{"id":"https://openalex.org/W62237469","doi":null,"title":"Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in rats.","display_name":"Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in rats.","publication_year":2011,"publication_date":"2011-04-25","ids":{"openalex":"https://openalex.org/W62237469","mag":"62237469","pmid":"https://pubmed.ncbi.nlm.nih.gov/21505724"},"language":"en","primary_location":{"id":"pmid:21505724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101912253","display_name":"Mei Han","orcid":"https://orcid.org/0000-0003-3834-6667","observed_orcids":["https://orcid.org/0000-0003-3834-6667"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei Han","raw_affiliation_strings":["Shanghai Medical College, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058341243","display_name":"Ruyi Huang","orcid":"https://orcid.org/0000-0003-3575-3793","observed_orcids":["https://orcid.org/0000-0003-3575-3793","https://orcid.org/0009-0006-2162-5204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru-Yi Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102089516","display_name":"Yimin Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Min Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhi-Qi Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-Qi Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088189767","display_name":"Yu\u2010Qiu Zhang","orcid":"https://orcid.org/0000-0001-6623-9629","observed_orcids":["https://orcid.org/0000-0001-6623-9629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Qiu Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0846,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74270446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"2","first_page":"106","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8259999752044678},{"id":"https://openalex.org/keywords/creb-signaling","display_name":"CREB signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.902999997138977},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.8389999866485596},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":1.0},{"id":"https://openalex.org/keywords/mek-inhibitor-u0126","display_name":"MEK inhibitor U0126","score":0.8799999952316284},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.6480000019073486},{"id":"https://openalex.org/keywords/peripheral-nerve-injury","display_name":"peripheral nerve injury","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8383128643035889},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8223467469215393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7279293537139893},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6479859352111816},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5781769752502441},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5679209232330322},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5544459819793701},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5453497767448425},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5208504796028137},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5133858919143677},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.42594146728515625},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35065802931785583},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.3390997052192688},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33417534828186035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30446016788482666},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.15492218732833862},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12623032927513123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1250554323196411},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.055451661348342896},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002070","descriptor_name":"Butadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020426","descriptor_name":"Sciatic Neuropathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020426","descriptor_name":"Sciatic Neuropathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059348","descriptor_name":"Peripheral Nerve Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D059348","descriptor_name":"Peripheral Nerve Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059348","descriptor_name":"Peripheral Nerve Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21505724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:62237469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1530030261","https://openalex.org/W1818221350","https://openalex.org/W1841237986","https://openalex.org/W1916850619","https://openalex.org/W1919059205","https://openalex.org/W1967880641","https://openalex.org/W1968422624","https://openalex.org/W1970328692","https://openalex.org/W1972659294","https://openalex.org/W1977472414","https://openalex.org/W1979859079","https://openalex.org/W1982599319","https://openalex.org/W1986475508","https://openalex.org/W1989274659","https://openalex.org/W2006161356","https://openalex.org/W2006589555","https://openalex.org/W2007122791","https://openalex.org/W2007166949","https://openalex.org/W2010376916","https://openalex.org/W2015592781","https://openalex.org/W2028269583","https://openalex.org/W2032656475","https://openalex.org/W2033402363","https://openalex.org/W2045441934","https://openalex.org/W2047794539","https://openalex.org/W2050370133","https://openalex.org/W2056688527","https://openalex.org/W2058020736","https://openalex.org/W2068412840","https://openalex.org/W2069482942","https://openalex.org/W2077358692","https://openalex.org/W2082967580","https://openalex.org/W2086475285","https://openalex.org/W2088031900","https://openalex.org/W2089633836","https://openalex.org/W2094350954","https://openalex.org/W2095435531","https://openalex.org/W2099854799","https://openalex.org/W2118977349","https://openalex.org/W2122778405","https://openalex.org/W2122824308","https://openalex.org/W2123258170","https://openalex.org/W2132829674","https://openalex.org/W2133316133","https://openalex.org/W2139743596","https://openalex.org/W2161455727","https://openalex.org/W2163993237","https://openalex.org/W2167580934","https://openalex.org/W2170019750","https://openalex.org/W2171778963","https://openalex.org/W2409860536"],"related_works":["https://openalex.org/W1967880641","https://openalex.org/W1608001793","https://openalex.org/W2027361472","https://openalex.org/W2350645073","https://openalex.org/W2010376916","https://openalex.org/W2152967912","https://openalex.org/W1977095522","https://openalex.org/W3131037657","https://openalex.org/W2401009769","https://openalex.org/W1879507096"],"abstract_inverted_index":{"The":[0,72],"present":[1],"study":[2],"is":[3],"to":[4,22,46,67,102,180],"investigate":[5],"whether":[6],"the":[7,23,40,60,93,98,112,121,133,159,176,181],"extracellular":[8],"signal-regulated":[9],"kinase":[10,147,148],"(ERK)":[11],"and":[12,77,86,157,163,173,189],"cAMP":[13],"response":[14,45,66],"element":[15],"binding":[16],"protein":[17,146],"(CREB)":[18],"signaling":[19],"pathway":[20],"contributes":[21,179],"initiation":[24,182],"of":[25,50,62,74,95,123,144,171,183],"chronic":[26],"constriction":[27],"injury":[28,103],"(CCI)-induced":[29],"neuropathic":[30],"pain":[31,187],"in":[32,44,65,92,126,135,138,175],"rats.":[33],"Mechanical":[34],"allodynia":[35,162],"was":[36,56,104,130],"assessed":[37,57],"by":[38,58],"measuring":[39,59],"hindpaw":[41],"withdrawal":[42,64],"threshold":[43],"a":[47,68],"calibrated":[48],"series":[49],"von":[51],"Frey":[52],"hairs.":[53],"Thermal":[54],"hyperalgesia":[55],"latency":[61],"paw":[63],"radiant":[69],"heat":[70],"source.":[71],"expressions":[73],"phosphor-ERK":[75],"(pERK)":[76],"phosphor-CREB":[78],"(pCREB)":[79],"were":[80],"examined":[81],"using":[82],"Western":[83],"blot":[84],"analysis":[85],"immunohistochemistry.":[87],"An":[88],"early":[89,191],"robust":[90],"increase":[91,134],"expression":[94,125,137],"pERK":[96,124],"on":[97,106],"spinal":[99,128,140,177],"cords":[100],"ipsilateral":[101,127],"observed":[105],"day":[107],"1":[108],"after":[109],"CCI,":[110],"when":[111],"CCI-induced":[113,160],"behavioral":[114],"hypersensitivity":[115],"had":[116],"not":[117],"developed":[118],"yet.":[119],"Moreover,":[120],"upregulation":[122],"cord":[129,178],"associated":[131],"with":[132],"pCREB":[136],"bilateral":[139],"cord.":[141],"Intrathecal":[142],"administration":[143],"mitogen-activated":[145],"(MEK)":[149],"inhibitor":[150],"U0126":[151],"before":[152],"CCI":[153],"can":[154],"efficiently":[155],"block":[156],"delay":[158],"mechanical":[161],"thermal":[164],"hyperalgesia.":[165],"These":[166],"data":[167],"suggest":[168],"that":[169],"activation":[170],"ERK":[172],"CREB":[174],"peripheral":[184],"nerve":[185],"injury-induced":[186],"hypersensitivity,":[188],"an":[190],"intervention":[192],"strategy":[193],"should":[194],"be":[195],"proposed.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}