{"id":"https://openalex.org/W6247252","doi":null,"title":"Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)","display_name":"Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)","publication_year":2010,"publication_date":"2010-01-21","ids":{"openalex":"https://openalex.org/W6247252","mag":"6247252"},"language":"en","primary_location":{"id":"pmh:oai:ediss.uni-goettingen.de:11858/00-1735-0000-0006-AD8D-0","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-1735-0000-0006-AD8D-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400625","display_name":"eDiss (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068084402","display_name":"Marieke Wottawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marieke Wottawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068084402"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.847000002861023},{"id":"https://openalex.org/keywords/oxygen-dependent-regulation","display_name":"oxygen-dependent regulation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/prolyl-4-hydroxylase","display_name":"prolyl 4-hydroxylase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/phd3","display_name":"PHD3","score":0.9620000123977661},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oxygen-dependent-degradation-domain","display_name":"oxygen-dependent degradation domain","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/reoxygenation","display_name":"reoxygenation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dimethyloxalylglycine","display_name":"dimethyloxalylglycine","score":0.7409999966621399},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6340000033378601},{"id":"https://openalex.org/keywords/cellular-stress-response","display_name":"cellular stress response","score":0.5550000071525574},{"id":"https://openalex.org/keywords/yeast-two-hybrid-screen","display_name":"yeast two-hybrid screen","score":0.640999972820282},{"id":"https://openalex.org/keywords/fih","display_name":"FIH","score":0.5799999833106995},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.620259165763855},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5031391978263855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.444705605506897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4149157404899597},{"id":"https://openalex.org/C77179829","wikidata":"https://www.wikidata.org/wiki/Q4677459","display_name":"Activating transcription factor","level":4,"score":0.4117977023124695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2640276253223419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2461909055709839},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06920859217643738},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0682607889175415}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ediss.uni-goettingen.de:11858/00-1735-0000-0006-AD8D-0","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-1735-0000-0006-AD8D-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306400625","display_name":"eDiss (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doctoralThesis"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/165592","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/165592","pdf_url":null,"source":{"id":"https://openalex.org/S4306401634","display_name":"GoeScholar  The Publication Server of the Georg-August-Universit\u00e4t G\u00f6ttingen (Georg-August-Universit\u00e4t G\u00f6ttingen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122495","host_organization_name":"Asklepios Klinik St. Georg","host_organization_lineage":["https://openalex.org/I4210122495"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:6247252","doi":null,"is_oa":false,"landing_page_url":"https://ediss.uni-goettingen.de/bitstream/11858/00-1735-0000-0006-AD8D-0/1/wottawa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W77915120","https://openalex.org/W197290738","https://openalex.org/W1501553911","https://openalex.org/W1503667331","https://openalex.org/W1749022239","https://openalex.org/W1899601083","https://openalex.org/W1906926948","https://openalex.org/W1963545628","https://openalex.org/W1967855521","https://openalex.org/W1968820967","https://openalex.org/W1970369203","https://openalex.org/W1970728706","https://openalex.org/W1976880272","https://openalex.org/W1977461220","https://openalex.org/W1977966865","https://openalex.org/W1984754431","https://openalex.org/W1986005575","https://openalex.org/W1988403143","https://openalex.org/W1992082275","https://openalex.org/W1996461969","https://openalex.org/W1997031088","https://openalex.org/W1998113157","https://openalex.org/W2003133433","https://openalex.org/W2007080316","https://openalex.org/W2007919022","https://openalex.org/W2010110394","https://openalex.org/W2010394923","https://openalex.org/W2010689545","https://openalex.org/W2014868633","https://openalex.org/W2016160962","https://openalex.org/W2016946354","https://openalex.org/W2017771655","https://openalex.org/W2019521269","https://openalex.org/W2020968632","https://openalex.org/W2027920581","https://openalex.org/W2028910606","https://openalex.org/W2035692565","https://openalex.org/W2037403843","https://openalex.org/W2042216712","https://openalex.org/W2047887493","https://openalex.org/W2050102194","https://openalex.org/W2053593146","https://openalex.org/W2053632669","https://openalex.org/W2054357354","https://openalex.org/W2055972615","https://openalex.org/W2056841699","https://openalex.org/W2057798327","https://openalex.org/W2057835131","https://openalex.org/W2059493348","https://openalex.org/W2062805420","https://openalex.org/W2064627937","https://openalex.org/W2066284211","https://openalex.org/W2068055557","https://openalex.org/W2069646782","https://openalex.org/W2069924169","https://openalex.org/W2072839085","https://openalex.org/W2073292880","https://openalex.org/W2076261819","https://openalex.org/W2079743290","https://openalex.org/W2079844104","https://openalex.org/W2080727542","https://openalex.org/W2082584138","https://openalex.org/W2083956390","https://openalex.org/W2085470258","https://openalex.org/W2085483520","https://openalex.org/W2085609942","https://openalex.org/W2086248882","https://openalex.org/W2086589468","https://openalex.org/W2089692551","https://openalex.org/W2090286778","https://openalex.org/W2095582000","https://openalex.org/W2100347985","https://openalex.org/W2102476325","https://openalex.org/W2108736984","https://openalex.org/W2112769256","https://openalex.org/W2114005496","https://openalex.org/W2115530260","https://openalex.org/W2117236885","https://openalex.org/W2119003997","https://openalex.org/W2123122199","https://openalex.org/W2125119838","https://openalex.org/W2125798501","https://openalex.org/W2128786395","https://openalex.org/W2130123676","https://openalex.org/W2130456602","https://openalex.org/W2136548506","https://openalex.org/W2141168063","https://openalex.org/W2144634347","https://openalex.org/W2145675430","https://openalex.org/W2147291971","https://openalex.org/W2147891751","https://openalex.org/W2149736876","https://openalex.org/W2150123812","https://openalex.org/W2150332104","https://openalex.org/W2151398015","https://openalex.org/W2160603649","https://openalex.org/W2163069245","https://openalex.org/W2164322102","https://openalex.org/W4295234608"],"related_works":["https://openalex.org/W7162235434","https://openalex.org/W2082064411","https://openalex.org/W2000482327","https://openalex.org/W7097309961","https://openalex.org/W2036001860","https://openalex.org/W2071039501","https://openalex.org/W2041341750","https://openalex.org/W2893490217","https://openalex.org/W2048851081","https://openalex.org/W1603685525"],"abstract_inverted_index":{"Die":[0],"Prolyl-4-Hydroxylase-Dom\u00e4ne-Enzyme":[1],"1-3":[2],"(PHD1-3)":[3],"sind":[4,29,42,308,311],"ma\u00dfgeblich":[5],"an":[6,33,105,225,346],"der":[7,9,11,22,34,48,73,106,108,133,147,159,169,188,197,201,215,226,233,252,261,280,298,333,347,358,364],"Regulation":[8,35,107,146,178,227,348,365],"Proteinstabilit\u00e4t":[10,134],"alpha-Untereinheit":[12],"des":[13,203],"Hypoxie-induzierbaren":[14],"Faktors":[15],"(HIF)":[16],"beteiligt,":[17],"welcher":[18],"als":[19,77],"wichtigster":[20],"Transkriptionsfaktor":[21],"Sauerstoff-abh\u00e4ngigen":[23],"Genexpression":[24],"angesehen":[25],"wird.":[26,136,250],"Des":[27],"Weiteren":[28],"die":[30,144,157,167,224,240,259,287,314,320,370,384],"PHDs":[31,49,359],"auch":[32,217],"Sauerstoff-abh\u00e4ngiger,":[36],"aber":[37,164],"HIF-unabh\u00e4ngiger":[38],"Prozesse":[39],"beteiligt.":[40],"Zus\u00e4tzlich":[41],"vermehrt":[43],"Hinweise":[44,338],"f\u00fcr":[45,58,319,369,383],"Isoform-spezifische":[46],"Eigenschaften":[47],"gefunden":[50],"worden.":[51],"Aus":[52],"diesen":[53],"Gr\u00fcnden":[54],"wurde":[55,141,258],"im":[56,205],"Institut":[57],"Herz-":[59],"und":[60,112,130],"Kreislaufphysiologie":[61],"ein":[62],"Yeast-two":[63],"hybrid":[64],"Screen":[65],"durchgef\u00fchrt,":[66],"mit":[67,92,272],"dessen":[68],"Hilfe":[69,273],"neben":[70,363],"anderen":[71],"Faktoren":[72],"aktivierende":[74],"Transkriptionsfaktor-4":[75],"(ATF-4)":[76],"neuer":[78],"Isoform-spezifischer":[79],"PHD3-Interaktionspartner":[80],"identifiziert":[81,222],"worden":[82],"ist.":[83,231,294,326,352],"Im":[84,137],"Gegensatz":[85],"dazu":[86],"konnte":[87,151,213,236,271,304],"keine":[88],"Interaktion":[89],"von":[90,120,228,244,274,290,323,335,349,366,374,376,386],"ATF-4":[91,103,128,229,245,253,291,324,345],"PHD1":[93],"oder":[94,156,166,193,277,390],"PHD2":[95,170],"sowie":[96],"dem":[97],"HIF-inhibierenden":[98],"Faktor":[99,302],"(FIH)":[100],"nachgewiesen":[101],"werden.":[102,306],"ist":[104,124,368],"zellul\u00e4ren":[109],"Stressantwort":[110],"beteiligt":[111,230,351],"seine":[113],"Expression":[114,172,200,283,334],"wird":[115],"wiederum":[116],"durch":[117,186,194,246,255,278,331],"verschieden":[118],"Arten":[119],"Stress":[121],"induziert.":[122],"Weiterhin":[123],"gezeigt":[125,152,237,284],"worden,":[126],"dass":[127,154,185,239,286,341],"posttranslationell":[129],"auf":[131,360],"Ebene":[132],"reguliert":[135],"Rahmen":[138],"dieser":[139],"Arbeit":[140,235],"nun":[142],"erstmals":[143],"Sauerstoff-abh\u00e4ngige":[145,219],"ATF-4-Stabilit\u00e4t":[148],"untersucht.":[149],"Es":[150],"werden,":[153,223,238,285,340],"Hypoxie":[155,343],"Runterregulation":[158,196,279],"PHD3":[160,198],"mRNA":[161,171,199,282],"Expression,":[162],"nicht":[163,292],"Normoxie":[165],"Verminderung":[168],"zu":[173,207,316],"erh\u00f6hten":[174],"ATF-4-Proteinleveln":[175],"f\u00fchrt.":[176],"Diese":[177],"erfolgt":[179],"zudem":[180],"HIF":[181],"unabh\u00e4ngig.":[182],"Reoxygenierungsexprimente":[183],"zeigten,":[184],"Inhibierung":[187],"PHD":[189],"Aktivit\u00e4t":[190],"mittles":[191],"DMOG-Behandlung":[192],"spezifische":[195],"Abbau":[202],"ATF-4-Proteins":[204],"Vergleich":[206],"normoxischen":[208],"Bedingungen":[209],"verlangsamt":[210],"war.":[211],"So":[212,379],"in":[214,342],"ATF-4-Sequenz":[216],"eine":[218,296],"Degradierungsdom\u00e4ne":[220],"(ODD)":[221],"In":[232,327],"vorliegenden":[234],"PHD3-abh\u00e4ngige":[241],"normoxische":[242,288,321],"Degradation":[243,254,289,322],"das":[247,256],"Ubiquitin-Proteasom-System":[248,257],"vermittelt":[249],"Bez\u00fcglich":[251],"Beteiligung":[260,297],"Ubiquitin-E3-Ligase":[262,315],"beta-Transductin":[263],"repeat":[264],"containing":[265],"protein":[266],"(\u00df":[267],"TRCP)":[268],"nachgewiesen.":[269],"Allerdings":[270],"Pull-down":[275],"Experimenten":[276],"\u00df-TRCP":[281],"\u00df-TRCP-abh\u00e4ngig":[293],"Auch":[295],"E3-Ubiquitin-Ligase":[299],"von-Hippel":[300],"Lindau":[301],"(pVHL)":[303],"ausgeschlossen":[305],"Daher":[307],"weitere":[309],"Studien":[310],"notwendig,":[312],"um":[313],"identifizieren,":[317],"welche":[318],"verantwortlich":[325],"weiteren":[328],"Versuchen":[329],"konnten":[330],"Untersuchung":[332],"ATF-4-Zielgenen":[336],"erste":[337],"erhalten":[339],"stabilisiertes":[344],"Zellschicksalsentscheidungen":[350],"Dieses":[353],"Wissen":[354],"\u00fcber":[355],"den":[356],"Einfluss":[357],"zus\u00e4tzliche":[361],"Regelwege,":[362],"HIF,":[367],"Entwicklung":[371],"klinischer":[372],"Anwendungen":[373],"PHD-Inhibitoren":[375],"gro\u00dfem":[377],"Nutzen.":[378],"k\u00f6nnten":[380,392],"diese":[381],"Inhibitoren":[382],"Behandlung":[385],"An\u00e4mien":[387],"genutzt":[388],"werden":[389],"sie":[391],"wegen":[393],"ihres":[394],"cytoprotktiven":[395],"Effekts":[396],"gegen":[397],"Gewebesch\u00e4den":[398],"Anwendung":[399],"finden.":[400]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
