{"id":"https://openalex.org/W63008272","doi":"https://doi.org/10.1007/978-1-4615-3898-1_15","title":"Pharmacokinetics of Commonly used Anti-Leukemic agents in Children","display_name":"Pharmacokinetics of Commonly used Anti-Leukemic agents in Children","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W63008272","doi":"https://doi.org/10.1007/978-1-4615-3898-1_15","mag":"63008272"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-3898-1_15","doi":"https://doi.org/10.1007/978-1-4615-3898-1_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-3898-1_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Childhood Leukemia: Present Problems and Future Prospects","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2499380366","display_name":"Childhood Leukemia: Present Problems and Future Prospects"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072781889","display_name":"W. Archie Bleyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Archie Bleyer","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Children\u2019s Hospital and Medical Center, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, Washington, 98105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Children\u2019s Hospital and Medical Center, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, Washington, 98105, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109539569","display_name":"David G. Poplack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Poplack","raw_affiliation_strings":["Leukemia Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA","Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024249524","display_name":"Frank M. Balis","orcid":"https://orcid.org/0000-0002-8117-6926","observed_orcids":["https://orcid.org/0000-0002-8117-6926"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank M. Balis","raw_affiliation_strings":["Leukemia Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leukemia Biology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05186533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"149","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.7590000033378601},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":1.0},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":1.0},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/intrathecal-chemotherapy","display_name":"intrathecal chemotherapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/meningeal-leukemia","display_name":"meningeal leukemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7509999871253967},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/teniposide","display_name":"teniposide","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.4950000047683716},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7958987951278687},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.7289162278175354},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.715764582157135},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.657206118106842},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6229697465896606},{"id":"https://openalex.org/C2777173762","wikidata":"https://www.wikidata.org/wiki/Q418529","display_name":"Mercaptopurine","level":2,"score":0.5867406725883484},{"id":"https://openalex.org/C2778707968","wikidata":"https://www.wikidata.org/wiki/Q417555","display_name":"Teniposide","level":4,"score":0.5727363228797913},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5472615957260132},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5204073190689087},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.4539473056793213},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44468724727630615},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.41904234886169434},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.41540828347206116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27436164021492004},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.18252810835838318}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-3898-1_15","doi":"https://doi.org/10.1007/978-1-4615-3898-1_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-3898-1_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Childhood Leukemia: Present Problems and Future Prospects","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W174306153","https://openalex.org/W184551449","https://openalex.org/W1481098920","https://openalex.org/W1643236602","https://openalex.org/W1909437603","https://openalex.org/W1931698261","https://openalex.org/W1937707643","https://openalex.org/W1939017986","https://openalex.org/W1966108600","https://openalex.org/W1966316671","https://openalex.org/W1985387827","https://openalex.org/W2014604974","https://openalex.org/W2026383337","https://openalex.org/W2031561085","https://openalex.org/W2034569729","https://openalex.org/W2037125325","https://openalex.org/W2044118975","https://openalex.org/W2058326606","https://openalex.org/W2072032394","https://openalex.org/W2096175229","https://openalex.org/W2103790960","https://openalex.org/W2256164548","https://openalex.org/W2411444793","https://openalex.org/W2412338107","https://openalex.org/W3043800854","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2098664152","https://openalex.org/W2372819473","https://openalex.org/W2286296573","https://openalex.org/W2017838616","https://openalex.org/W2058778365","https://openalex.org/W1997739107","https://openalex.org/W170801347","https://openalex.org/W2405162167","https://openalex.org/W7005181403","https://openalex.org/W2440786045"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}