{"id":"https://openalex.org/W62417862","doi":null,"title":"PI-3 kinase p110\u03b2: a therapeutic target in advanced prostate cancers.","display_name":"PI-3 kinase p110\u03b2: a therapeutic target in advanced prostate cancers.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W62417862","mag":"62417862","pmid":"https://pubmed.ncbi.nlm.nih.gov/25374921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219313"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4219313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219313","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084681260","display_name":"Benyi Li","orcid":"https://orcid.org/0000-0001-6242-5117","observed_orcids":["https://orcid.org/0000-0001-6242-5117"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Benyi Li","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center Kansas City, KS 66160, USA ; Department of Molecular & Integrative Physiology, The University of Kansas Medical Center Kansas City, KS 66160, USA ; Department of Pathology, Shaoxing People's Hospital Shaoxing 312000, China ; Department of Urology, Guangdong Medical College Zhanjiang 524001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center Kansas City, KS 66160, USA ; Department of Molecular & Integrative Physiology, The University of Kansas Medical Center Kansas City, KS 66160, USA ; Department of Pathology, Shaoxing People's Hospital Shaoxing 312000, China ; Department of Urology, Guangdong Medical College Zhanjiang 524001, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210128618","https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100956235","display_name":"Aijing Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160695","display_name":"Shaoxing People's Hospital","ror":"https://ror.org/05v58y004","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160695"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aijing Sun","raw_affiliation_strings":["Department of Pathology, Shaoxing People's Hospital Shaoxing 312000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shaoxing People's Hospital Shaoxing 312000, China","institution_ids":["https://openalex.org/I4210160695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103637043","display_name":"Wencong Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wencong Jiang","raw_affiliation_strings":["Department of Urology, Guangdong Medical College Zhanjiang 524001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Guangdong Medical College Zhanjiang 524001, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113835930","display_name":"James Brantley Thrasher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Brantley Thrasher","raw_affiliation_strings":["Department of Urology, The University of Kansas Medical Center Kansas City, KS 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Kansas Medical Center Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110174480","display_name":"Paul F. Terranova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Terranova","raw_affiliation_strings":["Department of Molecular & Integrative Physiology, The University of Kansas Medical Center Kansas City, KS 66160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Integrative Physiology, The University of Kansas Medical Center Kansas City, KS 66160, USA","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.669,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89357854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"3","first_page":"188","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.9039999842643738},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6740000247955322},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.652999997138977},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.7870000004768372},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.7490000128746033},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8068600296974182},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.7497018575668335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6388915777206421},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6075372099876404},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5588459372520447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5435045957565308},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.537031888961792},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4468291699886322},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4370274543762207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4158332943916321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25249168276786804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4219313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},{"id":"pmid:25374921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25374921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental urology","raw_type":"Journal Article"},{"id":"mag:62417862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25374921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4219313","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4219313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Urol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1370860281","display_name":"Prostate-targeted CRMP4 saRNA as anti-metastatic therapy","funder_award_id":"R21CA175279","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G343181842","display_name":"Center for Cancer Experimental Therapeutics","funder_award_id":"5p20rr015563-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W11570512","https://openalex.org/W1529396499","https://openalex.org/W1550997731","https://openalex.org/W1967224800","https://openalex.org/W1969481087","https://openalex.org/W1971525986","https://openalex.org/W1974740818","https://openalex.org/W1979475139","https://openalex.org/W1985196841","https://openalex.org/W1986976113","https://openalex.org/W1988864736","https://openalex.org/W1991740243","https://openalex.org/W1991761103","https://openalex.org/W1993240342","https://openalex.org/W1994824666","https://openalex.org/W2000795165","https://openalex.org/W2001430754","https://openalex.org/W2003873262","https://openalex.org/W2005528673","https://openalex.org/W2006231102","https://openalex.org/W2008473350","https://openalex.org/W2009044944","https://openalex.org/W2012652051","https://openalex.org/W2013330559","https://openalex.org/W2014766193","https://openalex.org/W2015177518","https://openalex.org/W2017181626","https://openalex.org/W2024676945","https://openalex.org/W2025378988","https://openalex.org/W2027239007","https://openalex.org/W2028707469","https://openalex.org/W2029063751","https://openalex.org/W2034294773","https://openalex.org/W2034703111","https://openalex.org/W2038444072","https://openalex.org/W2045645945","https://openalex.org/W2046844445","https://openalex.org/W2054318449","https://openalex.org/W2054917860","https://openalex.org/W2057370954","https://openalex.org/W2057472767","https://openalex.org/W2060635284","https://openalex.org/W2064063123","https://openalex.org/W2064100706","https://openalex.org/W2071591166","https://openalex.org/W2073100248","https://openalex.org/W2074342156","https://openalex.org/W2074831305","https://openalex.org/W2075750372","https://openalex.org/W2077438659","https://openalex.org/W2081365151","https://openalex.org/W2083107422","https://openalex.org/W2087693130","https://openalex.org/W2090583090","https://openalex.org/W2091453961","https://openalex.org/W2091926537","https://openalex.org/W2092284194","https://openalex.org/W2095819165","https://openalex.org/W2097830998","https://openalex.org/W2100288916","https://openalex.org/W2102103107","https://openalex.org/W2103205080","https://openalex.org/W2105762010","https://openalex.org/W2110534364","https://openalex.org/W2119207552","https://openalex.org/W2119378009","https://openalex.org/W2119504728","https://openalex.org/W2120145250","https://openalex.org/W2125727465","https://openalex.org/W2134629247","https://openalex.org/W2134690947","https://openalex.org/W2138264320","https://openalex.org/W2141125222","https://openalex.org/W2142839629","https://openalex.org/W2147001166","https://openalex.org/W2147087340","https://openalex.org/W2148643283","https://openalex.org/W2149299767","https://openalex.org/W2149470160","https://openalex.org/W2150798124","https://openalex.org/W2154176338","https://openalex.org/W2154787108","https://openalex.org/W2155416916","https://openalex.org/W2158499173","https://openalex.org/W2160084272","https://openalex.org/W2163148645","https://openalex.org/W2165177861","https://openalex.org/W2166087001","https://openalex.org/W2166188515","https://openalex.org/W2166435610","https://openalex.org/W2166848534","https://openalex.org/W2167009545","https://openalex.org/W2169961966","https://openalex.org/W2171041379","https://openalex.org/W2219978888","https://openalex.org/W2318012531","https://openalex.org/W2319433899","https://openalex.org/W2334585489","https://openalex.org/W2407217142","https://openalex.org/W3147884700","https://openalex.org/W4253510406"],"related_works":["https://openalex.org/W2973964053","https://openalex.org/W4210483903","https://openalex.org/W2326408864","https://openalex.org/W2259272571","https://openalex.org/W2027239007","https://openalex.org/W2711147105","https://openalex.org/W2605513847","https://openalex.org/W2607526681","https://openalex.org/W7024739875","https://openalex.org/W2168311307"],"abstract_inverted_index":{"Prostate":[0],"cancers":[1,47,115],"in":[2,13,36,73,89,112,127,144,156],"the":[3,23,74],"castration-resistant":[4],"stage":[5],"are":[6,10,48,53,84,140],"life-threatening":[7],"because":[8],"they":[9],"not":[11],"curable":[12],"clinic.":[14],"The":[15],"novel":[16,41,133],"androgen":[17],"receptor":[18],"inhibitor":[19,26],"Xandi":[20],"(Enzalutamide)":[21],"and":[22,69,86,102,116,123,129,139],"new":[24],"CYP17":[25],"Zytiga":[27],"(Abiraterone)":[28],"prolonged":[29],"patient":[30],"survival":[31],"only":[32],"a":[33],"few":[34],"months":[35],"advanced":[37,45,113],"prostate":[38,46,94,114,120],"cancers.":[39,95],"Therefore,":[40],"therapeutic":[42],"agents":[43],"for":[44,119],"urgently":[49],"needed.":[50],"PI-3":[51,106],"kinases":[52],"major":[54],"intracellular":[55],"signaling":[56],"molecules":[57],"that":[58,77,105],"regulate":[59],"multiple":[60],"signal":[61],"pathways":[62],"related":[63],"to":[64],"cellular":[65],"metabolism,":[66],"cytokinesis,":[67],"growth":[68],"survival.":[70],"Accumulating":[71],"evidence":[72],"literature":[75],"indicates":[76],"some":[78],"isoforms":[79],"of":[80],"this":[81,148,157],"kinase":[82,107],"family":[83],"oncogenic":[85],"abnormally":[87],"expressed":[88],"various":[90],"human":[91],"cancers,":[92],"including":[93],"Recent":[96],"extensive":[97],"studies":[98],"from":[99],"our":[100],"group":[101],"others":[103],"showed":[104],"p110\u03b2":[108],"is":[109,117],"aberrantly":[110],"overexpressed":[111],"critical":[118],"cancer":[121],"development":[122],"progression":[124],"as":[125],"demonstrated":[126],"cell-based":[128],"animal":[130],"models.":[131],"Importantly,":[132],"p110\u03b2-specific":[134],"inhibitors":[135],"have":[136],"been":[137,142],"developed":[138],"currently":[141],"testing":[143],"clinical":[145],"trials.":[146],"In":[147],"article,":[149],"we":[150],"will":[151],"briefly":[152],"summarize":[153],"recent":[154],"developments":[155],"regard.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}