{"id":"https://openalex.org/W62793449","doi":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","title":"Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.","display_name":"Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W62793449","doi":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","mag":"62793449","pmid":"https://pubmed.ncbi.nlm.nih.gov/1373378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/556605"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1992.tb05201.x","doi":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W62793449"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC556605","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111600375","display_name":"Andrew J. Dorner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.J. Dorner","raw_affiliation_strings":["Genetics Institute, Cambridge, MA 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Institute, Cambridge, MA 02140","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053527538","display_name":"Louise C. Wasley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L.C. Wasley","raw_affiliation_strings":["Genetics Institute, Cambridge, MA 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Institute, Cambridge, MA 02140","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015378855","display_name":"Randal J. Kaufman","orcid":"https://orcid.org/0000-0003-4277-316X","observed_orcids":["https://orcid.org/0000-0003-4277-316X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.J. Kaufman","raw_affiliation_strings":["Genetics Institute, Cambridge, MA 02140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics Institute, Cambridge, MA 02140","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":2.6851,"has_fulltext":false,"cited_by_count":346,"citation_normalized_percentile":{"value":0.8984105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"11","issue":"4","first_page":"1563","last_page":"1571"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucose-regulated-proteins","display_name":"glucose-regulated proteins","score":0.9419999718666077},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8119999766349792},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/grp94","display_name":"GRP94","score":0.7760000228881836},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/factor-viii","display_name":"factor VIII","score":0.9520000219345093},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tunicamycin","display_name":"tunicamycin","score":0.7120000123977661},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9660000205039978},{"id":"https://openalex.org/keywords/er-associated-degradation","display_name":"ER-associated degradation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.4059999883174896},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.9280821084976196},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7013270854949951},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6901397109031677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5666589140892029},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4578506052494049},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41570428013801575},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.41481178998947144},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28842052817344666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17162615060806274}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.1460-2075.1992.tb05201.x","doi":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1992.tb05201.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:143982","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC556605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:1373378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1373378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:556605","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC556605/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:143982","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC556605","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W50853672","https://openalex.org/W140599878","https://openalex.org/W1243421769","https://openalex.org/W1495548641","https://openalex.org/W1497407086","https://openalex.org/W1514223875","https://openalex.org/W1571732908","https://openalex.org/W1595512796","https://openalex.org/W1599264286","https://openalex.org/W1756091829","https://openalex.org/W1760671874","https://openalex.org/W1762774688","https://openalex.org/W1843936086","https://openalex.org/W1895982166","https://openalex.org/W1938755197","https://openalex.org/W1976137274","https://openalex.org/W1976492411","https://openalex.org/W1978197479","https://openalex.org/W1978659501","https://openalex.org/W1989526931","https://openalex.org/W1992155962","https://openalex.org/W2003088600","https://openalex.org/W2020437934","https://openalex.org/W2025732397","https://openalex.org/W2035826838","https://openalex.org/W2038312038","https://openalex.org/W2040080953","https://openalex.org/W2053823780","https://openalex.org/W2060333964","https://openalex.org/W2073305192","https://openalex.org/W2092198909","https://openalex.org/W2098551568","https://openalex.org/W2109544764","https://openalex.org/W2114360920","https://openalex.org/W2115070143","https://openalex.org/W2115397055","https://openalex.org/W2128635872","https://openalex.org/W2138665029","https://openalex.org/W2158636606","https://openalex.org/W2215417236"],"related_works":["https://openalex.org/W125347830","https://openalex.org/W1599264286","https://openalex.org/W1895982166","https://openalex.org/W4388596906","https://openalex.org/W3175479423","https://openalex.org/W1997451852","https://openalex.org/W2060719045","https://openalex.org/W7165404040","https://openalex.org/W1766750508","https://openalex.org/W2082257591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
