{"id":"https://openalex.org/W61430384","doi":null,"title":"Functional and metagenomic analysis of the human tongue dorsum using phage display","display_name":"Functional and metagenomic analysis of the human tongue dorsum using phage display","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W61430384","mag":"61430384"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18512","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18512/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022573513","display_name":"Samantha Easton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samantha Easton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022573513"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.765999972820282},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.8519999980926514},{"id":"https://openalex.org/keywords/phage-display-library","display_name":"phage display library","score":0.8209999799728394},{"id":"https://openalex.org/keywords/metagenomic-dna","display_name":"metagenomic DNA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.6710000038146973},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bsa","display_name":"BSA","score":0.5220000147819519},{"id":"https://openalex.org/keywords/affinity-selection","display_name":"affinity selection","score":0.4959999918937683},{"id":"https://openalex.org/keywords/16s-rrna-gene-diversity","display_name":"16S rRNA gene diversity","score":0.843999981880188}],"concepts":[{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.8454414010047913},{"id":"https://openalex.org/C108944566","wikidata":"https://www.wikidata.org/wiki/Q1524510","display_name":"Panning (audio)","level":4,"score":0.795846700668335},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.7319121360778809},{"id":"https://openalex.org/C10079403","wikidata":"https://www.wikidata.org/wiki/Q424475","display_name":"Phagemid","level":5,"score":0.6858310699462891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6041954755783081},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4812450110912323},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.4797893166542053},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4637395143508911},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43508633971214294},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.41007646918296814},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3497248888015747},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17688214778900146},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.14187273383140564},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1349647343158722},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C124913957","wikidata":"https://www.wikidata.org/wiki/Q1232548","display_name":"Zoom","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18512","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18512/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:61430384","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/18512/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":152,"referenced_works":["https://openalex.org/W169269219","https://openalex.org/W1255640785","https://openalex.org/W1500331881","https://openalex.org/W1505461764","https://openalex.org/W1523908218","https://openalex.org/W1527241561","https://openalex.org/W1533381682","https://openalex.org/W1575036214","https://openalex.org/W1589409035","https://openalex.org/W1591896176","https://openalex.org/W1591942886","https://openalex.org/W1623295381","https://openalex.org/W1791999417","https://openalex.org/W1792229740","https://openalex.org/W1855509646","https://openalex.org/W1907872891","https://openalex.org/W1955252499","https://openalex.org/W1964871486","https://openalex.org/W1966885403","https://openalex.org/W1968189773","https://openalex.org/W1969886111","https://openalex.org/W1970011982","https://openalex.org/W1970287311","https://openalex.org/W1970356980","https://openalex.org/W1970396767","https://openalex.org/W1972167942","https://openalex.org/W1972187895","https://openalex.org/W1982738606","https://openalex.org/W1991572260","https://openalex.org/W1992587080","https://openalex.org/W1992943660","https://openalex.org/W1993607801","https://openalex.org/W1995712383","https://openalex.org/W1995848683","https://openalex.org/W1997271047","https://openalex.org/W2004310044","https://openalex.org/W2005421221","https://openalex.org/W2007828684","https://openalex.org/W2008366266","https://openalex.org/W2009659777","https://openalex.org/W2011084061","https://openalex.org/W2011261569","https://openalex.org/W2011318746","https://openalex.org/W2011826751","https://openalex.org/W2012784177","https://openalex.org/W2013844532","https://openalex.org/W2017646214","https://openalex.org/W2019094601","https://openalex.org/W2021522529","https://openalex.org/W2022366078","https://openalex.org/W2025019766","https://openalex.org/W2025775702","https://openalex.org/W2026128357","https://openalex.org/W2026585683","https://openalex.org/W2027657428","https://openalex.org/W2031154947","https://openalex.org/W2031938605","https://openalex.org/W2040641243","https://openalex.org/W2041335890","https://openalex.org/W2042693949","https://openalex.org/W2045702474","https://openalex.org/W2046151407","https://openalex.org/W2047074561","https://openalex.org/W2050544751","https://openalex.org/W2054872543","https://openalex.org/W2057759034","https://openalex.org/W2057802960","https://openalex.org/W2057965171","https://openalex.org/W2059005097","https://openalex.org/W2060101911","https://openalex.org/W2061077498","https://openalex.org/W2061750017","https://openalex.org/W2061916904","https://openalex.org/W2063233948","https://openalex.org/W2068687524","https://openalex.org/W2069146737","https://openalex.org/W2069594417","https://openalex.org/W2069616003","https://openalex.org/W2070360032","https://openalex.org/W2070791176","https://openalex.org/W2075716829","https://openalex.org/W2076792045","https://openalex.org/W2080631871","https://openalex.org/W2084082403","https://openalex.org/W2084202098","https://openalex.org/W2090713266","https://openalex.org/W2093483615","https://openalex.org/W2093830129","https://openalex.org/W2094977427","https://openalex.org/W2096566061","https://openalex.org/W2097066978","https://openalex.org/W2097808005","https://openalex.org/W2098561534","https://openalex.org/W2098774480","https://openalex.org/W2100229346","https://openalex.org/W2101345437","https://openalex.org/W2103805072","https://openalex.org/W2105954277","https://openalex.org/W2106464940","https://openalex.org/W2109132453","https://openalex.org/W2110318148","https://openalex.org/W2112412292","https://openalex.org/W2113601822","https://openalex.org/W2115443756","https://openalex.org/W2116026879","https://openalex.org/W2117017850","https://openalex.org/W2119237104","https://openalex.org/W2123937142","https://openalex.org/W2124637227","https://openalex.org/W2125312485","https://openalex.org/W2125603375","https://openalex.org/W2125755185","https://openalex.org/W2126809954","https://openalex.org/W2127415562","https://openalex.org/W2128007276","https://openalex.org/W2128114769","https://openalex.org/W2131227009","https://openalex.org/W2131618998","https://openalex.org/W2131892542","https://openalex.org/W2132383729","https://openalex.org/W2134133524","https://openalex.org/W2134365852","https://openalex.org/W2142852675","https://openalex.org/W2144082229","https://openalex.org/W2144568881","https://openalex.org/W2144963203","https://openalex.org/W2145089143","https://openalex.org/W2146052711","https://openalex.org/W2147378425","https://openalex.org/W2147783737","https://openalex.org/W2150840120","https://openalex.org/W2156465688","https://openalex.org/W2158421363","https://openalex.org/W2160211110","https://openalex.org/W2161430581","https://openalex.org/W2161794223","https://openalex.org/W2162339585","https://openalex.org/W2162537107","https://openalex.org/W2162578061","https://openalex.org/W2164501001","https://openalex.org/W2166924822","https://openalex.org/W2167062509","https://openalex.org/W2167730457","https://openalex.org/W2169271627","https://openalex.org/W2170706168","https://openalex.org/W2176472482","https://openalex.org/W2183759441","https://openalex.org/W2314649741","https://openalex.org/W2372345645","https://openalex.org/W2418310681","https://openalex.org/W2419226793","https://openalex.org/W2616754551"],"related_works":["https://openalex.org/W1967955038","https://openalex.org/W4412659895","https://openalex.org/W1751207931","https://openalex.org/W3087752660","https://openalex.org/W7168031824","https://openalex.org/W3038753357","https://openalex.org/W2901105017","https://openalex.org/W4362634303","https://openalex.org/W2012915679","https://openalex.org/W2558550236"],"abstract_inverted_index":{"It":[0],"is":[1,26,99,118,161,175],"well":[2],"established":[3],"that":[4,115,278],"mixed":[5],"microbial":[6],"communities":[7],"contain":[8],"organisms":[9],"which":[10,58],"have":[11],"not":[12],"been":[13],"studied":[14],"by":[15,53,120,267],"conventional":[16],"culture-based":[17],"methods.":[18],"In":[19],"the":[20,62,73,91,121,126,136,142,196,202,208,233,270,293],"human":[21,40,63,74,183],"oral":[22,68],"cavity":[23],"this":[24,47,52,152,166,305],"number":[25],"estimated":[27],"at":[28],"around":[29],"50%.":[30],"Commensal":[31],"bacteria":[32],"develop":[33],"and":[34,46,66,82,123,139,158,174,222],"maintain":[35],"an":[36,100],"intimate":[37],"relationship":[38],"with":[39,171,269],"cells":[41],"without":[42],"triggering":[43],"proinflammatory":[44],"mechanisms":[45],"study":[48],"aims":[49],"to":[50,61,88,93,109,145,165,177,179,201,227,232,252,258],"explore":[51],"searching":[54],"for":[55,220],"bacterial":[56,147,172,180],"proteins":[57,144,149,173,215,302],"facilitate":[59],"binding":[60,148,223,229,301],"tongue":[64,75,294],"dorsum":[65,76,295],"wider":[67],"cavity.":[69],"Metagenomic":[70],"DNA":[71,108,117,255,281],"from":[72,189,307],"of":[77,106,141,162,204,216,236,272,298,311],"9":[78],"volunteers":[79],"was":[80,246,264,276],"extracted":[81],"a":[83,110,241,283,289,308],"phage":[84,122,127,237,262,284],"display":[85,98,238,263,285],"library":[86,239,259,286],"created,":[87],"our":[89],"knowledge":[90],"first":[92],"incorporate":[94],"metagenomic":[95,254,280],"DNA.":[96],"Phage":[97],"elegant":[101],"molecular":[102],"technique":[103,132],"involving":[104],"fusion":[105,143,214],"fragmented":[107],"phagemid":[111,212],"coat":[112],"protein,":[113],"such":[114,185],"inserted":[116],"encoded":[119],"displayed":[124],"on":[125],"surface.":[128],"The":[129],"affinity":[130,138],"selection":[131],"panning,":[133],"then":[134],"exploited":[135],"natural":[137],"specificity":[140],"identify":[146],"using,":[150],"in":[151,182,193,207,250,282,304],"case,":[153],"three":[154],"ligands:":[155],"IgA,":[156],"Fibronectin":[157],"BSA.":[159],"IgA":[160],"special":[163],"interest":[164,217],"group":[167],"as":[168,186],"it":[169,275],"interacts":[170],"poised":[176],"respond":[178],"numbers":[181],"secretions":[184],"saliva.":[187],"Proteins":[188],"panning":[190],"were":[191,198,218],"analysed":[192],"silico,":[194],"however,":[195],"majority":[197],"discarded":[199],"due":[200],"presence":[203],"stop":[205],"codons":[206],"protein":[209],"sequences.":[210],"Remaining":[211],"displaying":[213],"assessed":[219],"function":[221],"assays":[224],"carried":[225,248],"out":[226,249],"confirm":[228],"specificity.":[230],"Due":[231],"biased":[234],"nature":[235],"production,":[240],"16S":[242],"rRNA":[243],"gene":[244],"analysis":[245],"also":[247],"order":[251],"assess":[253],"diversity":[256],"prior":[257],"construction.":[260],"Because":[261],"used":[265],"successfully":[266],"colleagues":[268],"genomes":[271],"single":[273],"organisms,":[274],"believed":[277],"including":[279],"would":[287],"cast":[288],"wide":[290,309],"net":[291],"over":[292],"allowing":[296],"capture":[297],"many":[299],"more":[300],"occurring":[303],"environment":[306],"range":[310],"bacteria.":[312]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}