":[42,95],"under":[43],"acid":[44,108,125,137,145],"stress":[45,109],"so":[46],"as":[47],"gain":[49],"an":[50,118],"insight":[51],"into":[52],"acidic":[54],"adaptation":[55],"mycobacteria.":[57,148],"We":[58,83,98],"quantified":[59],"1032":[60],"proteins.":[61],"With":[62],"3-fold":[64],"change":[65],"threshold,":[66],"20":[67],"and":[68,80,117,134],"52":[69],"proteins":[70],"were":[71],"found":[72,99],"regulated":[73],"at":[74],"false":[75],"discovery":[76],"rates":[77],"5%":[79],"14%":[81],"respectively.":[82],"performed":[84],"systems":[86],"analysis":[87],"based":[88],"on":[89],"gene":[90],"ontology":[91],"for":[92],"global":[94],"expression":[96],"profile.":[97],"most":[102],"significant":[103],"changes":[104],"induced":[105],"by":[106],"include":[110],"downregulation":[112],"transmembrane":[114,132],"transporter":[115],"activity":[116],"upregulation":[119],"enzymes":[121],"involved":[122],"fatty":[124,136],"metabolism.":[126],"The":[127],"results":[128],"suggest":[129],"reduced":[131],"transport":[133],"increased":[135],"metabolism":[138],"probably":[139],"contribute":[140],"or":[142],"associate":[143],"with":[144],"tolerance":[146]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}