{"id":"https://openalex.org/W623047435","doi":"https://doi.org/10.1096/fasebj.20.5.a895-a","title":"Effect of ATP levels on human natural killer cell cytotoxic function","display_name":"Effect of ATP levels on human natural killer cell cytotoxic function","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W623047435","doi":"https://doi.org/10.1096/fasebj.20.5.a895-a","mag":"623047435"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.5.a895-a","doi":"https://doi.org/10.1096/fasebj.20.5.a895-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a895-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047285283","display_name":"Fred Duafalia Dudimah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred Duafalia Dudimah","raw_affiliation_strings":["Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090757520","display_name":"Margaret M. Whalen","orcid":"https://orcid.org/0000-0002-1511-9181","observed_orcids":["https://orcid.org/0000-0002-1511-9181"]},"institutions":[{"id":"https://openalex.org/I75256744","display_name":"Tennessee State University","ror":"https://ror.org/01fpczx89","country_code":"US","type":"education","lineage":["https://openalex.org/I75256744"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret M Whalen","raw_affiliation_strings":["Chemistry Tennessee State University 3500 John Merritt Blvd. Nashville TN 37209"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Tennessee State University 3500 John Merritt Blvd. Nashville TN 37209","institution_ids":["https://openalex.org/I75256744"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03930029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cytotoxic-function","display_name":"cytotoxic function","score":0.7049999833106995},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.972000002861023},{"id":"https://openalex.org/keywords/oligomycin","display_name":"oligomycin","score":1.0},{"id":"https://openalex.org/keywords/tributyltin","display_name":"tributyltin","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-complex-i-inhibition","display_name":"mitochondrial complex I inhibition","score":0.6759999990463257},{"id":"https://openalex.org/keywords/atp-synthase-inhibition","display_name":"ATP synthase inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.609000027179718},{"id":"https://openalex.org/keywords/environmental-contaminants","display_name":"environmental pollutants","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.9057892560958862},{"id":"https://openalex.org/C2779134199","wikidata":"https://www.wikidata.org/wiki/Q1076381","display_name":"Oligomycin","level":4,"score":0.7031542658805847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5890281200408936},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.5784981846809387},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4493810832500458},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4476279616355896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3730798363685608},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35391390323638916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30057352781295776},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27801668643951416},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.126306414604187},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.09221422672271729},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09089422225952148}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.5.a895-a","doi":"https://doi.org/10.1096/fasebj.20.5.a895-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.5.a895-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8758581475","display_name":null,"funder_award_id":"2S06GM0809228","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165012071","https://openalex.org/W2021112979","https://openalex.org/W140007275","https://openalex.org/W2027070198","https://openalex.org/W1994609808","https://openalex.org/W1974094412","https://openalex.org/W2049209352","https://openalex.org/W1578113273","https://openalex.org/W2149606834","https://openalex.org/W2015224451"],"abstract_inverted_index":{"The":[0,237],"purpose":[1],"of":[2,28,49,60,66,196,239],"this":[3,240],"study":[4,241],"is":[5,94,256],"to":[6,46,109,139,163,171,228,249,273],"investigate":[7],"the":[8,64],"relationship":[9],"between":[10],"ATP":[11,67,83,91,117,147,208,245,277],"levels":[12,65,118,209,246,278],"in":[13,102,146,218,266,276],"human":[14,103],"natural":[15],"killer":[16],"(NK)":[17],"cells":[18,24,37,43],"and":[19,38,54,72,98,135,200],"their":[20],"cytotoxic":[21,73,130,176,219,252,268],"function.":[22,131,220],"NK":[23,42,251,267],"are":[25],"a":[26,69,77,143,182],"subset":[27],"lymphocytes":[29],"that":[30,194,243,263],"act":[31],"as":[32,231],"primary":[33],"defense":[34],"against":[35],"tumor":[36],"virally":[39],"infected":[40],"cells.":[41],"were":[44],"exposed":[45],"various":[47,58],"concentrations":[48,195],"rotenone":[50],"(RO),":[51],"oligomycin":[52],"(OL),":[53],"tributyltin":[55],"(TBT)":[56],"for":[57],"lengths":[59],"time":[61],"before":[62],"determining":[63],"(using":[68],"chemiluminescent":[70],"assay)":[71],"function":[74,150,177,253,269],"(determined":[75],"by":[76,119,153,178,188,226,233,281],"chromium":[78],"release":[79],"assay).":[80],"RO":[81,113],"inhibits":[82,90],"production":[84],"at":[85],"Complex":[86],"I,":[87],"while":[88,181],"OL":[89,115,174],"synthase.":[92],"TBT":[93,203],"an":[95],"environmental":[96],"contaminant":[97],"has":[99],"been":[100],"detected":[101],"blood.":[104],"A":[105,167],"1":[106],"h":[107,134,137,158,161,169,184],"exposure":[108,170,185,227],"either":[110],"0.5":[111,164,172],"\u03bcM":[112,165,173],"or":[114,159],"reduced":[116,152,175,186],"about":[120,154,179,189],"20%":[121],"but":[122,254],"did":[123,204],"not":[124,205,224],"have":[125],"any":[126],"measurable":[127],"effect":[128],"on":[129],"Both":[132],"24":[133,157,168,211],"48":[136,160,183],"exposures":[138,162],"these":[140,229],"compounds":[141,230],"caused":[142,215],"20\u201325%":[144],"reduction":[145],"levels.":[148],"Cytotoxic":[149],"was":[151,192,223],"50%":[155],"after":[156,210],"RO.":[166],"50%,":[180],"it":[187],"75%.":[190],"It":[191],"observed":[193],"10,":[197],"25,":[198],"50,":[199],"100":[201],"nM":[202],"significantly":[206],"reduce":[207],"h,":[212],"however":[213],"they":[214],"significant":[216],"decreases":[217,265,275],"Cell":[221],"viability":[222],"affected":[225],"determined":[232],"trypan":[234],"blue":[235],"exclusion.":[236],"results":[238],"indicate":[242,262],"decreased":[244,250],"may":[247],"lead":[248],"there":[255],"no":[257],"absolute":[258],"association.":[259],"They":[260],"also":[261],"TBT\u2010induced":[264,274],"cannot":[270],"be":[271],"attributed":[272],"alone.":[279],"Supported":[280],"NIH":[282],"grant":[283],"2S06GM08092\u201028":[284]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
