{"id":"https://openalex.org/W617747635","doi":null,"title":"Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis","display_name":"Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W617747635","mag":"617747635"},"language":"en","primary_location":{"id":"mag:617747635","doi":null,"is_oa":false,"landing_page_url":"https://www.medicaljournals.se/forum/articles/14/2/47.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065349954","display_name":"Elizabeth Pavez Lori\u00e8","orcid":"https://orcid.org/0000-0002-2219-2790","observed_orcids":["https://orcid.org/0000-0002-2219-2790"]},"institutions":[{"id":"https://openalex.org/I170053871","display_name":"TeliaSonera (Sweden)","ror":"https://ror.org/05tqy0n53","country_code":"SE","type":"company","lineage":["https://openalex.org/I170053871"]},{"id":"https://openalex.org/I4210163533","display_name":"TeliaSonera (Finland)","ror":"https://ror.org/05f6pr134","country_code":"FI","type":"company","lineage":["https://openalex.org/I170053871","https://openalex.org/I4210163533"]}],"countries":["FI","SE"],"is_corresponding":true,"raw_author_name":"Elizabeth Pavez Lori\u00e8","raw_affiliation_strings":["Telia Company"],"raw_orcid":"https://orcid.org/0000-0002-2219-2790","affiliations":[{"raw_affiliation_string":"Telia Company","institution_ids":["https://openalex.org/I170053871","https://openalex.org/I4210163533"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065349954"],"corresponding_institution_ids":["https://openalex.org/I170053871","https://openalex.org/I4210163533"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid-metabolism","display_name":"retinoic acid metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/liarozole","display_name":"liarozole","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cyp26a1","display_name":"CYP26A1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/retinol-esterification","display_name":"retinol esterification","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lecithin-retinol-acyltransferase","display_name":"LRAT","score":0.9169999957084656},{"id":"https://openalex.org/keywords/retinol-dehydrogenase","display_name":"retinol dehydrogenase","score":0.8080000281333923},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/retinoic-acid-signaling","display_name":"retinoic acid signaling","score":0.703000009059906},{"id":"https://openalex.org/keywords/crabp2","display_name":"CRABP2","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hb-egf","display_name":"HB-EGF","score":0.9279999732971191},{"id":"https://openalex.org/keywords/keratin-expression","display_name":"keratin expression","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8636983633041382},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.8369473218917847},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5088322758674622},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4867725372314453},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4498615562915802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4365861415863037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4070836305618286},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.403744101524353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37346088886260986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36439114809036255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36143958568573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15353924036026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08109140396118164}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:617747635","doi":null,"is_oa":false,"landing_page_url":"https://www.medicaljournals.se/forum/articles/14/2/47.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":133,"referenced_works":["https://openalex.org/W79321944","https://openalex.org/W566534948","https://openalex.org/W622560015","https://openalex.org/W1026624669","https://openalex.org/W1508756121","https://openalex.org/W1542669094","https://openalex.org/W1556248806","https://openalex.org/W1577577364","https://openalex.org/W1580666592","https://openalex.org/W1583754236","https://openalex.org/W1752144300","https://openalex.org/W1756695767","https://openalex.org/W1899383916","https://openalex.org/W1914749837","https://openalex.org/W1919133853","https://openalex.org/W1927684145","https://openalex.org/W1927981786","https://openalex.org/W1932614435","https://openalex.org/W1934228009","https://openalex.org/W1945471866","https://openalex.org/W1951243148","https://openalex.org/W1964526720","https://openalex.org/W1965525014","https://openalex.org/W1965525538","https://openalex.org/W1968188698","https://openalex.org/W1971624992","https://openalex.org/W1974440231","https://openalex.org/W1976487421","https://openalex.org/W1978596704","https://openalex.org/W1979284740","https://openalex.org/W1981139157","https://openalex.org/W1981717373","https://openalex.org/W1984687860","https://openalex.org/W1987128150","https://openalex.org/W1987632739","https://openalex.org/W1987958985","https://openalex.org/W1988381039","https://openalex.org/W1992814353","https://openalex.org/W1992895406","https://openalex.org/W1999132350","https://openalex.org/W2001068122","https://openalex.org/W2001405592","https://openalex.org/W2002755152","https://openalex.org/W2003067274","https://openalex.org/W2003366894","https://openalex.org/W2003928686","https://openalex.org/W2004311699","https://openalex.org/W2005630031","https://openalex.org/W2006998778","https://openalex.org/W2011423923","https://openalex.org/W2014315882","https://openalex.org/W2015363515","https://openalex.org/W2015585109","https://openalex.org/W2016392505","https://openalex.org/W2016910688","https://openalex.org/W2017578370","https://openalex.org/W2019736888","https://openalex.org/W2022633251","https://openalex.org/W2028902508","https://openalex.org/W2031924160","https://openalex.org/W2035075164","https://openalex.org/W2036634303","https://openalex.org/W2038766225","https://openalex.org/W2041432079","https://openalex.org/W2041465863","https://openalex.org/W2044832199","https://openalex.org/W2049038526","https://openalex.org/W2049567155","https://openalex.org/W2049681230","https://openalex.org/W2049844563","https://openalex.org/W2049901124","https://openalex.org/W2051074585","https://openalex.org/W2053180010","https://openalex.org/W2054327488","https://openalex.org/W2058035002","https://openalex.org/W2063155796","https://openalex.org/W2064418777","https://openalex.org/W2066851739","https://openalex.org/W2067256177","https://openalex.org/W2068227633","https://openalex.org/W2068606328","https://openalex.org/W2069528909","https://openalex.org/W2069710660","https://openalex.org/W2071573565","https://openalex.org/W2071853996","https://openalex.org/W2074038170","https://openalex.org/W2074163835","https://openalex.org/W2076887183","https://openalex.org/W2082304625","https://openalex.org/W2083925624","https://openalex.org/W2085440811","https://openalex.org/W2085511966","https://openalex.org/W2087706552","https://openalex.org/W2088438981","https://openalex.org/W2088940256","https://openalex.org/W2090014155","https://openalex.org/W2091609827","https://openalex.org/W2093805751","https://openalex.org/W2096816528","https://openalex.org/W2103167833","https://openalex.org/W2106170890","https://openalex.org/W2107782429","https://openalex.org/W2108060879","https://openalex.org/W2114145258","https://openalex.org/W2118632977","https://openalex.org/W2120478364","https://openalex.org/W2122256734","https://openalex.org/W2123678483","https://openalex.org/W2129121975","https://openalex.org/W2133701034","https://openalex.org/W2136169651","https://openalex.org/W2138096813","https://openalex.org/W2148121263","https://openalex.org/W2150783991","https://openalex.org/W2151931731","https://openalex.org/W2158293853","https://openalex.org/W2159339348","https://openalex.org/W2160575541","https://openalex.org/W2162928813","https://openalex.org/W2163657392","https://openalex.org/W2168759136","https://openalex.org/W2170503291","https://openalex.org/W2187999838","https://openalex.org/W2278234077","https://openalex.org/W2298932343","https://openalex.org/W2342186378","https://openalex.org/W2342492425","https://openalex.org/W2398292728","https://openalex.org/W2412220898","https://openalex.org/W2412423361","https://openalex.org/W2417613675","https://openalex.org/W2488205590","https://openalex.org/W2488644792"],"related_works":["https://openalex.org/W2089123979","https://openalex.org/W1967728939","https://openalex.org/W627675333","https://openalex.org/W2056006467","https://openalex.org/W2298932343","https://openalex.org/W2891198120","https://openalex.org/W2096816528","https://openalex.org/W7099078672","https://openalex.org/W2156681779","https://openalex.org/W2036733405"],"abstract_inverted_index":{"The":[0,117,183],"biosynthesis":[1,98],"of":[2,38,46,68,90,99,108,120,150,158,163,179],"retinoic":[3],"acid":[4],"(RA)":[5],"from":[6,101],"retinol":[7,91,102],"is":[8,190],"controlled":[9],"by":[10],"several":[11],"enzymes,":[12],"e.g.":[13],"dehydrogenases":[14],"(RalDH2,":[15],"RoDH-4)":[16],"and":[17,48,53,58,81,126,197,207],"retinol-esterifying":[18],"enzyme":[19],"(LRAT),":[20],"whereas":[21,75],"its":[22],"degradation":[23],"mainly":[24],"involves":[25],"CYP26":[26,50,69,139,205],"enzymes.":[27],"In":[28,93,136],"keratinocytes,":[29],"RA":[30,47,64,100,134,196,200],"activates":[31],"the":[32,36,44,49,66,106,138,180],"nuclear":[33],"retinoid-receptors":[34],"inducing":[35],"transcription":[37],"many":[39],"genes.":[40],"Here,":[41],"we":[42],"examined":[43],"effects":[45],"inhibitors,":[51],"liarozole":[52],"talarozole,":[54],"on":[55],"retinoid":[56,213],"metabolism":[57],"RA-regulated":[59,121],"genes":[60,122],"in":[61,112,215],"organotypic":[62,216],"epidermis.":[63,217],"induced":[65],"expression":[67,107,119,189],"enzymes":[70],"already":[71],"after":[72,103,133,168,171],"8":[73],"h,":[74,85],"LRAT":[76],"exhibited":[77],"a":[78,87,96,147,175],"later":[79],"response":[80,113],"peaked":[82],"at":[83],"48":[84],"indicating":[86,174],"feedback":[88],"induction":[89,149],"esterification.":[92],"line":[94],"with":[95,155],"reduced":[97,110],"exogenous":[104,115,159,164,195],"RA,":[105],"RDH16":[109],"80%":[111],"to":[114,193,204],"RA.":[116,160],"mRNA":[118],"(KRT2,":[123],"KRT4,":[124],"CRABPII":[125],"HBEGF)":[127],"was":[128,166],"altered":[129],"within":[130],"24":[131],"h":[132],"exposure.":[135],"contrast,":[137],"inhibitors":[140],"caused":[141],"only":[142,152],"minor":[143],"effects,":[144],"except":[145],"for":[146,212],"clear-cut":[148],"CYP26A1":[151,188],"when":[153],"combined":[154],"minute":[156],"amounts":[157],"Cellular":[161],"accumulation":[162],"[H-3]RA":[165],"higher":[167],"talarozole":[169],"than":[170],"liarozole,":[172],"probably":[173],"greater":[176],"CYP26-inhibitory":[177],"potency":[178],"former":[181],"drug.":[182],"present":[184],"study":[185],"shows":[186],"that":[187],"extremely":[191],"sensitive":[192],"both":[194],"increased":[198],"endogenous":[199],"levels,":[201],"i.e.":[202],"due":[203],"inhibition,":[206],"thus":[208],"an":[209],"excellent":[210],"biomarker":[211],"signalling":[214]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}