{"id":"https://openalex.org/W615234879","doi":null,"title":"DNA methylation in the placenta and in cancerwith special reference to folate transporting genes","display_name":"DNA methylation in the placenta and in cancerwith special reference to folate transporting genes","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W615234879","mag":"615234879"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:oru-32599","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-32599","pdf_url":"https://oru.diva-portal.org/smash/get/diva2:668943/FULLTEXT02","source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://oru.diva-portal.org/smash/get/diva2:668943/FULLTEXT02","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086396822","display_name":"Sanja A. Farkas","orcid":"https://orcid.org/0000-0002-0418-7779","observed_orcids":["https://orcid.org/0000-0002-0418-7779"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sanja A. Farkas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0418-7779","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086396822"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":1.0},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.7519999742507935},{"id":"https://openalex.org/keywords/folate-receptor-alpha","display_name":"folate receptor alpha","score":0.9649999737739563},{"id":"https://openalex.org/keywords/proton-coupled-folate-transporter","display_name":"proton-coupled folate transporter","score":0.9929999709129333},{"id":"https://openalex.org/keywords/rfc1","display_name":"RFC1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9350000023841858},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mismatch-repair-genes","display_name":"mismatch repair genes","score":0.7239999771118164},{"id":"https://openalex.org/keywords/gpc6","display_name":"GPC6","score":0.7300000190734863},{"id":"https://openalex.org/keywords/dclre1c","display_name":"DCLRE1C","score":0.9990000128746033},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dna-repair-pathways","display_name":"DNA repair pathways","score":0.6520000100135803},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8026546239852905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7081224918365479},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6311339139938354},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5954020023345947},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.523182213306427},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.49231159687042236},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4752069413661957},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4631933569908142},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4473138749599457},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.4120934009552002},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40500375628471375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3725524842739105},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15119600296020508}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:oru-32599","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-32599","pdf_url":"https://oru.diva-portal.org/smash/get/diva2:668943/FULLTEXT02","source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:615234879","doi":null,"is_oa":false,"landing_page_url":"https://oru.diva-portal.org/smash/get/diva2:668943/FULLTEXT02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:oru-32599","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-32599","pdf_url":"https://oru.diva-portal.org/smash/get/diva2:668943/FULLTEXT02","source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W615234879.pdf","grobid_xml":"https://content.openalex.org/works/W615234879.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W2695383","https://openalex.org/W18890217","https://openalex.org/W25019841","https://openalex.org/W35229587","https://openalex.org/W41070928","https://openalex.org/W41559365","https://openalex.org/W54067915","https://openalex.org/W70318014","https://openalex.org/W72978705","https://openalex.org/W73005209","https://openalex.org/W76011220","https://openalex.org/W76023734","https://openalex.org/W79993163","https://openalex.org/W80384450","https://openalex.org/W81034644","https://openalex.org/W96041335","https://openalex.org/W115499559","https://openalex.org/W117600137","https://openalex.org/W122797940","https://openalex.org/W123256624","https://openalex.org/W136521892","https://openalex.org/W149338814","https://openalex.org/W150507068","https://openalex.org/W165899842","https://openalex.org/W170805287","https://openalex.org/W180423899","https://openalex.org/W182554932","https://openalex.org/W198276087","https://openalex.org/W198680231","https://openalex.org/W201022119","https://openalex.org/W205711943","https://openalex.org/W210114439","https://openalex.org/W215703139","https://openalex.org/W221292636","https://openalex.org/W227504219","https://openalex.org/W245958178","https://openalex.org/W292268073","https://openalex.org/W304904452","https://openalex.org/W349544356","https://openalex.org/W418526515","https://openalex.org/W438025326","https://openalex.org/W560614835","https://openalex.org/W565651545","https://openalex.org/W567221925","https://openalex.org/W569561805","https://openalex.org/W572769254","https://openalex.org/W580075088","https://openalex.org/W589850661","https://openalex.org/W592764749","https://openalex.org/W595836046","https://openalex.org/W596025320","https://openalex.org/W621494807","https://openalex.org/W627159260","https://openalex.org/W635132159","https://openalex.org/W637191880","https://openalex.org/W642304797","https://openalex.org/W652536948","https://openalex.org/W658036546","https://openalex.org/W823162085","https://openalex.org/W1483205653","https://openalex.org/W1502827089","https://openalex.org/W1510695270","https://openalex.org/W1554775680","https://openalex.org/W1563400903","https://openalex.org/W1591935558","https://openalex.org/W1596832726","https://openalex.org/W1597619535","https://openalex.org/W1626795338","https://openalex.org/W1630782554","https://openalex.org/W1658127082","https://openalex.org/W1678558584","https://openalex.org/W1824889457","https://openalex.org/W1938653536","https://openalex.org/W1940705123","https://openalex.org/W1944014095","https://openalex.org/W1963744267","https://openalex.org/W1966352905","https://openalex.org/W1967778225","https://openalex.org/W1968463372","https://openalex.org/W1973983045","https://openalex.org/W1974450480","https://openalex.org/W1974798829","https://openalex.org/W1975468068","https://openalex.org/W1976413584","https://openalex.org/W1976787939","https://openalex.org/W1979392717","https://openalex.org/W1983476428","https://openalex.org/W1989663044","https://openalex.org/W1990016987","https://openalex.org/W1990430883","https://openalex.org/W1993115563","https://openalex.org/W1994473465","https://openalex.org/W2000874199","https://openalex.org/W2003078066","https://openalex.org/W2005025180","https://openalex.org/W2006752058","https://openalex.org/W2007065267","https://openalex.org/W2008420899","https://openalex.org/W2009940298","https://openalex.org/W2010691380","https://openalex.org/W2014852291","https://openalex.org/W2017502278","https://openalex.org/W2021109810","https://openalex.org/W2023452084","https://openalex.org/W2023519068","https://openalex.org/W2025660630","https://openalex.org/W2027212435","https://openalex.org/W2027426795","https://openalex.org/W2037160755","https://openalex.org/W2039097638","https://openalex.org/W2039276888","https://openalex.org/W2043033879","https://openalex.org/W2043179683","https://openalex.org/W2043746949","https://openalex.org/W2046509449","https://openalex.org/W2053213384","https://openalex.org/W2053278429","https://openalex.org/W2054444927","https://openalex.org/W2059027047","https://openalex.org/W2060080945","https://openalex.org/W2060796996","https://openalex.org/W2060988596","https://openalex.org/W2064117044","https://openalex.org/W2064190035","https://openalex.org/W2064381749","https://openalex.org/W2065751798","https://openalex.org/W2067935707","https://openalex.org/W2069477672","https://openalex.org/W2070123583","https://openalex.org/W2071154937","https://openalex.org/W2071618746","https://openalex.org/W2071715768","https://openalex.org/W2074448914","https://openalex.org/W2079302244","https://openalex.org/W2080620002","https://openalex.org/W2086320165","https://openalex.org/W2090395089","https://openalex.org/W2092076185","https://openalex.org/W2095727856","https://openalex.org/W2097778420","https://openalex.org/W2098021159","https://openalex.org/W2098374588","https://openalex.org/W2099343472","https://openalex.org/W2100489386","https://openalex.org/W2103547637","https://openalex.org/W2103953947","https://openalex.org/W2104283475","https://openalex.org/W2106352068","https://openalex.org/W2106482095","https://openalex.org/W2106541980","https://openalex.org/W2109108939","https://openalex.org/W2109621565","https://openalex.org/W2109892705","https://openalex.org/W2110340584","https://openalex.org/W2113508481","https://openalex.org/W2114912562","https://openalex.org/W2114970231","https://openalex.org/W2115444345","https://openalex.org/W2115824225","https://openalex.org/W2118258530","https://openalex.org/W2118362078","https://openalex.org/W2119226590","https://openalex.org/W2123174009","https://openalex.org/W2125154191","https://openalex.org/W2126769386","https://openalex.org/W2126864090","https://openalex.org/W2127585900","https://openalex.org/W2130172966","https://openalex.org/W2130380419","https://openalex.org/W2130658314","https://openalex.org/W2130907138","https://openalex.org/W2134039025","https://openalex.org/W2134555277","https://openalex.org/W2135157239","https://openalex.org/W2136568746","https://openalex.org/W2137146162","https://openalex.org/W2140149776","https://openalex.org/W2140535402","https://openalex.org/W2140682268","https://openalex.org/W2143796272","https://openalex.org/W2145226640","https://openalex.org/W2145753519","https://openalex.org/W2145912883","https://openalex.org/W2146148857","https://openalex.org/W2147377553","https://openalex.org/W2148521032","https://openalex.org/W2148708125","https://openalex.org/W2151605226","https://openalex.org/W2151962624","https://openalex.org/W2155461556","https://openalex.org/W2157183541","https://openalex.org/W2158217645","https://openalex.org/W2160704282","https://openalex.org/W2162697628","https://openalex.org/W2163314116","https://openalex.org/W2166186613","https://openalex.org/W2166632132","https://openalex.org/W2166663163","https://openalex.org/W2167501668","https://openalex.org/W2171490806","https://openalex.org/W2325417132","https://openalex.org/W2329888282","https://openalex.org/W2402968832"],"related_works":["https://openalex.org/W2014936297","https://openalex.org/W2034373463","https://openalex.org/W2157203835","https://openalex.org/W7133086538","https://openalex.org/W2032622444","https://openalex.org/W1484570329","https://openalex.org/W1986558627","https://openalex.org/W2128337419","https://openalex.org/W2951032633","https://openalex.org/W2103082218"],"abstract_inverted_index":{"DNA":[0,74,88,136,161,176,192,293],"methylation":[1,75,89,137,189,271,294],"is":[2,12],"an":[3],"epigenetic":[4,38],"mechanism":[5],"that":[6,43,97,187],"regulates":[7],"the":[8,45,59,63,86,100,104,110,132,141,160,175,191,216,231,256,267,273,289],"gene":[9,106,143],"transcription.":[10],"Folate":[11],"used":[13],"in":[14,76,91,99,114,135,140,174,182,190,201,211,230,234,277,295],"cellular":[15],"synthesis":[16],"of":[17,52,103,227,258,269,272,292],"methyl":[18],"groups,":[19],"nucleic":[20],"acids":[21],"and":[22,30,37,68,80,119,144,156,179,204,218,243,279,299],"amino":[23],"acids.":[24],"In":[25,129,221],"complex":[26],"diseases":[27],"like":[28],"cancer":[29,93,203,236,296],"neural":[31],"tube":[32],"defects":[33],"(NTD),":[34],"various":[35],"genetic":[36],"alterations":[39],"can":[40],"be":[41,71],"found":[42,96,186,225],"disrupt":[44],"normal":[46],"cell":[47],"function.":[48],"The":[49],"main":[50],"goals":[51],"this":[53,259],"thesis":[54,260,283],"were":[55,107],"to":[56,147,239],"analyze":[57],"whether":[58],"genes":[60,173,195,210,228,249,276],"responsible":[61],"for":[62,250],"folate":[64,274],"transport":[65,275],"(FOLR1,":[66],"PCFT,":[67],"RFC1)":[69],"could":[70],"regulated":[72],"by":[73],"placenta,":[77],"blood":[78,120],"leukocytes":[79,121],"colorectal":[81,92,130,183,202,212,280],"cancer.":[82,184,281],"We":[83,185],"also":[84,285],"addressed":[85],"genome-wide":[87],"changes":[90,98],"andcervical":[94],"cancer.We":[95],"methylated":[101,162],"fraction":[102,163],"RFC1":[105,111,142],"dependent":[108],"on":[109,172],"80G>A":[112],"polymorphism":[113],"placental":[115],"specimens":[116,237],"with":[117,124],"NTDs":[118],"from":[122],"subjects":[123],"high":[125],"homocysteine":[126],"(Paper":[127,152],"I).":[128],"cancer,":[131,213],"greatest":[133],"difference":[134],"was":[138,145,170,196],"observed":[139],"related":[146],"a":[148,165,198,262],"lower":[149],"protein":[150],"expression":[151],"II).In":[153],"Paper":[154,168,222],"III":[155,169],"IV":[157],"we":[158,205,224,244],"studied":[159],"using":[164],"high-density":[166],"array.":[167],"focused":[171],"repair":[177,194],"pathway":[178],"frequently":[180],"mutated":[181],"aberrant":[188],"mismatch":[193],"not":[197],"frequent":[199],"event":[200],"identified":[206,245,300],"five":[207],"candidate":[208,248],"biomarker":[209,303],"among":[214],"them":[215],"GPC6":[217],"DCLRE1C":[219],"genes.":[220,304],"IV,":[223],"hypomethylation":[226],"involved":[229],"immune":[232],"system":[233],"cervical":[235,241],"compared":[238],"healthy":[240],"scrapes":[242],"twenty":[246],"four":[247],"further":[251],"evaluation":[252],"ofclinical":[253],"value.In":[254],"conclusion,":[255],"work":[257,284],"filled":[261],"relevant":[263],"knowledge":[264],"gap":[265],"regarding":[266],"role":[268,291],"differential":[270],"NTD":[278],"This":[282],"provided":[286],"insights":[287],"into":[288],"functional":[290],"specific":[297],"pathways":[298],"potential":[301],"novel":[302]},"counts_by_year":[{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}