{"id":"https://openalex.org/W63013890","doi":null,"title":"Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.","display_name":"Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W63013890","mag":"63013890","pmid":"https://pubmed.ncbi.nlm.nih.gov/7884411"},"language":"en","primary_location":{"id":"pmid:7884411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7884411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067913949","display_name":"Johannes Kornhuber","orcid":"https://orcid.org/0000-0002-8096-3987","observed_orcids":["https://orcid.org/0000-0002-8096-3987"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Kornhuber","raw_affiliation_strings":["Department of Psychiatry, University of W\u00fcrzburg, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of W\u00fcrzburg, Federal Republic of Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017177249","display_name":"Michael Weller","orcid":"https://orcid.org/0000-0002-1748-174X","observed_orcids":["https://orcid.org/0000-0002-1748-174X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Weller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050229484","display_name":"K. Schoppmeyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Schoppmeyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111448202","display_name":"P. Riederer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Riederer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.82,"has_fulltext":false,"cited_by_count":291,"citation_normalized_percentile":{"value":0.94992593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"43","issue":null,"first_page":"91","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amantadine","display_name":"amantadine","score":1.0},{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":1.0},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aminoadamantanes","display_name":"aminoadamantanes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7590000033378601},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9079999923706055},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9319999814033508},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.6880000233650208},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/psychotomimetic-effects","display_name":"psychotomimetic effects","score":0.6520000100135803},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8911606073379517},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.7810466289520264},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.661072313785553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.637223482131958},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5972443222999573},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.5494437217712402},{"id":"https://openalex.org/C2777374534","wikidata":"https://www.wikidata.org/wiki/Q409761","display_name":"Amantadine","level":2,"score":0.5422677397727966},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5243121385574341},{"id":"https://openalex.org/C2781065190","wikidata":"https://www.wikidata.org/wiki/Q7256512","display_name":"Psychotomimetic","level":4,"score":0.5068829655647278},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4773521423339844},{"id":"https://openalex.org/C2778851735","wikidata":"https://www.wikidata.org/wiki/Q407324","display_name":"Phencyclidine","level":4,"score":0.4130912125110626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4111859202384949},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2765064239501953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2571878731250763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10856962203979492}],"mesh":[{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D000547","descriptor_name":"Amantadine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006213","descriptor_name":"Hallucinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008559","descriptor_name":"Memantine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7884411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7884411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},{"id":"mag:63013890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7884411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1995046","https://openalex.org/W7526250","https://openalex.org/W70215990","https://openalex.org/W126850418","https://openalex.org/W1552342156","https://openalex.org/W1603224320","https://openalex.org/W1925729214","https://openalex.org/W1968840823","https://openalex.org/W1977453860","https://openalex.org/W1979106397","https://openalex.org/W1985757207","https://openalex.org/W1987414520","https://openalex.org/W1994997357","https://openalex.org/W1997243628","https://openalex.org/W1999205911","https://openalex.org/W2002920317","https://openalex.org/W2003793455","https://openalex.org/W2009134635","https://openalex.org/W2010024285","https://openalex.org/W2010044432","https://openalex.org/W2013820308","https://openalex.org/W2018928582","https://openalex.org/W2019378748","https://openalex.org/W2021099633","https://openalex.org/W2022869631","https://openalex.org/W2023321720","https://openalex.org/W2024795087","https://openalex.org/W2024868697","https://openalex.org/W2025073879","https://openalex.org/W2025340934","https://openalex.org/W2025497070","https://openalex.org/W2029568733","https://openalex.org/W2030147274","https://openalex.org/W2031920337","https://openalex.org/W2033818770","https://openalex.org/W2034383806","https://openalex.org/W2034453538","https://openalex.org/W2037435077","https://openalex.org/W2038590869","https://openalex.org/W2039182164","https://openalex.org/W2043736935","https://openalex.org/W2044779910","https://openalex.org/W2046203683","https://openalex.org/W2047172896","https://openalex.org/W2051859631","https://openalex.org/W2052988909","https://openalex.org/W2054484015","https://openalex.org/W2057670159","https://openalex.org/W2060298051","https://openalex.org/W2069304479","https://openalex.org/W2069994305","https://openalex.org/W2070585973","https://openalex.org/W2073486423","https://openalex.org/W2074095976","https://openalex.org/W2075718608","https://openalex.org/W2080591188","https://openalex.org/W2080641623","https://openalex.org/W2082249282","https://openalex.org/W2084334264","https://openalex.org/W2089214383","https://openalex.org/W2093755310","https://openalex.org/W2146204489","https://openalex.org/W2159359085","https://openalex.org/W2162941343","https://openalex.org/W2166985552","https://openalex.org/W2169073680","https://openalex.org/W2221822544","https://openalex.org/W2226347777","https://openalex.org/W2254580227","https://openalex.org/W2270370913","https://openalex.org/W2309042355","https://openalex.org/W2408483223","https://openalex.org/W2413790046","https://openalex.org/W2419175888","https://openalex.org/W2425546415","https://openalex.org/W2476525393","https://openalex.org/W2990362809"],"related_works":["https://openalex.org/W2072235811","https://openalex.org/W2025340934","https://openalex.org/W2749018","https://openalex.org/W2023243943","https://openalex.org/W2016595675","https://openalex.org/W2035769824","https://openalex.org/W76302322","https://openalex.org/W4390398623","https://openalex.org/W2100596982","https://openalex.org/W2409354322"],"abstract_inverted_index":{"The":[0],"pharmacological":[1],"inhibition":[2,129],"of":[3,21,82,89,114,117,130,155,166,171,176],"excitatory":[4],"amino":[5],"acid":[6],"neurotransmission":[7],"has":[8,28],"evolved":[9],"to":[10,31,125,144,161],"be":[11,86,145],"a":[12,33,80],"major":[13],"topic":[14],"in":[15,36,46,105,163],"neuropharmacology":[16],"since":[17],"enhanced":[18],"synaptic":[19],"action":[20],"glutamate":[22,65,133,138],"and":[23,43,45,56,69,75,92,101,116,150,153,170,180],"possibly":[24],"other":[25],"related":[26],"neurotransmitters":[27],"been":[29,96],"suggested":[30],"play":[32],"role":[34],"both":[35,165],"acute":[37],"neurological":[38,49],"conditions":[39],"such":[40,72,90],"as":[41,73,99],"ischemia":[42],"epilepsy":[44],"chronic":[47],"degenerative":[48],"diseases":[50],"including":[51],"Parkinson's":[52],"disease,":[53],"Huntington's":[54],"disease":[55],"Alzheimer's":[57],"disease.":[58],"While":[59],"antagonists":[60],"at":[61],"N-methyl-D-aspartate":[62],"(NMDA)":[63],"type":[64],"receptors":[66,139],"include":[67],"psychotomimetic":[68],"neurotoxic":[70],"agents":[71],"phencyclidine":[74],"MK-801,":[76],"the":[77,111,151,167,172,177],"aminoadamantanes":[78],"represent":[79],"class":[81],"drugs":[83,158],"which":[84,93,123],"may":[85],"largely":[87],"free":[88],"actions":[91],"have":[94,108,143,160],"already":[95,178],"used":[97],"clinically":[98],"antiviral":[100],"antiparkinsonian":[102],"agents.":[103],"Multiple":[104],"vitro":[106],"studies":[107],"recently":[109],"delineated":[110],"neuroprotective":[112,157],"properties":[113],"amantadine,":[115],"its":[118],"more":[119],"potent":[120],"congener,":[121],"memantine,":[122],"appear":[124],"mediate":[126],"neuroprotection":[127,136],"via":[128],"NMDA":[131],"receptor-dependent":[132],"activity.":[134],"Thus,":[135],"targeting":[137],"does":[140],"apparently":[141],"not":[142],"associated":[146],"with":[147],"prominent":[148],"psychotogenicity,":[149],"development":[152],"evaluation":[154],"new":[156],"will":[159],"performed":[162],"consideration":[164],"relative":[168],"safety":[169],"good":[173],"clinical":[174],"effect":[175],"known":[179],"established":[181],"aminoadamantanes.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
