{"id":"https://openalex.org/W621268534","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","title":"Caspase\u20109b Directly Interacts with c\u2010IAP1 to Drive an Agonist\u2010Independent Activation of the NF\u2010\u03baB Pathway and the Enhancement of Tumorigenicity in Non\u2010Small Cell Lung Cancer","display_name":"Caspase\u20109b Directly Interacts with c\u2010IAP1 to Drive an Agonist\u2010Independent Activation of the NF\u2010\u03baB Pathway and the Enhancement of Tumorigenicity in Non\u2010Small Cell Lung Cancer","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W621268534","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","mag":"621268534"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.894.2","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079674683","display_name":"Ngoc Vu","orcid":"https://orcid.org/0000-0001-7846-8162","observed_orcids":["https://orcid.org/0000-0001-7846-8162"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ngoc Vu","raw_affiliation_strings":["Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008240148","display_name":"Margaret A. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Park","raw_affiliation_strings":["Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States","VCU Massey Cancer Center, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States","institution_ids":["https://openalex.org/I2801770128"]},{"raw_affiliation_string":"VCU Massey Cancer Center, VA, United States","institution_ids":["https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002037091","display_name":"Michael D. Shultz","orcid":"https://orcid.org/0000-0001-7920-955X","observed_orcids":["https://orcid.org/0000-0001-7920-955X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Shultz","raw_affiliation_strings":["Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States","institution_ids":["https://openalex.org/I2801770128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020653101","display_name":"Amy C. Ladd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Ladd","raw_affiliation_strings":["Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009408265","display_name":"Charles Edward Chalfant","orcid":"https://orcid.org/0000-0002-5844-5235","observed_orcids":["https://orcid.org/0000-0002-5844-5235"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I2801770128","display_name":"Hunter Holmes McGuire VA Medical Center","ror":"https://ror.org/04fp78s33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801770128","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Chalfant","raw_affiliation_strings":["Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States","VCU Johnson Center, VA, United States","VCU Massey Cancer Center, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Virginia Commonwealth University (VCU), VA, United States","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Hunter Holmes McGuire Veterans Administration Medical Center, VA, United States","institution_ids":["https://openalex.org/I2801770128"]},{"raw_affiliation_string":"VCU Johnson Center, VA, United States","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"VCU Massey Cancer Center, VA, United States","institution_ids":["https://openalex.org/I4390039382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00484926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciap1","display_name":"cIAP1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ikappabalpha-degradation","display_name":"I\u03baB\u03b1 degradation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nik","display_name":"NIK","score":0.8330000042915344},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.6413896679878235},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.5299956202507019},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5217443704605103},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5154308080673218},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5123387575149536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5015482902526855},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.48567187786102295},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47903934121131897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4605731964111328},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4425595700740814},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.4188457131385803},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.37229302525520325},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3664420545101166},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.360588014125824},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2430303394794464},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17294976115226746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13713723421096802}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.894.2","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.894.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2322807801","https://openalex.org/W2328907496","https://openalex.org/W4223585350","https://openalex.org/W2008231783","https://openalex.org/W165126117","https://openalex.org/W2391158969","https://openalex.org/W2298420486","https://openalex.org/W3157618468","https://openalex.org/W3011776749","https://openalex.org/W1992160144"],"abstract_inverted_index":{"Caspase-9":[0],"has":[1,16,201],"two":[2],"isoforms":[3],"with":[4,132],"opposing":[5],"functions,":[6],"pro-apoptotic":[7],"caspase-9a":[8],"(C9a)":[9],"and":[10,24,82,98,113,170,176,187],"anti-apoptotic":[11],"caspase-9b":[12],"(C9b).":[13],"C9b":[14,48,74,107,121,131,158,185],"expression":[15,186],"been":[17,202],"reported":[18],"to":[19,51,77,109,210],"augment":[20],"the":[21,35,45,58,79,85,89,110,133,147,160,172,182,218],"anchorage-dependent":[22],"growth":[23,115,175],"tumorigenic":[25,199],"capacity":[26],"of":[27,37,84,88,116,130,136,146,164,178,212,222],"non-small":[28],"cell":[29],"lung":[30],"cancer":[31],"(NSCLC)":[32],"cells;":[33],"however,":[34],"mechanism":[36,200],"this":[38,103,156],"biological":[39],"observation":[40],"was":[41,190],"unknown.":[42],"Herein":[43],"for":[44,106],"first":[46],"time,":[47],"is":[49,66,75],"shown":[50,76],"have":[52],"a":[53,127,140,197,213],"dual":[54],"function":[55],"in":[56,143,192],"regulating":[57],"survival/oncogenic":[59],"nuclear":[60],"factor":[61,142],"\u03baB":[62],"(NF-\u03baB)":[63],"pathway,":[64],"which":[65,166,205],"independent":[67,221],"from":[68],"modulating":[69],"C9a":[70],"activation.":[71],"In":[72],"particular,":[73],"activate":[78],"canonical":[80],"arm":[81,87],"inhibit":[83],"non-canonical":[86],"NF-\u03baB":[90,94,148,168,188,219],"pathway":[91],"by":[92,120,204],"destabilizing":[93],"inhibitor":[95,135],"alpha":[96],"(I\u03baB-\u03b1)":[97],"NF-\u03baB-inducing":[99],"kinase":[100],"(NIK).":[101],"Importantly,":[102],"new":[104],"role":[105],"contributes":[108],"enhanced":[111],"survival":[112],"anchorage-independent":[114,174],"NSCLC":[117,179,194],"cells":[118],"conferred":[119],"expression.":[122],"Further":[123],"mechanistic":[124],"studies":[125],"demonstrated":[126],"direct":[128],"association":[129],"cellular":[134],"apoptosis":[137],"1":[138],"(c-IAP1),":[139],"regulatory":[141],"both":[144],"arms":[145],"network,":[149],"via":[150],"its":[151],"IAP-binding":[152],"motif":[153],"(IBM).":[154],"Through":[155],"interaction,":[157],"induces":[159],"E3":[161],"ligase":[162],"activity":[163],"c-IAP1,":[165],"regulates":[167,217],"activation,":[169],"promotes":[171],"viability,":[173],"tumorigenicity":[177],"cells.":[180],"Lastly,":[181],"link":[183],"between":[184],"activation":[189],"validated":[191],"human":[193],"tumors.":[195],"Overall,":[196],"novel":[198],"identified":[203],"alternative":[206],"mRNA":[207],"processing":[208],"leads":[209],"generation":[211],"protein":[214],"isoform":[215],"that":[216],"signaling":[220],"external":[223],"agonist.":[224]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
