{"id":"https://openalex.org/W631003382","doi":null,"title":"An in vitro Study of Drug-induced Degranulation of Human HMC-1 Mast Cells and Rat RBL-2H3 Cells","display_name":"An in vitro Study of Drug-induced Degranulation of Human HMC-1 Mast Cells and Rat RBL-2H3 Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W631003382","mag":"631003382"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-97850","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bachelorThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97850","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ava Tahmasebi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ava Tahmasebi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064839836","display_name":"Jennifer Skyt\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Skyt\u00e9n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hmc-1-cells","display_name":"HMC-1 cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":1.0},{"id":"https://openalex.org/keywords/codeine","display_name":"codeine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/compound-48-80","display_name":"compound 48/80","score":0.9440000057220459},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9179999828338623},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.9430000185966492},{"id":"https://openalex.org/keywords/beta-hexosaminidase","display_name":"beta-hexosaminidase","score":0.843999981880188},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.8610000014305115},{"id":"https://openalex.org/keywords/allergic-drug-reactions","display_name":"allergic drug reactions","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.9187966585159302},{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.7765630483627319},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6767371892929077},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5430738925933838},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4851844906806946},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4670841693878174},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.42344942688941956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41637760400772095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39506465196609497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33618226647377014},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32334965467453003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2900570034980774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24910157918930054},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06676274538040161}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-97850","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bachelorThesis"},{"id":"mag:631003382","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:777071/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-97850","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97850","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bachelorThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1503670912","https://openalex.org/W1516484156","https://openalex.org/W1873940529","https://openalex.org/W1923064046","https://openalex.org/W1972110039","https://openalex.org/W1974309418","https://openalex.org/W1980489721","https://openalex.org/W1986585141","https://openalex.org/W1987948153","https://openalex.org/W1990160588","https://openalex.org/W1990991524","https://openalex.org/W1994565985","https://openalex.org/W1995063959","https://openalex.org/W1998941878","https://openalex.org/W2000603720","https://openalex.org/W2002984825","https://openalex.org/W2007742656","https://openalex.org/W2009898571","https://openalex.org/W2011297047","https://openalex.org/W2029848691","https://openalex.org/W2035961375","https://openalex.org/W2037814379","https://openalex.org/W2048225817","https://openalex.org/W2063319456","https://openalex.org/W2078461697","https://openalex.org/W2086862954","https://openalex.org/W2117701707","https://openalex.org/W2163303312","https://openalex.org/W2170248440","https://openalex.org/W2232177832","https://openalex.org/W2471141885"],"related_works":["https://openalex.org/W2048225817","https://openalex.org/W2381726096","https://openalex.org/W1990991524","https://openalex.org/W2356579691","https://openalex.org/W2072973183","https://openalex.org/W4389001507","https://openalex.org/W2383161444","https://openalex.org/W4408143673","https://openalex.org/W2347200231","https://openalex.org/W2028683781"],"abstract_inverted_index":{"Mast":[0],"cells":[1,99,102],"and":[2,11,14,21,85,92,100,111,150],"basophils":[3],"participate":[4],"in":[5,70,152],"biological":[6],"responses":[7],"such":[8,18],"as":[9,19,81,147],"inflammation":[10],"allergic":[12],"reactions":[13],"contain":[15],"potent":[16],"mediators":[17,40],"histamine":[20],"cytokines.":[22],"Some":[23],"drugs,":[24],"for":[25],"example":[26],"opioids,":[27],"are":[28,145],"known":[29],"to":[30,53,66,155],"trigger":[31],"mast":[32,58,123,158],"cell":[33,59,77,124,136,143,159],"degranulation":[34,69,96,133],"with":[35],"the":[36,56,95,127,142],"release":[37],"of":[38,49,88,97,109,134,141],"immunogenic":[39],"that":[41],"may":[42],"cause":[43],"severe":[44],"side":[45],"effects.":[46],"The":[47,72],"aim":[48],"this":[50],"study":[51,67,156],"was":[52,79],"investigate":[54],"if":[55],"human":[57],"line":[60,78],"HMC-1":[61,98],"is":[62],"a":[63,82,132],"useful":[64,146],"model":[65],"codeine-induced":[68],"vitro.":[71],"rat":[73],"basophilic":[74],"leukemia":[75],"RBL-2H3":[76,101],"used":[80],"reference.":[83],"Time-":[84],"concentration-dependent":[86],"effects":[87],"codeine,":[89],"compound":[90,116],"48/80,":[91],"A23187":[93,130],"on":[94],"were":[103],"investigated":[104],"by":[105],"measuring":[106],"extracellular":[107],"levels":[108],"\u03b2-hexosaminidase":[110],"[3H]serotonin.":[112],"Neither":[113],"codeine":[114],"nor":[115],"48/80":[117],"produced":[118],"any":[119],"significant":[120],"basophil":[121],"or":[122],"degranulation,":[125],"whereas":[126],"calcium":[128],"ionophore":[129],"triggered":[131],"both":[135],"lines.":[137],"In":[138],"conclusion,":[139],"none":[140],"lines":[144],"relevant,":[148],"robust":[149],"reproducible":[151],"vitro":[153],"models":[154],"drug-induced":[157],"degranulation.":[160]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}