{"id":"https://openalex.org/W617829016","doi":null,"title":"Continuous versus intermittent therapy for moderate-to-severe psoriasis.","display_name":"Continuous versus intermittent therapy for moderate-to-severe psoriasis.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W617829016","mag":"617829016","pmid":"https://pubmed.ncbi.nlm.nih.gov/24129141"},"language":"en","primary_location":{"id":"pmid:24129141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013850771","display_name":"Marigdalia K. Ramirez\u2010Fort","orcid":"https://orcid.org/0000-0002-1918-7114","observed_orcids":["https://orcid.org/0000-0002-1918-7114"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marigdalia K Ramirez-Fort","raw_affiliation_strings":["Department of Dermatology, Tufts Medical Center, Boston, MA, USA. mramirezfort@tuftsmedicalcenter.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tufts Medical Center, Boston, MA, USA. mramirezfort@tuftsmedicalcenter.org","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030191956","display_name":"Adriane A. Levin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriane A Levin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066391147","display_name":"Shiu-chung Au","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiu-Chung Au","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049859852","display_name":"Alice Bendix Gottlieb","orcid":"https://orcid.org/0000-0002-2927-8618","observed_orcids":["https://orcid.org/0000-0002-2927-8618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice B Gottlieb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5864,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89198713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"4 Suppl 78","first_page":"S63","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intermittent-therapy","display_name":"intermittent therapy","score":0.7749999761581421},{"id":"https://openalex.org/keywords/continuous-treatment","display_name":"continuous treatment","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biologic-agents","display_name":"biologic agents","score":0.8190000057220459},{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":0.7960000038146973},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":1.0},{"id":"https://openalex.org/keywords/ustekinumab","display_name":"ustekinumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.6169999837875366},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":1.0},{"id":"https://openalex.org/keywords/conventional-systemic-therapy","display_name":"conventional systemic therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cumulative-toxicity","display_name":"cumulative toxicity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9749283790588379},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.8716027736663818},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.849737823009491},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.8017045259475708},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.7801337242126465},{"id":"https://openalex.org/C2778975655","wikidata":"https://www.wikidata.org/wiki/Q420305","display_name":"Ustekinumab","level":4,"score":0.6792117357254028},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5992330312728882},{"id":"https://openalex.org/C2911221801","wikidata":"https://www.wikidata.org/wiki/Q2742406","display_name":"Biologic Agents","level":3,"score":0.43449902534484863},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3583201766014099},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32957082986831665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3045017719268799},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.21601766347885132}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24129141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:617829016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W28053426","https://openalex.org/W28532211","https://openalex.org/W145099586","https://openalex.org/W1504143015","https://openalex.org/W1512117962","https://openalex.org/W1549908835","https://openalex.org/W1550569362","https://openalex.org/W1581115144","https://openalex.org/W1592628203","https://openalex.org/W1809686743","https://openalex.org/W1879089629","https://openalex.org/W1949832432","https://openalex.org/W1968731581","https://openalex.org/W1969262745","https://openalex.org/W1971186170","https://openalex.org/W1975199072","https://openalex.org/W1975463338","https://openalex.org/W1978738930","https://openalex.org/W1978909994","https://openalex.org/W1980120937","https://openalex.org/W1985118454","https://openalex.org/W1987367856","https://openalex.org/W1991234845","https://openalex.org/W1994790375","https://openalex.org/W1996773947","https://openalex.org/W1997189639","https://openalex.org/W1998103144","https://openalex.org/W1999140409","https://openalex.org/W2001932609","https://openalex.org/W2002991484","https://openalex.org/W2003533394","https://openalex.org/W2004012668","https://openalex.org/W2004348255","https://openalex.org/W2008716526","https://openalex.org/W2009653423","https://openalex.org/W2011224074","https://openalex.org/W2014579038","https://openalex.org/W2018404326","https://openalex.org/W2019217317","https://openalex.org/W2019714802","https://openalex.org/W2023943150","https://openalex.org/W2024143742","https://openalex.org/W2026261818","https://openalex.org/W2032411927","https://openalex.org/W2033978760","https://openalex.org/W2034530425","https://openalex.org/W2034702552","https://openalex.org/W2039691940","https://openalex.org/W2042082816","https://openalex.org/W2043287930","https://openalex.org/W2044221229","https://openalex.org/W2046897000","https://openalex.org/W2049798709","https://openalex.org/W2052364506","https://openalex.org/W2057221812","https://openalex.org/W2060359207","https://openalex.org/W2062110203","https://openalex.org/W2062748830","https://openalex.org/W2066723587","https://openalex.org/W2068729011","https://openalex.org/W2070576100","https://openalex.org/W2074901676","https://openalex.org/W2075066605","https://openalex.org/W2084464987","https://openalex.org/W2085417241","https://openalex.org/W2088249369","https://openalex.org/W2091732273","https://openalex.org/W2099706116","https://openalex.org/W2104645761","https://openalex.org/W2109745257","https://openalex.org/W2110039895","https://openalex.org/W2110846194","https://openalex.org/W2113029705","https://openalex.org/W2121588356","https://openalex.org/W2122555949","https://openalex.org/W2125190716","https://openalex.org/W2131493069","https://openalex.org/W2131592234","https://openalex.org/W2131863130","https://openalex.org/W2136032632","https://openalex.org/W2138234774","https://openalex.org/W2148876210","https://openalex.org/W2150703501","https://openalex.org/W2158181654","https://openalex.org/W2163089977","https://openalex.org/W2163232748","https://openalex.org/W2163456436","https://openalex.org/W2324161037","https://openalex.org/W2336000290","https://openalex.org/W2401279855","https://openalex.org/W2409431129","https://openalex.org/W2414236041","https://openalex.org/W2417878737","https://openalex.org/W2423963422","https://openalex.org/W2440702469","https://openalex.org/W2467745633","https://openalex.org/W3151671133"],"related_works":["https://openalex.org/W2799998466","https://openalex.org/W2124549038","https://openalex.org/W3041170273","https://openalex.org/W1966384071","https://openalex.org/W1997836945","https://openalex.org/W2404449696","https://openalex.org/W3090168531","https://openalex.org/W2108375718","https://openalex.org/W3205066254","https://openalex.org/W4255547384"],"abstract_inverted_index":{"Psoriasis":[0,129],"is":[1,108,112,137],"a":[2,138],"chronic":[3,12,139],"immune-mediated":[4],"inflammatory":[5,13,148],"disease":[6,140],"of":[7,30,37,59,121,147],"unknown":[8],"etiology.":[9],"Unlike":[10],"other":[11],"diseases":[14],"receiving":[15],"continuous":[16,44,57,78,142],"treatment,":[17],"psoriasis":[18],"has":[19],"traditionally":[20],"been":[21],"treated":[22],"intermittently":[23],"secondary":[24],"to":[25,96,126,151],"concern":[26],"for":[27,43,46,54,63,144],"cumulative":[28,127],"toxicity":[29],"conventional":[31,69,105],"systemic":[32,70,106],"therapies.":[33],"However,":[34],"the":[35,52,116],"development":[36],"targeted":[38],"anti-inflammatory":[39],"biologic":[40,73,81,93],"agents":[41,94],"allowed":[42],"therapy":[45,91,107],"most":[47],"patients.":[48],"Herein,":[49],"we":[50],"review":[51],"literature":[53],"intermittent":[55,119],"versus":[56],"use":[58,120],"widely":[60],"available":[61],"therapies":[62,71],"moderate-to-severe":[64],"psoriasis:":[65],"phototherapy,":[66],"topical":[67],"corticosteroids,":[68],"and":[72,88,99,123,133,150],"agents.":[74],"These":[75],"data":[76,117],"support":[77,118],"treatment":[79,143],"in":[80],"therapy,":[82],"such":[83],"as":[84],"etanercept,":[85],"adalimumab,":[86],"infliximab,":[87],"ustekinumab.":[89],"Intermittent":[90],"with":[92],"leads":[95],"decreased":[97],"efficacy":[98],"sometimes":[100],"increased":[101],"side":[102],"effects.":[103],"When":[104],"used":[109],"continuously,":[110],"it":[111,136],"more":[113],"efficacious;":[114],"however":[115],"methotrexate":[122],"cyclosporine":[124],"due":[125],"toxicities.":[128],"severity":[130],"may":[131],"wax":[132],"wane,":[134],"but":[135],"requiring":[141],"optimal":[145],"control":[146],"activity":[149],"minimise":[152],"cutaneous":[153],"involvement.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
