{"id":"https://openalex.org/W62194635","doi":null,"title":"The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.","display_name":"The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W62194635","mag":"62194635","pmid":"https://pubmed.ncbi.nlm.nih.gov/18078008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2291301"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2291301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2291301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2291301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051468925","display_name":"Paolo Gelosa","orcid":"https://orcid.org/0000-0003-4442-537X","observed_orcids":["https://orcid.org/0000-0003-4442-537X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Gelosa","raw_affiliation_strings":["Department of Pharmacological Sciences, University of Milan, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, University of Milan, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077095217","display_name":"Mauro Cimino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190397597","display_name":"University of Urbino","ror":"https://ror.org/04q4kt073","country_code":"IT","type":"education","lineage":["https://openalex.org/I190397597"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Cimino","raw_affiliation_strings":["University of Urbino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Urbino","institution_ids":["https://openalex.org/I190397597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060787546","display_name":"Alice Pignieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alice Pignieri","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004341489","display_name":"Elena Tremoli","orcid":"https://orcid.org/0000-0002-0929-6106","observed_orcids":["https://orcid.org/0000-0002-0929-6106","https://orcid.org/0000-0003-3426-6424"]},"institutions":[{"id":"https://openalex.org/I4210089474","display_name":"Centro Cardiologico Monzino","ror":"https://ror.org/006pq9r08","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210089474","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Tremoli","raw_affiliation_strings":["Centro Cardiologico Monzino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Cardiologico Monzino","institution_ids":["https://openalex.org/I4210089474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039901296","display_name":"Uliano Guerrini","orcid":"https://orcid.org/0000-0001-7291-5160","observed_orcids":["https://orcid.org/0000-0001-7291-5160"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Uliano Guerrini","raw_affiliation_strings":["University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041137998","display_name":"Luigi Sironi","orcid":"https://orcid.org/0000-0002-4738-3454","observed_orcids":["https://orcid.org/0000-0002-4738-3454"]},"institutions":[{"id":"https://openalex.org/I4210089474","display_name":"Centro Cardiologico Monzino","ror":"https://ror.org/006pq9r08","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210089474","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Sironi","raw_affiliation_strings":["Centro Cardiologico Monzino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Cardiologico Monzino","institution_ids":["https://openalex.org/I4210089474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.234,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93454012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"5","first_page":"567","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.4047999978065491,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hmg-coa-reductase-inhibition","display_name":"HMG-CoA reductase inhibition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/protein-isoprenylation","display_name":"isoprenylation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/farnesyl-pyrophosphate","display_name":"farnesyl pyrophosphate","score":0.906000018119812},{"id":"https://openalex.org/keywords/geranylgeranyl-pyrophosphate","display_name":"geranylgeranyl pyrophosphate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8130000233650208},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.7990000247955322},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6179999709129333},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.7402427196502686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7198048830032349},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.702060878276825},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.6526946425437927},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6145708560943604},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5672564506530762},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5392431616783142},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.46741533279418945},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4585025906562805},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.45274385809898376},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4505484700202942},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.44640398025512695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4154515862464905},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35947877168655396},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2044847309589386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20340758562088013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17793035507202148},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1620776355266571},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2291301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2291301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},{"id":"pmid:18078008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18078008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular health and risk management","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5bfb2922ad74454b8979c3887394c267","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5bfb2922ad74454b8979c3887394c267","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Vascular Health and Risk Management, Vol Volume 3, Pp 567-577 (2007)","raw_type":"article"},{"id":"pmh:oai:ora.uniurb.it:11576/1880302","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11576/1880302","pdf_url":null,"source":{"id":"https://openalex.org/S4377196377","display_name":"CINECA IRIS Institutional Research information system (University of Urbino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190397597","host_organization_name":"University of Urbino","host_organization_lineage":["https://openalex.org/I190397597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:62194635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18078008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2291301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2291301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Health Risk Manag","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2394613807","https://openalex.org/W7128466920"],"related_works":["https://openalex.org/W2062153793","https://openalex.org/W136933022","https://openalex.org/W2161503442","https://openalex.org/W1980113729","https://openalex.org/W7096196948","https://openalex.org/W2417625587","https://openalex.org/W127809968","https://openalex.org/W1974675375","https://openalex.org/W2383732181","https://openalex.org/W1987100782"],"abstract_inverted_index":{"Statin-induced":[0],"inhibition":[1],"ofHMG-CoA":[2],"reductase":[3],"reduces":[4],"cholesterol":[5,68,127],"production":[6],"and":[7,19,36,96,114,137,160,168],"prevents":[8],"the":[9,27,34,47,65,72,120,139,147,166],"formation":[10],"of":[11,30,43,49,88,99,111,141,150],"many":[12],"non-steroidal":[13],"isoprenoid":[14],"compounds,":[15],"such":[16,102,129],"as":[17,23,103,130,163,165],"farnesylpyrophosphate":[18],"geranylgeranylpyrophosphate,":[20],"that":[21,62,76,91,119,152],"act":[22],"lipid":[24],"attachments":[25],"for":[26],"post-translational":[28],"modification":[29],"various":[31],"proteins,":[32],"including":[33],"G-proteins":[35],"transcription":[37],"factors":[38],"involved":[39,155],"in":[40,67,112,115,156],"a":[41],"number":[42],"cell":[44,60],"processes.":[45],"However,":[46],"blockade":[48],"isoprenylation":[50],"elicited":[51],"by":[52],"statin":[53],"treatment":[54],"also":[55],"has":[56],"biological":[57],"effects":[58,75,124,149],"on":[59],"function":[61],"go":[63],"beyond":[64],"decrease":[66],"synthesis:":[69],"these":[70],"are":[71],"so-called":[73],"\"pleiotropic\"":[74],"mainly":[77],"relate":[78],"to":[79,126],"vascular":[80],"function.":[81,176],"Endothelial":[82],"dysfunction":[83,159],"is":[84],"an":[85],"independent":[86],"predictor":[87],"cardiovascular":[89,100],"events":[90],"correlates":[92],"with":[93],"inflammation":[94],"markers/mediators":[95],"robust":[97],"predictors":[98],"diseases":[101],"increased":[104],"high-sensitivity":[105],"C-reactive":[106],"protein":[107],"levels.":[108],"The":[109],"results":[110],"vivo":[113],"vitro":[116],"studies":[117],"indicate":[118],"statins":[121,151],"have":[122],"beneficial":[123],"unrelated":[125],"lowering,":[128],"improving":[131],"endothelial":[132,158,175],"function,":[133],"increasing":[134],"myocardial":[135],"perfusion,":[136],"enhancing":[138],"availability":[140],"nitric":[142],"oxide.":[143],"This":[144],"review":[145],"describes":[146],"pleiotropic":[148],"may":[153],"be":[154],"modulating/preventing":[157],"inflammatory":[161],"processes,":[162],"well":[164],"cellular":[167],"molecular":[169],"mechanisms":[170],"through":[171],"which":[172],"they":[173],"improve":[174]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}