{"id":"https://openalex.org/W629678974","doi":null,"title":"On the Cellular Basis of Aerobic Fitness : Intensity-Dependence and Time-Course of Cardiomyocyte and Endothelial Adaptations to Exercise Training","display_name":"On the Cellular Basis of Aerobic Fitness : Intensity-Dependence and Time-Course of Cardiomyocyte and Endothelial Adaptations to Exercise Training","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W629678974","mag":"629678974"},"language":"en","primary_location":{"id":"pmh:oai:brage.bibsys.no:11250/264609","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264609","pdf_url":"http://hdl.handle.net/11250/264609","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11250/264609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017452754","display_name":"Ole Johan Kemi","orcid":"https://orcid.org/0000-0003-1344-9512","observed_orcids":["https://orcid.org/0000-0003-1344-9512"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ole Johan Kemi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1344-9512","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017452754"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiorespiratory-fitness","display_name":"cardiorespiratory fitness","score":0.9919999837875366},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.8040000200271606},{"id":"https://openalex.org/keywords/vo2max","display_name":"VO2max","score":0.824999988079071},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cardiomyocyte-contractility","display_name":"cardiomyocyte contractility","score":0.9729999899864197},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.8180000185966492},{"id":"https://openalex.org/keywords/exercise-intensity","display_name":"exercise intensity","score":0.734000027179718},{"id":"https://openalex.org/keywords/detraining","display_name":"detraining","score":0.9710000157356262},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cardiac-adaptation","display_name":"cardiac adaptation","score":0.44200000166893005},{"id":"https://openalex.org/keywords/running-performance","display_name":"running performance","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.7646994590759277},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7241311073303223},{"id":"https://openalex.org/C196310339","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"VO2 max","level":4,"score":0.6588840484619141},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5998706817626953},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5861381888389587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5441738963127136},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.4842971861362457},{"id":"https://openalex.org/C171687745","wikidata":"https://www.wikidata.org/wiki/Q309252","display_name":"Physical fitness","level":2,"score":0.44216176867485046},{"id":"https://openalex.org/C99830354","wikidata":"https://www.wikidata.org/wiki/Q362854","display_name":"Endurance training","level":2,"score":0.4267372786998749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42335885763168335},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2961033880710602},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.2853134572505951},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2119811773300171},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:brage.bibsys.no:11250/264609","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264609","pdf_url":"http://hdl.handle.net/11250/264609","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/264609","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264609","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:629678974","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/7543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:brage.bibsys.no:11250/264609","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11250/264609","pdf_url":"http://hdl.handle.net/11250/264609","source":{"id":"https://openalex.org/S4306400255","display_name":"BIBSYS Brage (BIBSYS (Norway))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173212132","host_organization_name":"Vilnius University","host_organization_lineage":["https://openalex.org/I173212132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W629678974.pdf","grobid_xml":"https://content.openalex.org/works/W629678974.grobid-xml"},"referenced_works_count":188,"referenced_works":["https://openalex.org/W27626626","https://openalex.org/W68029762","https://openalex.org/W173084611","https://openalex.org/W193564708","https://openalex.org/W200311345","https://openalex.org/W203112842","https://openalex.org/W205077453","https://openalex.org/W1506251539","https://openalex.org/W1510710257","https://openalex.org/W1520650580","https://openalex.org/W1545621312","https://openalex.org/W1817200870","https://openalex.org/W1899025964","https://openalex.org/W1924197348","https://openalex.org/W1952841804","https://openalex.org/W1966762046","https://openalex.org/W1969804786","https://openalex.org/W1970901337","https://openalex.org/W1971474283","https://openalex.org/W1971599917","https://openalex.org/W1971608258","https://openalex.org/W1972258507","https://openalex.org/W1972565311","https://openalex.org/W1974081986","https://openalex.org/W1974968499","https://openalex.org/W1977427250","https://openalex.org/W1978652177","https://openalex.org/W1979852829","https://openalex.org/W1981451392","https://openalex.org/W1981785619","https://openalex.org/W1981980418","https://openalex.org/W1982875778","https://openalex.org/W1983161723","https://openalex.org/W1984689889","https://openalex.org/W1988036699","https://openalex.org/W1990864597","https://openalex.org/W1995252393","https://openalex.org/W1996208461","https://openalex.org/W1996564597","https://openalex.org/W1996858222","https://openalex.org/W2001206974","https://openalex.org/W2003046582","https://openalex.org/W2003854161","https://openalex.org/W2006610059","https://openalex.org/W2008716515","https://openalex.org/W2009338965","https://openalex.org/W2012601923","https://openalex.org/W2013444603","https://openalex.org/W2013898735","https://openalex.org/W2014942570","https://openalex.org/W2016255823","https://openalex.org/W2016832472","https://openalex.org/W2017397568","https://openalex.org/W2018182049","https://openalex.org/W2018379942","https://openalex.org/W2020509735","https://openalex.org/W2020948169","https://openalex.org/W2021677188","https://openalex.org/W2022185139","https://openalex.org/W2024549765","https://openalex.org/W2027024816","https://openalex.org/W2029777615","https://openalex.org/W2029853631","https://openalex.org/W2030858573","https://openalex.org/W2031729143","https://openalex.org/W2032984029","https://openalex.org/W2033988752","https://openalex.org/W2036108970","https://openalex.org/W2036424054","https://openalex.org/W2037017787","https://openalex.org/W2037653282","https://openalex.org/W2038482691","https://openalex.org/W2038536793","https://openalex.org/W2039603591","https://openalex.org/W2039830661","https://openalex.org/W2040165855","https://openalex.org/W2040353520","https://openalex.org/W2041672171","https://openalex.org/W2044110796","https://openalex.org/W2047998219","https://openalex.org/W2049325195","https://openalex.org/W2050824263","https://openalex.org/W2054597331","https://openalex.org/W2055869123","https://openalex.org/W2057116025","https://openalex.org/W2057232483","https://openalex.org/W2057872819","https://openalex.org/W2061485185","https://openalex.org/W2069106429","https://openalex.org/W2069198907","https://openalex.org/W2070045453","https://openalex.org/W2073507578","https://openalex.org/W2075696507","https://openalex.org/W2078223749","https://openalex.org/W2079286233","https://openalex.org/W2080706304","https://openalex.org/W2080889392","https://openalex.org/W2084123552","https://openalex.org/W2084313392","https://openalex.org/W2085036059","https://openalex.org/W2089638744","https://openalex.org/W2090502913","https://openalex.org/W2092145002","https://openalex.org/W2096073058","https://openalex.org/W2097216911","https://openalex.org/W2097653510","https://openalex.org/W2099461384","https://openalex.org/W2101047147","https://openalex.org/W2104750607","https://openalex.org/W2107590406","https://openalex.org/W2114488399","https://openalex.org/W2115013104","https://openalex.org/W2117631539","https://openalex.org/W2120337309","https://openalex.org/W2123216038","https://openalex.org/W2124346025","https://openalex.org/W2125702693","https://openalex.org/W2126092329","https://openalex.org/W2126129355","https://openalex.org/W2128814038","https://openalex.org/W2128916765","https://openalex.org/W2129689780","https://openalex.org/W2130553995","https://openalex.org/W2130844180","https://openalex.org/W2132706092","https://openalex.org/W2136315725","https://openalex.org/W2137444894","https://openalex.org/W2137611335","https://openalex.org/W2138553207","https://openalex.org/W2138559709","https://openalex.org/W2138783312","https://openalex.org/W2139453382","https://openalex.org/W2140313980","https://openalex.org/W2140609968","https://openalex.org/W2141260882","https://openalex.org/W2141573806","https://openalex.org/W2143374245","https://openalex.org/W2143745586","https://openalex.org/W2146433699","https://openalex.org/W2146745960","https://openalex.org/W2149868661","https://openalex.org/W2153340607","https://openalex.org/W2154261214","https://openalex.org/W2154370711","https://openalex.org/W2154626696","https://openalex.org/W2156565014","https://openalex.org/W2157581901","https://openalex.org/W2161570633","https://openalex.org/W2162391615","https://openalex.org/W2166157016","https://openalex.org/W2167704737","https://openalex.org/W2168275634","https://openalex.org/W2168352695","https://openalex.org/W2169182236","https://openalex.org/W2170164022","https://openalex.org/W2170220392","https://openalex.org/W2170268034","https://openalex.org/W2171806229","https://openalex.org/W2174795161","https://openalex.org/W2174826630","https://openalex.org/W2183330856","https://openalex.org/W2197264447","https://openalex.org/W2207994194","https://openalex.org/W2221652041","https://openalex.org/W2232331097","https://openalex.org/W2249641836","https://openalex.org/W2252761154","https://openalex.org/W2261813870","https://openalex.org/W2317845988","https://openalex.org/W2326572543","https://openalex.org/W2329993286","https://openalex.org/W2330306269","https://openalex.org/W2333169695","https://openalex.org/W2335161036","https://openalex.org/W2340746017","https://openalex.org/W2400407656","https://openalex.org/W2400797742","https://openalex.org/W2402152865","https://openalex.org/W2405442534","https://openalex.org/W2411947498","https://openalex.org/W2413156306","https://openalex.org/W2418862337","https://openalex.org/W2460651783","https://openalex.org/W2977097895","https://openalex.org/W3165153188","https://openalex.org/W4244168426","https://openalex.org/W4297791496","https://openalex.org/W4300379732"],"related_works":["https://openalex.org/W2154108762","https://openalex.org/W1999335573","https://openalex.org/W2151778033","https://openalex.org/W2393183612","https://openalex.org/W2139552357","https://openalex.org/W2354800296","https://openalex.org/W2617638941","https://openalex.org/W2067589291","https://openalex.org/W1920338912","https://openalex.org/W7027854800"],"abstract_inverted_index":{"Beneficial":[0],"effects":[1,170],"of":[2,131,154,171],"exercise":[3,68,83,103,110,160,172],"are":[4],"closely":[5,117],"associated":[6],"with":[7,63,118,136],"fitness":[8,143],"and":[9,30,33,40,57,75,88,93,97,122,135,150],"maximal":[10],"oxygen":[11,16,41],"uptake":[12],"(VO2max).":[13],"Capacity":[14],"for":[15,55,168],"transport":[17],"increases":[18,85],"mainly":[19],"by":[20],"improved":[21],"cardiac":[22,56,91],"function,":[23],"including":[24],"larger":[25],"chamber":[26],"volumes,":[27],"myocardial":[28],"hypertrophy,":[29,92],"enhanced":[31],"diastolic":[32],"systolic":[34],"function.":[35],"Higher":[36],"arterial":[37,58,98],"conductance,":[38],"capillarity,":[39],"utilization":[42],"in":[43,65,127],"skeletal":[44],"muscle":[45],"also":[46],"contribute.":[47],"The":[48,152],"present":[49],"thesis":[50],"investigates":[51],"the":[52,128],"cellular":[53],"basis":[54],"effects;":[59],"how":[60],"they":[61],"correlate":[62],"changes":[64],"VO2max":[66,115],"during":[67,76,125,133],"training":[69,84,138,157],"at":[70],"high":[71],"or":[72],"moderate":[73,108],"intensity,":[74],"detraining.\\n\\nThe":[77],"studies":[78],"show":[79],"that:\\n\\n1.":[80,141],"Regular":[81],"aerobic":[82,113],"running":[86],"performance":[87],"VO2max,":[89],"induces":[90],"improves":[94],"cardiomyocyte":[95,148],"contractility":[96],"endothelial":[99],"function.\\n\\n2.":[100,151],"High":[101],"intensity":[102,109],"is":[104,144],"more":[105],"effective":[106],"than":[107],"to":[111,147,156],"increase":[112],"fitness.\\n\\n3.":[114],"correlates":[116],"cardiomyocytes":[119],"size,":[120],"contractility,":[121],"calcium":[123],"handling":[124],"adaptation":[126,155],"first":[129],"weeks":[130],"exercise,":[132],"detraining,":[134],"different":[137],"intensities.\\n\\nWe":[139],"conclude":[140],"Aerobic":[142],"intimately":[145],"related":[146],"size":[149],"magnitude":[153],"depends":[158],"on":[159],"intensity.\\n\\n3.":[161],"Intensity":[162],"emerges":[163],"as":[164],"an":[165],"important":[166],"determinant":[167],"beneficial":[169],"training.":[173]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
