{"id":"https://openalex.org/W631693155","doi":null,"title":"Subjective food hypersensitivity: Studies on enterochromaffin cell secretion products and effects of seal oil therapy","display_name":"Subjective food hypersensitivity: Studies on enterochromaffin cell secretion products and effects of seal oil therapy","publication_year":2013,"publication_date":"2013-03-08","ids":{"openalex":"https://openalex.org/W631693155","mag":"631693155"},"language":"en","primary_location":{"id":"pmh:oai:bora.uib.no:1956/6720","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/6720","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1956/6720","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065813757","display_name":"Kine Gregersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kine Gregersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065813757"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seal-oil","display_name":"seal oil","score":0.6259999871253967},{"id":"https://openalex.org/keywords/enterochromaffin-cells","display_name":"enterochromaffin cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7450000047683716},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gastric-accommodation","display_name":"gastric accommodation","score":0.902999997138977},{"id":"https://openalex.org/keywords/dyspepsia","display_name":"dyspepsia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7900000214576721},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9169999957084656},{"id":"https://openalex.org/keywords/duodenal-administration","display_name":"duodenal administration","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.5299999713897705},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5149999856948853},{"id":"https://openalex.org/keywords/dietary-therapy","display_name":"dietary therapy","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.7852634191513062},{"id":"https://openalex.org/C90423213","wikidata":"https://www.wikidata.org/wiki/Q568290","display_name":"Enterochromaffin cell","level":4,"score":0.7025952339172363},{"id":"https://openalex.org/C2910883780","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food hypersensitivity","level":4,"score":0.5160993933677673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.51274573802948},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3483982980251312},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3256533145904541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3054846525192261},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2675195336341858},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23774147033691406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22858351469039917},{"id":"https://openalex.org/C2776027960","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food allergy","level":3,"score":0.16480332612991333},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.1337776780128479},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07234936952590942},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bora.uib.no:1956/6720","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/6720","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:631693155","doi":null,"is_oa":false,"landing_page_url":"https://bora.uib.no/bora-xmlui/bitstream/1956/6720/1/47657%20Gregersen%20main_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bora.uib.no:1956/6720","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1956/6720","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":170,"referenced_works":["https://openalex.org/W1488900451","https://openalex.org/W1510156095","https://openalex.org/W1557700842","https://openalex.org/W1560687283","https://openalex.org/W1607463688","https://openalex.org/W1802683447","https://openalex.org/W1828008232","https://openalex.org/W1964014336","https://openalex.org/W1964126585","https://openalex.org/W1966222463","https://openalex.org/W1966394345","https://openalex.org/W1967404752","https://openalex.org/W1968528693","https://openalex.org/W1969144895","https://openalex.org/W1970112855","https://openalex.org/W1970178265","https://openalex.org/W1971400768","https://openalex.org/W1972526677","https://openalex.org/W1972667757","https://openalex.org/W1974114749","https://openalex.org/W1974566555","https://openalex.org/W1974974855","https://openalex.org/W1975443403","https://openalex.org/W1975523098","https://openalex.org/W1975657006","https://openalex.org/W1975661117","https://openalex.org/W1979377324","https://openalex.org/W1979431125","https://openalex.org/W1979873552","https://openalex.org/W1980588138","https://openalex.org/W1981860873","https://openalex.org/W1982952653","https://openalex.org/W1983008895","https://openalex.org/W1984410748","https://openalex.org/W1985636605","https://openalex.org/W1986746242","https://openalex.org/W1991240731","https://openalex.org/W1992245040","https://openalex.org/W1992707234","https://openalex.org/W1993725963","https://openalex.org/W1996078707","https://openalex.org/W1997327345","https://openalex.org/W1997571842","https://openalex.org/W2000452998","https://openalex.org/W2002431248","https://openalex.org/W2002818394","https://openalex.org/W2003470472","https://openalex.org/W2004862250","https://openalex.org/W2011914193","https://openalex.org/W2012415800","https://openalex.org/W2014206072","https://openalex.org/W2014541894","https://openalex.org/W2017294467","https://openalex.org/W2018028043","https://openalex.org/W2018440490","https://openalex.org/W2018601267","https://openalex.org/W2018842471","https://openalex.org/W2019501820","https://openalex.org/W2020641398","https://openalex.org/W2020857104","https://openalex.org/W2023318110","https://openalex.org/W2024147885","https://openalex.org/W2024233889","https://openalex.org/W2026085319","https://openalex.org/W2026222211","https://openalex.org/W2028890830","https://openalex.org/W2029613657","https://openalex.org/W2032255794","https://openalex.org/W2033226130","https://openalex.org/W2035714071","https://openalex.org/W2037072244","https://openalex.org/W2039822351","https://openalex.org/W2040515757","https://openalex.org/W2042826377","https://openalex.org/W2043462457","https://openalex.org/W2045316710","https://openalex.org/W2045594664","https://openalex.org/W2047260156","https://openalex.org/W2047686598","https://openalex.org/W2049469050","https://openalex.org/W2049846847","https://openalex.org/W2052179356","https://openalex.org/W2059269695","https://openalex.org/W2060908841","https://openalex.org/W2061764527","https://openalex.org/W2064420667","https://openalex.org/W2065818402","https://openalex.org/W2066573736","https://openalex.org/W2066798524","https://openalex.org/W2068034273","https://openalex.org/W2070888548","https://openalex.org/W2074992169","https://openalex.org/W2075583206","https://openalex.org/W2076438268","https://openalex.org/W2077005896","https://openalex.org/W2077647940","https://openalex.org/W2078078010","https://openalex.org/W2079006650","https://openalex.org/W2080982981","https://openalex.org/W2081247915","https://openalex.org/W2083980457","https://openalex.org/W2084797144","https://openalex.org/W2085538087","https://openalex.org/W2085809883","https://openalex.org/W2086633404","https://openalex.org/W2087547193","https://openalex.org/W2088289743","https://openalex.org/W2089506227","https://openalex.org/W2091202704","https://openalex.org/W2091635150","https://openalex.org/W2092344011","https://openalex.org/W2092700691","https://openalex.org/W2093095026","https://openalex.org/W2094788185","https://openalex.org/W2095429986","https://openalex.org/W2096129454","https://openalex.org/W2096652486","https://openalex.org/W2097566770","https://openalex.org/W2097717264","https://openalex.org/W2097901958","https://openalex.org/W2100327483","https://openalex.org/W2101517152","https://openalex.org/W2102805175","https://openalex.org/W2104189614","https://openalex.org/W2105344046","https://openalex.org/W2105730511","https://openalex.org/W2109225320","https://openalex.org/W2114630563","https://openalex.org/W2115119750","https://openalex.org/W2118431918","https://openalex.org/W2122851161","https://openalex.org/W2123468521","https://openalex.org/W2124724575","https://openalex.org/W2125123579","https://openalex.org/W2128077096","https://openalex.org/W2128908882","https://openalex.org/W2129995381","https://openalex.org/W2130822078","https://openalex.org/W2132910924","https://openalex.org/W2135435249","https://openalex.org/W2137513278","https://openalex.org/W2139669280","https://openalex.org/W2140703378","https://openalex.org/W2142660233","https://openalex.org/W2144606035","https://openalex.org/W2149839188","https://openalex.org/W2152009902","https://openalex.org/W2153655311","https://openalex.org/W2154410960","https://openalex.org/W2157275283","https://openalex.org/W2157497304","https://openalex.org/W2158609768","https://openalex.org/W2158718693","https://openalex.org/W2159794114","https://openalex.org/W2161273650","https://openalex.org/W2162602142","https://openalex.org/W2162610091","https://openalex.org/W2162668960","https://openalex.org/W2163327463","https://openalex.org/W2164508567","https://openalex.org/W2167343594","https://openalex.org/W2167388403","https://openalex.org/W2169592605","https://openalex.org/W2171022089","https://openalex.org/W2241164591","https://openalex.org/W2341319633","https://openalex.org/W2415445784","https://openalex.org/W2797689176","https://openalex.org/W3191514827","https://openalex.org/W4248627171"],"related_works":["https://openalex.org/W1557700842","https://openalex.org/W1991741936","https://openalex.org/W2072555896","https://openalex.org/W2047686598","https://openalex.org/W7096117942","https://openalex.org/W2030204735","https://openalex.org/W134841629","https://openalex.org/W2008444105","https://openalex.org/W2977263556","https://openalex.org/W2300167454"],"abstract_inverted_index":{"Background:":[0],"Perceived":[1],"food":[2,87,161,307,329,363,434],"hypersensitivity":[3,162,308],"is":[4,19,46],"a":[5,26,70,93,164,251,345,371,424],"prevalent":[6],"condition":[7,18],"which":[8],"often":[9],"remains":[10],"medically":[11],"unexplained.":[12],"The":[13,49,341,392],"etiology":[14],"of":[15,25,28,43,51,62,79,96,197,205,207,228,257,282,298,348,381,394,403,432,446,466],"this":[16,415],"subjective":[17,86,160,306,328,362,433],"not":[20,148,385],"fully":[21],"understood,":[22],"mainly":[23],"because":[24],"lack":[27],"specific":[29],"diagnostic":[30],"methods,":[31],"together":[32],"with":[33,85,150,159,168,305,327,332,361,387],"limited":[34,372],"knowledge":[35],"about":[36],"underlying":[37],"pathogenetic":[38],"mechanisms.":[39,485],"Thus,":[40],"the":[41,52,58,76,144,181,185,194,198,211,220,375,378,398,404,430,444,463,467,478],"management":[42],"such":[44,436],"patients":[45,84,158,182,304,326,331,360],"challenging.":[47],"Aim:":[48],"objective":[50],"present":[53,342,468],"thesis":[54,343,469],"was":[55,147,269,273,384],"to":[56,68,74,135,311,369,473],"assess":[57],"potential":[59,445],"beneficial":[60,346],"effects":[61],"seal":[63,99,131,171,351,382],"oil":[64,100,352,383],"on":[65,353],"symptoms,":[66,117,193],"and":[67,174,177,210,219,233,244,288,337,356,400,411,443,482],"develop":[69],"novel":[71,252],"sample":[72],"protocol":[73],"investigate":[75],"putative":[77],"role":[78,373,425],"enteroendocrine":[80,427],"secretorial":[81],"compounds":[82],"in":[83,152,184,260,275,286,290,303,317,359,374,389,429,458],"hypersensitivity.":[88,364],"Results:":[89],"In":[90,155,248,278],"study":[91,156,249,276,279],"I,":[92],"single":[94],"dose":[95],"duodenal":[97,129,169,349],"administered":[98,130,170,350],"significantly":[101,138,237,301],"influenced":[102],"neither":[103],"gastric":[104,153,366,390],"accommodation,":[105],"as":[106,118,133,309,377,437,449],"examined":[107],"by":[108,120],"two":[109],"dimensional":[110],"(2D)":[111],"ultrasonographic":[112],"scanning,":[113],"nor":[114],"meal-induced":[115,140],"gastrointestinal":[116,141,229,453],"assessed":[119],"visual":[121],"analogue":[122],"scales":[123],"(VAS).":[124],"After":[125],"10":[126,243],"days\u2019":[127],"treatment,":[128,176],"oil,":[132,137],"compared":[134,310],"soy":[136],"reduced":[139],"symptoms.":[142,230],"However,":[143],"symptomatic":[145],"improvement":[146],"associated":[149,386],"improvements":[151,388],"accommodation.":[154,391],"II,":[157],"received":[163],"10-day":[165],"open":[166],"treatment":[167],"oil.":[172],"Before":[173],"after":[175],"1":[178],"month":[179],"post-treatment,":[180],"filled":[183],"Subjective":[186,214],"Health":[187],"Complaints":[188],"(SHC)":[189],"Inventory":[190],"for":[191,203,226,254,426,451],"nongastrointestinal":[192],"short":[195],"form":[196],"Nepean":[199],"Dyspepsia":[200],"Index":[201],"(SF-NDI)":[202],"evaluation":[204],"quality":[206],"life":[208],"(QoL),":[209],"Ulcer":[212],"Esophagitis":[213],"Symptoms":[215],"Scale":[216,224],"(UESS)":[217],"score":[218],"Gastrointestinal":[221],"Symptom":[222],"Rating":[223],"(GSRS)":[225],"assessment":[227],"Both":[231],"intestinal":[232,355],"extra-intestinal":[234,357],"complaints":[235,358],"were":[236,294,300,323],"improved":[238],"from":[239],"baseline,":[240],"both":[241,354],"at":[242],"30":[245],"days":[246],"post-treatment.":[247],"III,":[250],"method":[253,272],"direct":[255],"determination":[256],"serotonin":[258],"(5-HT)":[259],"gut":[261,291,318],"lavage":[262,292,319],"fluid":[263,293],"using":[264,447],"liquid":[265],"chromatography":[266],"mass":[267],"spectrometry":[268],"achieved.":[270],"This":[271],"applied":[274],"IV.":[277],"IV,":[280],"analyses":[281],"chromogranin":[283],"A":[284],"(CgA)":[285],"serum":[287],"5-HT":[289],"performed.":[295],"Serum":[296],"levels":[297,322,422],"CgA":[299,421],"lower":[302],"healthy":[312,338],"controls.":[313,339],"No":[314],"significant":[315],"differences":[316],"5-":[320],"HT":[321],"detected":[324],"between":[325,477],"hypersensitivity,":[330,435],"inflammatory":[333],"bowel":[334],"disease":[335],"(IBD)":[336],"Conclusion:":[340],"suggests":[344],"effect":[347,380],"Impaired":[365],"accommodation":[367],"seems":[368],"play":[370],"pathophysiology,":[376],"positive":[379],"mechanism":[393],"action":[395],"may":[396],"involve":[397],"anti-inflammatory":[399],"immune-modulating":[401],"properties":[402],"long-chain":[405],"omega-3":[406],"polyunsaturated":[407],"fatty":[408],"acids":[409],"(PUFAs),":[410],"further":[412,471],"studies":[413,465],"addressing":[414],"aspect":[416],"are":[417],"needed.":[418],"Decreased":[419],"systemic":[420],"suggest":[423],"alterations":[428],"pathophysiology":[431],"impaired":[438],"enterochromaffin":[439],"(EC)":[440],"cell":[441],"function,":[442],"granins":[448],"biomarkers":[450],"functional":[452],"disorders":[454],"should":[455],"be":[456],"explored":[457],"future":[459],"studies.":[460],"Taken":[461],"together,":[462],"hypothesis-generating":[464],"encourage":[470],"investigations":[472],"elucidate":[474],"causal":[475],"relationships":[476],"patients\u2019":[479],"unexplained":[480],"symptoms":[481],"possible":[483],"pathophysiological":[484]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
