{"id":"https://openalex.org/W61718445","doi":null,"title":"Anticancer effects of various Iranian native medicinal plants on human tumor cell lines.","display_name":"Anticancer effects of various Iranian native medicinal plants on human tumor cell lines.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W61718445","mag":"61718445","pmid":"https://pubmed.ncbi.nlm.nih.gov/17013538"},"language":"en","primary_location":{"id":"pmid:17013538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17013538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001475392","display_name":"Zahra Amirghofran","orcid":"https://orcid.org/0000-0002-1027-7906","observed_orcids":["https://orcid.org/0000-0002-1027-7906"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Z Amirghofran","raw_affiliation_strings":["Immunology Department and Autoimmune Disease Research Center, Shiraz University of Medical Science, 71345-1798 Shiraz, Iran. amirghz@sums.ac.ir"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Department and Autoimmune Disease Research Center, Shiraz University of Medical Science, 71345-1798 Shiraz, Iran. amirghz@sums.ac.ir","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026197103","display_name":"Mahmoud Bahmani","orcid":"https://orcid.org/0000-0002-9643-9274","observed_orcids":["https://orcid.org/0000-0002-9643-9274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bahmani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086199857","display_name":"Abbas Azadmehr","orcid":"https://orcid.org/0000-0002-7698-9885","observed_orcids":["https://orcid.org/0000-0002-7698-9885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Azadmehr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111620475","display_name":"Katayoon Javidnia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Javidnia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7049,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.84297101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"5","first_page":"428","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.3564000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.8029999732971191},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ferula-angulata","display_name":"Ferula angulata","score":0.9710000157356262},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.6449999809265137},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.875},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.8337604999542236},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.7765661478042603},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7050983905792236},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.584930956363678},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5657437443733215},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5543760061264038},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.518476665019989},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5127283334732056},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.482978492975235},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48179858922958374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47082310914993286},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.4617578685283661},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44284096360206604},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.42334628105163574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41398608684539795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3482270836830139},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3430235981941223},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.29996800422668457},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2733185887336731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21693482995033264},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18848657608032227},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.16924023628234863},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11399972438812256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09908813238143921},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007492","descriptor_name":"Iran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019661","descriptor_name":"Apiaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D031366","descriptor_name":"Stachys","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D032061","descriptor_name":"Galium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17013538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17013538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Comparative Study"},{"id":"mag:61718445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17013538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W82180628","https://openalex.org/W1764225789","https://openalex.org/W1974542892","https://openalex.org/W1978269554","https://openalex.org/W1984866351","https://openalex.org/W1987117443","https://openalex.org/W2006384362","https://openalex.org/W2006929002","https://openalex.org/W2023508013","https://openalex.org/W2024489495","https://openalex.org/W2026045511","https://openalex.org/W2056546826","https://openalex.org/W2069326436","https://openalex.org/W2100162670","https://openalex.org/W2102582532","https://openalex.org/W2105348435","https://openalex.org/W2157786523","https://openalex.org/W2166664278","https://openalex.org/W2726969204"],"related_works":["https://openalex.org/W7096650515","https://openalex.org/W2994504552","https://openalex.org/W2096399425","https://openalex.org/W7096839045","https://openalex.org/W3103133417","https://openalex.org/W2530130364","https://openalex.org/W2134555755","https://openalex.org/W1998400626","https://openalex.org/W1807753928","https://openalex.org/W4312234103"],"abstract_inverted_index":{"In":[0,185,226,241,254],"this":[1,264],"study":[2,265],"the":[3,39,80,86,90,96,98,204,236,260,272,280,289],"antineoplastic":[4],"activity":[5,100,269],"of":[6,9,51,53,79,92,126,147,165,208,218,283,291],"methanolic":[7],"extracts":[8,40,81,198,261],"six":[10],"medicinal":[11],"plants":[12],"that":[13,76,259,277],"are":[14],"native":[15],"to":[16,38,88,153,155,288],"Iran,":[17],"including":[18],"Galium":[19],"mite,":[20],"Ferulago":[21],"angulata,":[22],"Stachys":[23],"obtusicrena,":[24],"Cirsium":[25],"bracteosum":[26,113],"and":[27,41,61,111,131,158,195,210,238,276],"Echinophora":[28],"cinerea":[29,110,160],"was":[30,48,69,106,161,174,224],"investigated.":[31],"Different":[32],"tumor":[33,93,268],"cell":[34,67,104,150,205,274,284],"lines":[35,68,275],"were":[36],"exposed":[37],"cytotoxic":[42],"analysis":[43,64,217,244],"using":[44],"MTT":[45],"colorimetric":[46],"assay":[47],"performed.":[49],"Quantification":[50],"percentage":[52],"cells":[54,137],"undergoing":[55],"apoptotic":[56],"changes":[57],"by":[58,121,177],"flow":[59,186],"cytometry,":[60],"DNA":[62,215,242],"fragmentation":[63,216,243],"on":[65,203],"sensitive":[66],"then":[70],"carried":[71],"out.":[72],"Results":[73],"obtained":[74],"indicated":[75,258],"almost":[77],"all":[78],"more":[82,181,231],"or":[83],"less":[84,116,140],"had":[85],"capacity":[87],"decrease":[89],"proliferation":[91,138],"cells.":[94,212,240,253],"Among":[95],"plants,":[97],"highest":[99],"against":[101,271],"K562":[102,209,237],"leukemia":[103,273],"line":[105],"found":[107,162],"for":[108],"E.":[109,132,159,191],"C.":[112,189],"with":[114,124],"IC50":[115,125],"than":[117,141,182,232],"20":[118],"microg/ml":[119],"followed":[120],"G.":[122,228,245,292],"mite":[123,229,246],"39.8":[127],"microg/ml.":[128,168],"F.":[129,156,193],"angulata":[130,157,194],"cinerea,":[133,192],"mostly":[134,175],"inhibited":[135],"Jurkat":[136,211,239],"(IC50":[139,180],"8":[142],"microg/ml).":[143,184],"Fifty":[144],"percent":[145],"inhibition":[146],"Fen":[148],"bladder":[149],"carcinoma":[151,172],"due":[152,287],"exposure":[154],"at":[163],"concentrations":[164],"nearly":[166],"180":[167],"A549,":[169],"a":[170],"lung":[171],"cell,":[173],"affected":[176],"S.":[178,196],"obtusicrena":[179,197],"200":[183],"cytometry":[187],"analysis,":[188],"bracteosum,":[190],"demonstrated":[199],"no":[200,221],"remarkable":[201],"effects":[202],"cycle":[206],"profile":[207],"Moreover,":[213],"in":[214,235,251,263],"treated":[219],"cells,":[220],"ladder":[222,249],"formation":[223,250],"detected.":[225],"contrary,":[227],"caused":[230],"40%":[233],"apoptosis":[234,278],"extract":[247,290],"produced":[248],"these":[252,256],"conclusion,":[255],"results":[257],"used":[262],"have":[266],"anti":[267],"particularly":[270],"is":[279],"possible":[281],"cause":[282],"death":[285],"observed":[286],"mite.":[293]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}