{"id":"https://openalex.org/W62731575","doi":null,"title":"Dyspepsia, irritable bowel syndrome, and constipation: review and what's new.","display_name":"Dyspepsia, irritable bowel syndrome, and constipation: review and what's new.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W62731575","mag":"62731575","pmid":"https://pubmed.ncbi.nlm.nih.gov/12120117"},"language":"en","primary_location":{"id":"pmid:12120117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12120117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in gastroenterological disorders","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111911202","display_name":"Michael Camilleri","orcid":"https://orcid.org/0000-0001-6472-7514","observed_orcids":["https://orcid.org/0000-0001-6472-7514"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M Camilleri","raw_affiliation_strings":["Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111911202"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.8657,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.75280344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"1","issue":"1","first_page":"2","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-dyspepsia","display_name":"functional dyspepsia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/functional-gastrointestinal-disorders","display_name":"functional gastrointestinal disorders","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dysmotility","display_name":"dysmotility","score":0.6790000200271606},{"id":"https://openalex.org/keywords/visceral-hypersensitivity","display_name":"visceral hypersensitivity","score":0.8090000152587891},{"id":"https://openalex.org/keywords/post-infectious-irritable-bowel-syndrome","display_name":"post-infectious irritable bowel syndrome","score":0.7839999794960022},{"id":"https://openalex.org/keywords/serotonergic-agents","display_name":"serotonergic agents","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adrenergic-agents","display_name":"adrenergic agents","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6819999814033508},{"id":"https://openalex.org/keywords/psychosocial-factors","display_name":"psychosocial factors","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.9170424938201904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9038383960723877},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.5901484489440918},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.561514675617218},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5462886095046997},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.5047210454940796},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4994924068450928},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4891681969165802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47914189100265503},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42393213510513306},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.42074185609817505},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19708219170570374},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.16335517168045044},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003109","descriptor_name":"Colonic Diseases, Functional","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12120117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12120117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in gastroenterological disorders","raw_type":"Journal Article"},{"id":"mag:62731575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12120117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6361535861","display_name":"Alpha 2 Adrenergic Control in Irritable Bowel Syndrome","funder_award_id":"K24DK002638","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8012676028","display_name":"Alpha-2 Adrenergic Control of Colonic Function in IBS","funder_award_id":"R01DK054681","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W63929106","https://openalex.org/W1595004889","https://openalex.org/W1661728798","https://openalex.org/W1986422164","https://openalex.org/W2020256228","https://openalex.org/W2024341371","https://openalex.org/W2030727832","https://openalex.org/W2038297562","https://openalex.org/W2065019547","https://openalex.org/W2070888548","https://openalex.org/W2072114316","https://openalex.org/W2074347208","https://openalex.org/W2090012397","https://openalex.org/W2106629204","https://openalex.org/W2118329435","https://openalex.org/W2156286274","https://openalex.org/W2166386674","https://openalex.org/W2170541585","https://openalex.org/W2175762975","https://openalex.org/W2221884590","https://openalex.org/W2258939930","https://openalex.org/W2334848097"],"related_works":["https://openalex.org/W2432231507","https://openalex.org/W1422642361","https://openalex.org/W1994479252","https://openalex.org/W6990501120","https://openalex.org/W2967358513","https://openalex.org/W2026986449","https://openalex.org/W2037402292","https://openalex.org/W2611129735","https://openalex.org/W2093602553","https://openalex.org/W2038856894"],"abstract_inverted_index":{"Functional":[0],"gastrointestinal":[1,10],"disorders":[2,58],"are":[3,67,95],"collections":[4],"of":[5,15,64,76,85],"symptoms":[6],"attributable":[7],"to":[8,69],"the":[9,13,77,97],"tract":[11],"in":[12,55],"absence":[14],"mucosal,":[16],"structural,":[17],"or":[18],"biochemical":[19],"disease.":[20],"The":[21,50],"two":[22],"most":[23],"common":[24,33],"disorders,":[25],"irritable":[26],"bowel":[27],"syndrome":[28],"and":[29,59,82,89,92],"functional":[30],"dyspepsia,":[31],"have":[32,102],"etiopathogenetic":[34],"features,":[35],"notably":[36],"psychosocial":[37],"disturbances,":[38],"dysmotility,":[39],"heightened":[40],"sensitivity,":[41],"and,":[42],"possibly,":[43],"an":[44,74],"association":[45],"with":[46],"a":[47,103],"postinfective":[48],"state.":[49],"third":[51],"condition":[52],"is":[53,73],"constipation,":[54],"which":[56],"transit":[57],"abnormal":[60],"evacuation":[61],"represent":[62],"disturbances":[63],"function":[65],"that":[66,100],"amenable":[68],"therapy.":[70],"This":[71],"review":[72],"update":[75],"control":[78],"mechanisms,":[79],"pathophysiology,":[80],"investigation,":[81],"potential":[83],"pharmacotherapies":[84],"these":[86,107],"disorders.":[87,108],"Serotonergic":[88],"adrenergic":[90],"agents":[91],"neurotrophic":[93],"factors":[94],"among":[96],"novel":[98],"approaches":[99],"may":[101],"significant":[104],"impact":[105],"on":[106]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}