{"id":"https://openalex.org/W632862394","doi":null,"title":"Detecting Signatures of Selection within the Dog Genome","display_name":"Detecting Signatures of Selection within the Dog Genome","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W632862394","mag":"632862394"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-209335","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209335","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061370149","display_name":"Abhirami Ratnakumar","orcid":"https://orcid.org/0000-0001-9623-0377","observed_orcids":["https://orcid.org/0000-0001-9623-0377"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abhirami Ratnakumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9623-0377","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061370149"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.09759999811649323,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dog-domestication","display_name":"dog domestication","score":0.7889999747276306},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.765999972820282},{"id":"https://openalex.org/keywords/selective-sweeps","display_name":"selective sweeps","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dog-breeds","display_name":"dog breeds","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phenotypic-diversity","display_name":"phenotypic diversity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/recombination-hotspots","display_name":"recombination hotspots","score":0.8230000138282776},{"id":"https://openalex.org/keywords/prdm9","display_name":"PRDM9","score":0.953000009059906},{"id":"https://openalex.org/keywords/recombination-mapping","display_name":"recombination mapping","score":0.527999997138977},{"id":"https://openalex.org/keywords/grey-wolf","display_name":"grey wolf","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5610755085945129},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.48454156517982483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4137861728668213},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41327643394470215},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39389562606811523},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.325543612241745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2939029932022095},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2880120277404785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1381513774394989}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-209335","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209335","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:632862394","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:656760/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-209335","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-209335","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W647727056","https://openalex.org/W1510408342","https://openalex.org/W1516680128","https://openalex.org/W1540989094","https://openalex.org/W1581230381","https://openalex.org/W1598797451","https://openalex.org/W1963756058","https://openalex.org/W1963998725","https://openalex.org/W1965621126","https://openalex.org/W1970283686","https://openalex.org/W1974440260","https://openalex.org/W1975455171","https://openalex.org/W1977512069","https://openalex.org/W1980514449","https://openalex.org/W1981244256","https://openalex.org/W1982855130","https://openalex.org/W1983556126","https://openalex.org/W1986349269","https://openalex.org/W1987882116","https://openalex.org/W1988260965","https://openalex.org/W1993351732","https://openalex.org/W1994539671","https://openalex.org/W1994730862","https://openalex.org/W2000764403","https://openalex.org/W2003515720","https://openalex.org/W2008712670","https://openalex.org/W2013550946","https://openalex.org/W2014342923","https://openalex.org/W2023699618","https://openalex.org/W2024439539","https://openalex.org/W2024459631","https://openalex.org/W2029983700","https://openalex.org/W2038473742","https://openalex.org/W2045716211","https://openalex.org/W2047657819","https://openalex.org/W2057420639","https://openalex.org/W2069681711","https://openalex.org/W2073073728","https://openalex.org/W2075292410","https://openalex.org/W2081901919","https://openalex.org/W2084922050","https://openalex.org/W2086303086","https://openalex.org/W2087260514","https://openalex.org/W2090665773","https://openalex.org/W2094608127","https://openalex.org/W2100990361","https://openalex.org/W2102600110","https://openalex.org/W2102992354","https://openalex.org/W2103575733","https://openalex.org/W2110866891","https://openalex.org/W2111400550","https://openalex.org/W2111534865","https://openalex.org/W2113699551","https://openalex.org/W2114611642","https://openalex.org/W2114796514","https://openalex.org/W2115894247","https://openalex.org/W2118020384","https://openalex.org/W2119279196","https://openalex.org/W2119978637","https://openalex.org/W2122603731","https://openalex.org/W2126204254","https://openalex.org/W2127640118","https://openalex.org/W2130122556","https://openalex.org/W2130224796","https://openalex.org/W2135030836","https://openalex.org/W2140233505","https://openalex.org/W2140784970","https://openalex.org/W2140960450","https://openalex.org/W2150950360","https://openalex.org/W2151550426","https://openalex.org/W2155670634","https://openalex.org/W2156866331","https://openalex.org/W2157149092","https://openalex.org/W2159664283","https://openalex.org/W2160563322","https://openalex.org/W2161313275","https://openalex.org/W2164785275","https://openalex.org/W2165141658","https://openalex.org/W2170301165","https://openalex.org/W2171777347","https://openalex.org/W2259938310","https://openalex.org/W2336414374","https://openalex.org/W2916427899","https://openalex.org/W3173461329","https://openalex.org/W4300196896"],"related_works":["https://openalex.org/W412499502","https://openalex.org/W2102185362","https://openalex.org/W2134440374","https://openalex.org/W2233881958","https://openalex.org/W6929363924","https://openalex.org/W2252561783","https://openalex.org/W3016543023","https://openalex.org/W2103571477","https://openalex.org/W2292190728","https://openalex.org/W2102488404"],"abstract_inverted_index":{"Deciphering":[0],"the":[1,10,54,63,72,88,118,172,221,235,261,266,269,279,287,303,332,339,342],"genetic":[2,48,55,173],"basis":[3,56],"of":[4,9,13,38,57,82,100,137,223,237,259,305,334,341],"phenotypic":[5,58,90],"diversity":[6,91],"is":[7,62,268],"one":[8,271],"central":[11],"aims":[12],"biological":[14],"research.":[15],"Domestic":[16],"animals":[17],"provide":[18],"a":[19,35,80,205,227,274],"unique":[20],"opportunity":[21],"for":[22,160,196,248,315],"making":[23],"substantial":[24],"progress":[25],"towards":[26],"this":[27,121],"goal.":[28],"Intense":[29],"positive":[30,102],"selection":[31,103,134,199],"has":[32,85,242,336],"lead":[33,86,337],"to":[34,50,87,112,128,151,245,272,285,338],"rich":[36,317],"reservoir":[37],"phenotypes":[39],"and":[40,106,148,167,203,216,229,255,319],"underlying":[41,175,214],"genotypes":[42],"that":[43,296,310,320,331],"can":[44,219,230],"be":[45,246],"interrogated":[46],"using":[47],"tools":[49],"gain":[51],"insight":[52],"into":[53],"diversity.":[59],"The":[60,239],"dog":[61,94,153,267],"most":[64],"phenotypically":[65],"diverse":[66],"mammal.":[67],"It":[68],"was":[69],"domesticated":[70],"from":[71,145,183,189],"grey":[73],"wolf":[74],"11-30,000":[75],"years":[76],"ago.":[77],"After":[78],"domestication,":[79],"period":[81],"intense":[83],"breeding":[84],"massive":[89],"seen":[92],"amongst":[93],"breeds":[95],"today.":[96],"These":[97],"two":[98],"phases":[99],"strong":[101],"at":[104,107],"domestication":[105,154],"breed":[108,176],"creation":[109],"are":[110,313,323],"likely":[111],"have":[113,124,273],"left":[114],"their":[115],"signature":[116],"on":[117,226],"genome.":[119],"In":[120,208],"thesis,":[122],"we":[123,178,210,308],"analysed":[125],"genome-wide":[126,180,280],"patterns":[127],"detect":[129,152],"genomic":[130],"regions":[131],"involved":[132,162],"in":[133,135,163,186,200,253,292,300,345],"both":[136],"these":[138,311,321],"phases.":[139],"We":[140,157,193,277,294],"used":[141,179,278],"whole":[142],"genome":[143],"sequences":[144],"60":[146],"dogs":[147,188,301],"12":[149],"wolves,":[150],"selective":[155],"sweeps.":[156],"find":[158,194,295],"evidence":[159,195],"genes":[161,197],"memory":[164],"formation,":[165],"neurotransmission":[166],"starch":[168],"digestion.":[169],"To":[170],"decipher":[171],"signals":[174],"diversity,":[177],"genotype":[181,281],"data":[182,282],">170,000":[184],"SNPs":[185],"509":[187],"46":[190],"different":[191],"breeds.":[192,207],"under":[198],"many":[201],"breeds,":[202],"only":[204,270],"few":[206],"addition,":[209],"identify":[211],"novel":[212],"sweeps":[213],"morphology":[215],"behavior.":[217],"Recombination":[218],"influence":[220],"configuration":[222],"alleles":[224],"present":[225],"haplotype,":[228],"thus":[231],"increase":[232],"or":[233],"decrease":[234],"efficiency":[236],"selection.":[238],"PRDM9":[240,335],"protein":[241],"been":[243],"shown":[244],"important":[247],"determining":[249],"recombination":[250,290,297,343],"hotspot":[251],"locations":[252],"humans":[254],"other":[256],"mammals,":[257],"but":[258],"all":[260],"mammals":[262],"studied":[263],"so":[264],"far":[265],"non-functional":[275],"PRDM9.":[276,306],"described":[283],"above":[284],"characterise":[286],"fine":[288],"scale":[289],"map":[291],"dogs.":[293,346],"hotspots":[298,312],"exist":[299],"despite":[302],"absence":[304,333],"Moreover,":[307],"show":[309,330],"enriched":[314],"GC":[316],"peaks":[318,322],"getting":[324],"stronger":[325],"over":[326],"time.":[327],"Our":[328],"results":[329],"stabilisation":[340],"landscape":[344]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
