{"id":"https://openalex.org/W62605014","doi":null,"title":"THE PHARMACOKINETICS OF METAL- BASED ENGINEERED NANOMATERIALS, FOCUSING ON THE BLOOD-BRAIN BARRIER","display_name":"THE PHARMACOKINETICS OF METAL- BASED ENGINEERED NANOMATERIALS, FOCUSING ON THE BLOOD-BRAIN BARRIER","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W62605014","mag":"62605014"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:pharmacy_etds-1020","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/pharmacy_etds/21","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Pharmacy","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dan Mo","orcid":"https://orcid.org/0000-0003-4877-7532","observed_orcids":["https://orcid.org/0000-0003-4877-7532"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dan Mo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4877-7532","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0037867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9269999861717224},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerium-oxide-nanoparticles","display_name":"cerium oxide nanoparticles","score":0.968999981880188},{"id":"https://openalex.org/keywords/particle-size-effects","display_name":"particle size effects","score":0.8569999933242798},{"id":"https://openalex.org/keywords/in-situ-brain-perfusion","display_name":"in situ brain perfusion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/iron-oxide-nanoparticles","display_name":"iron oxide nanoparticles","score":0.7559999823570251},{"id":"https://openalex.org/keywords/magnetic-hyperthermia","display_name":"magnetic hyperthermia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alternating-magnetic-field","display_name":"alternating magnetic field","score":0.8980000019073486},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.7400000095367432},{"id":"https://openalex.org/keywords/surface-modification","display_name":"surface modification","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7142254710197449},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6638600826263428},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.6274608969688416},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.509800136089325},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.48542317748069763},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.46593397855758667},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4412866532802582},{"id":"https://openalex.org/C2985453986","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Blood circulation","level":2,"score":0.42203909158706665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41727009415626526},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41455140709877014},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3495117425918579},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.31304416060447693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27886953949928284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22411996126174927},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1577809751033783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0737428069114685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07136330008506775},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:pharmacy_etds-1020","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/pharmacy_etds/21","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Pharmacy","raw_type":"text"},{"id":"mag:62605014","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1020&context=pharmacy_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":293,"referenced_works":["https://openalex.org/W3011556","https://openalex.org/W20548302","https://openalex.org/W66478222","https://openalex.org/W129468013","https://openalex.org/W158557124","https://openalex.org/W161347900","https://openalex.org/W187680792","https://openalex.org/W200888742","https://openalex.org/W230768509","https://openalex.org/W265890007","https://openalex.org/W1497001479","https://openalex.org/W1502599279","https://openalex.org/W1513748157","https://openalex.org/W1523800899","https://openalex.org/W1542982772","https://openalex.org/W1546539693","https://openalex.org/W1553061387","https://openalex.org/W1575138345","https://openalex.org/W1606934029","https://openalex.org/W1663248968","https://openalex.org/W1764204891","https://openalex.org/W1796054280","https://openalex.org/W1849301772","https://openalex.org/W1900516676","https://openalex.org/W1930600253","https://openalex.org/W1963559493","https://openalex.org/W1965097716","https://openalex.org/W1965600613","https://openalex.org/W1966086465","https://openalex.org/W1966420953","https://openalex.org/W1966476051","https://openalex.org/W1966805498","https://openalex.org/W1967083835","https://openalex.org/W1967172758","https://openalex.org/W1967349354","https://openalex.org/W1967837025","https://openalex.org/W1968446642","https://openalex.org/W1968937054","https://openalex.org/W1970347315","https://openalex.org/W1970776550","https://openalex.org/W1971178238","https://openalex.org/W1971646119","https://openalex.org/W1972388591","https://openalex.org/W1972743002","https://openalex.org/W1972892744","https://openalex.org/W1973091091","https://openalex.org/W1974220340","https://openalex.org/W1974430276","https://openalex.org/W1974958710","https://openalex.org/W1977479596","https://openalex.org/W1981020935","https://openalex.org/W1981777363","https://openalex.org/W1983059267","https://openalex.org/W1983574965","https://openalex.org/W1985649857","https://openalex.org/W1985833391","https://openalex.org/W1985858988","https://openalex.org/W1986666150","https://openalex.org/W1988633693","https://openalex.org/W1990456103","https://openalex.org/W1991116092","https://openalex.org/W1991649944","https://openalex.org/W1991659188","https://openalex.org/W1991940799","https://openalex.org/W1992431969","https://openalex.org/W1992560561","https://openalex.org/W1992758695","https://openalex.org/W1995195889","https://openalex.org/W1995379479","https://openalex.org/W1995704440","https://openalex.org/W1996139192","https://openalex.org/W1997215103","https://openalex.org/W1998027562","https://openalex.org/W1999636430","https://openalex.org/W1999733648","https://openalex.org/W2000068330","https://openalex.org/W2000893894","https://openalex.org/W2002422065","https://openalex.org/W2002552120","https://openalex.org/W2002934128","https://openalex.org/W2003110090","https://openalex.org/W2003336829","https://openalex.org/W2003516044","https://openalex.org/W2005392040","https://openalex.org/W2006036339","https://openalex.org/W2006237391","https://openalex.org/W2007313055","https://openalex.org/W2007859813","https://openalex.org/W2007987609","https://openalex.org/W2008095114","https://openalex.org/W2008427429","https://openalex.org/W2008673454","https://openalex.org/W2012128752","https://openalex.org/W2012288596","https://openalex.org/W2013137776","https://openalex.org/W2015541518","https://openalex.org/W2016194530","https://openalex.org/W2016475688","https://openalex.org/W2017770974","https://openalex.org/W2017925961","https://openalex.org/W2018522439","https://openalex.org/W2018657604","https://openalex.org/W2018709506","https://openalex.org/W2019375221","https://openalex.org/W2019407615","https://openalex.org/W2019599343","https://openalex.org/W2020327600","https://openalex.org/W2020718055","https://openalex.org/W2021946861","https://openalex.org/W2022014262","https://openalex.org/W2022405655","https://openalex.org/W2022473220","https://openalex.org/W2022556212","https://openalex.org/W2023524202","https://openalex.org/W2024601575","https://openalex.org/W2025188006","https://openalex.org/W2025547067","https://openalex.org/W2025860570","https://openalex.org/W2027020520","https://openalex.org/W2027162787","https://openalex.org/W2027175712","https://openalex.org/W2028559375","https://openalex.org/W2028797616","https://openalex.org/W2028834783","https://openalex.org/W2029871153","https://openalex.org/W2031035316","https://openalex.org/W2031560835","https://openalex.org/W2032186406","https://openalex.org/W2032696984","https://openalex.org/W2034339622","https://openalex.org/W2034496824","https://openalex.org/W2034938649","https://openalex.org/W2035816996","https://openalex.org/W2036210778","https://openalex.org/W2036459378","https://openalex.org/W2036821782","https://openalex.org/W2037041572","https://openalex.org/W2037822353","https://openalex.org/W2038246612","https://openalex.org/W2039032149","https://openalex.org/W2040330716","https://openalex.org/W2042356295","https://openalex.org/W2042363578","https://openalex.org/W2043482793","https://openalex.org/W2045020855","https://openalex.org/W2046437084","https://openalex.org/W2050081396","https://openalex.org/W2050591869","https://openalex.org/W2050911262","https://openalex.org/W2051103642","https://openalex.org/W2051502464","https://openalex.org/W2052905573","https://openalex.org/W2053520747","https://openalex.org/W2053526250","https://openalex.org/W2054228642","https://openalex.org/W2054355070","https://openalex.org/W2055233461","https://openalex.org/W2055542425","https://openalex.org/W2055908419","https://openalex.org/W2055928148","https://openalex.org/W2056735962","https://openalex.org/W2057910069","https://openalex.org/W2058706238","https://openalex.org/W2058963501","https://openalex.org/W2059422902","https://openalex.org/W2059756358","https://openalex.org/W2059864970","https://openalex.org/W2059877047","https://openalex.org/W2060090434","https://openalex.org/W2060170440","https://openalex.org/W2061834068","https://openalex.org/W2062322931","https://openalex.org/W2062506676","https://openalex.org/W2062848331","https://openalex.org/W2063318887","https://openalex.org/W2065165216","https://openalex.org/W2065527895","https://openalex.org/W2066125316","https://openalex.org/W2066292216","https://openalex.org/W2068101890","https://openalex.org/W2068794534","https://openalex.org/W2069015247","https://openalex.org/W2069828783","https://openalex.org/W2070573684","https://openalex.org/W2070581948","https://openalex.org/W2071636590","https://openalex.org/W2071659125","https://openalex.org/W2072357913","https://openalex.org/W2073126015","https://openalex.org/W2073608260","https://openalex.org/W2074928268","https://openalex.org/W2076895064","https://openalex.org/W2077825977","https://openalex.org/W2077861065","https://openalex.org/W2078004577","https://openalex.org/W2079094085","https://openalex.org/W2079731426","https://openalex.org/W2079921510","https://openalex.org/W2082359583","https://openalex.org/W2083107194","https://openalex.org/W2083516894","https://openalex.org/W2084329490","https://openalex.org/W2084470335","https://openalex.org/W2084871302","https://openalex.org/W2085016142","https://openalex.org/W2085841542","https://openalex.org/W2086077849","https://openalex.org/W2086929181","https://openalex.org/W2087045033","https://openalex.org/W2087468617","https://openalex.org/W2089427989","https://openalex.org/W2089711681","https://openalex.org/W2089994706","https://openalex.org/W2090107650","https://openalex.org/W2090866080","https://openalex.org/W2091082990","https://openalex.org/W2094399039","https://openalex.org/W2094760556","https://openalex.org/W2094816534","https://openalex.org/W2094842452","https://openalex.org/W2094919382","https://openalex.org/W2095405748","https://openalex.org/W2095512576","https://openalex.org/W2097016322","https://openalex.org/W2097095007","https://openalex.org/W2097616315","https://openalex.org/W2097903633","https://openalex.org/W2099324707","https://openalex.org/W2099374439","https://openalex.org/W2100225360","https://openalex.org/W2101312385","https://openalex.org/W2102349289","https://openalex.org/W2102606231","https://openalex.org/W2102663937","https://openalex.org/W2105030694","https://openalex.org/W2106600662","https://openalex.org/W2107529590","https://openalex.org/W2107623675","https://openalex.org/W2108018418","https://openalex.org/W2109771022","https://openalex.org/W2110639369","https://openalex.org/W2111115146","https://openalex.org/W2113972541","https://openalex.org/W2113999268","https://openalex.org/W2114055382","https://openalex.org/W2117099482","https://openalex.org/W2120599419","https://openalex.org/W2120919579","https://openalex.org/W2124676127","https://openalex.org/W2125123295","https://openalex.org/W2125865280","https://openalex.org/W2126205988","https://openalex.org/W2128242634","https://openalex.org/W2132895584","https://openalex.org/W2133703103","https://openalex.org/W2133802587","https://openalex.org/W2135732933","https://openalex.org/W2137910140","https://openalex.org/W2140181820","https://openalex.org/W2144232916","https://openalex.org/W2145028641","https://openalex.org/W2145093335","https://openalex.org/W2147816095","https://openalex.org/W2149262099","https://openalex.org/W2150117626","https://openalex.org/W2151201474","https://openalex.org/W2153283071","https://openalex.org/W2154385453","https://openalex.org/W2156188810","https://openalex.org/W2157852238","https://openalex.org/W2158558808","https://openalex.org/W2159622512","https://openalex.org/W2160743259","https://openalex.org/W2166926604","https://openalex.org/W2167728247","https://openalex.org/W2167806590","https://openalex.org/W2169207702","https://openalex.org/W2169580001","https://openalex.org/W2169735064","https://openalex.org/W2172191264","https://openalex.org/W2182619086","https://openalex.org/W2182668131","https://openalex.org/W2190720904","https://openalex.org/W2246596405","https://openalex.org/W2287331364","https://openalex.org/W2313163121","https://openalex.org/W2314130278","https://openalex.org/W2348480074","https://openalex.org/W2464038372","https://openalex.org/W2485373561","https://openalex.org/W2792632218","https://openalex.org/W3128501802","https://openalex.org/W4255118252"],"related_works":["https://openalex.org/W2061834068","https://openalex.org/W3175247551","https://openalex.org/W2056735962","https://openalex.org/W2315570520","https://openalex.org/W2085841542","https://openalex.org/W3181565056","https://openalex.org/W3015477236","https://openalex.org/W3217479238","https://openalex.org/W2156188810","https://openalex.org/W2528096704"],"abstract_inverted_index":{"Metal-based":[0],"engineered":[1],"nanomaterials":[2],"(ENMs)":[3],"have":[4],"potential":[5,283,307,340],"to":[6,15,23,95,209,245,288,308],"revolutionize":[7],"diagnosis,":[8],"drug":[9],"delivery":[10],"and":[11,27,44,85,121,129,131,152,169,212,215,240,253,302,343],"manufactured":[12],"products,":[13],"leading":[14],"greater":[16],"human":[17],"ENM":[18,25,54,74,92],"exposure.":[19],"It":[20],"is":[21,207],"crucial":[22],"understand":[24],"pharmacokinetics":[26],"their":[28,57,217,223,326],"association":[29,124,140,155],"with":[30,126,161,296,315,320,334],"biological":[31,238],"barriers":[32],"such":[33,41],"as":[34,42],"the":[35,65,77,80,83,97,119,149,167,186,190,194,201,264,306,313,329,332,346],"blood-brain":[36],"barrier":[37],"(BBB).":[38],"Physicochemical":[39],"parameters":[40],"size":[43,100,236],"surface":[45,188],"modification":[46],"of":[47,99,106,148,156,189,222,266,300],"ENMs":[48,61,108,214,319],"play":[49],"an":[50],"important":[51],"role":[52],"in":[53,79,118,175,200,237,243,263,345],"fate,":[55],"including":[56],"brain":[58,81,86,123,154,170,177,195,284,333],"association.":[59],"Multifunctional":[60],"showed":[62,114,180,233,273],"advantages":[63],"across":[64,312,328],"highly":[66],"regulated":[67],"BBB.":[68],"There":[69],"are":[70],"limited":[71],"reports":[72],"on":[73,101,185],"distribution":[75,165],"among":[76],"blood":[78,120,138],"vasculature,":[82],"BBB,":[84],"parenchyma.":[87,196],"In":[88],"this":[89],"study,":[90],"ceria":[91,107,113,134,159,183],"was":[93,172],"used":[94],"study":[96],"effect":[98],"its":[102,164],"pharmacokinetics.":[103],"Four":[104],"sizes":[105,128],"were":[109],"studied.":[110,173],"Five":[111],"nm":[112,133,145,158,182],"a":[115,136,297],"longer":[116],"half-life":[117],"higher":[122,137],"compared":[125,160],"other":[127,162],"15":[130],"30":[132],"had":[135],"cell":[139],"than":[141,193],"5":[142,157,181],"or":[143],"55":[144],"ceria.":[146],"Because":[147],"long":[150],"circulation":[151],"high":[153],"sizes,":[163],"between":[166],"BBB":[168,191,280,294,314,330],"parenchyma":[171],"The":[174],"situ":[176],"perfusion":[178],"technique":[179],"(99%)":[184],"luminal":[187],"rather":[192],"For":[197],"biomedical":[198],"applications":[199],"central":[202],"nervous":[203],"system":[204],"(CNS),":[205],"it":[206],"vital":[208],"develop":[210],"stable":[211],"biocompatible":[213],"enhance":[216,309,325],"uptake":[218],"by":[219],"taking":[220],"advantage":[221],"unique":[224],"properties.":[225],"Cross-linked":[226],"nanoassemblies":[227],"entrapping":[228],"iron":[229],"oxide":[230],"nanoparticles":[231],"(CNA-IONPs)":[232],"controlled":[234],"particle":[235],"conditions":[239],"less":[241],"toxicity":[242],"comparison":[244],"Citrate-IONPs.":[246],"CNA-IONPs":[247],"considerably":[248],"enhanced":[249],"MRI":[250],"T2":[251],"relaxivities":[252],"generated":[254],"heat":[255],"at":[256],"mild":[257,274],"hyperthermic":[258],"temperatures":[259],"(40":[260],"~":[261],"42\u00b0C)":[262],"presence":[265],"alternating":[267],"magnetic":[268],"field":[269],"(AMF).":[270],"Numerous":[271],"researchers":[272],"whole":[275],"body":[276],"hyperthermia":[277,292,301],"can":[278,324],"increase":[279],"permeability":[281,295],"for":[282,341],"therapeutic":[285],"application.":[286],"Compared":[287],"conventional":[289],"hyperthermia,":[290],"AMF-induced":[291],"increased":[293],"shorter":[298],"duration":[299],"lower":[303],"temperature,":[304],"providing":[305],"IONP":[310],"flux":[311,327],"reduced":[316],"toxicity.":[317],"Overall,":[318],"optimized":[321],"physicochemical":[322],"properties":[323],"into":[331],"desirable":[335],"pharmacokinetics,":[336],"which":[337],"provide":[338],"great":[339],"diagnosis":[342],"therapy":[344],"CNS.":[347]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
