{"id":"https://openalex.org/W620734541","doi":"https://doi.org/10.1097/cco.0000000000000198","title":"Synovial sarcoma diagnosis and management in the era of targeted therapies","display_name":"Synovial sarcoma diagnosis and management in the era of targeted therapies","publication_year":2015,"publication_date":"2015-06-04","ids":{"openalex":"https://openalex.org/W620734541","doi":"https://doi.org/10.1097/cco.0000000000000198","mag":"620734541","pmid":"https://pubmed.ncbi.nlm.nih.gov/26049271"},"language":"en","primary_location":{"id":"doi:10.1097/cco.0000000000000198","doi":"https://doi.org/10.1097/cco.0000000000000198","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0000000000000198","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012955112","display_name":"Myrella Vlenterie","orcid":"https://orcid.org/0000-0002-4523-4084","observed_orcids":["https://orcid.org/0000-0002-4523-4084"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Myrella Vlenterie","raw_affiliation_strings":["aDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands bSarcoma Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands bSarcoma Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I2802934949","https://openalex.org/I4210121186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048969933","display_name":"Robin L. Jones","orcid":"https://orcid.org/0000-0003-4173-3844","observed_orcids":["https://orcid.org/0000-0003-4173-3844"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin L. Jones","raw_affiliation_strings":["Sarcoma Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom","Royal Marsden NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom","institution_ids":["https://openalex.org/I1325846038"]},{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust","institution_ids":["https://openalex.org/I1325846038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055163903","display_name":"Winette T.A. van der Graaf","orcid":"https://orcid.org/0000-0001-7549-3338","observed_orcids":["https://orcid.org/0000-0001-7549-3338"]},"institutions":[{"id":"https://openalex.org/I1325846038","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["GB","NL"],"is_corresponding":true,"raw_author_name":"Winette T.A. van der Graaf","raw_affiliation_strings":["Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands","to Professor Winette T.A. van der Graaf, MD, PhD, Department of Medical Oncology, 452, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: [email\u00a0protected]","Royal Marsden NHS Foundation Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"to Professor Winette T.A. van der Graaf, MD, PhD, Department of Medical Oncology, 452, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"Royal Marsden NHS Foundation Trust","institution_ids":["https://openalex.org/I1325846038"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055163903"],"corresponding_institution_ids":["https://openalex.org/I1325846038","https://openalex.org/I2802934949"],"apc_list":null,"apc_paid":null,"fwci":0.5605,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.52023529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"4","first_page":"316","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":1.0},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.5879999995231628},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7760000228881836},{"id":"https://openalex.org/keywords/rare-tumor","display_name":"rare tumor","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9050390720367432},{"id":"https://openalex.org/C2776910622","wikidata":"https://www.wikidata.org/wiki/Q2619315","display_name":"Synovial sarcoma","level":3,"score":0.7788865566253662},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6198309063911438},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6061091423034668},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5743141174316406},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4950985014438629},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.4493381381034851},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4109545648097992},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34510311484336853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3299529552459717},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.320250540971756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1291518211364746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013584","descriptor_name":"Sarcoma, Synovial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013584","descriptor_name":"Sarcoma, Synovial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013584","descriptor_name":"Sarcoma, Synovial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013584","descriptor_name":"Sarcoma, Synovial","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/cco.0000000000000198","doi":"https://doi.org/10.1097/cco.0000000000000198","is_oa":false,"landing_page_url":"https://doi.org/10.1097/cco.0000000000000198","pdf_url":null,"source":{"id":"https://openalex.org/S179395531","display_name":"Current Opinion in Oncology","issn_l":"1040-8746","issn":["1040-8746","1080-8140","1531-703X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Oncology","raw_type":"journal-article"},{"id":"pmid:26049271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26049271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/154052","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/154052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Oncology, 27, 4, pp. 316-22","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/154052","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/154052","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Opinion in Oncology, 27, 316 - 22","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327811","display_name":"PharmaMar","ror":"https://ror.org/02h694m69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1547298604","https://openalex.org/W1557081012","https://openalex.org/W1588528216","https://openalex.org/W1967378899","https://openalex.org/W1973726986","https://openalex.org/W1973855155","https://openalex.org/W1977144004","https://openalex.org/W1981280742","https://openalex.org/W1983033105","https://openalex.org/W1983368815","https://openalex.org/W1985429138","https://openalex.org/W1990255585","https://openalex.org/W1993866317","https://openalex.org/W1995357936","https://openalex.org/W1999662775","https://openalex.org/W2002007120","https://openalex.org/W2003667539","https://openalex.org/W2005472071","https://openalex.org/W2012227952","https://openalex.org/W2013286412","https://openalex.org/W2013509436","https://openalex.org/W2018067088","https://openalex.org/W2018712929","https://openalex.org/W2033478581","https://openalex.org/W2038208403","https://openalex.org/W2044183760","https://openalex.org/W2045513649","https://openalex.org/W2071760913","https://openalex.org/W2075641085","https://openalex.org/W2096534781","https://openalex.org/W2101304964","https://openalex.org/W2101776780","https://openalex.org/W2102595806","https://openalex.org/W2107230638","https://openalex.org/W2110841476","https://openalex.org/W2111895468","https://openalex.org/W2116056899","https://openalex.org/W2117981962","https://openalex.org/W2118475754","https://openalex.org/W2121446024","https://openalex.org/W2128609422","https://openalex.org/W2134731586","https://openalex.org/W2136344041","https://openalex.org/W2141118160","https://openalex.org/W2144530818","https://openalex.org/W2149285292","https://openalex.org/W2152274262","https://openalex.org/W2158657726","https://openalex.org/W2160028990","https://openalex.org/W2163261207","https://openalex.org/W2165119413","https://openalex.org/W2166190052","https://openalex.org/W2169582178","https://openalex.org/W2170583701","https://openalex.org/W2989800034","https://openalex.org/W4231696556","https://openalex.org/W6675541574","https://openalex.org/W6702668397"],"related_works":["https://openalex.org/W2605508826","https://openalex.org/W2032102970","https://openalex.org/W2014997217","https://openalex.org/W2773879876","https://openalex.org/W4386089067","https://openalex.org/W2182022734","https://openalex.org/W2967046715","https://openalex.org/W2912268438","https://openalex.org/W1839430567","https://openalex.org/W7112171635"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Synovial":[3],"sarcomas":[4,59],"are":[5],"a":[6,13,96,134],"distinct":[7],"soft":[8],"tissue":[9],"sarcoma":[10],"subtype,":[11],"with":[12,40,50,115,179],"predilection":[14],"for":[15,82,99],"young":[16],"adults.":[17],"Despite":[18],"its":[19],"common":[20],"translocation,":[21],"there":[22,94],"is":[23,63,95,131],"substantial":[24],"heterogeneity":[25],"in":[26,34,48,85,118,121,145,191,195],"patient":[27,76,140,181,187],"outcome.":[28],"This":[29],"review":[30],"discusses":[31],"recent":[32],"developments":[33],"diagnosis,":[35],"prognostication,":[36],"and":[37,46,62,74,165],"treatments,":[38],"together":[39],"the":[41,83,157,172,183],"role":[42],"of":[43,57,160,175,185],"targeted":[44],"agents":[45],"immunotherapy":[47],"patients":[49],"synovial":[51,58],"sarcoma.":[52],"RECENT":[53],"FINDINGS:":[54],"Tumor":[55],"behavior":[56,86,164],"remains":[60,92],"inexplicable":[61],"therefore":[64],"poorly":[65],"predictable.":[66],"Although":[67],"many":[68],"variables":[69],"seem":[70],"to":[71,73,128,133,138,143,155,171],"contribute":[72],"influence":[75],"outcome,":[77],"no":[78],"underlying":[79,158],"pathophysiology":[80],"accounting":[81],"variability":[84],"has":[87],"been":[88,110],"unraveled.":[89],"As":[90],"prognosis":[91],"poor,":[93],"wistful":[97],"search":[98],"new":[100,167],"therapies.":[101],"In":[102],"preclinical":[103,126],"testing,":[104],"several":[105],"receptor":[106],"tyrosine":[107],"kinases":[108],"have":[109],"suggested":[111],"as":[112],"therapeutic":[113,168],"targets":[114],"interesting":[116,125],"results":[117,130],"vitro":[119],"or":[120],"vivo.":[122],"However,":[123],"translating":[124],"outcome":[127,188],"clinical":[129,146],"difficult,":[132],"large":[135],"extent":[136],"due":[137],"limited":[139],"numbers":[141],"available":[142],"participate":[144],"trials.":[147],"SUMMARY:":[148],"By":[149],"defining":[150],"predictive":[151],"variables,":[152],"researchers":[153],"try":[154],"understand":[156],"cause":[159],"this":[161,196],"tumor's":[162],"biologic":[163],"develop":[166],"targets.":[169],"Owing":[170],"minimal":[173],"number":[174],"prospective":[176],"studies":[177,194],"usually":[178],"small":[180],"numbers,":[182],"strength":[184],"improving":[186],"will":[189],"be":[190],"collaborative":[192],"international":[193],"rare":[197],"tumor":[198],"type.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
