{"id":"https://openalex.org/W62825534","doi":"https://doi.org/10.1007/978-1-4615-2421-2_47","title":"Cyclin B Degradation as a Target of Antiproliferative Drug Action","display_name":"Cyclin B Degradation as a Target of Antiproliferative Drug Action","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W62825534","doi":"https://doi.org/10.1007/978-1-4615-2421-2_47","mag":"62825534"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4615-2421-2_47","doi":"https://doi.org/10.1007/978-1-4615-2421-2_47","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-2421-2_47","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cell Cycle","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2503497183","display_name":"The Cell Cycle"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111919928","display_name":"Steven W. Sherwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven W. Sherwood","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112774387","display_name":"Robert Simoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Simoni","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008863425","display_name":"ROBERT T. SCHIMKE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Schimke","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04390244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"405","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-b-degradation","display_name":"cyclin B degradation","score":0.906000018119812},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-cycle-perturbation","display_name":"cell cycle disruption","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":1.0},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-target-interactions","display_name":"drug-target interactions","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7619447708129883},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7052236795425415},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.6671015024185181},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6598372459411621},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5602267980575562},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.5185813903808594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4958284795284271},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.49049490690231323},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41419869661331177},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32845646142959595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30750441551208496},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2686884105205536},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2409903109073639},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2061077356338501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17888566851615906},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4615-2421-2_47","doi":"https://doi.org/10.1007/978-1-4615-2421-2_47","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4615-2421-2_47","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cell Cycle","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W131532494","https://openalex.org/W1493515436","https://openalex.org/W1503898156","https://openalex.org/W1510384743","https://openalex.org/W1528484209","https://openalex.org/W1554581519","https://openalex.org/W1588497817","https://openalex.org/W1660415778","https://openalex.org/W1749865514","https://openalex.org/W1873367784","https://openalex.org/W1917160910","https://openalex.org/W1963641700","https://openalex.org/W1963750681","https://openalex.org/W1973916918","https://openalex.org/W1997876679","https://openalex.org/W2038348468","https://openalex.org/W2052162735","https://openalex.org/W2056059709","https://openalex.org/W2084136914","https://openalex.org/W2084593619","https://openalex.org/W2085815176","https://openalex.org/W2105690686","https://openalex.org/W2119765806","https://openalex.org/W2129646494","https://openalex.org/W2141441260","https://openalex.org/W2327876243","https://openalex.org/W2439108596"],"related_works":["https://openalex.org/W2038610929","https://openalex.org/W2022078345","https://openalex.org/W2082561030","https://openalex.org/W1988873477","https://openalex.org/W1992509138","https://openalex.org/W4403342587","https://openalex.org/W2260538639","https://openalex.org/W2021092136","https://openalex.org/W1971988781","https://openalex.org/W2068770719"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}