{"id":"https://openalex.org/W631496994","doi":null,"title":"Investigations into the bioavailability of manufactured nanoparticles in fish","display_name":"Investigations into the bioavailability of manufactured nanoparticles in fish","publication_year":2011,"publication_date":"2011-12-31","ids":{"openalex":"https://openalex.org/W631496994","mag":"631496994"},"language":"en","primary_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:9397","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10036/3608","pdf_url":"http://hdl.handle.net/10036/3608","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10036/3608","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007907438","display_name":"Rhys M. Goodhead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rhys M. Goodhead","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007907438"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10753","display_name":"Microplastics and Plastic Pollution","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engineered-nanoparticles","display_name":"engineered nanoparticles","score":0.9679999947547913},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nanotoxicology","display_name":"nanotoxicology","score":0.8870000243186951},{"id":"https://openalex.org/keywords/fish","display_name":"fish","score":0.6299999952316284},{"id":"https://openalex.org/keywords/rainbow-trout-hepatocytes","display_name":"rainbow trout hepatocytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/high-throughput-toxicity-testing","display_name":"high-throughput toxicity screening","score":0.8109999895095825},{"id":"https://openalex.org/keywords/coherent-anti-stokes-raman-scattering-microscopy","display_name":"coherent anti-Stokes Raman scattering microscopy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.6610000133514404},{"id":"https://openalex.org/keywords/metal-oxide-nanoparticles","display_name":"metal oxide nanoparticles","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/xenobiotic-detoxification","display_name":"xenobiotic detoxification","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gill","display_name":"gill","score":0.5419999957084656},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.972000002861023},{"id":"https://openalex.org/keywords/corophium","display_name":"Corophium","score":0.7440000176429749},{"id":"https://openalex.org/keywords/daphnia","display_name":"Daphnia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/zebrafish-embryos","display_name":"zebrafish embryos","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.8551716804504395},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6288933753967285},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.546619713306427},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3857359290122986},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36004024744033813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33385223150253296},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2967764735221863},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.2619219422340393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20398765802383423},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11828598380088806}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:uilis.unsyiah.ac.id:9397","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10036/3608","pdf_url":"http://hdl.handle.net/10036/3608","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},{"id":"pmh:hdl:10068/1001754","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/1001754","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:figshare.com:article/29692436","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Investigations_into_the_bioavailability_of_manufactured_nanoparticles_in_fish/29692436","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:ore.exeter.ac.uk:10036/3608","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10036/3608","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or dissertation"},{"id":"mag:631496994","doi":null,"is_oa":false,"landing_page_url":"https://ore.exeter.ac.uk/repository/bitstream/handle/10036/3608/GoodheadR.pdf?sequence=2","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uilis.unsyiah.ac.id:9397","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10036/3608","pdf_url":"http://hdl.handle.net/10036/3608","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W631496994.pdf","grobid_xml":"https://content.openalex.org/works/W631496994.grobid-xml"},"referenced_works_count":319,"referenced_works":["https://openalex.org/W11476871","https://openalex.org/W27243663","https://openalex.org/W185414759","https://openalex.org/W1136070835","https://openalex.org/W1489018618","https://openalex.org/W1492410262","https://openalex.org/W1493943931","https://openalex.org/W1507082667","https://openalex.org/W1580906881","https://openalex.org/W1845242231","https://openalex.org/W1964123007","https://openalex.org/W1964529114","https://openalex.org/W1964659137","https://openalex.org/W1964976590","https://openalex.org/W1965140424","https://openalex.org/W1965774747","https://openalex.org/W1965800158","https://openalex.org/W1965887408","https://openalex.org/W1966318343","https://openalex.org/W1966476051","https://openalex.org/W1966548146","https://openalex.org/W1966653689","https://openalex.org/W1967133409","https://openalex.org/W1967953506","https://openalex.org/W1968073275","https://openalex.org/W1968146349","https://openalex.org/W1968509967","https://openalex.org/W1968796677","https://openalex.org/W1968922381","https://openalex.org/W1969883222","https://openalex.org/W1972624235","https://openalex.org/W1973621793","https://openalex.org/W1973912200","https://openalex.org/W1974311404","https://openalex.org/W1974670319","https://openalex.org/W1975124652","https://openalex.org/W1976239547","https://openalex.org/W1977304780","https://openalex.org/W1977449568","https://openalex.org/W1977529440","https://openalex.org/W1978078543","https://openalex.org/W1978653530","https://openalex.org/W1980182356","https://openalex.org/W1980230824","https://openalex.org/W1980656296","https://openalex.org/W1980926666","https://openalex.org/W1981119571","https://openalex.org/W1982956641","https://openalex.org/W1983523620","https://openalex.org/W1983947197","https://openalex.org/W1984232298","https://openalex.org/W1986492157","https://openalex.org/W1986962256","https://openalex.org/W1987202454","https://openalex.org/W1987923976","https://openalex.org/W1988675168","https://openalex.org/W1988992033","https://openalex.org/W1989365000","https://openalex.org/W1989721262","https://openalex.org/W1990865636","https://openalex.org/W1990995931","https://openalex.org/W1992008232","https://openalex.org/W1992021686","https://openalex.org/W1992083269","https://openalex.org/W1992169898","https://openalex.org/W1992476453","https://openalex.org/W1995584082","https://openalex.org/W1995734581","https://openalex.org/W1996083851","https://openalex.org/W1996157249","https://openalex.org/W1996635921","https://openalex.org/W1997215103","https://openalex.org/W1997430900","https://openalex.org/W1999830563","https://openalex.org/W2001018320","https://openalex.org/W2001629471","https://openalex.org/W2002027884","https://openalex.org/W2002096583","https://openalex.org/W2002289950","https://openalex.org/W2002903271","https://openalex.org/W2003753489","https://openalex.org/W2004010748","https://openalex.org/W2004771577","https://openalex.org/W2006033584","https://openalex.org/W2006262997","https://openalex.org/W2006925023","https://openalex.org/W2006933992","https://openalex.org/W2007108968","https://openalex.org/W2007166597","https://openalex.org/W2007507065","https://openalex.org/W2007792678","https://openalex.org/W2007862532","https://openalex.org/W2008666705","https://openalex.org/W2009514849","https://openalex.org/W2010431759","https://openalex.org/W2010721224","https://openalex.org/W2010788644","https://openalex.org/W2011299920","https://openalex.org/W2011424097","https://openalex.org/W2011679767","https://openalex.org/W2013344058","https://openalex.org/W2013944096","https://openalex.org/W2014436754","https://openalex.org/W2014540793","https://openalex.org/W2014574480","https://openalex.org/W2014935324","https://openalex.org/W2016085763","https://openalex.org/W2016752876","https://openalex.org/W2016928279","https://openalex.org/W2017539542","https://openalex.org/W2017587678","https://openalex.org/W2017899735","https://openalex.org/W2018347503","https://openalex.org/W2018753658","https://openalex.org/W2018858346","https://openalex.org/W2019002404","https://openalex.org/W2019442418","https://openalex.org/W2019504738","https://openalex.org/W2020761921","https://openalex.org/W2020915539","https://openalex.org/W2021534535","https://openalex.org/W2021988675","https://openalex.org/W2022014262","https://openalex.org/W2022071559","https://openalex.org/W2023493447","https://openalex.org/W2023967504","https://openalex.org/W2024350498","https://openalex.org/W2025095419","https://openalex.org/W2025188006","https://openalex.org/W2025260323","https://openalex.org/W2025407923","https://openalex.org/W2026518358","https://openalex.org/W2027308433","https://openalex.org/W2029087621","https://openalex.org/W2029527682","https://openalex.org/W2029931493","https://openalex.org/W2030532544","https://openalex.org/W2030635479","https://openalex.org/W2031139648","https://openalex.org/W2031474784","https://openalex.org/W2032124634","https://openalex.org/W2032363233","https://openalex.org/W2032441721","https://openalex.org/W2032706441","https://openalex.org/W2033125684","https://openalex.org/W2033300348","https://openalex.org/W2033473289","https://openalex.org/W2033975744","https://openalex.org/W2034582824","https://openalex.org/W2035440283","https://openalex.org/W2035869908","https://openalex.org/W2036821231","https://openalex.org/W2037360063","https://openalex.org/W2037789918","https://openalex.org/W2039522048","https://openalex.org/W2040066643","https://openalex.org/W2040231410","https://openalex.org/W2041742565","https://openalex.org/W2042141261","https://openalex.org/W2042779319","https://openalex.org/W2042940583","https://openalex.org/W2043632405","https://openalex.org/W2044766599","https://openalex.org/W2044794349","https://openalex.org/W2045467456","https://openalex.org/W2046340162","https://openalex.org/W2046731067","https://openalex.org/W2047794820","https://openalex.org/W2047942846","https://openalex.org/W2048046367","https://openalex.org/W2049271296","https://openalex.org/W2050087790","https://openalex.org/W2050686260","https://openalex.org/W2051318522","https://openalex.org/W2051582405","https://openalex.org/W2052391871","https://openalex.org/W2052720751","https://openalex.org/W2053302198","https://openalex.org/W2054921925","https://openalex.org/W2055222641","https://openalex.org/W2055944585","https://openalex.org/W2056008081","https://openalex.org/W2056262153","https://openalex.org/W2058122340","https://openalex.org/W2059582977","https://openalex.org/W2060618834","https://openalex.org/W2061643511","https://openalex.org/W2061967106","https://openalex.org/W2062183794","https://openalex.org/W2062485439","https://openalex.org/W2062558287","https://openalex.org/W2063138798","https://openalex.org/W2063311638","https://openalex.org/W2064468334","https://openalex.org/W2068025923","https://openalex.org/W2069633428","https://openalex.org/W2070634315","https://openalex.org/W2070909089","https://openalex.org/W2071255536","https://openalex.org/W2071340283","https://openalex.org/W2071841412","https://openalex.org/W2072214543","https://openalex.org/W2072423838","https://openalex.org/W2073100513","https://openalex.org/W2073794770","https://openalex.org/W2073831955","https://openalex.org/W2074945181","https://openalex.org/W2075295443","https://openalex.org/W2075654807","https://openalex.org/W2075895312","https://openalex.org/W2076217449","https://openalex.org/W2076664843","https://openalex.org/W2077228161","https://openalex.org/W2077410934","https://openalex.org/W2077456968","https://openalex.org/W2077537727","https://openalex.org/W2078112977","https://openalex.org/W2078583545","https://openalex.org/W2078970865","https://openalex.org/W2081070652","https://openalex.org/W2081335840","https://openalex.org/W2081455948","https://openalex.org/W2081745487","https://openalex.org/W2083026714","https://openalex.org/W2083404959","https://openalex.org/W2083844537","https://openalex.org/W2084132208","https://openalex.org/W2084609412","https://openalex.org/W2085404072","https://openalex.org/W2086754387","https://openalex.org/W2087121983","https://openalex.org/W2089864491","https://openalex.org/W2090051887","https://openalex.org/W2090230055","https://openalex.org/W2090424147","https://openalex.org/W2091633783","https://openalex.org/W2093882645","https://openalex.org/W2094437628","https://openalex.org/W2095397755","https://openalex.org/W2096215142","https://openalex.org/W2099191918","https://openalex.org/W2099317575","https://openalex.org/W2102122862","https://openalex.org/W2105012459","https://openalex.org/W2106081860","https://openalex.org/W2106412044","https://openalex.org/W2110166605","https://openalex.org/W2110230017","https://openalex.org/W2111163976","https://openalex.org/W2112142763","https://openalex.org/W2112620612","https://openalex.org/W2114514942","https://openalex.org/W2114882618","https://openalex.org/W2115029038","https://openalex.org/W2116386755","https://openalex.org/W2118236535","https://openalex.org/W2118492507","https://openalex.org/W2121170935","https://openalex.org/W2121425724","https://openalex.org/W2123605247","https://openalex.org/W2124371680","https://openalex.org/W2124730634","https://openalex.org/W2124877851","https://openalex.org/W2125737305","https://openalex.org/W2125988036","https://openalex.org/W2127209661","https://openalex.org/W2128857954","https://openalex.org/W2129403092","https://openalex.org/W2130538711","https://openalex.org/W2131118500","https://openalex.org/W2133808589","https://openalex.org/W2134405865","https://openalex.org/W2135265997","https://openalex.org/W2135488990","https://openalex.org/W2135980592","https://openalex.org/W2137554916","https://openalex.org/W2138003976","https://openalex.org/W2138573825","https://openalex.org/W2138575451","https://openalex.org/W2139820378","https://openalex.org/W2139826715","https://openalex.org/W2140940676","https://openalex.org/W2145870802","https://openalex.org/W2146308402","https://openalex.org/W2148226925","https://openalex.org/W2148558214","https://openalex.org/W2149312609","https://openalex.org/W2151570064","https://openalex.org/W2152638739","https://openalex.org/W2152917827","https://openalex.org/W2156188810","https://openalex.org/W2157489799","https://openalex.org/W2160798065","https://openalex.org/W2160877966","https://openalex.org/W2160890470","https://openalex.org/W2161325709","https://openalex.org/W2163360515","https://openalex.org/W2163557347","https://openalex.org/W2164883560","https://openalex.org/W2165716266","https://openalex.org/W2166591277","https://openalex.org/W2166926604","https://openalex.org/W2168059777","https://openalex.org/W2169282855","https://openalex.org/W2170536006","https://openalex.org/W2170705451","https://openalex.org/W2170828858","https://openalex.org/W2171736291","https://openalex.org/W2187204375","https://openalex.org/W2285424332","https://openalex.org/W2320474880","https://openalex.org/W2330647316","https://openalex.org/W2331190804","https://openalex.org/W2335703178","https://openalex.org/W2382676978","https://openalex.org/W3140098542","https://openalex.org/W3145924874","https://openalex.org/W3150248096","https://openalex.org/W3174377003"],"related_works":["https://openalex.org/W2033975744","https://openalex.org/W4308853798","https://openalex.org/W37022538","https://openalex.org/W791148093","https://openalex.org/W2056008081","https://openalex.org/W4294795802","https://openalex.org/W2800508423","https://openalex.org/W2765834160","https://openalex.org/W3088102354","https://openalex.org/W2571028552"],"abstract_inverted_index":{"The":[0,201,561,696,823],"field":[1],"of":[2,15,20,29,45,54,64,74,86,120,138,144,161,167,192,225,229,268,286,303,314,327,349,357,417,429,432,442,465,467,498,505,520,535,544,553,558,599,644,679,689,699,721,751,825,846,873],"nanotoxicology":[3,55,811],"has":[4,56,726,831],"emerged":[5],"as":[6,277,592],"a":[7,131,159,165,219,283,312,342,570,593,638,763,880],"discipline":[8],"in":[9,22,66,96,114,250,271,378,394,397,404,456,471,493,524,547,608,692,737,743,754,795,827,879],"parallel":[10],"with":[11,458,495,538,657,670,762,799,813,829,848,871],"the":[12,18,26,34,42,46,51,60,67,142,190,205,223,247,251,256,262,265,269,308,347,350,354,408,414,418,427,430,440,472,506,511,518,521,525,529,536,545,548,635,647,653,658,671,693,708,712,740,748,783,789,805,833],"rapid":[13],"expansion":[14],"nanotechnology":[16],"and":[17,36,62,72,99,116,212,259,288,294,306,317,364,368,371,391,396,475,532,551,601,627,660,663,731,761,782,818],"use":[19],"nanomaterials":[21,65,75],"modern":[23],"life.":[24],"Assessing":[25],"potential":[27,226,386,571,713],"impacts":[28],"manufactured":[30],"nanoparticles":[31],"(MNPs)":[32],"on":[33,50,311,439,517,681,687,765,807,851],"environment":[35],"human":[37],"health":[38],"is":[39,735,861],"critical":[40],"to":[41,76,81,94,110,129,158,186,189,198,244,299,323,335,345,374,451,488,606,620,646,703,716,724,747,815,875],"sustainable":[43],"development":[44],"nano-industry.":[47],"Current":[48],"knowledge":[49,115],"ecological":[52],"implications":[53],"major":[57],"uncertainties":[58],"surrounding":[59],"fate":[61],"behaviour":[63,519],"exposure":[68,197,526,598,715,839,863],"environment.":[69],"Bioavailability,":[70],"uptake":[71,390,441,466,509,568,698,821],"partitioning":[73,377],"organisms":[77],"are":[78,89,421,758,792],"key":[79],"determinates":[80],"toxicity,":[82],"yet":[83],"these":[84,121,179,193],"foundations":[85],"basic":[87],"data":[88,554,757,784],"only":[90],"now":[91],"just":[92],"starting":[93],"emerge":[95],"any":[97,168],"useful":[98,220],"coherent":[100,236],"manner":[101],"for":[102,124,136,170,222,281,387,410,485,510,573,578,597,637,652,714,780,810,820,843,865],"aquatic":[103],"animals.":[104,611],"This":[105,540],"thesis":[106,273,745],"work":[107,270,614],"set":[108],"out":[109],"address":[111],"this":[112,232,272,559,613,738,744],"gap":[113],"further":[117,786,869],"our":[118],"understanding":[119,806],"important":[122,595],"principles":[123],"fish.":[125,445],"\\n\\nIn":[126,424],"an":[127,278,777,862],"attempt":[128],"develop":[130],"high":[132],"through-put":[133],"screening":[134,224],"system":[135,221],"toxicity":[137,210,844],"MNPs,":[139,781,847],"studies":[140,180,516,557,741,768],"assessing":[141],"utility":[143,809],"primary":[145],"isolated":[146,181],"rainbow":[147],"trout":[148,182,339,362],"(Oncorhynchus":[149],"mykiss)":[150],"hepatocytes":[151,183,215,340,773],"found":[152,185],"they":[153],"showed":[154,208,384],"very":[155],"limited":[156],"responses":[157,195],"range":[160,285,313],"MNPs.":[162,230],"There":[163,500],"was":[164,242,275,297,321,359,649,666,676],"lack":[166],"evidence":[169,872],"either":[171],"lipid":[172],"peroxidation":[173],"or":[174,412,686],"xenobiotic":[175],"detoxification":[176],"activity.":[177],"In":[178,231,381,612],"were":[184,333,372,437,449,469,501,618],"be":[187,336],"unresponsive":[188],"induction":[191,479],"biological":[194,330],"after":[196],"positive":[199],"controls.":[200],"findings":[202],"demonstrated":[203,528],"that":[204,213,246,563,580,771,788,796,836,858,867],"MNPs":[206,291,305,328,332,358,403,443,455,492,523,579,607,790,826,866],"tested":[207,791],"low":[209],"generally":[211],"fish":[214,486,772],"do":[216,581,774],"not":[217,582,727,775,793],"provide":[218],"toxic":[227,794],"effects":[228,504],"cell":[233,257],"culture":[234,252],"work,":[235],"anti-Stokes":[237],"Raman":[238],"scattering":[239],"(CARS)":[240],"microscopy":[241],"applied":[243,298,322],"demonstrate":[245],"particles":[248,626,706],"supplied":[249],"medium":[253,527],"did":[254],"cross":[255],"membrane":[258],"enter":[260],"into":[261,292,338,361,444,707],"exposed":[263,450,487,619,694],"cells.\\n\\nIn":[264],"second":[266],"phase":[267],"CARS":[274,296,320,383,419,800],"investigated":[276,438],"experimental":[279,587],"technique":[280,420],"tracing":[282,388],"wide":[284],"metal":[287,289],"oxide":[290],"cells":[293],"tissues.":[295],"evaluate":[300],"initial":[301],"detection":[302],"different":[304,376],"investigate":[307],"imaging":[309,402],"capability":[310],"cells,":[315],"tissues":[316],"organisms.":[318],"Finally,":[319,855],"assess":[324],"localisation":[325],"ability":[326],"within":[329,353],"matrices.":[331],"shown":[334,373],"taken":[337],"using":[341],"3D":[343],"reconstruction":[344],"determine":[346],"origin":[348],"MNP":[351,567],"signal":[352],"cell.":[355],"Uptake":[356],"established":[360,857],"gill":[363,474],"kidney":[365,476],"tissue,":[366],"corophium":[367],"daphnia":[369],"species":[370],"have":[375,769,802],"zebrafish":[379],"embryos.":[380],"summary":[382],"great":[385],"particle":[389],"bio-distribution":[392],"both":[393],"vitro":[395],"vivo.":[398],"Particular":[399],"benefits":[400],"include":[401],"living":[405],"organisms,":[406,722],"without":[407],"need":[409],"labelling":[411],"fixing":[413],"material.":[415],"Limitations":[416],"also":[422],"discussed.":[423],"chapter":[425,588],"4,":[426],"consequences":[428],"presence":[431],"natural":[433,584],"organic":[434],"matter":[435],"(NOM)":[436],"Carp":[446],"(Cyprinus":[447],"carpio)":[448],"cerium":[452,468],"dioxide":[453],"(CeO2)":[454],"combination":[457,494,828],"NOM":[459,507,564,830],"over":[460],"28":[461],"days.":[462],"Elevated":[463],"levels":[464],"measured":[470],"brain,":[473],"tissue":[477],"by":[478],"coupled":[480],"plasma":[481],"mass":[482],"spectroscopy":[483],"(ICP-MS)":[484],"50":[489],"\u03bcg/l":[490,497],"CeO2":[491,513,522],"250":[496],"NOM.":[499,539],"no":[502,677],"such":[503],"enhancing":[508],"bulk":[512,630,659,704],"particles.":[514],"Detailed":[515],"highly":[530],"complex":[531],"dynamic":[533],"nature":[534],"interactions":[537],"study":[541,824],"discusses":[542],"some":[543],"difficulties":[546],"techniques,":[549],"analysis":[550],"interpretation":[552],"derived":[555],"from":[556],"nature.":[560],"finding":[562],"may":[565,841],"enhance":[566],"presents":[569],"issue":[572],"current":[574],"risk":[575,852],"assessment":[576,853],"criteria":[577],"consider":[583],"conditions.\\n\\nThe":[585],"final":[586],"considered":[589,730],"maternal":[590,672,859],"transfer":[591,643,860,874],"potentially":[594],"route":[596,864],"embryos":[600],"early":[602,718],"life":[603,719,838,877],"stage":[604],"animals":[605],"live":[609],"bearing":[610],"guppies":[615],"(Poecilia":[616],"reticulata)":[617],"7":[621],"nm":[622],"silver":[623],"citrate":[624,628],"stabilised":[625,629],"sized":[631],"particles,":[632],"dosed":[633],"via":[634],"diet":[636],"full":[639],"gestation":[640],"cycle.":[641],"Maternal":[642],"Ag":[645,680,701,705],"larvae":[648],"significantly":[650,667],"higher":[651,668],"nanoparticulate":[654],"treatment":[655],"compared":[656,669,702],"control":[661],"treatments":[662],"larval":[664,682],"burden":[665],"sires.":[673],"However,":[674],"there":[675],"impact":[678,850],"survival,":[683],"birth":[684],"weights,":[685],"indices":[688],"body":[690],"condition":[691],"adults.":[695],"enhanced":[697],"nano":[700],"guppy":[709],"offspring":[710],"emphasises":[711],"sensitive":[717,876],"stages":[720,878],"which":[723],"date":[725],"been":[728],"widely":[729],"suggests":[732,787],"greater":[733],"research":[734],"needed":[736],"area.\\n\\nCollectively,":[739],"conducted":[742],"contribute":[746],"science":[749],"base":[750],"nanotoxicology,":[752],"specifically":[753],"areas":[755],"where":[756],"especially":[759],"lacking":[760],"focus":[764],"bioavailability.":[766],"These":[767],"identified":[770,832],"offer":[776],"effective":[778],"screen":[779],"produced":[785],"form.":[797],"Working":[798],"I":[801],"helped":[803],"advance":[804],"its":[808,816],"studies,":[812],"regards":[814],"application":[817],"limitation":[819],"analyses.":[822],"fundamental":[834],"change":[835],"real":[837],"scenarios":[840],"instigate":[842],"assessments":[845],"significant":[849],"criteria.":[854],"I\u2019ve":[856],"requires":[868],"study,":[870],"non-mammalian":[881],"system.":[882]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}