{"id":"https://openalex.org/W631564277","doi":null,"title":"Increased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration","display_name":"Increased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration","publication_year":2009,"publication_date":"2009-09-29","ids":{"openalex":"https://openalex.org/W631564277","mag":"631564277"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9043","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9043/1/Olsen_MS_2009.pdf","pdf_url":"https://d-scholarship.pitt.edu/9043/1/Olsen_MS_2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084972949","display_name":"Adam S. Olsen","orcid":"https://orcid.org/0000-0003-0957-9867","observed_orcids":["https://orcid.org/0000-0003-0957-9867"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Adam S. Olsen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0957-9867","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084972949"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine-self-administration","display_name":"cocaine self-administration","score":0.8790000081062317},{"id":"https://openalex.org/keywords/attentional-lapses","display_name":"attentional lapses","score":0.8529999852180481},{"id":"https://openalex.org/keywords/reaction-time-variability","display_name":"reaction time variability","score":0.984000027179718},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8460000157356262},{"id":"https://openalex.org/keywords/attentional-control","display_name":"attentional control","score":0.6629999876022339},{"id":"https://openalex.org/keywords/behavioral-variability","display_name":"behavioral variability","score":0.6380000114440918},{"id":"https://openalex.org/keywords/long-term-drug-effects","display_name":"long-term drug effects","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.622397243976593},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5858422517776489},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.5466126203536987},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.47118499875068665},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.44211941957473755},{"id":"https://openalex.org/C126139899","wikidata":"https://www.wikidata.org/wiki/Q4818236","display_name":"Attentional control","level":3,"score":0.4118371903896332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3468959927558899},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.34476953744888306},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.24977272748947144},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19915828108787537},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.18050289154052734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1694587767124176},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9043","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9043/1/Olsen_MS_2009.pdf","pdf_url":"https://d-scholarship.pitt.edu/9043/1/Olsen_MS_2009.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:631564277","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9043/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1888424353","https://openalex.org/W1897167961","https://openalex.org/W1938992588","https://openalex.org/W1985428145","https://openalex.org/W1987534418","https://openalex.org/W2016406795","https://openalex.org/W2017588448","https://openalex.org/W2026360954","https://openalex.org/W2040092455","https://openalex.org/W2058103878","https://openalex.org/W2070796637","https://openalex.org/W2080693567","https://openalex.org/W2086295830","https://openalex.org/W2115132834","https://openalex.org/W2117671876","https://openalex.org/W2124548728","https://openalex.org/W2146991344","https://openalex.org/W2162259968","https://openalex.org/W2166208293","https://openalex.org/W2166464173","https://openalex.org/W2188981074","https://openalex.org/W2263717046"],"related_works":["https://openalex.org/W2016990438","https://openalex.org/W2070932372","https://openalex.org/W3017020266","https://openalex.org/W1987621639","https://openalex.org/W1963720507","https://openalex.org/W2033977288","https://openalex.org/W2027229658","https://openalex.org/W4213175498","https://openalex.org/W2324384208","https://openalex.org/W1506842545"],"abstract_inverted_index":{"In":[0,152],"humans,":[1],"cocaine":[2,92,103,125,233,252,278],"use":[3],"has":[4,53,76],"long":[5,303],"been":[6,308],"associated":[7],"with":[8],"poor":[9],"attentional":[10,56,171,327],"control":[11,203],"and":[12,44,105,140,198,290,329],"decreased":[13],"efficiency":[14],"in":[15,35,58,70,128,221,231,241,258,285,310,324,333],"goal-oriented":[16],"behavior.":[17],"Animal":[18],"models":[19],"of":[20,38,41,66,90,157,170,245,261,301,320,326],"these":[21],"stereotypic":[22],"drug":[23,83],"effects,":[24],"however,":[25],"have":[26,307],"thus":[27],"far":[28],"failed":[29],"to":[30,78,81,111,124,136,141,147,154,166,173,210,237,281,298],"produce":[31],"quantifiable":[32],"data":[33,275],"sets":[34],"part":[36],"because":[37],"a":[39,112,180,255],"lack":[40],"species":[42],"differences":[43,216],"analysis":[45,65,75,163],"techniques.":[46],"Recent":[47],"work":[48],"(Hervey":[49],"et":[50],"al.":[51],"2006)":[52],"successfully":[54],"quantified":[55],"lapses":[57,172],"disorders":[59,312],"such":[60,313],"as":[61,314],"ADHD":[62],"through":[63],"the":[64,82,88,129,149,168,202,211,222,228,232,242,246,251,259,265,299,318,321,330],"response":[67,95,161,183,212,247,287],"time":[68,96,162,184,213,248,288],"variations":[69],"simple":[71,115,286],"tasks,":[72,289],"but":[73],"this":[74,292],"yet":[77],"be":[79],"applied":[80,209],"abuse":[84],"scenario.":[85],"To":[86],"determine":[87],"effects":[89],"chronic":[91],"administration":[93,150,279],"on":[94],"variability,":[97,158],"14":[98],"rhesus":[99],"macaque":[100],"monkeys":[101],"(8":[102],"administering":[104],"6":[106],"performance-matched":[107],"controls)":[108],"were":[109,134,208,217],"subjected":[110],"50":[113],"trial":[114],"attention":[116],"task.":[117],"This":[118],"task":[119,143],"was":[120,164,194,235],"performed":[121,165],"W-F":[122],"prior":[123,146],"self-administration":[126],"sessions":[127,144,190,200],"test":[130],"group.":[131,204],"Treatment":[132],"groups":[133,220],"compared":[135],"both":[137,317],"each":[138],"other":[139],"baseline":[142],"recorded":[145],"beginning":[148],"paradigm.":[151],"addition":[153],"typical":[155],"measures":[156],"an":[159,238],"ex-Gaussian":[160,206],"quantify":[167],"contribution":[169],"overall":[174],"variability.":[175],"The":[176],"cocaine-administering":[177],"group":[178,234,253],"had":[179],"significantly":[181],"higher":[182],"standard":[185],"deviation":[186],"than":[187],"their":[188],"pre-administration":[189,272],"(p<0.05).":[191,273],"No":[192],"difference":[193],"observed":[195,218],"between":[196,219],"pre-":[197],"post-administration":[199,269],"for":[201],"When":[205],"methods":[207],"datasets,":[214],"no":[215],"normal":[223],"mean":[224],"(mu),":[225],"suggesting":[226,316],"that":[227,277,291],"variability":[229,284,293],"increase":[230,257,294],"due":[236,297],"increased":[239,282],"skew":[240],"right":[243],"tail":[244,267],"distribution.":[249],"Indeed,":[250],"showed":[254],"significant":[256],"value":[260,263],"tau(exponential":[262],"representing":[264],"distribution":[266],"magnitude)":[268],"versus":[270],"tau":[271],"These":[274],"suggest":[276],"leads":[280],"behavioral":[283],"is":[295],"primarily":[296],"prevalence":[300],"abnormally":[302],"responses.":[304],"Similar":[305],"results":[306],"demonstrated":[309],"clinical":[311],"ADHD,":[315],"relevance":[319],"primate":[322],"model":[323],"studies":[325],"processing":[328],"possible":[331],"similarity":[332],"affected":[334],"brain":[335],"regions":[336],"or":[337],"transmitter":[338],"systems.":[339]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}