{"id":"https://openalex.org/W62225952","doi":null,"title":"Laboratory aspects of tick-borne diseases: lyme, human granulocytic ehrlichiosis and babesiosis.","display_name":"Laboratory aspects of tick-borne diseases: lyme, human granulocytic ehrlichiosis and babesiosis.","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W62225952","mag":"62225952","pmid":"https://pubmed.ncbi.nlm.nih.gov/12764539"},"language":"en","primary_location":{"id":"pmid:12764539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12764539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018050522","display_name":"M E Aguero-Rosenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marie E Aguero-Rosenfeld","raw_affiliation_strings":["Clinical Laboratories, Room 1J-11a, Westchester Medical Center, Valhalla, NY 10595, USA. m_aguero-rosenfeld@nymc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratories, Room 1J-11a, Westchester Medical Center, Valhalla, NY 10595, USA. m_aguero-rosenfeld@nymc.edu","institution_ids":["https://openalex.org/I1321686444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018050522"],"corresponding_institution_ids":["https://openalex.org/I1321686444"],"apc_list":null,"apc_paid":null,"fwci":0.8008,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.64817705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"70","issue":"3","first_page":"197","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12833","display_name":"Bartonella species infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/human-granulocytic-ehrlichiosis","display_name":"human granulocytic ehrlichiosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/babesiosis","display_name":"babesiosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tick-borne-disease","display_name":"tick-borne diseases","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ixodes-scapularis","display_name":"Ixodes scapularis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erythema-migrans","display_name":"erythema migrans","score":0.9240000247955322},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/western-blot","display_name":"Western blot","score":0.6700000166893005},{"id":"https://openalex.org/keywords/buffy-coat-smear","display_name":"buffy coat smear","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pcr","display_name":"PCR","score":0.48100000619888306},{"id":"https://openalex.org/keywords/culture","display_name":"culture","score":0.6340000033378601},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.8859999775886536},{"id":"https://openalex.org/keywords/emerging-infectious-diseases","display_name":"emerging infectious diseases","score":0.5529999732971191},{"id":"https://openalex.org/keywords/laboratory-diagnosis","display_name":"laboratory diagnosis","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2778101375","wikidata":"https://www.wikidata.org/wiki/Q2845432","display_name":"Ehrlichiosis","level":3,"score":0.9071168899536133},{"id":"https://openalex.org/C2777553296","wikidata":"https://www.wikidata.org/wiki/Q201989","display_name":"Lyme disease","level":2,"score":0.8186454772949219},{"id":"https://openalex.org/C2778145968","wikidata":"https://www.wikidata.org/wiki/Q797668","display_name":"Babesiosis","level":2,"score":0.7972536087036133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7240657806396484},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.665245532989502},{"id":"https://openalex.org/C2781453105","wikidata":"https://www.wikidata.org/wiki/Q1497962","display_name":"Ixodes scapularis","level":4,"score":0.6535152792930603},{"id":"https://openalex.org/C2776005033","wikidata":"https://www.wikidata.org/wiki/Q184243","display_name":"Tick-borne disease","level":3,"score":0.5943238735198975},{"id":"https://openalex.org/C2779620486","wikidata":"https://www.wikidata.org/wiki/Q10304508","display_name":"Tick","level":2,"score":0.49255165457725525},{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.4706006944179535},{"id":"https://openalex.org/C2780581805","wikidata":"https://www.wikidata.org/wiki/Q797656","display_name":"Babesia","level":2,"score":0.4626193344593048},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4569369852542877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4554150104522705},{"id":"https://openalex.org/C2776307562","wikidata":"https://www.wikidata.org/wiki/Q15968355","display_name":"LYME","level":4,"score":0.43655824661254883},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13266611099243164}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001404","descriptor_name":"Babesiosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001404","descriptor_name":"Babesiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001404","descriptor_name":"Babesiosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008193","descriptor_name":"Lyme Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016873","descriptor_name":"Ehrlichiosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016873","descriptor_name":"Ehrlichiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016873","descriptor_name":"Ehrlichiosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017282","descriptor_name":"Tick-Borne Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017282","descriptor_name":"Tick-Borne Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017282","descriptor_name":"Tick-Borne Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D019411","descriptor_name":"Clinical Laboratory Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12764539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12764539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Mount Sinai journal of medicine, New York","raw_type":"Journal Article"},{"id":"mag:62225952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12764539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W182113194","https://openalex.org/W1505039596","https://openalex.org/W1636622863","https://openalex.org/W1780111211","https://openalex.org/W1841638115","https://openalex.org/W1964538232","https://openalex.org/W1973203032","https://openalex.org/W2010321932","https://openalex.org/W2017184491","https://openalex.org/W2018800131","https://openalex.org/W2047283050","https://openalex.org/W2061265918","https://openalex.org/W2063367477","https://openalex.org/W2063784933","https://openalex.org/W2066630192","https://openalex.org/W2076721603","https://openalex.org/W2076911266","https://openalex.org/W2078648743","https://openalex.org/W2079843643","https://openalex.org/W2093042558","https://openalex.org/W2094657145","https://openalex.org/W2103128190","https://openalex.org/W2104084745","https://openalex.org/W2104648036","https://openalex.org/W2104672622","https://openalex.org/W2111899400","https://openalex.org/W2112517692","https://openalex.org/W2113478594","https://openalex.org/W2113832787","https://openalex.org/W2114769172","https://openalex.org/W2117022997","https://openalex.org/W2118763814","https://openalex.org/W2119694576","https://openalex.org/W2121581558","https://openalex.org/W2124645143","https://openalex.org/W2131184698","https://openalex.org/W2132546705","https://openalex.org/W2144417260","https://openalex.org/W2146846385","https://openalex.org/W2150577340","https://openalex.org/W2158591166","https://openalex.org/W2162689245","https://openalex.org/W2164291489","https://openalex.org/W2164506125","https://openalex.org/W2169070912","https://openalex.org/W2313788533","https://openalex.org/W2321967194","https://openalex.org/W2323602777","https://openalex.org/W2328264635","https://openalex.org/W2337380954","https://openalex.org/W2340249602","https://openalex.org/W2417152106","https://openalex.org/W4249779616"],"related_works":["https://openalex.org/W2118565212","https://openalex.org/W2063471268","https://openalex.org/W2002959132","https://openalex.org/W2322991968","https://openalex.org/W2344599923","https://openalex.org/W2111637012","https://openalex.org/W2140654869","https://openalex.org/W7096038728","https://openalex.org/W1548312788","https://openalex.org/W2113381969"],"abstract_inverted_index":{"Lyme":[0,24,39],"disease,":[1],"human":[2],"granulocytic":[3],"ehrlichiosis":[4],"(HGE)":[5],"and":[6,14,26,52,114,122,138,166],"babesiosis":[7,27,115],"are":[8,22,55,107,116,216],"emerging":[9],"infections":[10,125],"in":[11,136,140,149,218],"the":[12,33,59,85,111,172,176,188,207],"northeastern":[13],"midwestern":[15],"United":[16],"States,":[17],"where":[18],"Ixodes":[19],"scapularis":[20],"ticks":[21],"prevalent.":[23],"disease":[25,40],"have":[28,171],"also":[29],"been":[30],"reported":[31],"on":[32],"West":[34],"Coast,":[35],"but":[36,199],"less":[37],"frequently.":[38],"presents":[41],"frequently":[42,79],"with":[43,69,119,128,195],"a":[44,90,94],"skin":[45,71],"lesion":[46,60],"known":[47],"as":[48,93],"erythema":[49],"migrans":[50],"(EM),":[51],"diagnostic":[53,155],"tests":[54],"not":[56],"necessary":[57],"if":[58],"is":[61],"classical.":[62],"Those":[63],"patients":[64],"presenting":[65],"without":[66],"EM":[67],"or":[68,192],"atypical":[70],"lesions":[72],"may":[73,126,147],"need":[74],"laboratory":[75,81,130],"confirmation.":[76],"The":[77],"most":[78],"used":[80],"modality":[82],"consists":[83],"of":[84,144,175,206],"2-step":[86],"serological":[87],"assays,":[88],"employing":[89],"sensitive":[91],"ELISA":[92],"first":[95],"step,":[96],"followed":[97],"by":[98,110,183,204,211],"IgG":[99],"and/or":[100,134],"IgM":[101],"immunoblots.":[102],"Current":[103],"guidelines":[104],"for":[105,157,187],"interpretation":[106],"those":[108],"recommended":[109],"CDC.":[112],"HGE":[113,137,159],"febrile":[117],"illnesses":[118],"non-specific":[120],"signs":[121],"symptoms.":[123],"Both":[124],"present":[127],"routine":[129],"abnormalities,":[131],"including":[132],"leukopenia":[133],"thrombocytopenia":[135],"anemia":[139],"babesiosis.":[141],"Moderate":[142],"elevations":[143],"liver":[145],"enzymes":[146],"occur":[148],"all":[150],"three":[151,177],"tick-borne":[152],"infections.":[153],"Specific":[154],"modalities":[156],"acute-phase":[158],"include":[160],"buffy":[161],"coat":[162],"smear":[163],"examination,":[164],"culture":[165],"PCR.":[167],"Culture":[168],"appears":[169],"to":[170],"greatest":[173],"sensitivity":[174],"tests.":[178],"Babesiosis":[179],"can":[180],"be":[181,202],"diagnosed":[182],"peripheral":[184],"blood":[185],"examination":[186],"intraerythrocytic":[189],"parasites,":[190],"PCR":[191],"serology.":[193],"Co-infections":[194],"these":[196],"agents":[197],"exist,":[198],"they":[200],"should":[201],"documented":[203],"detection":[205],"organisms":[208],"rather":[209],"than":[210],"serology,":[212],"since":[213],"seroprevalence":[214],"rates":[215],"high":[217],"endemic":[219],"areas.":[220]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}