{"id":"https://openalex.org/W618775405","doi":null,"title":"An investigation of genetic risk factors in primary open-angle glaucoma","display_name":"An investigation of genetic risk factors in primary open-angle glaucoma","publication_year":2009,"publication_date":"2009-07-01","ids":{"openalex":"https://openalex.org/W618775405","mag":"618775405"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18777","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18777/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041213206","display_name":"S. Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041213206"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lmx1b","display_name":"Lmx1b","score":0.9900000095367432},{"id":"https://openalex.org/keywords/foxc1","display_name":"FOXC1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":1.0},{"id":"https://openalex.org/keywords/normal-tension-glaucoma","display_name":"normal-tension glaucoma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/high-tension-glaucoma","display_name":"high-tension glaucoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":0.9929999709129333},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.777999997138977},{"id":"https://openalex.org/keywords/trabecular-meshwork","display_name":"trabecular meshwork","score":0.7889999747276306},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9139999747276306},{"id":"https://openalex.org/keywords/white-british-population","display_name":"white British population","score":0.7749999761581421},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.46399998664855957},{"id":"https://openalex.org/keywords/replication-study","display_name":"replication study","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.8148800134658813},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.7634586095809937},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.64552241563797},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6067371964454651},{"id":"https://openalex.org/C2781147369","wikidata":"https://www.wikidata.org/wiki/Q18029808","display_name":"Myocilin","level":4,"score":0.5212541222572327},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5205436944961548},{"id":"https://openalex.org/C2780179686","wikidata":"https://www.wikidata.org/wiki/Q17300307","display_name":"Normal tension glaucoma","level":4,"score":0.47744327783584595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4621824026107788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4370178282260895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3588758111000061},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22571268677711487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15683788061141968},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18777","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18777/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:618775405","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18777/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":415,"referenced_works":["https://openalex.org/W4699062","https://openalex.org/W20895949","https://openalex.org/W37407963","https://openalex.org/W52359312","https://openalex.org/W65360543","https://openalex.org/W75611160","https://openalex.org/W87871173","https://openalex.org/W91085208","https://openalex.org/W91769371","https://openalex.org/W92049793","https://openalex.org/W96926736","https://openalex.org/W115218216","https://openalex.org/W132121957","https://openalex.org/W133596747","https://openalex.org/W162667471","https://openalex.org/W234353291","https://openalex.org/W581315480","https://openalex.org/W658651614","https://openalex.org/W1443481807","https://openalex.org/W1480620097","https://openalex.org/W1483355412","https://openalex.org/W1485371658","https://openalex.org/W1493533123","https://openalex.org/W1501828520","https://openalex.org/W1512008184","https://openalex.org/W1512231570","https://openalex.org/W1517748724","https://openalex.org/W1518187476","https://openalex.org/W1520259177","https://openalex.org/W1521185539","https://openalex.org/W1524354116","https://openalex.org/W1529788780","https://openalex.org/W1548936982","https://openalex.org/W1551890621","https://openalex.org/W1562353524","https://openalex.org/W1577867902","https://openalex.org/W1581725900","https://openalex.org/W1584688353","https://openalex.org/W1591298719","https://openalex.org/W1591818011","https://openalex.org/W1592004976","https://openalex.org/W1593353239","https://openalex.org/W1603519445","https://openalex.org/W1636022999","https://openalex.org/W1752988765","https://openalex.org/W1789824814","https://openalex.org/W1834622832","https://openalex.org/W1841005193","https://openalex.org/W1860511215","https://openalex.org/W1874460601","https://openalex.org/W1887682009","https://openalex.org/W1891283710","https://openalex.org/W1907435754","https://openalex.org/W1923939500","https://openalex.org/W1956294409","https://openalex.org/W1962217919","https://openalex.org/W1964022954","https://openalex.org/W1965161244","https://openalex.org/W1965399667","https://openalex.org/W1965952143","https://openalex.org/W1966028855","https://openalex.org/W1969415039","https://openalex.org/W1969426707","https://openalex.org/W1971341028","https://openalex.org/W1971485090","https://openalex.org/W1971983221","https://openalex.org/W1972799586","https://openalex.org/W1972864922","https://openalex.org/W1972971823","https://openalex.org/W1972972345","https://openalex.org/W1973640772","https://openalex.org/W1973755623","https://openalex.org/W1974689966","https://openalex.org/W1974960154","https://openalex.org/W1975088893","https://openalex.org/W1975696308","https://openalex.org/W1975890854","https://openalex.org/W1976431559","https://openalex.org/W1977132553","https://openalex.org/W1978673893","https://openalex.org/W1978849123","https://openalex.org/W1980080954","https://openalex.org/W1980296697","https://openalex.org/W1981147791","https://openalex.org/W1981504117","https://openalex.org/W1982878020","https://openalex.org/W1983103567","https://openalex.org/W1984618569","https://openalex.org/W1986248969","https://openalex.org/W1986278788","https://openalex.org/W1986862398","https://openalex.org/W1987445566","https://openalex.org/W1988156393","https://openalex.org/W1988872141","https://openalex.org/W1989399186","https://openalex.org/W1989534065","https://openalex.org/W1990245848","https://openalex.org/W1990630872","https://openalex.org/W1991958238","https://openalex.org/W1992178795","https://openalex.org/W1992606116","https://openalex.org/W1993169971","https://openalex.org/W1993271689","https://openalex.org/W1994279963","https://openalex.org/W1995226816","https://openalex.org/W1995312072","https://openalex.org/W1995882746","https://openalex.org/W1995887719","https://openalex.org/W1995920709","https://openalex.org/W1996381116","https://openalex.org/W1996729817","https://openalex.org/W1998021510","https://openalex.org/W1998662169","https://openalex.org/W1999488803","https://openalex.org/W2000100368","https://openalex.org/W2001328897","https://openalex.org/W2002205804","https://openalex.org/W2002228001","https://openalex.org/W2002579513","https://openalex.org/W2002665311","https://openalex.org/W2003959496","https://openalex.org/W2003960557","https://openalex.org/W2004038195","https://openalex.org/W2004075829","https://openalex.org/W2004260482","https://openalex.org/W2004291269","https://openalex.org/W2004422857","https://openalex.org/W2005144583","https://openalex.org/W2005203972","https://openalex.org/W2005641281","https://openalex.org/W2005935256","https://openalex.org/W2006072192","https://openalex.org/W2006741626","https://openalex.org/W2007929650","https://openalex.org/W2007992196","https://openalex.org/W2008013676","https://openalex.org/W2008321551","https://openalex.org/W2009170774","https://openalex.org/W2009171533","https://openalex.org/W2011263846","https://openalex.org/W2011335970","https://openalex.org/W2012130396","https://openalex.org/W2012440149","https://openalex.org/W2012905663","https://openalex.org/W2013141386","https://openalex.org/W2015408724","https://openalex.org/W2016444344","https://openalex.org/W2018071295","https://openalex.org/W2018412721","https://openalex.org/W2019093817","https://openalex.org/W2019452716","https://openalex.org/W2019610144","https://openalex.org/W2020476067","https://openalex.org/W2021953612","https://openalex.org/W2023287786","https://openalex.org/W2024222016","https://openalex.org/W2024250984","https://openalex.org/W2025796428","https://openalex.org/W2026103376","https://openalex.org/W2027696689","https://openalex.org/W2027759113","https://openalex.org/W2028243025","https://openalex.org/W2028824141","https://openalex.org/W2029197206","https://openalex.org/W2029875925","https://openalex.org/W2030095678","https://openalex.org/W2030739854","https://openalex.org/W2030820499","https://openalex.org/W2031264242","https://openalex.org/W2031890747","https://openalex.org/W2032731418","https://openalex.org/W2033867289","https://openalex.org/W2034113208","https://openalex.org/W2034209104","https://openalex.org/W2034571512","https://openalex.org/W2034607546","https://openalex.org/W2035107735","https://openalex.org/W2036139614","https://openalex.org/W2036362108","https://openalex.org/W2037179295","https://openalex.org/W2037191423","https://openalex.org/W2037548402","https://openalex.org/W2039286089","https://openalex.org/W2040411269","https://openalex.org/W2040604400","https://openalex.org/W2041316820","https://openalex.org/W2042103448","https://openalex.org/W2042130706","https://openalex.org/W2042335805","https://openalex.org/W2042916275","https://openalex.org/W2043266178","https://openalex.org/W2043923159","https://openalex.org/W2043984120","https://openalex.org/W2044121529","https://openalex.org/W2044224356","https://openalex.org/W2044649637","https://openalex.org/W2044753638","https://openalex.org/W2045810268","https://openalex.org/W2046365203","https://openalex.org/W2046485437","https://openalex.org/W2046696024","https://openalex.org/W2047176946","https://openalex.org/W2047593629","https://openalex.org/W2048020747","https://openalex.org/W2048350685","https://openalex.org/W2048764470","https://openalex.org/W2049924560","https://openalex.org/W2050100864","https://openalex.org/W2050209293","https://openalex.org/W2052515869","https://openalex.org/W2052588684","https://openalex.org/W2052783288","https://openalex.org/W2053212314","https://openalex.org/W2053286732","https://openalex.org/W2053576831","https://openalex.org/W2053929720","https://openalex.org/W2054212910","https://openalex.org/W2054485576","https://openalex.org/W2055110202","https://openalex.org/W2055197330","https://openalex.org/W2056077890","https://openalex.org/W2056328047","https://openalex.org/W2056416921","https://openalex.org/W2057266151","https://openalex.org/W2057836968","https://openalex.org/W2060057046","https://openalex.org/W2060313264","https://openalex.org/W2060419306","https://openalex.org/W2061008984","https://openalex.org/W2061541185","https://openalex.org/W2062077786","https://openalex.org/W2062557057","https://openalex.org/W2062810731","https://openalex.org/W2062831483","https://openalex.org/W2063559118","https://openalex.org/W2065486619","https://openalex.org/W2065670354","https://openalex.org/W2065780069","https://openalex.org/W2066669827","https://openalex.org/W2066765872","https://openalex.org/W2066931960","https://openalex.org/W2068440992","https://openalex.org/W2069769149","https://openalex.org/W2070298717","https://openalex.org/W2071788329","https://openalex.org/W2072088948","https://openalex.org/W2072290838","https://openalex.org/W2072372062","https://openalex.org/W2072988220","https://openalex.org/W2073537216","https://openalex.org/W2073974037","https://openalex.org/W2074754379","https://openalex.org/W2077037485","https://openalex.org/W2077243943","https://openalex.org/W2079080309","https://openalex.org/W2079194549","https://openalex.org/W2079273778","https://openalex.org/W2079501979","https://openalex.org/W2080570055","https://openalex.org/W2080645218","https://openalex.org/W2080968716","https://openalex.org/W2081283430","https://openalex.org/W2081362596","https://openalex.org/W2082297686","https://openalex.org/W2083195184","https://openalex.org/W2083428241","https://openalex.org/W2084352924","https://openalex.org/W2085076314","https://openalex.org/W2086876060","https://openalex.org/W2087156500","https://openalex.org/W2089066758","https://openalex.org/W2089423523","https://openalex.org/W2089817566","https://openalex.org/W2090323725","https://openalex.org/W2093726485","https://openalex.org/W2093921862","https://openalex.org/W2094407546","https://openalex.org/W2094922652","https://openalex.org/W2095123953","https://openalex.org/W2095392517","https://openalex.org/W2096028394","https://openalex.org/W2096048016","https://openalex.org/W2097450671","https://openalex.org/W2097690951","https://openalex.org/W2097751246","https://openalex.org/W2099573670","https://openalex.org/W2099842384","https://openalex.org/W2100083659","https://openalex.org/W2100159037","https://openalex.org/W2100556262","https://openalex.org/W2100570737","https://openalex.org/W2100942747","https://openalex.org/W2101199309","https://openalex.org/W2101375158","https://openalex.org/W2102060212","https://openalex.org/W2102112915","https://openalex.org/W2102164187","https://openalex.org/W2102337184","https://openalex.org/W2104489424","https://openalex.org/W2106353366","https://openalex.org/W2106369180","https://openalex.org/W2106433994","https://openalex.org/W2107364268","https://openalex.org/W2107889007","https://openalex.org/W2108214367","https://openalex.org/W2108335639","https://openalex.org/W2109347434","https://openalex.org/W2110149781","https://openalex.org/W2110590643","https://openalex.org/W2110755408","https://openalex.org/W2111122566","https://openalex.org/W2111608717","https://openalex.org/W2112715420","https://openalex.org/W2113784410","https://openalex.org/W2115912163","https://openalex.org/W2116493905","https://openalex.org/W2118471878","https://openalex.org/W2119444585","https://openalex.org/W2119897520","https://openalex.org/W2119909636","https://openalex.org/W2120711134","https://openalex.org/W2121775724","https://openalex.org/W2122281425","https://openalex.org/W2123977931","https://openalex.org/W2126060767","https://openalex.org/W2126327941","https://openalex.org/W2126843316","https://openalex.org/W2128891694","https://openalex.org/W2129856680","https://openalex.org/W2130017948","https://openalex.org/W2130526740","https://openalex.org/W2131617470","https://openalex.org/W2133095706","https://openalex.org/W2135185268","https://openalex.org/W2135680359","https://openalex.org/W2137221550","https://openalex.org/W2137541496","https://openalex.org/W2138177109","https://openalex.org/W2139077400","https://openalex.org/W2139839934","https://openalex.org/W2140572701","https://openalex.org/W2140594570","https://openalex.org/W2141043702","https://openalex.org/W2142011909","https://openalex.org/W2142301722","https://openalex.org/W2142769921","https://openalex.org/W2142861117","https://openalex.org/W2143189496","https://openalex.org/W2143334732","https://openalex.org/W2144206769","https://openalex.org/W2144353399","https://openalex.org/W2144645229","https://openalex.org/W2145195065","https://openalex.org/W2145435350","https://openalex.org/W2145587966","https://openalex.org/W2145821935","https://openalex.org/W2146100842","https://openalex.org/W2147093603","https://openalex.org/W2148584466","https://openalex.org/W2148890166","https://openalex.org/W2149664489","https://openalex.org/W2150024705","https://openalex.org/W2150644839","https://openalex.org/W2151744853","https://openalex.org/W2151765974","https://openalex.org/W2152352220","https://openalex.org/W2152664025","https://openalex.org/W2154176728","https://openalex.org/W2154886355","https://openalex.org/W2155303688","https://openalex.org/W2156051412","https://openalex.org/W2157890401","https://openalex.org/W2157892812","https://openalex.org/W2158230021","https://openalex.org/W2158372110","https://openalex.org/W2159487337","https://openalex.org/W2161217159","https://openalex.org/W2161968833","https://openalex.org/W2162530578","https://openalex.org/W2163474244","https://openalex.org/W2164419843","https://openalex.org/W2164763690","https://openalex.org/W2165771683","https://openalex.org/W2167134067","https://openalex.org/W2169113983","https://openalex.org/W2169299900","https://openalex.org/W2169441945","https://openalex.org/W2170357997","https://openalex.org/W2182471170","https://openalex.org/W2183676102","https://openalex.org/W2188060873","https://openalex.org/W2199335975","https://openalex.org/W2206075217","https://openalex.org/W2312965913","https://openalex.org/W2317938351","https://openalex.org/W2336238528","https://openalex.org/W2342118129","https://openalex.org/W2360665023","https://openalex.org/W2397507282","https://openalex.org/W2398911000","https://openalex.org/W2399924607","https://openalex.org/W2401910999","https://openalex.org/W2408876769","https://openalex.org/W2412061527","https://openalex.org/W2412717394","https://openalex.org/W2412739496","https://openalex.org/W2418947395","https://openalex.org/W2468187845","https://openalex.org/W2903822341","https://openalex.org/W2917323190","https://openalex.org/W3145351529","https://openalex.org/W4245839829","https://openalex.org/W4321429563","https://openalex.org/W4323899169","https://openalex.org/W7098572460"],"related_works":["https://openalex.org/W1552392497","https://openalex.org/W6999462359","https://openalex.org/W997641414","https://openalex.org/W2175207930","https://openalex.org/W1996273065","https://openalex.org/W2138177109","https://openalex.org/W2434553194","https://openalex.org/W2075286956","https://openalex.org/W2807017062","https://openalex.org/W2973116460"],"abstract_inverted_index":{"Primary":[0],"open-angle":[1],"glaucoma":[2,56,86,122,176],"(POAG)":[3],"is":[4],"a":[5,9,43,71,83,102,114,152,158,232,267,279,292],"multifactorial":[6],"disease":[7],"with":[8,21,42,180,184,204,266],"strong":[10,53],"genetic":[11,104,154],"\\ncomponent.":[12],"Notably":[13],"however,":[14],"few":[15],"genes":[16],"have":[17],"been":[18,109],"robustly":[19],"associated":[20,41],"POAG":[22,205,258,317],"in":[23,28,67,85,124,151,157,165,198,226,289,318],"\\nthe":[24],"general":[25],"population.":[26],"Genes":[27],"which":[29],"mutation":[30,197,222],"causes":[31],"anterior":[32],"segment":[33],"angle":[34],"\\nanomalies,":[35],"including":[36,62],"LMX1B":[37,238,310,325],"and":[38,51,64,78,80,142,188,217,285],"FOXC1":[39],"are":[40,52],"high":[44,115],"incidence":[45],"of":[46,90,93,117,119,126,135,147,160,168,171,194,236,272,282,295],"\\nglaucoma":[47,148],"to":[48,69,111,145,261,315,328],"about":[49],"33-75%":[50],"candidates":[54],"for":[55,113,214],"susceptibility.":[57],"In":[58,130],"\\naddition,":[59],"growth":[60],"factors":[61],"TGF\u03b22":[63,141,216],"BMP4":[65,143],"act":[66],"concert":[68],"maintain":[70],"\\nbalance":[72],"between":[73],"extracellular":[74],"matrix":[75],"(ECM)":[76],"deposition":[77],"degradation":[79],"may":[81,312],"play":[82],"\\nrole":[84],"pathogenesis":[87],"through":[88],"misregulation":[89],"ECM":[91],"synthesis":[92],"the":[94,133,138,166,257,262,296,319],"\\ntrabecular":[95],"meshwork":[96],"(TM).":[97],"Furthermore,":[98],"OPTN":[99,195,220],"E50K":[100,196,221],"mutation,":[101],"known":[103],"locus":[105],"\\nfor":[106],"POAG,":[107],"has":[108],"shown":[110],"account":[112],"percentage":[116],"13.5%":[118],"familial":[120],"\\nnormal-tension":[121],"(NTG)":[123],"individuals":[125,203,259],"white":[127,201],"British":[128,162,202,321],"origin.":[129],"this":[131,227],"study,":[132],"\\ncontribution":[134],"variation":[136],"at":[137],"LMX1B,":[139],"FOXC1,":[140,215],"loci":[144],"risk":[146,271],"was":[149,206],"investigated":[150],"case-control":[153],"association":[155],"study":[156,230],"cohort":[159,281],"\\nwhite":[161,320],"descent":[163],"recruited":[164,288],"North-East":[167],"England":[169],"comprised":[170],"272":[172],"patients":[173,179,183],"\\nwith":[174],"high-tension":[175],"(HTG),":[177],"37":[178],"NTG,":[181],"58":[182],"ocular":[185],"\\nhypertension":[186],"(OHT),":[187],"276":[189],"normal":[190],"controls.":[191],"The":[192,219,229],"role":[193],"\\nthese":[199],"unrelated":[200],"also":[207,224],"examined.":[208],"No":[209],"significant":[210,233],"\\nassociations":[211],"were":[212],"identified":[213,231],"BMP4.":[218],"\\nwas":[223],"absent":[225],"cohort.":[228],"under":[234],"representation":[235],"\\ntwo":[237],"haplotypes":[239,311],"[ATG;":[240],"P":[241,245,249,253],"=":[242,246,250,254,300],"5.0E-4":[243],"(permutation":[244,252],"0.01),":[247],"GCAGAC;":[248],"\\n5.0E-4":[251],"0.0150)]":[255],"among":[256],"compared":[260],"control":[263],"\\npopulation,":[264],"consistent":[265],"0.3":[268],"fold":[269],"decreased":[270],"developing":[273],"POAG.":[274],"A":[275],"replication":[276],"\\nstudy":[277],"involving":[278],"second":[280],"222":[283],"NTGs":[284],"108":[286],"HTGs":[287],"London":[290],"\\nshowed":[291],"similar":[293],"distribution":[294],"ATG":[297],"haplotype":[298],"(P":[299],"0.0047)":[301],"but":[302],"did":[303],"not":[304],"withstand":[305],"\\npermutation":[306],"testing.":[307],"\\nIn":[308],"conclusion,":[309],"influence":[313],"susceptibility":[314],"develop":[316],"population,":[322],"suggesting":[323],"altered":[324],"function":[326],"predisposes":[327],"\\nglaucomatous":[329],"damage.":[330]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
