{"id":"https://openalex.org/W62928576","doi":null,"title":"Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids.","display_name":"Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids.","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W62928576","mag":"62928576","pmid":"https://pubmed.ncbi.nlm.nih.gov/20133229"},"language":"en","primary_location":{"id":"pmid:20133229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20133229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044734672","display_name":"Bing He","orcid":"https://orcid.org/0000-0002-9694-6591","observed_orcids":["https://orcid.org/0000-0002-9694-6591"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing He","raw_affiliation_strings":["Department of Endocrinology, Shengjing Affiliated Hospital, China Medical University, Shenyang 110004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Shengjing Affiliated Hospital, China Medical University, Shenyang 110004, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783628","display_name":"Sheng Zhao","orcid":"https://orcid.org/0009-0003-6199-0052","observed_orcids":["https://orcid.org/0009-0003-6199-0052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheng Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441686","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-6885-5166","observed_orcids":["https://orcid.org/0000-0002-6885-5166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047350976","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-9402-1093","observed_orcids":["https://orcid.org/0000-0002-9402-1093","https://orcid.org/0000-0002-6152-3484"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100454711","display_name":"Ping Han","orcid":"https://orcid.org/0000-0001-7325-2346","observed_orcids":["https://orcid.org/0000-0001-7325-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7475,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83707652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"9","issue":"1","first_page":"49","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.2971000075340271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.2971000075340271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-salicylate","display_name":"sodium salicylate","score":1.0},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hepatic-glucose-production","display_name":"hepatic glucose production","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glucose-utilization","display_name":"glucose utilization","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.5400000214576721},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8053442239761353},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7472893595695496},{"id":"https://openalex.org/C2779134981","wikidata":"https://www.wikidata.org/wiki/Q414547","display_name":"Sodium salicylate","level":2,"score":0.7435276508331299},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7359275221824646},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.7258307933807373},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6745487451553345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6093759536743164},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5309967994689941},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.43889957666397095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27250152826309204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2172507345676422},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1068885326385498}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012980","descriptor_name":"Sodium Salicylate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012980","descriptor_name":"Sodium Salicylate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20133229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20133229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:62928576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20133229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W18347160","https://openalex.org/W77807290","https://openalex.org/W122190768","https://openalex.org/W1534360145","https://openalex.org/W1975844837","https://openalex.org/W1976428700","https://openalex.org/W2013895711","https://openalex.org/W2042144976","https://openalex.org/W2044482587","https://openalex.org/W2054415546","https://openalex.org/W2069324669","https://openalex.org/W2077467622","https://openalex.org/W2108377598","https://openalex.org/W2113184924","https://openalex.org/W2121632504","https://openalex.org/W2126654945","https://openalex.org/W2127301790","https://openalex.org/W2138883403","https://openalex.org/W2149591938","https://openalex.org/W2150359408","https://openalex.org/W2215629512","https://openalex.org/W2359987680"],"related_works":["https://openalex.org/W2349776521","https://openalex.org/W2001201112","https://openalex.org/W2384876904","https://openalex.org/W2369453810","https://openalex.org/W2145855378","https://openalex.org/W2393263794","https://openalex.org/W2041909478","https://openalex.org/W2356296950","https://openalex.org/W2045658416","https://openalex.org/W2123898559"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"reported":[4],"that":[5,30],"high-dose":[6],"salicylates":[7,57],"improve":[8],"free":[9,187],"fatty":[10,188,231],"acids":[11,189,232],"(FFAs)-induced":[12],"insulin":[13,77,92,139,234,265],"resistance":[14,235],"and":[15,79,90,140,148,156,177,194,202,219,244,263,268],"beta-cell":[16],"dysfunction":[17],"in":[18,62,109,153,199,241],"vitro,":[19],"but":[20],"the":[21,31,54,71,82,114,119,134,154,191,196,200,221,242,249,255],"mechanism":[22,84],"remains":[23],"uncertain.":[24],"In":[25],"insulin-resistant":[26,63],"rats,":[27],"we":[28],"found":[29],"supplementation":[32],"of":[33,41,47,56,73,118,168,185,230,248,257],"sodium":[34,74,252],"salicylate":[35,75,101,206,253],"is":[36],"associated":[37],"with":[38,125,161,166],"a":[39,45],"reduction":[40],"plasma":[42,186],"malondialdehyde":[43],"(MDA),":[44],"marker":[46],"oxidative":[48,59,238,258,275],"stress.":[49,276],"Few":[50],"studies":[51],"have":[52],"investigated":[53],"effects":[55],"on":[58,76],"stress":[60,239],"levels":[61,147,193,240],"animal":[64],"models.":[65],"This":[66],"study":[67],"aimed":[68],"to":[69,80,274],"assess":[70],"effect":[72],"sensitivity":[78],"explore":[81],"potential":[83,271],"by":[85,144,216,224,236],"which":[86],"it":[87],"improves":[88],"hepatic":[89,173,262],"peripheral":[91,264],"resistance.":[93,266],"METHODS:":[94],"Intralipid+heparin":[95],"(IH),":[96],"saline":[97],"(SAL),":[98],"or":[99],"intralipid+heparin+sodium":[100],"(IHS)":[102],"were":[103,142,159],"separately":[104],"infused":[105],"for":[106],"7":[107],"hours":[108,117],"normal":[110],"Wistar":[111],"rats.":[112],"During":[113],"last":[115],"2":[116],"infusion,":[120],"hyperinsulinemic-euglycemic":[121],"clamping":[122],"was":[123,131],"performed":[124],"[6-3H]":[126],"glucose":[127,130,135,174,179],"tracer.":[128],"Plasma":[129,138],"measured":[132,160],"using":[133],"oxygenase":[136],"method.":[137],"C-peptide":[141],"determined":[143],"radioimmunoassay.":[145],"MDA":[146,192,214],"glutathione":[149],"peroxidase":[150],"(GSH-PX)":[151],"activity":[152,198,223],"liver":[155,201,243],"skeletal":[157],"muscle":[158,203],"colorimetric":[162],"kits.":[163],"RESULTS:":[164],"Compared":[165],"infusion":[167,171],"SAL,":[169],"IH":[170],"increased":[172,190,220],"production":[175],"(HGP),":[176],"decreased":[178,195,208],"utilization":[180],"(GU)":[181],"(P<0.05).":[182,226],"The":[183,246],"elevation":[184,229],"GSH-PX":[197,222],"(P<0.01).":[204],"Sodium":[205],"treatment":[207],"HGP,":[209],"elevated":[210],"GU":[211],"(P<0.05),":[212],"reduced":[213],"content":[215],"60%":[217],"(P<0.01),":[218],"35%":[225],"CONCLUSIONS:":[227],"Short-term":[228],"induces":[233],"enhancing":[237],"muscle.":[245],"administration":[247],"anti-inflammatory":[250],"drug":[251],"reduces":[254],"degree":[256],"stress,":[259],"therefore":[260],"improving":[261],"IKK-beta":[267],"NF-kappaB":[269],"provide":[270],"pathogenic":[272],"links":[273]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
