{"id":"https://openalex.org/W62927713","doi":null,"title":"Effects of retinoic acid in the mouse olfactory sensory systems","display_name":"Effects of retinoic acid in the mouse olfactory sensory systems","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W62927713","mag":"62927713"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-1371","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074180471","display_name":"Maria H\u00f6rnberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria H\u00f6rnberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074180471"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.13279999792575836,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/olfactory-receptor-neurons","display_name":"olfactory sensory neurons","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vomeronasal-sensory-neurons","display_name":"vomeronasal sensory neurons","score":0.8769999742507935},{"id":"https://openalex.org/keywords/accessory-olfactory-system","display_name":"accessory olfactory system","score":0.8090000152587891},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"retinoic acid receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dominant-negative-receptor","display_name":"dominant negative receptor","score":0.7039999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.652999997138977},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.6809999942779541},{"id":"https://openalex.org/keywords/olfactory-epithelium","display_name":"olfactory epithelium","score":0.6309999823570251},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7020233869552612},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6415949463844299},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.6370270252227783},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.6285492181777954},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5318828225135803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5144250988960266},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5079677700996399},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5019876956939697},{"id":"https://openalex.org/C2775908076","wikidata":"https://www.wikidata.org/wiki/Q3142126","display_name":"Sensory neuron","level":3,"score":0.4515572488307953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14370056986808777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08223548531532288}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-1371","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:62927713","doi":null,"is_oa":false,"landing_page_url":"https://umu.diva-portal.org/smash/get/diva2:140788/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-1371","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400361","display_name":"DiVA at Ume\u00e5 University (Ume\u00e5 University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I90267481","host_organization_name":"Ume\u00e5 University","host_organization_lineage":["https://openalex.org/I90267481"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W1490537199","https://openalex.org/W1493169362","https://openalex.org/W1527331090","https://openalex.org/W1539635511","https://openalex.org/W1570165358","https://openalex.org/W1571089910","https://openalex.org/W1583906479","https://openalex.org/W1585587409","https://openalex.org/W1590811805","https://openalex.org/W1603858169","https://openalex.org/W1649056280","https://openalex.org/W1740677000","https://openalex.org/W1804958350","https://openalex.org/W1819949295","https://openalex.org/W1877772628","https://openalex.org/W1912063668","https://openalex.org/W1923589122","https://openalex.org/W1946401635","https://openalex.org/W1950894243","https://openalex.org/W1965398787","https://openalex.org/W1968164494","https://openalex.org/W1968597070","https://openalex.org/W1969045051","https://openalex.org/W1970256374","https://openalex.org/W1970401714","https://openalex.org/W1971045517","https://openalex.org/W1971456880","https://openalex.org/W1972375217","https://openalex.org/W1974326501","https://openalex.org/W1974795720","https://openalex.org/W1975781078","https://openalex.org/W1976405146","https://openalex.org/W1978331009","https://openalex.org/W1978628739","https://openalex.org/W1980298497","https://openalex.org/W1981747897","https://openalex.org/W1982351586","https://openalex.org/W1983547347","https://openalex.org/W1983646382","https://openalex.org/W1984495434","https://openalex.org/W1984509210","https://openalex.org/W1986206639","https://openalex.org/W1987265928","https://openalex.org/W1988182516","https://openalex.org/W1990656070","https://openalex.org/W1991804615","https://openalex.org/W1993316321","https://openalex.org/W1994663223","https://openalex.org/W1995089930","https://openalex.org/W1996860147","https://openalex.org/W1999170657","https://openalex.org/W1999633796","https://openalex.org/W1999756818","https://openalex.org/W2004715908","https://openalex.org/W2004836530","https://openalex.org/W2005072665","https://openalex.org/W2005637545","https://openalex.org/W2006999333","https://openalex.org/W2008118471","https://openalex.org/W2010216395","https://openalex.org/W2010364898","https://openalex.org/W2010990554","https://openalex.org/W2013978625","https://openalex.org/W2016392505","https://openalex.org/W2017018649","https://openalex.org/W2018348038","https://openalex.org/W2019753855","https://openalex.org/W2019997163","https://openalex.org/W2020791858","https://openalex.org/W2023631751","https://openalex.org/W2024630703","https://openalex.org/W2026315931","https://openalex.org/W2026613561","https://openalex.org/W2028725915","https://openalex.org/W2029459747","https://openalex.org/W2034927169","https://openalex.org/W2035079860","https://openalex.org/W2037768057","https://openalex.org/W2038316650","https://openalex.org/W2038752480","https://openalex.org/W2039343730","https://openalex.org/W2047419060","https://openalex.org/W2047593587","https://openalex.org/W2047673461","https://openalex.org/W2047734673","https://openalex.org/W2048772732","https://openalex.org/W2050841388","https://openalex.org/W2051033394","https://openalex.org/W2051154660","https://openalex.org/W2052564417","https://openalex.org/W2052726655","https://openalex.org/W2053789319","https://openalex.org/W2055573396","https://openalex.org/W2055958441","https://openalex.org/W2056422973","https://openalex.org/W2056892917","https://openalex.org/W2058351795","https://openalex.org/W2058532063","https://openalex.org/W2058797597","https://openalex.org/W2059313753","https://openalex.org/W2060019534","https://openalex.org/W2060922035","https://openalex.org/W2061051147","https://openalex.org/W2061737733","https://openalex.org/W2061915587","https://openalex.org/W2062611934","https://openalex.org/W2062728419","https://openalex.org/W2069186336","https://openalex.org/W2070841172","https://openalex.org/W2070966492","https://openalex.org/W2071957609","https://openalex.org/W2072248036","https://openalex.org/W2073020869","https://openalex.org/W2076163730","https://openalex.org/W2079120043","https://openalex.org/W2079130098","https://openalex.org/W2081858421","https://openalex.org/W2081918629","https://openalex.org/W2083009583","https://openalex.org/W2085511966","https://openalex.org/W2085860649","https://openalex.org/W2087179850","https://openalex.org/W2089193539","https://openalex.org/W2089340953","https://openalex.org/W2090340745","https://openalex.org/W2091268459","https://openalex.org/W2092921145","https://openalex.org/W2097186487","https://openalex.org/W2100202927","https://openalex.org/W2100316885","https://openalex.org/W2100617165","https://openalex.org/W2101344684","https://openalex.org/W2103279555","https://openalex.org/W2106489915","https://openalex.org/W2107897069","https://openalex.org/W2109535272","https://openalex.org/W2110104273","https://openalex.org/W2113208089","https://openalex.org/W2121846582","https://openalex.org/W2122659024","https://openalex.org/W2122827236","https://openalex.org/W2124147072","https://openalex.org/W2124674257","https://openalex.org/W2127534323","https://openalex.org/W2132335701","https://openalex.org/W2133427405","https://openalex.org/W2133831748","https://openalex.org/W2136001493","https://openalex.org/W2136178930","https://openalex.org/W2136231875","https://openalex.org/W2136791900","https://openalex.org/W2140718203","https://openalex.org/W2148128487","https://openalex.org/W2148871843","https://openalex.org/W2154598676","https://openalex.org/W2155599378","https://openalex.org/W2165044121","https://openalex.org/W2165108884","https://openalex.org/W2166646853","https://openalex.org/W2169103594","https://openalex.org/W2185475290","https://openalex.org/W2398364572"],"related_works":["https://openalex.org/W2146899811","https://openalex.org/W2052090289","https://openalex.org/W2124562175","https://openalex.org/W2010990554","https://openalex.org/W292486557","https://openalex.org/W1976452465","https://openalex.org/W2050841388","https://openalex.org/W1547775803","https://openalex.org/W1980298497","https://openalex.org/W3173276142"],"abstract_inverted_index":{"A":[0,57],"common":[1],"characteristic":[2],"in":[3,23,37,52,60,71,79,125,201,204,224,235,254,333,362,395],"neurodegenerative":[4],"diseases":[5],"of":[6,11,17,26,35,40,82,88,97,105,121,139,160,179,184,206,220,232,267,272,289,296,302,323,367,392],"the":[7,27,38,67,72,80,83,103,110,122,126,133,145,153,158,177,180,185,207,211,225,230,236,265,270,283,287,294,309,343,363,368,378,389,396],"brain":[8],"is":[9,46,66],"death":[10,361],"specific":[12],"neuronal":[13,55,360],"populations.":[14],"The":[15],"lack":[16],"neuron":[18,94],"proliferation":[19],"and":[20,54,76,102,129,141,147,155,257,351],"axon":[21],"extension":[22],"most":[24],"parts":[25],"central":[28],"nervous":[29],"system":[30,119,286,366],"leads":[31],"to":[32,48,62,109,264,377],"chronic":[33],"loss":[34],"neurons":[36,70,124,271,336,375,394],"case":[39],"injury":[41],"or":[42],"disease.":[43],"Therefore":[44],"it":[45],"essential":[47],"identify":[49],"signals":[50],"involved":[51],"neurogenesis":[53],"survival.":[56,406],"favorable":[58],"model":[59],"which":[61],"study":[63],"these":[64,161],"events":[65],"olfactory":[68,74,84,92,118,135,146,181,212,226,237,256,274,285,334,365],"sensory":[69,93,123,335,374,393],"main":[73,284],"epithelium":[75,128,149,398],"their":[77,106,130,405],"target":[78,131],"glomeruli":[81,299],"bulb.":[85,136],"In":[86,282],"spite":[87],"constant":[89],"regeneration,":[90],"each":[91],"maintain":[95],"expression":[96,138,172],"one":[98,305],"particular":[99],"odorant":[100],"receptor":[101,253],"specificity":[104],"axonal":[107,268,346],"projections":[108],"glomeruli.":[111],"Most":[112],"mammals":[113],"also":[114],"have":[115],"an":[116,320],"accessory":[117,134,364],"consisting":[120],"vomeronasal":[127,148,258,373,397],"area":[132],"Differential":[137],"receptors":[140],"other":[142],"genes":[143,169,187,223],"divides":[144],"into":[150],"zones,":[151],"but":[152],"function":[154],"mechanisms":[156],"underlying":[157],"establishment":[159,266],"zones":[162,178],"are":[163],"still":[164],"elusive.":[165],"We":[166,195,260,354],"identified":[167,186],"four":[168],"with":[170,176,293,300],"graded":[171],"patterns":[173],"that":[174,197,245,262,388],"correlated":[175],"epithelium.":[182,227],"One":[183],"encodes":[188],"a":[189,202,215,241,248,358],"retinoic":[190,217,233,251,327,330,402],"acid":[191,218,234,252,331,403],"synthesizing":[192],"enzyme,":[193],"RALDH-2.":[194],"showed":[196],"RALDH-2":[198],"was":[199,291,316],"expressed":[200,222,247],"gradient":[203],"cells":[205],"lamina":[208],"propria":[209],"underneath":[210],"epithelium,":[213],"suggesting":[214,319],"possible":[216],"regulation":[219,322],"zonally":[221],"To":[228],"investigate":[229],"role":[231],"systems,":[238],"we":[239],"generated":[240],"transgenic":[242],"mouse":[243],"strain":[244],"selectively":[246],"dominant":[249],"negative":[250],"mature":[255],"neurons.":[259],"found":[261,355],"subsequent":[263],"projections,":[269],"both":[273],"systems":[275],"died":[276,381],"prematurely":[277],"by":[278,326,341,348,382],"retrograde":[279,383],"caspase-3":[280,384],"activation.":[281,385],"onset":[288],"apoptosis":[290,340],"associated":[292],"appearance":[295],"incorrect":[297],"heterogenous":[298],"axons":[301],"more":[303],"than":[304],"OR":[306],"identity.":[307],"Additionally,":[308],"activity":[310,350],"regulated":[311,318],"cell":[312],"adhesion":[313],"molecule":[314],"kirrel-2":[315,352],"down":[317],"additional":[321],"this":[324],"gene":[325],"acid.":[328],"Deficient":[329],"signaling":[332],"could":[337],"thus":[338],"induce":[339],"changing":[342],"parameters":[344],"for":[345,357,404],"competition":[347],"neural":[349],"expression.":[353],"evidence":[356],"selective":[359],"dnRAR":[369],"mice,":[370],"where":[371],"only":[372],"belonging":[376],"basal":[379],"zone":[380],"This":[386],"implies":[387],"two":[390],"populations":[391],"differently":[399],"depend":[400],"on":[401]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
