{"id":"https://openalex.org/W628163091","doi":"https://doi.org/10.5551/jat1973.15.1_63","title":"Deficiency of Serum Cholesteryl-ester Transfer Activity in Patients with Familial Hyperalphalipoproteinemia","display_name":"Deficiency of Serum Cholesteryl-ester Transfer Activity in Patients with Familial Hyperalphalipoproteinemia","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W628163091","doi":"https://doi.org/10.5551/jat1973.15.1_63","mag":"628163091"},"language":"en","primary_location":{"id":"doi:10.5551/jat1973.15.1_63","doi":"https://doi.org/10.5551/jat1973.15.1_63","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_63","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_63/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_63/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105358629","display_name":"Hiroshi Mabuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi MABUCHI","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105524872","display_name":"Junji Koizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junji KOIZUMI","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033621234","display_name":"Akira YOSHIMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira YOSHIMURA","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112502980","display_name":"Ichiro Michishita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro MICHISHITA","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193575","display_name":"Mitsuaki TAKEDA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuaki TAKEDA","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113528994","display_name":"Kouji KAJINAMI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouji KAJINAMI","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086360610","display_name":"Hideaki Itoh","orcid":"https://orcid.org/0000-0002-9359-1051","observed_orcids":["https://orcid.org/0000-0002-9359-1051"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki ITOH","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111373075","display_name":"Takanobu WAKASUGI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanobu WAKASUGI","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100849203","display_name":"Ryoyu Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoyu TAKEDA","raw_affiliation_strings":["The Second Department of Internal Medicine, Kanazawa University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Internal Medicine, Kanazawa University School of Medicine","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009964081","display_name":"Kosei Ueda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosei UEDA","raw_affiliation_strings":["Department of Internal Medicine, Komatsu Municipal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Komatsu Municipal Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089474661","display_name":"Tadayoshi Takegoshi","orcid":"https://orcid.org/0000-0002-2327-1511","observed_orcids":["https://orcid.org/0000-0002-2327-1511"]},"institutions":[{"id":"https://openalex.org/I4210088459","display_name":"Fukui Prefectural Hospital","ror":"https://ror.org/006qqk144","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088459"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadayoshi TAKEGOSHI","raw_affiliation_strings":["Department of Internal Medicine, Fukui Prefectural Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Fukui Prefectural Hospital","institution_ids":["https://openalex.org/I4210088459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2294,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.71789645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"63","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7128999829292297,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.06769999861717224,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9200000166893005},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hdl-particle-size","display_name":"HDL particle size","score":0.8500000238418579},{"id":"https://openalex.org/keywords/heterozygous-carriers","display_name":"heterozygous carriers","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lipoprotein-pattern","display_name":"lipoprotein pattern","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.8413345813751221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7642611265182495},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7533172369003296},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6831216812133789},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.6163173913955688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5746875405311584},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.4883229434490204},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4858972430229187},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4653858244419098},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.4495738744735718},{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.44875583052635193},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.42242249846458435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3028765916824341},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21960806846618652},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.056095778942108154},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5551/jat1973.15.1_63","doi":"https://doi.org/10.5551/jat1973.15.1_63","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_63","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_63/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5551/jat1973.15.1_63","doi":"https://doi.org/10.5551/jat1973.15.1_63","is_oa":true,"landing_page_url":"https://doi.org/10.5551/jat1973.15.1_63","pdf_url":"https://www.jstage.jst.go.jp/article/jat1973/15/1/15_1_63/_pdf","source":{"id":"https://openalex.org/S4210238089","display_name":"The Journal of Japan Atherosclerosis Society","issn_l":"0386-2682","issn":["0386-2682","2185-8284"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313348","host_organization_name":"Japan Atherosclerosis Society","host_organization_lineage":["https://openalex.org/P4310313348"],"host_organization_lineage_names":["Japan Atherosclerosis Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Japan Atherosclerosis Society","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W628163091.pdf","grobid_xml":"https://content.openalex.org/works/W628163091.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1549422500","https://openalex.org/W1871390990","https://openalex.org/W1994322898","https://openalex.org/W2067767944","https://openalex.org/W2176854923","https://openalex.org/W4243946355"],"related_works":["https://openalex.org/W2067767944","https://openalex.org/W2606148699","https://openalex.org/W2409111896","https://openalex.org/W2009938059","https://openalex.org/W1634900854","https://openalex.org/W2606440334","https://openalex.org/W606128459","https://openalex.org/W2405890318","https://openalex.org/W2072710993","https://openalex.org/W2024004208"],"abstract_inverted_index":{"Lipoprotein":[0],"patterns":[1],"and":[2,56,102,155,202,217,235,250,265],"cholesteryl-ester":[3],"transfer":[4,141,175,211],"activity":[5,142],"(CETA)":[6],"were":[7,41,109,124,136,160],"examined":[8],"in":[9,106,129,145,162,189,199,214,262,266],"2":[10,86],"patients":[11,191],"with":[12,192],"familial":[13],"hyperalphalipoproteinemia":[14],"(FHALP).":[15],"The":[16,185],"proband":[17],"was":[18,35,143,170],"a":[19,51,60],"healthy":[20],"58-year-old":[21],"Japanese":[22],"male":[23],"who":[24],"had,":[25],"an":[26,166,236],"HDL":[27,33,49,65,77,97,159,177],"cholesterol":[28,34,78,98,101,203],"of":[29,44,71,96,131,165,173,187,205,209,222,229,233,239,247,254,268],"301mg/dl.":[30],"His":[31],"sister's":[32],"174mg/dl,":[36],"which":[37],"suggested":[38],"that":[39,120],"both":[40,47,146],"homozygous,":[42],"carrier":[43],"FHALP.":[45,223],"In":[46],"subjects":[48],"showed":[50,75,88,244],"high":[52],"cholesterol/apo":[53],"A-I":[54,105],"ratio":[55],"appeared":[57],"to":[58,99,103,178],"be":[59,260],"large-size":[61],"particle":[62,200],"than":[63,82,111,138],"normal":[64,89,139,183,231,252],"on":[66],"agarose":[67],"gel":[68],"chromatography.":[69],"Two":[70],"the":[72,94,132,163,197,230],"proband's":[73],"children":[74,87,108,123],"higher":[76,110],"levels":[79,90,128,253],"(67,":[80],"83mg/dl)":[81],"normal,":[83],"but":[84,116,241],"another":[85,220],"(57,":[91],"54mg/dl).":[92],"However,":[93],"ratios":[95],"total":[100],"apo":[104],"all":[107,121,130],"normal.":[112],"These":[113],"data":[114],"suggest,":[115],"do":[117],"not":[118],"prove,":[119],"his":[122],"heterozygotes.":[125],"Apo":[126],"B":[127],"family":[133],"members":[134],"studied":[135,144,207],"lower":[137],"(47-80mg/dl).Cholesteryl-ester":[140],"patients.":[147],"When":[148],"serum":[149,153],"or":[150],"lipoprotein":[151],"deficient":[152],"(d>1.21)":[154],"[3H]cholesteryl":[156],"ester":[157],"labeled":[158],"incubated":[161],"presence":[164],"LCAT":[167],"inhibitor,":[168,240],"there":[169],"no":[171],"evidence":[172],"cholesterylester":[174],"from":[176],"VLDL":[179],"and/or":[180],"LDL,":[181],"unlike":[182],"subjects.":[184],"deficiency":[186],"CETA":[188],"these":[190],"FHALP":[193,258],"presumably":[194],"accounted":[195],"for":[196],"increase":[198],"size":[201],"enrichment":[204],"HDL.We":[206],"inhibitors":[208,249],"lipid":[210],"protein":[212],"(LTP-I)":[213],"S.":[215,224,243],"Y.":[216,218,225,242],"S.,":[219],"patient":[221],"have":[226],"only":[227],"one-third":[228],"level":[232,238,246],"LTP-I":[234,248,255],"increased":[237,245],"near":[251],"activity.":[256],"Thus,":[257],"may":[259],"heterogenous":[261],"clinical":[263],"features":[264],"mechanism":[267],"pathogenesis.":[269]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}