{"id":"https://openalex.org/W63001716","doi":null,"title":"Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina.","display_name":"Voltage-gated sodium channel alpha-subunits Na(v)1.1, Na(v)1.2, and Na(v)1.6 in the distal mammalian retina.","publication_year":2007,"publication_date":"2007-11-27","ids":{"openalex":"https://openalex.org/W63001716","mag":"63001716","pmid":"https://pubmed.ncbi.nlm.nih.gov/18079688"},"language":"en","primary_location":{"id":"pmid:18079688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114257020","display_name":"Deb Kumar Mojumder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44461941","display_name":"University of Houston","ror":"https://ror.org/048sx0r50","country_code":"US","type":"education","lineage":["https://openalex.org/I44461941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deb K Mojumder","raw_affiliation_strings":["University of Houston College of Optometry, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Houston College of Optometry, Houston, TX, USA","institution_ids":["https://openalex.org/I44461941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074824430","display_name":"Laura J. Frishman","orcid":"https://orcid.org/0000-0002-4226-5109","observed_orcids":["https://orcid.org/0000-0002-4226-5109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J Frishman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083470381","display_name":"Deborah C. Otteson","orcid":"https://orcid.org/0000-0001-6093-6837","observed_orcids":["https://orcid.org/0000-0001-6093-6837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deborah C Otteson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763775","display_name":"David M. Sherry","orcid":"https://orcid.org/0000-0003-1568-0611","observed_orcids":["https://orcid.org/0000-0003-1568-0611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M Sherry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2502,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87237779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"2163","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.24009999632835388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.9959999918937683},{"id":"https://openalex.org/keywords/outer-plexiform-layer","display_name":"outer plexiform layer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/horizontal-cells","display_name":"horizontal cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/amacrine-cells","display_name":"amacrine cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/photoreceptor-terminals","display_name":"photoreceptor terminals","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cnqx","display_name":"CNQX","score":0.9449999928474426},{"id":"https://openalex.org/keywords/electroretinography","display_name":"electroretinogram","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.742355465888977},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6943087577819824},{"id":"https://openalex.org/C2781099447","wikidata":"https://www.wikidata.org/wiki/Q4113797","display_name":"Inner plexiform layer","level":3,"score":0.6186488270759583},{"id":"https://openalex.org/C2777585161","wikidata":"https://www.wikidata.org/wiki/Q2357246","display_name":"Outer plexiform layer","level":3,"score":0.5556389093399048},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5015273094177246},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.49659281969070435},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.4538213014602661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44739073514938354},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43579035997390747},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.41818517446517944},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.41211235523223877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3504672050476074},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34209832549095154},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.15431949496269226},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003623","descriptor_name":"Dark Adaptation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013779","descriptor_name":"Tetrodotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017949","descriptor_name":"Retinal Cone Photoreceptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017949","descriptor_name":"Retinal Cone Photoreceptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018750","descriptor_name":"6-Cyano-7-nitroquinoxaline-2,3-dione","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018750","descriptor_name":"6-Cyano-7-nitroquinoxaline-2,3-dione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D025042","descriptor_name":"Amacrine Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051248","descriptor_name":"Retinal Horizontal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D062550","descriptor_name":"NAV1.1 Voltage-Gated Sodium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062551","descriptor_name":"NAV1.2 Voltage-Gated Sodium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062557","descriptor_name":"NAV1.6 Voltage-Gated Sodium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18079688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:63001716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18079688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2135443574","display_name":"Proximal retinal responses and the ERG","funder_award_id":"R01EY006671","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4234980597","display_name":"UC Davis/NIH NeuroMab Facility","funder_award_id":"U24NS050606","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000082556","display_name":"Genetics and Biology of Malignant Glioma","funder_award_id":"P01CA095616","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000873646","display_name":"Center Core Grant for Vision Research","funder_award_id":"P30EY007551","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026320782","https://openalex.org/W1145264062","https://openalex.org/W2006096621","https://openalex.org/W2009461974","https://openalex.org/W1966824553","https://openalex.org/W2919694579","https://openalex.org/W2163173709","https://openalex.org/W2029037638","https://openalex.org/W2044659112","https://openalex.org/W7097776730"],"abstract_inverted_index":{"PURPOSE:":[0],"Recent":[1],"studies":[2],"indicate":[3],"the":[4,14,23,29,125,136,173,177,230,255,299,321,336],"presence":[5,300],"of":[6,25,34,128,135,154,176,215,301,327,340],"functional":[7,196],"voltage-gated":[8],"sodium":[9],"channels":[10,27,198,329,342],"(Na(v)":[11],"channels)":[12],"in":[13,17,28,79,84,93,124,190,254,289,293,298,330,335,343],"distal":[15],"retina":[16],"several":[18],"species.":[19,87],"This":[20,313],"study":[21],"examined":[22],"distribution":[24],"Na(v)":[26,70,197,328,341],"outer":[30],"plexiform":[31],"layer":[32],"(OPL)":[33],"rat,":[35],"mouse,":[36],"and":[37,42,60,74,82,102,112,149,179,211,222,310],"rabbit":[38,99],"retinas.":[39],"METHODS:":[40],"Immunohistochemical":[41],"electroretinographic":[43],"approaches":[44],"were":[45,104,291],"used.":[46],"RESULTS:":[47],"Antibodies":[48],"specific":[49],"for":[50,109,195,245],"Na(v)1":[51,185,246,251,262],"alpha-subunits":[52],"appropriately":[53],"labeled":[54],"retinal":[55],"ganglion":[56,311],"cells,":[57,96],"their":[58],"axons,":[59],"amacrine":[61],"cells":[62,81,101,120,236,345],"that":[63,114],"are":[64],"known":[65],"to":[66,118,172,279,307,325,347],"have":[67,158,267],"tetrodotoxin":[68],"(TTX)-sensitive":[69],"channels.":[71],"Pan-Na(v),":[72],"Na(v)1.2,":[73,111],"Na(v)1.6":[75,113],"labeling":[76,90,108,130,139,156,178,187,244,253,264],"was":[77,91,115,121,131,140,167,188,199,257,276],"found":[78],"horizontal":[80,95,100,119,150,344],"processes":[83,103],"all":[85],"three":[86,238],"Weaker":[88],"Na(v)1.1":[89,138],"observed":[92,189],"rodent":[94],"but":[97,224],"some":[98,153],"prominently":[105],"labeled.":[106],"Additional":[107],"Na(v)1.1,":[110],"not":[116,168,225,277],"attributable":[117],"also":[122,265],"present":[123,269],"OPL.":[126,337],"Much":[127],"this":[129,155,281],"diffusely":[132],"distributed.":[133],"Some":[134,248],"additional":[137,249],"associated":[141,160,258],"with":[142,161,259,317],"photoreceptor":[143,148,260],"terminals.":[144,261],"By":[145],"exclusion":[146],"using":[147],"cell":[151,163,192,272,333],"markers,":[152],"could":[157],"been":[159,268],"bipolar":[162,191,271,332],"dendrites,":[164,273],"although":[165,274],"colocalization":[166],"directly":[169],"established":[170],"due":[171,324],"diffuse":[174,250],"nature":[175],"limits":[180],"on":[181,270,320],"anatomical":[182],"resolution.":[183],"No":[184],"alpha-subunit":[186,252,263],"bodies.":[193],"Testing":[194],"performed":[200],"by":[201,284,296],"recording":[202],"full":[203],"field":[204],"flash":[205],"electroretinograms":[206],"from":[207,237],"dark-adapted":[208,231],"rats":[209,290],"before":[210],"after":[212],"intravitreal":[213],"injections":[214],"TTX,":[216],"6-cyano-7-nitroquinoxaline-2,3-dione":[217],"(CNQX),":[218],"or":[219],"TTX+CNQX.":[220],"TTX":[221,297,318],"CNQX+TTX,":[223],"CNQX":[226,302],"alone,":[227],"greatly":[228],"attenuated":[229],"cone-driven":[232,287],"b-waves.":[233],"CONCLUSIONS:":[234],"Horizontal":[235],"different":[239],"mammalian":[240],"retinas":[241],"showed":[242],"prominent":[243],"alpha-subunits.":[247],"OPL":[256],"may":[266],"it":[275],"possible":[278],"establish":[280],"localization":[282],"unequivocally":[283],"immunostaining.":[285],"However,":[286],"b-waves":[288],"reduced":[292],"maximum":[294],"amplitude":[295],"which":[303],"blocks":[304],"synaptic":[305],"input":[306],"horizontal,":[308],"amacrine,":[309],"cells.":[312],"finding":[314],"is":[315],"consistent":[316],"effects":[319],"b-wave":[322],"being":[323],"blockade":[326],"cone":[331],"dendrites":[334],"The":[338],"role":[339],"remains":[346],"be":[348],"determined.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}