{"id":"https://openalex.org/W63276172","doi":null,"title":"Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload.","display_name":"Accumulation of arachidonate in triacylglycerols and unesterified fatty acids during ischemia and reflow in the isolated rat heart. Correlation with the loss of contractile function and the development of calcium overload.","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W63276172","mag":"63276172","pmid":"https://pubmed.ncbi.nlm.nih.gov/3090888","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888304"},"language":"en","primary_location":{"id":"pmid:3090888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888304/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028113693","display_name":"Karen P. Burton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K P Burton","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038526875","display_name":"Louis Maximilian Buja","orcid":"https://orcid.org/0000-0001-8386-7029","observed_orcids":["https://orcid.org/0000-0001-8386-7029"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Buja","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111829370","display_name":"A Sen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Sen","raw_affiliation_strings":["University of Texas, Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410707","display_name":"James T. Willerson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J T Willerson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107559060","display_name":"Kenneth R. Chien","orcid":"https://orcid.org/0000-0002-2759-8378","observed_orcids":["https://orcid.org/0000-0002-2759-8378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K R Chien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.8491,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.984729,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"124","issue":"2","first_page":"238","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9559999704360962},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9290000200271606},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9599999785423279},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.7360000014305115},{"id":"https://openalex.org/keywords/calcium-overload","display_name":"calcium overload","score":0.8690000176429749},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8619999885559082},{"id":"https://openalex.org/keywords/membrane-phospholipids","display_name":"membrane phospholipids","score":0.824999988079071},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7099999785423279},{"id":"https://openalex.org/keywords/isolated-perfused-rat-heart","display_name":"isolated perfused rat heart","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.4950000047683716},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.546999990940094},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8365441560745239},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7423796057701111},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6342904567718506},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.6265703439712524},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.6043163537979126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5692800879478455},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5268722176551819},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4669989347457886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.405825138092041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4018755555152893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32292789220809937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.285203754901886},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1330561339855194},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3090888","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1888304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:63276172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3090888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1888304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1608744359","https://openalex.org/W1777997311","https://openalex.org/W1908770638","https://openalex.org/W1966279438","https://openalex.org/W1970771347","https://openalex.org/W1977782419","https://openalex.org/W1991417512","https://openalex.org/W1994747574","https://openalex.org/W1996633032","https://openalex.org/W1997664942","https://openalex.org/W2016052636","https://openalex.org/W2024759152","https://openalex.org/W2029160550","https://openalex.org/W2041757099","https://openalex.org/W2054722098","https://openalex.org/W2064287942","https://openalex.org/W2069718832","https://openalex.org/W2071766920","https://openalex.org/W2090303199","https://openalex.org/W2133950117","https://openalex.org/W2149444048","https://openalex.org/W2152311269","https://openalex.org/W2153856379","https://openalex.org/W2155765639","https://openalex.org/W2410892011","https://openalex.org/W2436906790","https://openalex.org/W2462108591"],"related_works":["https://openalex.org/W2087320217","https://openalex.org/W2158972828","https://openalex.org/W161486489","https://openalex.org/W2038410731","https://openalex.org/W2064287942","https://openalex.org/W2103211766","https://openalex.org/W2405075262","https://openalex.org/W3092477719","https://openalex.org/W2405644656","https://openalex.org/W2027815818"],"abstract_inverted_index":{"Alterations":[0],"in":[1,53,72,84,122,131,163,217,227,247,260,308,320,343],"triacylglycerol":[2,137,248,288,305],"and":[3,33,41,58,68,117,145,154,207,243,256,263,326,339],"phospholipid":[4],"metabolism":[5],"are":[6,277],"known":[7],"to":[8,23,97,147,223,251],"occur":[9],"during":[10,66,254,324],"the":[11,28,37,42,49,132,175,239,333,344],"evolution":[12],"of":[13,19,30,39,44,48,82,93,101,115,136,143,152,168,170,177,181,205,214,236,241,273,283,304,335,341],"myocardial":[14,45,64,87,178],"ischemic":[15,309],"injury.":[16,46],"The":[17,165],"purpose":[18],"this":[20,85],"study":[21],"was":[22,89,138,249],"explore":[24],"potential":[25],"relationships":[26],"between":[27],"accumulation":[29,38,169,232,340],"arachidonic":[31,133,172,183,242,262],"acid":[32,51,134,173,184,231],"other":[34,218,244,264],"fatty":[35,50,56,157,220,230,245,266,285,297,322],"acids,":[36,57],"triacylglycerol,":[40,54],"progression":[43],"Measurements":[47],"levels":[52,162],"unesterified":[55,171,265],"calcium":[59,124,342],"content":[60,135,240],"were":[61,185],"correlated":[62],"with":[63,70,91,110,149,279,328,332],"function":[65],"ischemia":[67,69,83,116,144,153,325,327],"reflow":[71,329],"an":[73,280],"isolated":[74],"perfused":[75],"rat":[76],"heart":[77],"preparation.":[78],"After":[79],"10":[80,141,203],"minutes":[81,114,142,204,213,235],"model,":[86],"dysfunction":[88,338],"reversible,":[90],"recovery":[92],"left":[94],"ventricular":[95],"+dP/dt":[96],"82.0%":[98],"+/-":[99,193,200,209],"4.8%":[100],"control":[102,197],"values":[103],"upon":[104],"reperfusion.":[105],"Hearts":[106],"did":[107],"not":[108],"recover":[109],"reperfusion":[111],"after":[112,140,202,211,233,269,289],"30":[113,212,234],"displayed":[118],"a":[119,224,257,270,301,317],"significant":[120,225],"increase":[121,130,148,226,252,259,319],"tissue":[123],"content.":[125],"A":[126],"significant,":[127],"nearly":[128],"threefold":[129],"found":[139,250],"continued":[146],"longer":[150,271],"periods":[151],"reflow.":[155],"Other":[156],"acids":[158,221,246,267,286,298,323],"also":[159],"showed":[160],"increased":[161],"triacylglycerol.":[164],"time":[166],"course":[167],"paralleled":[174],"loss":[176],"function.":[179],"Levels":[180],"free":[182,219,229,261,284,321],"(in":[186],"nanomoles":[187],"per":[188],"gram":[189],"wet":[190],"weight)":[191],"11.1":[192],"2.1":[194],"(SEM)":[195],"for":[196],"hearts,":[198],"17.3":[199],"1.9":[201],"ischemia,":[206,255],"38.4":[208],"2.5":[210],"ischemia.":[215,237,274],"Increases":[216],"contributed":[222],"total":[228],"Thus,":[238],"early":[253],"major":[258,302,318],"occurred":[268],"period":[272],"These":[275],"findings":[276],"consistent":[278],"initial":[281],"reincorporation":[282],"into":[287],"release":[290],"from":[291],"membrane":[292,296],"phospholipids,":[293],"suggesting":[294],"that":[295,306,316],"may":[299],"be":[300],"source":[303],"accumulates":[307],"myocardium.":[310],"In":[311],"addition,":[312],"these":[313],"results":[314],"suggest":[315],"correlates":[330],"temporally":[331],"development":[334],"severe":[336],"contractile":[337],"heart.":[345]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}