{"id":"https://openalex.org/W615663449","doi":null,"title":"Adrenergic control of proteolysis in brown adipocytes","display_name":"Adrenergic control of proteolysis in brown adipocytes","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W615663449","mag":"615663449"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-08132012-112809","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/etd-08132012-112809","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110141161","display_name":"Banafsheh Moazed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Banafsheh Moazed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110141161"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brown-adipocytes","display_name":"brown adipocytes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/adrenergic-regulation","display_name":"adrenergic regulation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lysosomal-proteolysis","display_name":"lysosomal proteolysis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mitochondrial-protein-degradation","display_name":"mitochondrial protein degradation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9850000143051147},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/preadipocyte-differentiation","display_name":"preadipocyte differentiation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.7489455938339233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38848888874053955},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3754349946975708},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32332879304885864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31633812189102173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1857258379459381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15764692425727844},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11251777410507202}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/etd-08132012-112809","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/etd-08132012-112809","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/etd-08132012-112809","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/etd-08132012-112809","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:615663449","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/handle/10388/etd-08132012-112809","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1548927886","https://openalex.org/W2072647859","https://openalex.org/W2310475159","https://openalex.org/W2086732531","https://openalex.org/W2460214837","https://openalex.org/W1990085938","https://openalex.org/W336729164","https://openalex.org/W2279619540","https://openalex.org/W2260800911","https://openalex.org/W4403851803"],"abstract_inverted_index":{"Brown":[0,224],"adipose":[1],"tissue":[2,8,36],"(BAT)":[3],"is":[4,57,95],"a":[5,60,193,227],"sympathetically":[6],"innervated":[7],"involved":[9],"in":[10,22,35,77,86,109,133,208,222],"control":[11,65,245],"of":[12,40,63,80,92,117,131,139,156,172,175,189,196,202,211,217,238,246,254,259],"thermoregulation":[13],"and":[14,32,44,66,128,141],"energy":[15,28],"balance.":[16],"BAT":[17,70,81],"growth":[18],"and/or":[19],"atrophy":[20,37,82,220],"occur":[21],"response":[23],"to":[24,58,97,112],"the":[25,49,64,67,90,129,149,187,200,243],"need":[26],"for":[27,52,230],"dissipation.":[29],"Fasting,":[30],"deacclimation,":[31],"lactation":[33],"result":[34],"by":[38,121,168,257],"loss":[39,91,201,253],"cells,":[41],"mitochondrial":[42,93,180,190],"proteins,":[43],"uncoupling":[45],"protein":[46,143,232],"1":[47],"(UCP1),":[48],"molecular":[50],"basis":[51],"thermogenesis.":[53],"The":[54,137,236],"overall":[55],"objective":[56],"gain":[59,226],"better":[61],"understanding":[62],"mechanisms":[68],"underlying":[69],"atrophy.":[71],"Specific":[72],"objectives":[73],"are:":[74],"(1)":[75],"whether":[76,89],"vivo":[78],"patterns":[79],"can":[83],"be":[84],"reproduced":[85],"culture.":[87],"(2)":[88],"proteins":[94,191],"due":[96],"lysosomal":[98,160,231,239],"proteolysis":[99,101],"or":[100],"within":[102],"mitochondria,":[103],"under":[104,242],"adrenergic":[105],"influence.":[106],"Mouse":[107],"pre-adipocytes":[108,225],"culture":[110],"differentiated":[111],"brown":[113,212,218],"adipocytes.":[114],"Increased":[115],"expression":[116],"UCP1":[118,151,176,203,255],"was":[119,125,153,162,165],"induced":[120],"norepinephrine":[122],"(NE).":[123],"NE":[124,185,205],"then":[126],"removed":[127],"pattern":[130],"change":[132],"thermogenic":[134],"capacity":[135,229],"evaluated.":[136],"number":[138],"cells":[140],"their":[142],"content":[144,152],"did":[145],"not":[146,166],"change,":[147],"whereas":[148],"cell":[150],"decreased.":[154],"Expression":[155],"cathepsin":[157],"D":[158],"(a":[159],"protease)":[161],"differentiation-dependent,":[163],"but":[164],"affected":[167],"NE.":[169],"Direct":[170],"estimates":[171],"turnover":[173],"rates":[174],"as":[177,179,192,248],"well":[178],"translation":[181],"products":[182],"indicated":[183],"that":[184],"reduces":[186],"degradation":[188,233],"whole.":[194],"Addition":[195],"autophagic":[197],"blockers":[198],"reduced":[199],"upon":[204],"removal.":[206],"Therefore,":[207],"vitro":[209],"cultures":[210],"adipocytes":[213],"mimic":[214],"some":[215],"aspects":[216],"fat":[219],"seen":[221],"vivo.":[223],"large":[228],"during":[234],"differentiation.":[235],"activity":[237],"proteases":[240],"seems":[241],"inhibitory":[244],"NE,":[247],"its":[249],"removal":[250],"causes":[251],"net":[252],"preventable":[256],"inhibitors":[258],"autophagy.":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}