{"id":"https://openalex.org/W61735942","doi":null,"title":"Clinical evidence that acitretin is esterified to etretinate when administered with ethanol","display_name":"Clinical evidence that acitretin is esterified to etretinate when administered with ethanol","publication_year":1992,"publication_date":"1992-02-26","ids":{"openalex":"https://openalex.org/W61735942","mag":"61735942"},"language":"en","primary_location":{"id":"mag:61735942","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7049951","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103561200","display_name":"Bradford K. Jensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradford K. Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071919820","display_name":"C.L. Chaws","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.L. Chaws","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014121767","display_name":"Christine A. Huselton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Huselton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.00388673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.08389999717473984,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acitretin","display_name":"acitretin","score":1.0},{"id":"https://openalex.org/keywords/etretinate","display_name":"etretinate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.7540000081062317},{"id":"https://openalex.org/keywords/ethyl-esterification","display_name":"ethyl esterification","score":0.9520000219345093},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7829999923706055},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.8650000095367432},{"id":"https://openalex.org/keywords/food-drug-interactions","display_name":"food-drug interactions","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2776705134","wikidata":"https://www.wikidata.org/wiki/Q554297","display_name":"Etretinate","level":3,"score":0.895417332649231},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.8141111135482788},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6949578523635864},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6653396487236023},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6387912631034851},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6007646322250366},{"id":"https://openalex.org/C2778496887","wikidata":"https://www.wikidata.org/wiki/Q341500","display_name":"Acitretin","level":3,"score":0.5628458261489868},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.518435001373291},{"id":"https://openalex.org/C3941253","wikidata":"https://www.wikidata.org/wiki/Q47270","display_name":"Half-life","level":3,"score":0.4708927273750305},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.4384806454181671},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.41608792543411255},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.41425377130508423},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4122034013271332},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.41147780418395996},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3176366686820984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3134702742099762},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2674941420555115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2271619737148285},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11679095029830933},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0801534652709961},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:61735942","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/7049951","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024382342","https://openalex.org/W2076922311","https://openalex.org/W2122649118","https://openalex.org/W2062518961","https://openalex.org/W1963524090","https://openalex.org/W2068071074","https://openalex.org/W2330231913","https://openalex.org/W1988383065","https://openalex.org/W4287009094","https://openalex.org/W7036009804"],"abstract_inverted_index":{"A":[0,27,60,68,91,119,126,131,137],"previously":[1],"unexpected":[2],"metabolic":[3],"pathway,":[4],"ethyl":[5,123],"esterification":[6,124],"of":[7,26,64,125],"acitretin":[8],"(A)":[9,149],"to":[10,56,127],"etretinate":[11],"(E),":[12,153],"was":[13,45,100],"studied":[14],"in":[15,38,87,144],"10":[16],"healthy":[17],"subjects.":[18],"Subjects":[19],"received":[20],"single":[21],"100":[22],"mg":[23],"oral":[24],"doses":[25],"with":[28,34,103,118,134],"a":[29,39,48,72,154],"standard":[30],"meal":[31],"alone":[32],"or":[33],"concomitant":[35],"ethanol":[36,77,93,109],"ingestion":[37],"2-way":[40],"randomized":[41],"crossover":[42],"design.":[43],"Ethanol":[44],"ingested":[46],"over":[47],"3-hour":[49],"period.":[50],"Blood":[51,76],"samples":[52],"were":[53,69,79,85,113],"collected":[54],"up":[55],"48":[57],"hours":[58],"after":[59],"administration.":[61],"Plasma":[62],"concentrations":[63,78,84,105,112],"E,A":[65],"and":[66,92,138],"13-cis":[67],"determined":[70,81],"by":[71],"specific":[73],"HPLC":[74],"assay.":[75],"also":[80],"E":[82,98,104,111,128,139],"plasma":[83],"observed":[86],"all":[88],"subjects":[89],"following":[90],"intake.":[94],"The":[95],"mean":[96],"peak":[97],"concentration":[99],"59":[101],"ng/ml,":[102],"generally":[106],"dependent":[107],"on":[108],"concentrations.":[110],"not":[114],"detectable":[115],"during":[116],"treatment":[117],"alone.":[120],"In":[121],"conclusion,":[122],"occurs":[129],"when":[130],"is":[132],"given":[133],"ethanol.":[135],"Both":[136],"are":[140],"teratogenic,":[141],"but":[142],"differ":[143],"elimination":[145],"half-life;":[146],"2":[147],"days":[148,152],"vs":[150],"120":[151],"profound":[155],"pharmacokinetic":[156],"difference.":[157]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
