{"id":"https://openalex.org/W62083797","doi":null,"title":"Abstract 1463: Titin Isoform Phosphorylation in Failing Human Myocardium","display_name":"Abstract 1463: Titin Isoform Phosphorylation in Failing Human Myocardium","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W62083797","mag":"62083797"},"language":"en","primary_location":{"id":"mag:62083797","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.116.suppl_16.II_301-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103099830","display_name":"Attila Borb\u00e9ly","orcid":"https://orcid.org/0000-0002-6019-6274","observed_orcids":["https://orcid.org/0000-0002-6019-6274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Attila Borb\u00e9ly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6019-6274","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002233320","display_name":"Nazha Hamdani","orcid":"https://orcid.org/0000-0002-3053-0008","observed_orcids":["https://orcid.org/0000-0002-3053-0008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nazha Hamdani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3053-0008","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066456218","display_name":"In\u00eas Falc\u00e3o\u2010Pires","orcid":"https://orcid.org/0000-0003-1937-3782","observed_orcids":["https://orcid.org/0000-0003-1937-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"In\u00eas Falc\u00e3o\u2010Pires","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1937-3782","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060727278","display_name":"Istvan Ferenc Edes","orcid":"https://orcid.org/0000-0001-8062-825X","observed_orcids":["https://orcid.org/0000-0001-8062-825X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Istv\u00e1n \u00c9des","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060298206","display_name":"Adelino Ferreira Leite-Moreira","orcid":"https://orcid.org/0000-0001-7808-3596","observed_orcids":["https://orcid.org/0000-0001-7808-3596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adelino Leite\u2010Moreira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7808-3596","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019586059","display_name":"Ger J.M. Stienen","orcid":"https://orcid.org/0000-0001-5829-0328","observed_orcids":["https://orcid.org/0000-0001-5829-0328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ger J.M. Stienen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5829-0328","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008468085","display_name":"Jolanda van der Velden","orcid":"https://orcid.org/0000-0001-5224-5788","observed_orcids":["https://orcid.org/0000-0001-5224-5788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanda van der Velden","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5224-5788","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016743789","display_name":"Walter J. Paulus","orcid":"https://orcid.org/0000-0002-1597-1737","observed_orcids":["https://orcid.org/0000-0002-1597-1737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter J. Paulus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1597-1737","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.05009999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titin","display_name":"titin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/titin-isoforms","display_name":"titin isoforms","score":0.7310000061988831},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7440000176429749},{"id":"https://openalex.org/keywords/resting-tension","display_name":"resting tension","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C90671521","wikidata":"https://www.wikidata.org/wiki/Q74314","display_name":"Titin","level":4,"score":0.9292788505554199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8912202715873718},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7479445338249207},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7118708491325378},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3643677532672882},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33467185497283936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3249274492263794},{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.21768927574157715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21615561842918396},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.16736429929733276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08030986785888672},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:62083797","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.116.suppl_16.II_301-b","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153195779","https://openalex.org/W7100723826","https://openalex.org/W2738635102","https://openalex.org/W98944900","https://openalex.org/W2340327686","https://openalex.org/W201880695","https://openalex.org/W2098587086","https://openalex.org/W2119871412","https://openalex.org/W1973429465","https://openalex.org/W2626807018"],"abstract_inverted_index":{"Titin":[0],"lowers":[1],"myocardial":[2],"diastolic":[3],"stiffness":[4],"by":[5,20],"shifting":[6],"its":[7,22],"isoform":[8,18],"expression":[9],"from":[10],"the":[11,15],"stiff":[12],"N2B":[13],"to":[14],"compliant":[16],"N2BA":[17],"and":[19],"increasing":[21],"phosphorylation.":[23],"Resting":[24],"tension":[25],"(RT)":[26],"of":[27],"cardio...":[28]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}