{"id":"https://openalex.org/W631070754","doi":"https://doi.org/10.1371/journal.pone.0125777","title":"Noise-Driven Causal Inference in Biomolecular Networks","display_name":"Noise-Driven Causal Inference in Biomolecular Networks","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W631070754","doi":"https://doi.org/10.1371/journal.pone.0125777","mag":"631070754","pmid":"https://pubmed.ncbi.nlm.nih.gov/26030907","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4452541"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0125777","doi":"https://doi.org/10.1371/journal.pone.0125777","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0125777","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0125777","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071537554","display_name":"Robert J. Prill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Prill","raw_affiliation_strings":["IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America","institution_ids":["https://openalex.org/I4210114115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045147674","display_name":"ROBERT M. VOGEL","orcid":"https://orcid.org/0000-0001-5400-5024","observed_orcids":["https://orcid.org/0000-0001-5400-5024"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Vogel","raw_affiliation_strings":["ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan- Kettering Cancer Center, 1275 York Avenue, Box 460, New York, N.Y. 10065, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan- Kettering Cancer Center, 1275 York Avenue, Box 460, New York, N.Y. 10065, United States of America","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065396462","display_name":"Guillermo Cecchi","orcid":"https://orcid.org/0000-0003-1013-8348","observed_orcids":["https://orcid.org/0000-0003-1013-8348"]},"institutions":[{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo A. Cecchi","raw_affiliation_strings":["IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America","institution_ids":["https://openalex.org/I4210114115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023421069","display_name":"Gr\u00e9goire Y Altan-Bonnet","orcid":"https://orcid.org/0000-0002-7283-3162","observed_orcids":["https://orcid.org/0000-0002-7283-3162","https://orcid.org/0000-0002-9602-8133"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gr\u00e9goire Altan-Bonnet","raw_affiliation_strings":["ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan- Kettering Cancer Center, 1275 York Avenue, Box 460, New York, N.Y. 10065, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunoDynamics Group, Program in Computational Biology and Immunology, Memorial Sloan- Kettering Cancer Center, 1275 York Avenue, Box 460, New York, N.Y. 10065, United States of America","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000065699","display_name":"Gustavo A. Stolovitzky","orcid":"https://orcid.org/0000-0002-9618-2819","observed_orcids":["https://orcid.org/0000-0002-9618-2819"]},"institutions":[{"id":"https://openalex.org/I4210114115","display_name":"IBM Research - Thomas J. Watson Research Center","ror":"https://ror.org/0265w5591","country_code":"US","type":"facility","lineage":["https://openalex.org/I1341412227","https://openalex.org/I4210114115"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gustavo Stolovitzky","raw_affiliation_strings":["IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBM T. J. Watson Research Center, 1101 Kitchawan Road, Route 134, Yorktown Heights, N.Y. 10598, United States of America","institution_ids":["https://openalex.org/I4210114115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000065699"],"corresponding_institution_ids":["https://openalex.org/I4210114115"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.7888,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67869843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"e0125777","last_page":"e0125777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causal-inference","display_name":"causal inference","score":0.828000009059906},{"id":"https://openalex.org/keywords/noise-propagation","display_name":"noise propagation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/stochastic-gene-regulation","display_name":"stochastic gene regulation","score":0.6930000185966492},{"id":"https://openalex.org/keywords/covariance-matrix","display_name":"covariance matrix","score":0.7900000214576721},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5770000219345093},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.859000027179718},{"id":"https://openalex.org/keywords/synthetic-gene-networks","display_name":"synthetic gene networks","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7139999866485596},{"id":"https://openalex.org/keywords/biomolecular-networks","display_name":"biomolecular networks","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C166151441","wikidata":"https://www.wikidata.org/wiki/Q4923601","display_name":"Causation","level":2,"score":0.652070939540863},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.6502386927604675},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6419843435287476},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.5971555709838867},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.5019268989562988},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.497905969619751},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48381322622299194},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.48212504386901855},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4503428637981415},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4345672130584717},{"id":"https://openalex.org/C185142706","wikidata":"https://www.wikidata.org/wiki/Q1134404","display_name":"Covariance matrix","level":2,"score":0.43372824788093567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4173222780227661},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3357561230659485},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3207228183746338},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.22514283657073975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22398948669433594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20896479487419128},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20177772641181946},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18619227409362793},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15591704845428467},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0125777","doi":"https://doi.org/10.1371/journal.pone.0125777","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0125777","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4452541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4452541","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26030907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26030907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:plo:pone00:0125777","doi":null,"is_oa":false,"landing_page_url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125777","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4b40f314cef54e839d3b1b82ebc9e325","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4b40f314cef54e839d3b1b82ebc9e325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 6, p e0125777 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0125777","doi":"https://doi.org/10.1371/journal.pone.0125777","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0125777","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4548552132","display_name":"Self-organization of T lymphocyte activation into collective immune responses","funder_award_id":"R56AI083408","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4620100914","display_name":"Systems Biology of Diversity in Cancer","funder_award_id":"U54CA148967","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7981691343","display_name":null,"funder_award_id":"AI083408","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8144399313","display_name":"Quantitative modeling of the phenotypic variability of individual T cells and the","funder_award_id":"R01AI083408","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000124117","display_name":null,"funder_award_id":"CA148967","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W114565888","https://openalex.org/W284239745","https://openalex.org/W1642251103","https://openalex.org/W1975686358","https://openalex.org/W1987862415","https://openalex.org/W2012964934","https://openalex.org/W2017277760","https://openalex.org/W2031822229","https://openalex.org/W2040535441","https://openalex.org/W2046451925","https://openalex.org/W2057453987","https://openalex.org/W2060630008","https://openalex.org/W2063116057","https://openalex.org/W2063131697","https://openalex.org/W2073307618","https://openalex.org/W2079296583","https://openalex.org/W2101567517","https://openalex.org/W2102787760","https://openalex.org/W2107342968","https://openalex.org/W2114849571","https://openalex.org/W2115368299","https://openalex.org/W2117057692","https://openalex.org/W2153568634","https://openalex.org/W2153683741","https://openalex.org/W2171280873","https://openalex.org/W2178225550","https://openalex.org/W2944782266","https://openalex.org/W3008437073","https://openalex.org/W3021559346","https://openalex.org/W3133236490","https://openalex.org/W4394214217","https://openalex.org/W4394514579","https://openalex.org/W7075292137"],"related_works":["https://openalex.org/W2314462191","https://openalex.org/W2073307618","https://openalex.org/W2080493956","https://openalex.org/W2523640714","https://openalex.org/W2615138554","https://openalex.org/W4391222373","https://openalex.org/W2379366756","https://openalex.org/W6980461880","https://openalex.org/W4409574120","https://openalex.org/W7097741442"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"and":[2,15,67,108,148],"protein":[3,123],"concentrations":[4],"dynamically":[5],"fluctuate":[6],"because":[7],"of":[8,36,47,87,104,118,122,162],"stochastic":[9],"(\"noisy\")":[10],"regulation.":[11],"Consequently,":[12],"biological":[13],"signaling":[14,153,179],"genetic":[16],"networks":[17],"not":[18,63],"only":[19],"translate":[20],"stimuli":[21],"with":[22],"functional":[23],"response":[24],"but":[25],"also":[26],"random":[27],"fluctuations.":[28],"Intuitively,":[29],"this":[30],"feature":[31],"manifests":[32],"as":[33,79],"the":[34,39,43,48,95,102,109,113,119,159],"accumulation":[35],"fluctuations":[37],"from":[38,168],"network":[40],"source":[41],"to":[42,72,151,171],"target.":[44],"Taking":[45],"advantage":[46],"fact":[49],"that":[50,61],"noise":[51,166],"propagates":[52],"directionally,":[53],"we":[54],"developed":[55],"a":[56,99,105,169,172],"method":[57,82,128],"for":[58,83,129],"causation":[59,84,130,137],"prediction":[60,131],"does":[62],"require":[64],"time-lagged":[65],"observations":[66],"therefore":[68],"can":[69],"be":[70],"applied":[71],"data":[73],"generated":[74],"by":[75],"destructive":[76],"assays":[77],"such":[78],"immunohistochemistry.":[80],"Our":[81],"prediction,":[85],"\"Inference":[86],"Network":[88],"Directionality":[89],"Using":[90],"Covariance":[91],"Elements":[92],"(INDUCE),\"":[93],"exploits":[94],"theoretical":[96],"relationship":[97],"between":[98],"change":[100],"in":[101,112,132,141,149,154,175],"strength":[103],"causal":[106],"interaction":[107],"associated":[110],"changes":[111],"single":[114],"cell":[115],"measured":[116],"entries":[117],"covariance":[120,163],"matrix":[121],"concentrations.":[124],"We":[125,157],"validated":[126],"our":[127],"two":[133],"experimental":[134],"systems":[135],"where":[136],"is":[138],"well":[139],"established:":[140],"an":[142,176],"E.":[143],"coli":[144],"synthetic":[145],"gene":[146],"network,":[147],"MEK":[150],"ERK":[152],"mammalian":[155,178],"cells.":[156],"report":[158],"first":[160],"analysis":[161],"elements":[164],"documenting":[165],"propagation":[167],"kinase":[170],"phosphorylated":[173],"substrate":[174],"endogenous":[177],"network.":[180]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
