{"id":"https://openalex.org/W630648374","doi":"https://doi.org/10.2527/1990.683640x","title":"Dose response in growth of pigs injected daily with porcine somatotropin from 57 to 103 kilograms.","display_name":"Dose response in growth of pigs injected daily with porcine somatotropin from 57 to 103 kilograms.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W630648374","doi":"https://doi.org/10.2527/1990.683640x","mag":"630648374","pmid":"https://pubmed.ncbi.nlm.nih.gov/2318730"},"language":"en","primary_location":{"id":"doi:10.2527/1990.683640x","doi":"https://doi.org/10.2527/1990.683640x","is_oa":false,"landing_page_url":"https://doi.org/10.2527/1990.683640x","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D G McLaren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D G McLaren","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036954300","display_name":"Peter J. Bechtel","orcid":"https://orcid.org/0000-0002-1398-9001","observed_orcids":["https://orcid.org/0000-0002-1398-9001"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P J Bechtel","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003191363","display_name":"G L Grebner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G L Grebner","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059473579","display_name":"JAN E. NOVAKOFSKI","orcid":"https://orcid.org/0000-0002-2890-8892","observed_orcids":["https://orcid.org/0000-0002-2890-8892"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Novakofski","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","Office of the Vice Chancellor for Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Office of the Vice Chancellor for Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085685045","display_name":"FLOYD K. MCKEITH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F K McKeith","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R W Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Jones","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033203919","display_name":"Ronald H. Dalrymple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R H Dalrymple","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072719186","display_name":"Robert A. Easter","orcid":"https://orcid.org/0009-0007-2027-4577","observed_orcids":["https://orcid.org/0009-0007-2027-4577"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Easter","raw_affiliation_strings":["Dept. of Anim. Sci., University of Illinois, Urbana 61801","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Anim. Sci., University of Illinois, Urbana 61801","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":4368,"currency":"USD","value_usd":4368},"apc_paid":null,"fwci":5.977,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96154657,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"68","issue":"3","first_page":"640","last_page":"640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.08470000326633453,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13338","display_name":"Pharmacological Effects and Assays","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-somatotropin","display_name":"porcine somatotropin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/growth-promoting-hormones","display_name":"growth-promoting hormones","score":0.5239999890327454},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8989999890327454},{"id":"https://openalex.org/keywords/average-daily-gain","display_name":"average daily gain","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gain-to-feed-ratio","display_name":"gain:feed ratio","score":0.871999979019165},{"id":"https://openalex.org/keywords/feed-intake","display_name":"feed intake","score":0.8259999752044678},{"id":"https://openalex.org/keywords/structural-soundness","display_name":"structural soundness","score":0.9010000228881836},{"id":"https://openalex.org/keywords/barrow","display_name":"barrows","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gilts","display_name":"gilts","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6019999980926514},{"id":"https://openalex.org/keywords/quadratic-response-curve","display_name":"quadratic response curve","score":0.48100000619888306},{"id":"https://openalex.org/keywords/exponential-regression","display_name":"exponential regression","score":0.503000020980835},{"id":"https://openalex.org/keywords/swine-growth","display_name":"swine growth","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.6591988801956177},{"id":"https://openalex.org/C173419221","wikidata":"https://www.wikidata.org/wiki/Q4390467","display_name":"Crossbreed","level":2,"score":0.5897641181945801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5009951591491699},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48375654220581055},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4828222692012787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46573296189308167},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.45343461632728577},{"id":"https://openalex.org/C207892153","wikidata":"https://www.wikidata.org/wiki/Q11570","display_name":"Kilogram","level":3,"score":0.4360389709472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19374823570251465}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2527/1990.683640x","doi":"https://doi.org/10.2527/1990.683640x","is_oa":false,"landing_page_url":"https://doi.org/10.2527/1990.683640x","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},{"id":"pmid:2318730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2318730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of animal science","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6875,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"},{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1574567216","https://openalex.org/W2402799159","https://openalex.org/W2414709657","https://openalex.org/W1833606823","https://openalex.org/W2399327626","https://openalex.org/W2007900214","https://openalex.org/W2397130132","https://openalex.org/W284639607","https://openalex.org/W1541952558","https://openalex.org/W2119237225"],"abstract_inverted_index":{"Exogenous":[0],"administration":[1],"of":[2,47,91,126,153,165,238],"porcine":[3],"somatotropin":[4],"(PST)":[5],"has":[6],"been":[7,33],"shown":[8],"to":[9,28,41,99,117,155,234,244,255],"promote":[10],"growth":[11,57],"in":[12,236],"the":[13,43,124,127,226,262],"pig;":[14],"however,":[15],"dose-response":[16,227],"relationships":[17],"and":[18,23,49,54,56,64,75,112,133,157,178,195,204,229,247,277],"interactions":[19],"with":[20,82],"PST":[21,52,193,211],"source":[22,194],"sex":[24],"for":[25,123,131,142,151,176,183,201,242],"animals":[26],"taken":[27],"market":[29],"weight":[30,267],"have":[31,278],"not":[32,136,169,181],"established":[34],"clearly.":[35],"The":[36],"present":[37],"study":[38],"was":[39,232],"conducted":[40],"determine":[42],"relationship":[44],"between":[45],"dosage":[46],"pituitary-derived":[48],"recombinantly":[50],"manufactured":[51],"(pPST":[53],"rPST)":[55],"(ADG),":[58],"structural":[59],"soundness,":[60],"gain-to-feed":[61],"ratio":[62],"(G/F)":[63],"average":[65],"daily":[66],"feed":[67],"intake":[68],"(ADF).":[69],"Crossbred":[70],"barrows":[71,177],"(n":[72,77],"=":[73,78,161],"113)":[74],"gilts":[76,179],"97)":[79],"were":[80,107,199,253],"injected":[81],"either":[83],"saline,":[84],"1.5,":[85],"3.0,":[86],"6.0":[87,230],"or":[88,93,146,185],"9.0":[89],"mg/d":[90],"pPST":[92,132,156],"rPST":[94,134,158],"from":[95],"57":[96],"+/-":[97,101],".3":[98],"103.5":[100,245],".7":[102],"kg":[103,246],"live":[104],"weight.":[105],"Pigs":[106],"housed":[108],"five":[109],"per":[110],"pen":[111],"had":[113,212],"ad":[114],"libitum":[115],"access":[116],"an":[118],"18%":[119],"crude":[120],"protein":[121],"diet":[122],"duration":[125],"experiment.":[128],"Response":[129,174],"curves":[130,175],"did":[135,168,180],"differ":[137,182],"(P":[138,160,170,187,206,217],"greater":[139,171,188,218,283],"than":[140,172,189,208,219,284],".20)":[141],"ADG,":[143,202],"soundness":[144,186,216],"score":[145],"ADF.":[147],"Although":[148],"regression":[149,222],"coefficients":[150],"response":[152,241],"G/F":[154,203,280],"differed":[159],".05),":[162],"pairwise":[163],"comparisons":[164],"treatment":[166,263],"means":[167],".10).":[173],"ADG":[184],".05).":[190],"Averaged":[191],"over":[192],"sex,":[196],"quadratic":[197],"dose-responses":[198],"detected":[200],"ADF":[205],"less":[207,275],".01),":[209],"but":[210],"no":[213],"effect":[214],"on":[215],".25).":[220],"Exponential":[221],"models":[223],"best":[224],"described":[225],"relationships,":[228],"mg.pig-1.d-1":[231],"predicted":[233,254],"result":[235],"95%":[237],"maximal":[239],"achievable":[240],"days":[243],"G/F.":[248],"At":[249],"this":[250],"dose,":[251],"pigs":[252],"grow":[256],".15":[257],"kg/d":[258,273],"(20%)":[259],"faster":[260],"during":[261],"period,":[264],"reach":[265],"slaughter":[266],"11.6":[268],"d":[269],"earlier,":[270],"consume":[271],".56":[272],"(19%)":[274],"feed,":[276],"a":[279],".095":[281],"(36%)":[282],"controls.":[285]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}