{"id":"https://openalex.org/W630259226","doi":null,"title":"Cellular and molecular mechanisms behind methylmercury-induced neurotoxicity.","display_name":"Cellular and molecular mechanisms behind methylmercury-induced neurotoxicity.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W630259226","mag":"630259226"},"language":"en","primary_location":{"id":"pmh:oai:brage.bibsys.no:11250/264003","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264003","pdf_url":"http://hdl.handle.net/11250/264003","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11250/264003","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022577652","display_name":"Parvinder Kaur","orcid":"https://orcid.org/0000-0001-9154-3278","observed_orcids":["https://orcid.org/0000-0001-9154-3278","https://orcid.org/0009-0009-7595-1576"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Parvinder Kaur","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9154-3278","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022577652"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylmercury","display_name":"methylmercury","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8489999771118164},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8159999847412109},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/diethyldithiocarbamate","display_name":"diethyldithiocarbamate","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mercury-uptake","display_name":"mercury uptake","score":0.4269999861717224},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.3799999952316284},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-culture-model","display_name":"cell culture model","score":0.5509999990463257},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2780373914","wikidata":"https://www.wikidata.org/wiki/Q414075","display_name":"Methylmercury","level":3,"score":0.9256109595298767},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7727136611938477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7555844783782959},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7336716055870056},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.524692714214325},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4643687605857849},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4611089825630188},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3783036470413208},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3501826524734497},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.343334436416626},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24379554390907288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13833975791931152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0594048798084259},{"id":"https://openalex.org/C71572567","wikidata":"https://www.wikidata.org/wiki/Q864231","display_name":"Bioaccumulation","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:brage.bibsys.no:11250/264003","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264003","pdf_url":"http://hdl.handle.net/11250/264003","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/264003","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264003","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:630259226","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/7577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:brage.bibsys.no:11250/264003","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264003","pdf_url":"http://hdl.handle.net/11250/264003","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W630259226.pdf","grobid_xml":"https://content.openalex.org/works/W630259226.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W9884865","https://openalex.org/W28309201","https://openalex.org/W65800616","https://openalex.org/W67297763","https://openalex.org/W140025526","https://openalex.org/W148369991","https://openalex.org/W163623393","https://openalex.org/W173690104","https://openalex.org/W1122013619","https://openalex.org/W1502023791","https://openalex.org/W1511922485","https://openalex.org/W1524203275","https://openalex.org/W1529804537","https://openalex.org/W1541909806","https://openalex.org/W1543026124","https://openalex.org/W1551663317","https://openalex.org/W1602515604","https://openalex.org/W1606920154","https://openalex.org/W1680863695","https://openalex.org/W1758480227","https://openalex.org/W1775749144","https://openalex.org/W1904887938","https://openalex.org/W1916645464","https://openalex.org/W1926598832","https://openalex.org/W1967380123","https://openalex.org/W1972343917","https://openalex.org/W1975324682","https://openalex.org/W1977410382","https://openalex.org/W1978483995","https://openalex.org/W1978854230","https://openalex.org/W1980000538","https://openalex.org/W1981145358","https://openalex.org/W1985451517","https://openalex.org/W1986789223","https://openalex.org/W1988152888","https://openalex.org/W1990005405","https://openalex.org/W1994238140","https://openalex.org/W1995019025","https://openalex.org/W1995813003","https://openalex.org/W1998078640","https://openalex.org/W1999619268","https://openalex.org/W1999994059","https://openalex.org/W2001984338","https://openalex.org/W2003178719","https://openalex.org/W2005390270","https://openalex.org/W2009016920","https://openalex.org/W2009165454","https://openalex.org/W2009946484","https://openalex.org/W2010133778","https://openalex.org/W2015263033","https://openalex.org/W2018084397","https://openalex.org/W2021768378","https://openalex.org/W2023205648","https://openalex.org/W2023400558","https://openalex.org/W2024653190","https://openalex.org/W2028164957","https://openalex.org/W2031338620","https://openalex.org/W2034128042","https://openalex.org/W2034542419","https://openalex.org/W2039229929","https://openalex.org/W2039729598","https://openalex.org/W2039867424","https://openalex.org/W2043515387","https://openalex.org/W2045116385","https://openalex.org/W2049038392","https://openalex.org/W2051176464","https://openalex.org/W2052974794","https://openalex.org/W2053658205","https://openalex.org/W2055923164","https://openalex.org/W2058410551","https://openalex.org/W2059075664","https://openalex.org/W2062361496","https://openalex.org/W2063063986","https://openalex.org/W2063180703","https://openalex.org/W2064117575","https://openalex.org/W2064946335","https://openalex.org/W2065912251","https://openalex.org/W2066817362","https://openalex.org/W2067580224","https://openalex.org/W2067884641","https://openalex.org/W2068254130","https://openalex.org/W2068561089","https://openalex.org/W2068630344","https://openalex.org/W2070299858","https://openalex.org/W2071245122","https://openalex.org/W2072467017","https://openalex.org/W2072757324","https://openalex.org/W2074354584","https://openalex.org/W2078294826","https://openalex.org/W2081298113","https://openalex.org/W2085057506","https://openalex.org/W2085222910","https://openalex.org/W2085430333","https://openalex.org/W2086692763","https://openalex.org/W2087182466","https://openalex.org/W2088953298","https://openalex.org/W2091481654","https://openalex.org/W2094954778","https://openalex.org/W2095055513","https://openalex.org/W2099837366","https://openalex.org/W2101704560","https://openalex.org/W2103279359","https://openalex.org/W2103964183","https://openalex.org/W2104049876","https://openalex.org/W2105433251","https://openalex.org/W2105775395","https://openalex.org/W2111757144","https://openalex.org/W2112684021","https://openalex.org/W2119455109","https://openalex.org/W2120465860","https://openalex.org/W2122001860","https://openalex.org/W2124930146","https://openalex.org/W2127031191","https://openalex.org/W2129735882","https://openalex.org/W2131040926","https://openalex.org/W2132661781","https://openalex.org/W2138717871","https://openalex.org/W2148810367","https://openalex.org/W2148959908","https://openalex.org/W2149484230","https://openalex.org/W2153367437","https://openalex.org/W2153393001","https://openalex.org/W2165688438","https://openalex.org/W2166439728","https://openalex.org/W2169162863","https://openalex.org/W2169729819","https://openalex.org/W2171782015","https://openalex.org/W2188751783","https://openalex.org/W2329057544","https://openalex.org/W2338544821","https://openalex.org/W2339953928","https://openalex.org/W2398441191","https://openalex.org/W2403099907","https://openalex.org/W2414929738","https://openalex.org/W2431870374"],"related_works":["https://openalex.org/W7205787612","https://openalex.org/W2065055202","https://openalex.org/W7065406987","https://openalex.org/W2032989232","https://openalex.org/W2004079119","https://openalex.org/W1988152888","https://openalex.org/W3137856187","https://openalex.org/W7021099914","https://openalex.org/W4321378680","https://openalex.org/W2887193964"],"abstract_inverted_index":{"Printed":[0],"by":[1],"NTNU-trykk":[2],"Cellul\u00e6re":[3],"og":[4,15,30,65,110,122,135,157,186,191,205,255,303,327],"molekyl\u00e6re":[5,55],"mekanismer":[6,99],"ved":[7],"metylkvikks\u00f8lvindusert":[8],"nevrotoksisitet":[9,324],"Kvikks\u00f8lv":[10],"er":[11,44,67,103,125,130],"et":[12,88],"metall":[13],"kjent":[14],"brukt":[16,137],"til":[17,184,199,215,224,241,263,274,288,305,357],"mange":[18,27],"forskjellige":[19],"form\u00e5l":[20],"i":[21,26,81,117,144,154,193,211,213,229,239,247,251,253,269,272,309,325,341],"flere":[22,93],"hundre":[23],"\u00e5r.Kvikks\u00f8lv":[24],"inng\u00e5r":[25],"kjemiske":[28],"forbindelser":[29],"p\u00e5":[31,92,318],"1950-tallet":[32],"ble":[33,136,152,164,182,331],"det":[34,82,332],"vist":[35,333],"at":[36,351],"en":[37],"organisk":[38],"form":[39],"for":[40,47,69,127,140],"kvikks\u00f8lv,":[41],"metylkvikks\u00f8lv":[42],"(MeHg),":[43],"nevrotoksisk.Til":[45],"tross":[46],"omfattende":[48],"forskning":[49],"kjenner":[50],"vi":[51,316],"fortsatt":[52],"ikke":[53],"den":[54,345],"mekanismen":[56],"som":[57,138,170,178,297],"ligger":[58],"bak":[59,100],"MeHg's":[60],"giftighet.MeHg":[61],"reagerer":[62],"med":[63,166,175,222,258,286],"thiol-grupper":[64],"disse":[66],"vesentlige":[68],"enzymers":[70],"normale":[71],"funksjon.P\u00e5":[72],"denne":[73,313],"m\u00e5ten":[74],"kan":[75,232,291,300,321,336,355],"MeHg":[76,204,225,228,268,290,340],"skade":[77],"de":[78,97,120,310],"fleste":[79],"enzymer":[80],"cellul\u00e6re":[83,94,146],"maskineriet.MeHg's":[84],"giftvirkningen":[85],"skyldes":[86],"trolig":[87],"multippel":[89],"av":[90,96,105,112,114,188,196,203,219,227,236,244,267,278,295,339],"effekter":[91],"prosesser.En":[95],"viktige":[98],"MeHg-indusert":[101,128,207,323],"giftighet":[102],"dannelse":[104],"reaktive":[106],"oksygen":[107],"radikaler":[108],"(ROS)":[109],"reduksjon":[111],"mengden":[113,338],"glutation":[115],"(GSH)":[116],"celler.Balansen":[118],"mellom":[119],"antioksidante":[121],"reduktive":[123],"prosesser":[124,147],"viktig":[126],"nevrotoksisitet.Cellekultursystemer":[129],"mindre":[131],"komplekse":[132],"enn":[133],"hjernen":[134,360],"modell":[139],"\u00e5":[141,306,358],"studere":[142],"forandringene":[143],"slike":[145],"etter":[148],"MeHg-eksponering.MeHg-indusert":[149],"oksidativt":[150],"stress":[151],"studert":[153],"prim\u00e6re":[155],"nevroner":[156,212,231,238],"astrocytter":[158,216],"fra":[159,353],"stor-og":[160],"lillehjernen,":[161],"samt":[162,343],"cellelinjer.Cellekulturene":[163],"behandlet":[165],"N-acetyl":[167],"cystein":[168],"(NAC)":[169],"\u00f8ker":[171],"cellul\u00e6rt":[172,180,201,265],"GSH":[173,192,197,245],"eller":[174,260],"dietylmaleat":[176],"(DEM)":[177],"reduserer":[179],"GSH-innhold.Fluorescensmikroskopi":[181],"benyttet":[183],"identifisering":[185],"kvantifisering":[187],"cellul\u00e6r":[189],"ROS":[190],"levende":[194],"celler.Reduksjon":[195],"f\u00f8rte":[198,262],"\u00f8kt":[200,234,264],"opptak":[202,266],"forsterket":[206],"oksidativ":[208],"stress.Redusert":[209],"GSH-niv\u00e5":[210],"forhold":[214,240,273],"viser":[217],"betydningen":[218],"nevron-glia":[220],"interaksjon":[221],"hensyn":[223,287],"nevrotoksisitet.\u00d8kningen":[226],"cerebellare":[230,237,242,254,270],"forklare":[233,307],"f\u00f8lsomhet":[235],"astrocytter.Modulasjonen":[243],"forklarer":[246],"noen":[248],"grad":[249],"forskjellen":[250],"ROS-endringer":[252],"kortikale":[256,275],"kulturer.Behandling":[257],"NAC":[259],"DEM":[261],"kulturer":[271],"kulturer.Epidemiologiske":[276],"studier":[277],"fiskespisende":[279],"populasjoner":[280],"har":[281,315],"gitt":[282],"noe":[283],"forskjellig":[284],"resultat":[285],"hvordan":[289,319,334],"p\u00e5virke":[292,301,322],"hjernens":[293],"utvikling.Mengden":[294],"ern\u00e6ringsfaktorer":[296],"dokosaheksaensyre":[298],"(DHA)":[299],"MeHg-giftighet":[302],"bidra":[304,356],"uoverensstemmelsene":[308],"ulike":[311],"studiene.I":[312],"avhandlingen":[314],"sett":[317],"DHA":[320,335],"cellelinjer":[326],"prim\u00e6r-cellekulturer.I":[328],"prim\u00e6r":[329],"cellekulturer":[330],"redusere":[337,344],"cellene":[342],"oksidative":[346],"effekt.Dette":[347],"st\u00f8tter":[348],"hypotesen":[349],"om":[350],"n\u00e6ringsstoffer":[352],"fisk":[354],"beskytte":[359],"mot":[361],"MeHg.":[362]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
