{"id":"https://openalex.org/W624910444","doi":null,"title":"Pediatric Lupus in South Africa","display_name":"Pediatric Lupus in South Africa","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W624910444","mag":"624910444"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9985","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9985","pdf_url":"http://hdl.handle.net/10161/9985","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/9985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088292283","display_name":"Laura B. Lewandowski","orcid":"https://orcid.org/0000-0002-4253-2545","observed_orcids":["https://orcid.org/0000-0002-4253-2545"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura B. Lewandowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4253-2545","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088292283"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-systemic-lupus-erythematosus","display_name":"pediatric lupus","score":0.8420000076293945},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.7540000081062317},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/african-children","display_name":"African children","score":0.4869999885559082},{"id":"https://openalex.org/keywords/south-africa","display_name":"South Africa","score":0.5659999847412109},{"id":"https://openalex.org/keywords/sledai","display_name":"SLEDAI","score":0.6269999742507935},{"id":"https://openalex.org/keywords/slicc-acr-damage-index","display_name":"SLICC/ACR damage index","score":0.8180000185966492},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.7319999933242798},{"id":"https://openalex.org/keywords/nephrology","display_name":"nephrology","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.6451081037521362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3954234719276428},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3621402680873871},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.3329029679298401},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14477568864822388},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9985","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9985","pdf_url":"http://hdl.handle.net/10161/9985","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:624910444","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/9985","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/9985","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/9985","pdf_url":"http://hdl.handle.net/10161/9985","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W624910444.pdf","grobid_xml":"https://content.openalex.org/works/W624910444.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W117849968","https://openalex.org/W128146708","https://openalex.org/W1483165618","https://openalex.org/W1583773754","https://openalex.org/W1831090765","https://openalex.org/W1968838316","https://openalex.org/W1972050346","https://openalex.org/W1974071543","https://openalex.org/W1979795777","https://openalex.org/W1981435187","https://openalex.org/W1982134628","https://openalex.org/W1991365922","https://openalex.org/W1999306274","https://openalex.org/W2000054950","https://openalex.org/W2005929599","https://openalex.org/W2010623154","https://openalex.org/W2016784847","https://openalex.org/W2018455360","https://openalex.org/W2026799112","https://openalex.org/W2030936832","https://openalex.org/W2033201708","https://openalex.org/W2033361436","https://openalex.org/W2034993403","https://openalex.org/W2039006858","https://openalex.org/W2043121105","https://openalex.org/W2052311257","https://openalex.org/W2058595591","https://openalex.org/W2070527591","https://openalex.org/W2084604810","https://openalex.org/W2084928543","https://openalex.org/W2085480748","https://openalex.org/W2087573340","https://openalex.org/W2087785715","https://openalex.org/W2089755936","https://openalex.org/W2092235909","https://openalex.org/W2094907328","https://openalex.org/W2095341592","https://openalex.org/W2098488998","https://openalex.org/W2101261084","https://openalex.org/W2105713311","https://openalex.org/W2109894241","https://openalex.org/W2111940985","https://openalex.org/W2114755203","https://openalex.org/W2119280075","https://openalex.org/W2122346246","https://openalex.org/W2128890757","https://openalex.org/W2129400985","https://openalex.org/W2130077869","https://openalex.org/W2132755269","https://openalex.org/W2135160440","https://openalex.org/W2135584310","https://openalex.org/W2137367392","https://openalex.org/W2141182128","https://openalex.org/W2145896537","https://openalex.org/W2146831240","https://openalex.org/W2147116962","https://openalex.org/W2151779481","https://openalex.org/W2156695948","https://openalex.org/W2156783747","https://openalex.org/W2160095199","https://openalex.org/W2165513789","https://openalex.org/W2170836382","https://openalex.org/W2177646845","https://openalex.org/W2235150943","https://openalex.org/W2242677070","https://openalex.org/W2250515698","https://openalex.org/W2413370388","https://openalex.org/W2414784657","https://openalex.org/W2437180747","https://openalex.org/W2471147573","https://openalex.org/W2486559230"],"related_works":["https://openalex.org/W2482503989","https://openalex.org/W4309072595","https://openalex.org/W4281686174","https://openalex.org/W2030936832","https://openalex.org/W2413370388","https://openalex.org/W2734979400","https://openalex.org/W2188522317","https://openalex.org/W7161701279","https://openalex.org/W3119839748","https://openalex.org/W2708961727"],"abstract_inverted_index":{"Background:":[0],"In":[1,48],"North":[2,181,264],"America":[3],"and":[4,10,59,126,132,135,164,168,176,207,272,351],"Europe,":[5],"SLE":[6,24,34,71,97],"is":[7,27,333,368],"more":[8,57,61],"common":[9],"severe":[11,214,279],"in":[12,18,25,35,100,142,221,262,319,340,363,378],"people":[13],"of":[14,23,33,92,110,130,152,188,245,270,304,325,337],"African":[15,68,113],"extraction":[16],"than":[17,64,252,360],"Caucasians;":[19],"however,":[20],"the":[21,31,89,107,111,173,236,263,288,295,305,334,372],"epidemiology":[22],"Africa":[26,36,102,146,341],"largely":[28],"undetermined.":[29],"Historically,":[30],"incidence":[32],"was":[37,200],"presumed":[38],"to":[39,178,242,287,316,342,353,370],"be":[40,73],"low,":[41],"but":[42],"recent":[43],"studies":[44],"challenge":[45],"this":[46,84,93,379],"theory.":[47],"general,":[49],"children":[50,69,345],"present":[51,346],"with":[52,70,213,225,229,302,347],"higher":[53,251,358],"disease":[54,166,280,349],"activity,":[55],"require":[56],"therapy,":[58],"accrue":[60],"organ":[62,300,355],"damage":[63,301,356],"adult-onset":[65],"patients.":[66,328],"Although":[67],"may":[72],"at":[74,139,281,357],"high":[75,94,348,380],"risk":[76,95,373,381],"for":[77,155,172,375],"poor":[78,376],"outcomes,":[79],"little":[80],"research":[81,367],"has":[82],"investigated":[83],"population.":[85,382],"We":[86,119],"have":[87],"initiated":[88],"first":[90],"registry":[91,336],"pediatric":[96,131],"(pSLE)":[98],"population":[99],"South":[101,112,145],"(SA).":[103],"Here,":[104],"we":[105],"report":[106],"initial":[108],"findings":[109],"pSLE":[114,183,290,327,338,361],"patients":[115,137,189,192,211,224,261,339],"(PULSE":[116],"cohort).":[117],"Methods:":[118],"conducted":[120],"a":[121,308,320],"cross":[122],"sectional":[123],"analysis":[124],"(retrospective":[125],"prospective":[127],"chart":[128],"review)":[129],"adult":[133],"rheumatology":[134],"nephrology":[136],"seen":[138],"2":[140],"centers":[141],"Cape":[143],"Town,":[144],"from":[147],"1988-2014":[148],"meeting":[149],"American":[150,182,265],"College":[151],"Rheumatology":[153],"criteria":[154],"pSLE.":[156],"Patient":[157],"age,":[158],"gender,":[159],"race,":[160],"presenting":[161],"features,":[162],"clinical":[163],"serologic":[165],"markers,":[167],"treatment":[169,257],"were":[170,256],"recorded":[171],"PULSE":[174,296,331],"cohort":[175,266,277,291,297,306,324,332],"compared":[177,286,315],"an":[179],"established":[180],"cohort.":[184],"Results:":[185],"Initial":[186],"review":[187],"yielded":[190],"72":[191],"(age":[193],"11.5;":[194],"83%":[195],"female).":[196],"The":[197,275,330],"racial":[198],"distribution":[199],"68%":[201],"colored,":[202],"26%":[203],"black,":[204],"5%":[205],"white,":[206],"3%":[208],"Asian/Indian.":[209],"Most":[210],"presented":[212,228],"lupus":[215],"nephritis":[216],"(LN)":[217],"(renal":[218],"biopsy":[219],"performed":[220],"58%)).":[222],"Of":[223],"LN,":[226],"93%":[227],"ISN":[230],"class":[231],"III":[232],"or":[233],"higher.":[234],"Within":[235],"SA":[237,276],"cohort,":[238],"13%":[239],"went":[240],"on":[241],"develop":[243],"ESRD,":[244],"which":[246],"9%":[247],"required":[248,369],"transplant,":[249],"strikingly":[250],"NA":[253,289],"peers.":[254],"There":[255],"differences":[258],"between":[259],"cohorts:":[260],"had":[267,278,298],"increased":[268],"use":[269],"MMF":[271],"biologic":[273],"therapies.":[274],"diagnosis":[282],"(mean":[283,312],"SLEDAI":[284],"20.6),":[285],"(SLEDAI":[292],"4.8).":[293],"Also,":[294],"end":[299,354],"63%":[303],"having":[307],"SLICC":[309,313],"score":[310],">0":[311],"1.9),":[314],"only":[317],"23%":[318],"previously":[321],"reported":[322],"US":[323],"221":[326],"Conclusions:":[329],"largest":[335],"date.":[343],"These":[344],"activity":[350],"progress":[352],"rates":[359],"cohorts":[362],"developed":[364],"nations.":[365],"Further":[366],"determine":[371],"factors":[374],"outcomes":[377]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
