{"id":"https://openalex.org/W617294916","doi":null,"title":"Elite control of HIV Infection: implications for vaccines and treatment.","display_name":"Elite control of HIV Infection: implications for vaccines and treatment.","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W617294916","mag":"617294916","pmid":"https://pubmed.ncbi.nlm.nih.gov/17720999"},"language":"en","primary_location":{"id":"pmid:17720999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17720999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in HIV medicine : a publication of the International AIDS Society, USA","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce D Walker","raw_affiliation_strings":["Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016518899"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":4.6186,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.95876289,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"15","issue":"4","first_page":"134","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elite-controllers","display_name":"elite controllers","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hiv-vaccine-development","display_name":"HIV vaccine development","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.5920000076293945},{"id":"https://openalex.org/keywords/whole-genome-analysis","display_name":"whole-genome analysis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/immune-response-to-hiv","display_name":"immune response to HIV","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5580431222915649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49067389965057373},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4537903666496277},{"id":"https://openalex.org/C2775987171","wikidata":"https://www.wikidata.org/wiki/Q192797","display_name":"Elite","level":3,"score":0.4351571202278137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38087227940559387},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35396450757980347},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.09208416938781738},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17720999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17720999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Topics in HIV medicine : a publication of the International AIDS Society, USA","raw_type":"Journal Article"},{"id":"mag:617294916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17720999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024475842","https://openalex.org/W2138575726","https://openalex.org/W2784914116","https://openalex.org/W2046596313","https://openalex.org/W7097147956","https://openalex.org/W2164571059","https://openalex.org/W3143111051","https://openalex.org/W3093428310","https://openalex.org/W4295069435","https://openalex.org/W3005294581"],"abstract_inverted_index":{"Spontaneous":[0],"and":[1,34,60,164,182,196],"sustained":[2],"(\"elite,\"":[3],"or":[4],"aviremic)":[5],"control":[6,109,151,157,192],"of":[7,22,85,95,125,130,180,193],"HIV":[8,12,50,75,152,194],"infection":[9,195],"(ie,":[10],"maintaining":[11],"RNA":[13],"to":[14,25,74,90,102,134,150,155],"less":[15],"than":[16],"50":[17],"copies/mL":[18],"in":[19,27,30,121,145,171,177,217,220],"the":[20,49,71,92,98,104,141,156,169,178],"absence":[21],"therapy)":[23],"appears":[24],"occur":[26],"approximately":[28],"1":[29],"300":[31,54],"HIV-infected":[32,40],"persons,":[33],"represents":[35],"a":[36,43,86,122,188,229],"distinct":[37],"phenotype":[38],"among":[39],"individuals.":[41],"Through":[42],"recently":[44],"established":[45],"international":[46],"collaboration":[47],"called":[48],"Controller":[51],"Consortium,":[52],"over":[53],"elite":[55,77,126],"controllers":[56,78],"have":[57,160],"been":[58],"identified":[59],"blood":[61],"samples":[62],"collected.":[63],"These":[64,173],"ongoing":[65],"studies":[66,120,132],"will":[67,81,138],"not":[68],"only":[69],"examine":[70],"immune":[72],"responses":[73],"that":[76,137],"generate,":[79],"but":[80],"also":[82],"make":[83],"use":[84],"newly":[87],"available":[88,227],"approach":[89],"defining":[91],"genetic":[93,105],"basis":[94,106],"disease.":[96],"Specifically,":[97],"consortium":[99],"is":[100,133,226],"attempting":[101],"determine":[103],"underlying":[107],"spontaneous":[108,191],"by":[110,167,203],"performing":[111],"whole":[112],"genome":[113],"analysis":[114],"scans":[115],"together":[116],"with":[117,161],"functional":[118],"immunology":[119],"large":[123],"population":[124],"controllers.":[127],"The":[128,223],"goal":[129],"these":[131],"provide":[135],"insights":[136],"help":[139],"define":[140],"crucial":[142],"parameters":[143],"present":[144],"persons":[146],"who":[147],"are":[148],"able":[149],"infection,":[153],"similar":[154],"most":[158],"people":[159],"Epstein-Barr":[162],"virus":[163,170],"varicella,":[165],"namely":[166],"holding":[168],"check.":[172],"findings":[174],"could":[175],"assist":[176],"development":[179,201],"vaccines":[181],"new":[183],"therapies.":[184],"This":[185],"article":[186],"summarizes":[187],"presentation":[189,225],"on":[190],"its":[197],"implications":[198],"for":[199],"vaccine":[200],"made":[202],"Bruce":[204],"D.":[205],"Walker,":[206],"MD,":[207],"at":[208,231],"an":[209],"International":[210],"AIDS":[211],"Society-USA":[212],"Continuing":[213],"Medical":[214],"Education":[215],"course":[216],"New":[218],"York":[219],"March":[221],"2007.":[222],"original":[224],"as":[228],"Webcast":[230],"www.iasusa.org.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}