{"id":"https://openalex.org/W632153003","doi":null,"title":"Teneur de la chitine des parois, relation avec la r\u00e9sistance des levures \u00e0 l'amphot\u00e9ricine B","display_name":"Teneur de la chitine des parois, relation avec la r\u00e9sistance des levures \u00e0 l'amphot\u00e9ricine B","publication_year":2003,"publication_date":"2003-02-04","ids":{"openalex":"https://openalex.org/W632153003","mag":"632153003"},"language":"fr","primary_location":{"id":"pmh:oai:univ-lorraine.fr:univ-lorraine-ori-13181","doi":null,"is_oa":false,"landing_page_url":"http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0244_BAHMED.pdf","pdf_url":"http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0244_BAHMED.pdf","source":{"id":"https://openalex.org/S4306400741","display_name":"Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102194","host_organization_name":"Laboratoire de Cristallographie, R\u00e9sonance Magn\u00e9tique et Mod\u00e9lisations","host_organization_lineage":["https://openalex.org/I4210102194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/735262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074241171","display_name":"Karim Bahmed","orcid":"https://orcid.org/0000-0001-9854-5452","observed_orcids":["https://orcid.org/0000-0001-9854-5452","https://orcid.org/0000-0002-8932-1331"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karim Bahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074241171"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitin-content","display_name":"chitin content","score":0.6729999780654907},{"id":"https://openalex.org/keywords/yeast-cell-wall","display_name":"yeast cell wall","score":0.8870000243186951},{"id":"https://openalex.org/keywords/amphotericin-b-resistance","display_name":"amphotericin B resistance","score":0.9470000267028809},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/spheroplasts","display_name":"spheroplasts","score":0.7639999985694885},{"id":"https://openalex.org/keywords/ergosterol","display_name":"ergosterol","score":0.8199999928474426},{"id":"https://openalex.org/keywords/chitinase","display_name":"chitinase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glucanase","display_name":"glucanase","score":0.6800000071525574},{"id":"https://openalex.org/keywords/phosphatase","display_name":"phosphatase","score":0.7179999947547913},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8830000162124634},{"id":"https://openalex.org/keywords/rhodotorula","display_name":"Rhodotorula","score":0.921999990940094},{"id":"https://openalex.org/keywords/schizosaccharomyces","display_name":"Schizosaccharomyces","score":0.9670000076293945},{"id":"https://openalex.org/keywords/kluyveromyces","display_name":"Kluyveromyces","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antifungal-mechanism-of-action","display_name":"antifungal mechanism","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.595467746257782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521824061870575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37516242265701294}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:univ-lorraine.fr:univ-lorraine-ori-13181","doi":null,"is_oa":false,"landing_page_url":"http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0244_BAHMED.pdf","pdf_url":"http://docnum.univ-lorraine.fr/prive/SCD_T_2003_0244_BAHMED.pdf","source":{"id":"https://openalex.org/S4306400741","display_name":"Publications Et Travaux Academiques de Lorraine (Universite de Lorraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210102194","host_organization_name":"Laboratoire de Cristallographie, R\u00e9sonance Magn\u00e9tique et Mod\u00e9lisations","host_organization_lineage":["https://openalex.org/I4210102194"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"pmh:hdl:10068/735262","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/735262","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-01746935v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/tel-01746935v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiologie et Parasitologie. Universit\u00e9 Henri Poincar\u00e9 - Nancy 1, 2003. Fran\u00e7ais. ⟨NNT : 2003NAN12505⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:632153003","doi":null,"is_oa":false,"landing_page_url":"https://hal.univ-lorraine.fr/tel-01746935","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/735262","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/735262","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"id":"https://metadata.un.org/sdg/15","display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392215738","https://openalex.org/W2030243343","https://openalex.org/W7135315207","https://openalex.org/W2041314540","https://openalex.org/W1995906718","https://openalex.org/W1813925975","https://openalex.org/W6990994288","https://openalex.org/W1977847407","https://openalex.org/W6982677100","https://openalex.org/W3045119736"],"abstract_inverted_index":{"Afin":[0],"de":[1,5,48,60,66,86,108,136,142,147,168,175,180,188,194,256,262,319,327,334,381,385,409,416,454,469,486,491],"d\u00e9finir":[2],"le":[3,122,165,186,197,237],"r\u00f4le":[4,174],"la":[6,11,14,49,55,134,145,155,159,176,190,201,242,257,263,281,320,363,373,401,470,473],"paroi":[7,88,177,258],"et":[8,23,34,102,121,139,144,193,224,280,342,361,472],"en":[9,140,309,392],"particulier":[10,141],"chitine":[12,67,264,310,338,348,386,398,410,455,474],"dans":[13,103,164,178,200,387,456],"r\u00e9sistance":[15,61,146,202,282,300,321,439],"des":[16,43,58,64,71,124,126,203,218,239,254,269,285,293,324,383,390,397,428,446,460],"levures":[17,39,84,127,149,204,208,240,246,286,295,328],"\u00e0":[18,79,91,96,110,150,205,232,249,287,301,394,427,440,444,479],"l'Amphot\u00e9ricine":[19],"E,":[20],"plusieurs":[21],"esp\u00e8ces":[22],"souches":[24,72,114,326,359,434,447],"sont":[25,89,115,303,350],"utilis\u00e9es":[26],"pour":[27,481,488],"cette":[28,417],"\u00e9tude":[29],":":[30],"Rhodotorula,":[31],"Schizosaccharomyces,":[32],"Candida":[33,51],"Kluyveromyces.":[35],"Bien":[36],"que":[37,63,98,154,311,317,345,356,362,372],"ces":[38,104,137,148,227],"ne":[40,128,272],"soient":[41],"pas":[42,158],"agents":[44],"pathog\u00e8nes":[45],"(\u00e0":[46],"l'exception":[47,261],"souche":[50,364,374],"albicans),":[52],"elles":[53],"ont":[54,74,209,297,436],"caract\u00e9ristique":[56],"d'avoir":[57],"diff\u00e9rences":[59,107],"ainsi":[62,196],"taux":[65,333,384,408,429,453],"diff\u00e9rents.":[68],"Les":[69,336],"sph\u00e9roplastes":[70],"\u00e9tudi\u00e9es":[73],"montr\u00e9":[75],"une":[76,299,367,395,438],"sensibilit\u00e9":[77,109],"\u00e9lev\u00e9e":[78,371],"l'AmE.":[80,151,169,288],"En":[81],"effet,":[82],"les":[83,99,106,113,183,207,221,225,245,267,291,305,346,354,358,388,407,420,433,457,483],"d\u00e9barrass\u00e9es":[85],"leur":[87],"3":[90],"6":[92],"fois":[93],"plus":[94,230,247,307,370],"sensibles":[95,231],"l'AmE":[97,111,181,302,441,487],"cellules":[100,219,313],"intactes,":[101],"conditions":[105],"entre":[112,133,276],"moins":[116],"prononc\u00e9es.":[117],"De":[118],"plus,":[119],"l'extraction":[120],"dosage":[123],"st\u00e9rols":[125,138],"montrent":[129,273,344],"aucune":[130,274],"relation":[131,275],"directe":[132],"quantit\u00e9":[135],"l'ergost\u00e9rol":[143],"Ceci":[152],"montre":[153,259],"membrane":[156],"n'est":[157],"seule":[160],"structure":[161,191],"cellulaire":[162],"impliqu\u00e9e":[163],"m\u00e9canisme":[166],"d'action":[167,485],"Il":[170],"existe":[171],"donc":[172],"un":[173,477],"l'action":[179],"sur":[182,406],"levures.":[184,492],"Dans":[185],"but":[187],"perturber":[189],"pari\u00e9tale":[192,475],"cibler":[195],"compos\u00e9":[198],"intervenant":[199],"l'antifongique,":[206],"\u00e9t\u00e9":[210],"trait\u00e9es":[211],"par":[212,241,442],"diff\u00e9rentes":[213,421],"enzymes.":[214],"Or,":[215],"apr\u00e8s":[216],"incubation":[217],"avec":[220],"prot\u00e9ases,":[222],"phosphatases":[223],"glucanases":[226],"derni\u00e8res":[228],"deviennent":[229],"cet":[233,250],"antifongique.":[234,251],"Par":[235,289],"contre,":[236,290],"traitement":[238],"chitinase":[243,402,471],"rend":[244],"r\u00e9sistantes":[248],"L'analyse":[252],"quantitative":[253],"constituants":[255,271],"qu'\u00e0":[260],"qui":[265,296,377,435],"varie,":[266],"teneurs":[268],"autres":[270,325],"leurs":[277,312],"variations":[278],"quantitatives":[279],"(et":[283],"sensibilit\u00e9)":[284],"parois":[292,389,458],"deux":[294,306],"acquis":[298,437],"toutes":[304],"riches":[308],"m\u00e8res":[314,360,448],"respectives,":[315],"alors":[316],"l'augmentation":[318,382,451],",":[322],"intrins\u00e8que":[323],"s'accompagne":[329],"d'une":[330,464],"diminution":[331,467],"du":[332,452],"chitine.":[335],"activit\u00e9s":[337],"synth\u00e9tases,":[339],"CSI,":[340],"CSII":[341],"CSIII":[343],"trois":[347],"synth\u00e9tases":[349],"pr\u00e9sentes":[351],"tant":[352],"chez":[353,357,419,432],"mutants":[355,391,461],"Kb":[365],"pr\u00e9sente":[366],"activit\u00e9":[368],"enzymatique":[369],"Kbm.":[375],"Ce":[376],"rejette":[378],"l":[379],"'hypoth\u00e8se":[380],"cons\u00e9quence":[393],"activation":[396],"synth\u00e9tases.":[399],"Comme":[400],"peut":[403],"aussi":[404],"agir":[405],"pari\u00e9tale,":[411],"nous":[412],"avons":[413],"v\u00e9rifi\u00e9":[414],"l'expression":[415],"enzyme":[418,424],"souches.":[422],"Cette":[423],"est":[425,476],"d\u00e9tect\u00e9e":[426],"tr\u00e8s":[430],"faibles":[431],"comparaison":[443],"l'activite":[445],"respectives.":[449],"Ainsi":[450],"cellulaires":[459],"semble":[462],"r\u00e9sulter":[463],"r\u00e9pression":[465],"ou":[466],"d'activit\u00e9s":[468],"\u00e9l\u00e9ment":[478],"retenir":[480],"expliquer":[482],"m\u00e9canismes":[484],"chaque":[489],"type":[490]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2016-06-24T00:00:00"}