{"id":"https://openalex.org/W6292226","doi":"https://doi.org/10.2165/11594440-000000000-00000","title":"Pharmacogenetic Risk for Adverse Reactions to Irinotecan in the Major Ethnic Populations of Singapore","display_name":"Pharmacogenetic Risk for Adverse Reactions to Irinotecan in the Major Ethnic Populations of Singapore","publication_year":2011,"publication_date":"2011-11-11","ids":{"openalex":"https://openalex.org/W6292226","doi":"https://doi.org/10.2165/11594440-000000000-00000","mag":"6292226","pmid":"https://pubmed.ncbi.nlm.nih.gov/22077505"},"language":"en","primary_location":{"id":"doi:10.2165/11594440-000000000-00000","doi":"https://doi.org/10.2165/11594440-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/11594440-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032261500","display_name":"Cynthia Sung","orcid":"https://orcid.org/0000-0001-8603-4022","observed_orcids":["https://orcid.org/0000-0001-8603-4022"]},"institutions":[{"id":"https://openalex.org/I2799333108","display_name":"Health Sciences Authority","ror":"https://ror.org/02ybkn114","country_code":"SG","type":"government","lineage":["https://openalex.org/I1291357265","https://openalex.org/I2799333108"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Cynthia Sung","raw_affiliation_strings":["Health Products Regulation Group, Health Sciences Authority, Singapore. cynthia_sung@hsa.gov.sg","Health Products Regulation Group, Health Sciences Authority, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, Singapore. cynthia_sung@hsa.gov.sg","institution_ids":["https://openalex.org/I2799333108"]},{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, Singapore","institution_ids":["https://openalex.org/I2799333108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006735649","display_name":"Pui Ling Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799333108","display_name":"Health Sciences Authority","ror":"https://ror.org/02ybkn114","country_code":"SG","type":"government","lineage":["https://openalex.org/I1291357265","https://openalex.org/I2799333108"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pui Ling Lee","raw_affiliation_strings":["Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","Health Products Regulation Group, Health Sciences Authority, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","institution_ids":["https://openalex.org/I2799333108"]},{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, Singapore","institution_ids":["https://openalex.org/I2799333108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031396654","display_name":"Liesbet Li-Bei Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799333108","display_name":"Health Sciences Authority","ror":"https://ror.org/02ybkn114","country_code":"SG","type":"government","lineage":["https://openalex.org/I1291357265","https://openalex.org/I2799333108"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Liesbet L. Tan","raw_affiliation_strings":["Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","Health Products Regulation Group, Health Sciences Authority, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","institution_ids":["https://openalex.org/I2799333108"]},{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, Singapore","institution_ids":["https://openalex.org/I2799333108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110131750","display_name":"Dorothy Toh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799333108","display_name":"Health Sciences Authority","ror":"https://ror.org/02ybkn114","country_code":"SG","type":"government","lineage":["https://openalex.org/I1291357265","https://openalex.org/I2799333108"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Dorothy S.L. Toh","raw_affiliation_strings":["Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","Health Products Regulation Group, Health Sciences Authority, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, 11 Biopolis Way #11-03, Singapore, 138667","institution_ids":["https://openalex.org/I2799333108"]},{"raw_affiliation_string":"Health Products Regulation Group, Health Sciences Authority, Singapore","institution_ids":["https://openalex.org/I2799333108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032261500"],"corresponding_institution_ids":["https://openalex.org/I2799333108"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.0868,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70687301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"12","first_page":"1167","last_page":"1175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ugt1a1","display_name":"UGT1A1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ugt1a1-28","display_name":"UGT1A1*28","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ugt1a1-6","display_name":"UGT1A1*6","score":0.996999979019165},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-safety-regulation","display_name":"drug safety regulation","score":0.621999979019165},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.8581006526947021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7856221199035645},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6709747314453125},{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.6166236400604248},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5594856142997742},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5256651043891907},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.46282726526260376},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.4422530233860016},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.42783206701278687},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4244949221611023},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4134528636932373},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.36539456248283386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3587847352027893},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3366941213607788},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2567943334579468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17480292916297913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17051175236701965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11411061882972717},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0761517882347107},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0758291482925415},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012846","descriptor_name":"Singapore","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/11594440-000000000-00000","doi":"https://doi.org/10.2165/11594440-000000000-00000","is_oa":false,"landing_page_url":"https://doi.org/10.2165/11594440-000000000-00000","pdf_url":null,"source":{"id":"https://openalex.org/S49488433","display_name":"Drug Safety","issn_l":"0114-5916","issn":["0114-5916","1179-1942"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Safety","raw_type":"journal-article"},{"id":"pmid:22077505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22077505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug safety","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W174857828","https://openalex.org/W1976583726","https://openalex.org/W1978761887","https://openalex.org/W1979824822","https://openalex.org/W1982728538","https://openalex.org/W1989569315","https://openalex.org/W1991883790","https://openalex.org/W1992918749","https://openalex.org/W1993088391","https://openalex.org/W2011980082","https://openalex.org/W2019327917","https://openalex.org/W2023000498","https://openalex.org/W2026441538","https://openalex.org/W2031340221","https://openalex.org/W2031555481","https://openalex.org/W2038750466","https://openalex.org/W2042276392","https://openalex.org/W2067330808","https://openalex.org/W2089755320","https://openalex.org/W2090367734","https://openalex.org/W2095822339","https://openalex.org/W2096033615","https://openalex.org/W2100917151","https://openalex.org/W2107262592","https://openalex.org/W2110523081","https://openalex.org/W2119347977","https://openalex.org/W2121503597","https://openalex.org/W2122517534","https://openalex.org/W2122747751","https://openalex.org/W2127532818","https://openalex.org/W2133953387","https://openalex.org/W2138574787","https://openalex.org/W2155636605","https://openalex.org/W2167501156","https://openalex.org/W2322536880","https://openalex.org/W2616257794"],"related_works":["https://openalex.org/W2066831905","https://openalex.org/W1518800019","https://openalex.org/W2089755320","https://openalex.org/W2626409107","https://openalex.org/W2405274447","https://openalex.org/W4225420111","https://openalex.org/W160648935","https://openalex.org/W1987776423","https://openalex.org/W1414129449","https://openalex.org/W2404478431"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}