{"id":"https://openalex.org/W6136884","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","title":"Experimental model of the interplay between TBL1\u2010mediated activation and Siah\u20101\u2010induced poly\u2010ubiquitination of \u03b2\u2010catenin","display_name":"Experimental model of the interplay between TBL1\u2010mediated activation and Siah\u20101\u2010induced poly\u2010ubiquitination of \u03b2\u2010catenin","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W6136884","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","mag":"6136884"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.849.2","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010147592","display_name":"Yoana N. Dimitrova","orcid":"https://orcid.org/0000-0003-1547-5781","observed_orcids":["https://orcid.org/0000-0003-1547-5781"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoana N. Dimitrova","raw_affiliation_strings":["Biochemistry Center for Structural Biology Vanderbilt University Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Center for Structural Biology Vanderbilt University Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003392314","display_name":"Walter Chazin","orcid":"https://orcid.org/0000-0002-2180-0790","observed_orcids":["https://orcid.org/0000-0002-2180-0790"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J. Chazin","raw_affiliation_strings":["Biochemistry Center for Structural Biology Vanderbilt University Nashville TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Center for Structural Biology Vanderbilt University Nashville TN","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00039363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.07800000160932541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tbl1","display_name":"TBL1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/siah1","display_name":"SIAH1","score":1.0},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.9380000233650208},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8289999961853027},{"id":"https://openalex.org/keywords/scf-ubiquitin-ligase","display_name":"SCF ubiquitin ligase","score":0.8259999752044678},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.7979999780654907},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6539999842643738},{"id":"https://openalex.org/keywords/beta-catenin-degradation","display_name":"\u03b2-catenin degradation","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8361576199531555},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7781230211257935},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.645293653011322},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6163124442100525},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.562143862247467},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.5134673714637756},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.451340913772583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42022383213043213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3965708315372467},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2149045467376709},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20388689637184143},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1825750768184662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10071966052055359}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.849.2","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.849.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4726035980","display_name":"Structural Biology of U-box E3 Ubiquitin Ligases","funder_award_id":"R01GM075156","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970861248","https://openalex.org/W2054919679","https://openalex.org/W2102368462","https://openalex.org/W2016556888","https://openalex.org/W3110810129","https://openalex.org/W2007249806","https://openalex.org/W3195663446","https://openalex.org/W2043590168","https://openalex.org/W94091198","https://openalex.org/W2040788846"],"abstract_inverted_index":{"\u03b2\u2010catenin":[0,116,131],"is":[1,13,111,127],"a":[2,26,56,118,175],"critical":[3],"factor":[4],"in":[5,94,95,150],"the":[6,65,81,90,101,123,147,158,178,182],"Wnt":[7],"signaling":[8],"pathway":[9],"and":[10,18,71,84,89,139,153,156,166],"its":[11],"function":[12],"maintained":[14],"by":[15,46],"balancing":[16],"activation":[17,70],"degradation":[19],"signals.":[20],"TBL1":[21,32,40,83,126,138],"has":[22,33],"been":[23,35,87],"identified":[24],"as":[25,55,117],"transcriptional":[27],"co\u2010activator":[28],"of":[29,74,80,103,125,160,177],"\u03b2\u2010catenin.":[30,75,104],"Remarkably,":[31],"also":[34],"associated":[36],"with":[37,169],"an":[38],"SCF":[39],"\u2010like":[41],"E3":[42,58,120],"ubiquitin":[43],"ligase,":[44],"initiated":[45],"Siah\u20101":[47,52,85,110,140],"upon":[48],"DNA":[49],"damage,":[50],"while":[51],"itself":[53],"functions":[54],"potent":[57],"ligase.":[59,121],"Our":[60,105],"studies":[61],"focus":[62],"on":[63],"understanding":[64],"complex":[66],"interplay":[67],"between":[68],"TBL1\u2010mediated":[69],"Siah\u20101\u2010induced":[72],"poly\u2010ubiquitination":[73,102],"Protocols":[76],"for":[77,142],"recombinant":[78],"production":[79],"full\u2010length":[82],"have":[86,107,145,173],"developed":[88],"proteins":[91],"were":[92],"used":[93],"vitro":[96],"ubiquitination":[97],"assays":[98],"to":[99,113,129,135],"probe":[100],"results":[106],"shown":[108],"that":[109],"able":[112],"efficiently":[114],"poly\u2010ubiquitinate":[115],"simple":[119],"Interestingly,":[122],"addition":[124],"seen":[128],"inhibit":[130],"ubiquitination.":[132],"In":[133],"order":[134],"understand":[136],"how":[137],"compete":[141],"\u03b2\u2010catenin,":[143],"we":[144,172],"mapped":[146],"binding":[148],"domains":[149],"Siah\u20101\u2010\u03b2":[151],"\u2010catenin":[152],"TBL1\u2010\u03b2\u2010catenin":[154],"complexes":[155],"characterized":[157],"strength":[159],"their":[161],"interactions.":[162],"Combining":[163],"our":[164],"biochemical":[165],"biophysical":[167],"data":[168],"computational":[170],"approaches,":[171],"designed":[174],"model":[176],"molecular":[179],"events":[180],"regulating":[181],"functional":[183],"state":[184],"of\u03b2\u2010catenin.":[185],"Support:":[186],"NIH":[187],"5R01GM075156\u201004.":[188]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}