{"id":"https://openalex.org/W614598140","doi":"https://doi.org/10.2504/kds.54.305","title":"Involvement of Spinal Ca^<2+> Channels and Intracellular Signal Transducing System in Nitrous Oxide-induced Analgesia","display_name":"Involvement of Spinal Ca^<2+> Channels and Intracellular Signal Transducing System in Nitrous Oxide-induced Analgesia","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W614598140","doi":"https://doi.org/10.2504/kds.54.305","mag":"614598140"},"language":"en","primary_location":{"id":"doi:10.2504/kds.54.305","doi":"https://doi.org/10.2504/kds.54.305","is_oa":true,"landing_page_url":"http://doi.org/10.2504/kds.54.305","pdf_url":"https://www.jstage.jst.go.jp/article/kds/54/3/54_KJ00003278482/_pdf","source":{"id":"https://openalex.org/S6700441","display_name":"The Journal of the Kyushu Dental Society","issn_l":"0368-6833","issn":["0368-6833","1880-8719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697144","host_organization_name":"The Kyushu Dental Society","host_organization_lineage":["https://openalex.org/P4322697144"],"host_organization_lineage_names":["The Kyushu Dental Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Kyushu Dental Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/kds/54/3/54_KJ00003278482/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113737149","display_name":"Shiro Kasai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I200314755","display_name":"Kyushu Dental University","ror":"https://ror.org/03bwzch55","country_code":"JP","type":"education","lineage":["https://openalex.org/I200314755"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shiro Kasai","raw_affiliation_strings":["Department of Dental Anesthesiology Kyushu Dental College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Anesthesiology Kyushu Dental College","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I200314755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113737149"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I200314755"],"apc_list":null,"apc_paid":null,"fwci":0.2148,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50394302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"3","first_page":"305","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitrous-oxide","display_name":"nitrous oxide","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.7739999890327454},{"id":"https://openalex.org/keywords/n-type-calcium-channels","display_name":"N-type calcium channels","score":0.847000002861023},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9110000133514404},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.6330000162124634},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tail-flick-latency","display_name":"tail-flick latency","score":0.6830000281333923},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C2777573673","wikidata":"https://www.wikidata.org/wiki/Q905750","display_name":"Nitrous oxide","level":2,"score":0.8458077907562256},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5867506265640259},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.48943081498146057},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4627302885055542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44438886642456055},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.41719380021095276},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3509351909160614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3313975930213928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21199551224708557},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1940174102783203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08732447028160095},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2504/kds.54.305","doi":"https://doi.org/10.2504/kds.54.305","is_oa":true,"landing_page_url":"http://doi.org/10.2504/kds.54.305","pdf_url":"https://www.jstage.jst.go.jp/article/kds/54/3/54_KJ00003278482/_pdf","source":{"id":"https://openalex.org/S6700441","display_name":"The Journal of the Kyushu Dental Society","issn_l":"0368-6833","issn":["0368-6833","1880-8719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697144","host_organization_name":"The Kyushu Dental Society","host_organization_lineage":["https://openalex.org/P4322697144"],"host_organization_lineage_names":["The Kyushu Dental Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Kyushu Dental Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2504/kds.54.305","doi":"https://doi.org/10.2504/kds.54.305","is_oa":true,"landing_page_url":"http://doi.org/10.2504/kds.54.305","pdf_url":"https://www.jstage.jst.go.jp/article/kds/54/3/54_KJ00003278482/_pdf","source":{"id":"https://openalex.org/S6700441","display_name":"The Journal of the Kyushu Dental Society","issn_l":"0368-6833","issn":["0368-6833","1880-8719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697144","host_organization_name":"The Kyushu Dental Society","host_organization_lineage":["https://openalex.org/P4322697144"],"host_organization_lineage_names":["The Kyushu Dental Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Kyushu Dental Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W614598140.pdf","grobid_xml":"https://content.openalex.org/works/W614598140.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7145093339","https://openalex.org/W1996142513","https://openalex.org/W7208378838","https://openalex.org/W1998285701","https://openalex.org/W1986754758","https://openalex.org/W2135295743","https://openalex.org/W2043225310","https://openalex.org/W2089756815","https://openalex.org/W2325498427","https://openalex.org/W3042031408"],"abstract_inverted_index":{"Nitrous":[0],"oxide":[1],"(":[2,80,110,144,156,173,187,199],"N20":[3,59,86,102,136],")":[4,82,117,151,160,179,194,204],"has":[5],"a":[6,167],"potent":[7],"antirlociceptive":[8],"action":[9],"\uff0c":[10,35,138,180,241],"\u2191he":[11],"spinal":[12],"Ca2":[13,48,147,190,218],"\uff0b":[14,49,148,191,219],"channel":[15,149,192,220],"and":[16,33,51,66,195,221],"the":[17,44,47,52,106,133,153,213,225,229],"intracel\u4e14ular":[18],"signal":[19,54],"transducing":[20,55],"system":[21,56],"have":[22],"recently":[23],"been":[24],"suggestedto":[25],"play":[26],"an":[27],"important":[28],"role":[29],"in":[30,58,67,98,152,169,224,234],"pain":[31],"transmission":[32],"modulation":[34],"The":[36],"present":[37],"study":[38],"was":[39],"undertaken":[40],"to":[41,75,119],"evaluate":[42],"further":[43],"involvement":[45],"of":[46,127,135,228],"channels":[50],"intracellular":[53],"activity":[57,150,193],"analgesia":[60,235],"by":[61,162,166,237],"investigating":[62],"tail":[63,114],"-flick":[64,115],"latency":[65,116],"vitto":[68],"autoradiography":[69],"\uff0e":[70,101,131,208],"Wister":[71],"rats":[72],"were":[73],"exposed":[74],"either":[76],"70":[77,84],"\uff05":[78,85,89,111,121,164,178],"N2":[79],"contro1":[81],"or":[83],"with":[87,215],"30":[88,96,123],"02":[90],"for":[91],"2":[92],"hours":[93],"after":[94,125],"staying":[95],"minutes":[97,124],"plastic":[99],"box":[100],"produced":[103],"arlalgesia":[104],"\uff1a":[105,176],"percent":[107],"maximal":[108],"effect":[109],"MPE":[112],"\uff1b":[113],"increased":[118],"79":[120],"at":[122],"starting":[126],"N":[128,145,216,238],"\uff0cO":[129,239],"inhalation":[130,240],"At":[132],"end":[134],"exposure":[137],"1251":[139],"\u4e00":[140],"\u03c9":[141],"CgTx":[142],"binding":[143,172,186,198],"type":[146,189,217],"spiral":[154,230],"cord":[155,231],"Rexed":[157],"I":[158],"-H":[159],"decreased":[161,168],"20":[163],"accompanied":[165],"3H":[170,182,196],"-forskolin":[171],"adenylate":[174,222],"cyclase":[175,223],"22":[177],"while":[181],"-PN":[183],"200":[184],"-110":[185],"L":[188],"-GTP":[197],"G":[200],"-prote":[201],"\u6b63":[202],"n":[203],"did":[205],"not":[206],"changed":[207],"These":[209],"results":[210],"suggest":[211],"that":[212],"interactions":[214],"dorsal":[226],"horn":[227],"are":[232],"involved":[233],"induced":[236]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}