{"id":"https://openalex.org/W6156749","doi":"https://doi.org/10.1016/j.jaci.2003.08.028","title":"Interactions of eosinophil granule proteins with skin","display_name":"Interactions of eosinophil granule proteins with skin","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W6156749","doi":"https://doi.org/10.1016/j.jaci.2003.08.028","mag":"6156749","pmid":"https://pubmed.ncbi.nlm.nih.gov/14610493"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2003.08.028","doi":"https://doi.org/10.1016/j.jaci.2003.08.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2003.08.028","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103464712","display_name":"Mark D.P. Davis","orcid":"https://orcid.org/0000-0003-0936-580X","observed_orcids":["https://orcid.org/0000-0003-0936-580X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D.P Davis","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086876","display_name":"Douglas A. Plager","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A Plager","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018741229","display_name":"Terry J. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry J George","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036208771","display_name":"Ellen A. Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen A Weiss","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089757484","display_name":"Gerald J. Gleich","orcid":"https://orcid.org/0000-0002-6317-0811","observed_orcids":["https://orcid.org/0000-0002-6317-0811"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J Gleich","raw_affiliation_strings":["Departments of Immunology and Medicine, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Immunology and Medicine, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080324106","display_name":"Kristin M. Leiferman","orcid":"https://orcid.org/0000-0001-9421-0575","observed_orcids":["https://orcid.org/0000-0001-9421-0575"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin M Leiferman","raw_affiliation_strings":["Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":1.5315,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.80409499,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"112","issue":"5","first_page":"988","last_page":"994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.4465000033378601,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.4465000033378601,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.2363000065088272,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophil-granule-proteins","display_name":"eosinophil granule proteins","score":1.0},{"id":"https://openalex.org/keywords/eosinophil-cationic-protein","display_name":"eosinophil cationic protein","score":0.996999979019165},{"id":"https://openalex.org/keywords/eosinophil-derived-neurotoxin","display_name":"eosinophil-derived neurotoxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eosinophil-peroxidase","display_name":"eosinophil peroxidase","score":1.0},{"id":"https://openalex.org/keywords/major-basic-protein","display_name":"major basic protein","score":1.0},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.5590000152587891},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.6169999837875366},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C2778081958","wikidata":"https://www.wikidata.org/wiki/Q14906786","display_name":"Eosinophil peroxidase","level":4,"score":0.8822764158248901},{"id":"https://openalex.org/C2910475272","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil Granule Proteins","level":5,"score":0.8786662817001343},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.816310703754425},{"id":"https://openalex.org/C60483475","wikidata":"https://www.wikidata.org/wiki/Q1886099","display_name":"Major basic protein","level":4,"score":0.7950083017349243},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7764672040939331},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6337963342666626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4912382960319519},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4882510006427765},{"id":"https://openalex.org/C2910759140","wikidata":"https://www.wikidata.org/wiki/Q3800087","display_name":"Pyrilamine","level":4,"score":0.48309946060180664},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47618189454078674},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.467756986618042},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.373396635055542},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3296757638454437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32584771513938904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20219337940216064},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2010430097579956},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07182255387306213},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.06340929865837097},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011738","descriptor_name":"Pyrilamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047208","descriptor_name":"Eosinophil-Derived Neurotoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047209","descriptor_name":"Eosinophil Peroxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jaci.2003.08.028","doi":"https://doi.org/10.1016/j.jaci.2003.08.028","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2003.08.028","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:14610493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14610493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1189270403","display_name":null,"funder_award_id":"AI 34577","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3048955356","display_name":"ASTHMA AND ALLERGIC DISEASE CENTER PROGRAM GRANT","funder_award_id":"5p50ai011483-13","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4981684286","display_name":null,"funder_award_id":"AI 09728","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G515077985","display_name":null,"funder_award_id":"AI-11483","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5265033475","display_name":"Training Grant in Allergic Diseases","funder_award_id":"T32AI007047","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G659161913","display_name":null,"funder_award_id":"AI07047","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W312641347","https://openalex.org/W1488555984","https://openalex.org/W1507892700","https://openalex.org/W1549023602","https://openalex.org/W1558693276","https://openalex.org/W1561235434","https://openalex.org/W1562857066","https://openalex.org/W1583258274","https://openalex.org/W1606940682","https://openalex.org/W1671018864","https://openalex.org/W1797234058","https://openalex.org/W1943694240","https://openalex.org/W1964102602","https://openalex.org/W1975824793","https://openalex.org/W1979355707","https://openalex.org/W1980534733","https://openalex.org/W1982493133","https://openalex.org/W1984137925","https://openalex.org/W1987823557","https://openalex.org/W1991046721","https://openalex.org/W1995883493","https://openalex.org/W1996693481","https://openalex.org/W2006641366","https://openalex.org/W2008353413","https://openalex.org/W2050967598","https://openalex.org/W2056100133","https://openalex.org/W2063196721","https://openalex.org/W2079041573","https://openalex.org/W2080272330","https://openalex.org/W2085328825","https://openalex.org/W2089961321","https://openalex.org/W2090639986","https://openalex.org/W2093548393","https://openalex.org/W2112945537","https://openalex.org/W2113169680","https://openalex.org/W2130671398","https://openalex.org/W2136239275","https://openalex.org/W2138251267","https://openalex.org/W2138422023","https://openalex.org/W2142587628","https://openalex.org/W2145079214","https://openalex.org/W2155494562","https://openalex.org/W2156309972","https://openalex.org/W2158077048","https://openalex.org/W2160696897","https://openalex.org/W2166344498","https://openalex.org/W2166592629","https://openalex.org/W2187357944","https://openalex.org/W2320683364","https://openalex.org/W2398060890","https://openalex.org/W2417122831","https://openalex.org/W2432533224","https://openalex.org/W3134983447","https://openalex.org/W3134986606","https://openalex.org/W4285719527","https://openalex.org/W4361798048"],"related_works":["https://openalex.org/W2154313292","https://openalex.org/W2118731971","https://openalex.org/W2338907343","https://openalex.org/W1561235434","https://openalex.org/W2470180731","https://openalex.org/W2063953755","https://openalex.org/W2063923767","https://openalex.org/W2025823378","https://openalex.org/W641243853","https://openalex.org/W2416226571"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}